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Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysphonia

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 168-173页

作者： Richard Heyes Charles H.Adler Nan Zhang David g.Lott Stephen f.Bansberg Department of Otorhinolaryngology-Head and Neck Surgery Mayo Clinic ArizonaPhoenixArizonaUSA Department of Neurology Mayo Clinic ArizonaPhoenixArizonaUSA Department of Biostatistics and Bioinformatics Mayo Clinic ArizonaPhoenixArizonaUSA

Objectives: This study aims to analyze the impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysphonia (AdSD).Methods: A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed. Only patients who had received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two cohorts to analyze age, with an age of first treatment cutoff of 60 years. Patients were divided into male and female cohorts to analyze ***: The final analysis included 398 patients. The mean dose of BoNT-A per treatment was significantly higher in the younger cohort (4.4 vs. 3.9 units,p = 0.048). The mean maximal benefit was similar (72% vs. 70%,p = 0.48);however, the mean length of benefit was significantly shorter in younger patients (3.0 vs. 3.6 months,p gnificantly higher in the female cohort (4.2 vs. 3.6 units,p = 0.02). The mean maximal benefit was similar (69% vs. 75%,p = 0.58), as was the mean length of benefit (3.2 vs. 3.5 months,p = 0.11).Conclusions: This study suggests that age and sex influence BoNT-A dosing and outcomes in AdSD.

关键词： adductor age gender outcomes sex spasmodic dysphonia

Three Dimensional Modeling of Pulverized Coal Combustion in a 600 MW Corner fired Boiler

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Journal of Thermal Science 2000年第4期9卷 376-380页

作者： Sandro Dal-Secco (Department MfTT, E.D.f., 6 Quai Watier, 78400 Chatou, france) Departement MfTT E.D.F. Chatou France

The three-dimensional code ESTET developed at the LNH has been used to predict the reactive flow in a 600 MW coal fired boiler. Assuming a no-slip condition between the gas and the coal, the equations for a gas-particle mixture can be written. The pulverized coal particle size distribution is represented by a discrete number of particle size groups determined by the measured fineness distribution. The combustion models taking into account the pyrolysis of the particle and the heterogeneous combustion of char have been validated using intensive measurements performed on the 600 MW utility boiler. Heat fluxes were measured along the walls of the furnace and satisfactory agreement between computation and measurements has been achieved in terms of maximum flux location and heat flux intensity. Local measurements of velocities using LDV probe, gas temperature and gas species concentrations were performed in the vicinity of one burner and compared with the computed variables. Again we have observed a good agreement between the computations and the measurements in terms of jet penetration, temperature distribution, oxygen concentration and ash content.

关键词： mathematical model pulverized coal combustion corner-fired boiler.

Study of ~3He inelastic scattering on ^(13)C and ^(14)C at 37.9 MeV

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Chinese Physics C 2014年第3期38卷 22-25页

作者： M.N.El-Hammamy A.Attia f.A.El-Akkad A.M.Abdel-Moneim Physics Department Faculty of ScienceDamanhurDamanhur University Physics Department Faculty of ScienceAlexandriaAlexandria University

The differential cross sections of elastic and inelastic scattering of ~3He ions on ^（13）C and ^（14）C have been studied at an energy of 37.9 MeV with a double folding model based on M3Y-Reid effective nucleon-nucleon *** resulted parameters have been used for the standard Distorted Wave Born Approximation calculations of angular distributions corresponding to different excitations levels of ^（13）C and ^（14）C and deformation parameters have been deduced.

关键词： elastic scattering inelastic scattering double folding deformation parameter DWBA

Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements

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Journal of Otology 2015年第1期10卷 13-17页

作者： Misun Hwang Ryan Marovich Samuel S.Shin David Chi Barton f.Branstetter IV Department of Radiology University of Pittsburgh Medical Center Department of Otolaryngology University of Pittsburgh Medical Center Department of Neurosurgery University of Pittsburgh Medical Center Department of Otolaryngology Children's Hospital of Pittsburgh

Enlarged vestibular aqueduct(EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multidetector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. Seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients(ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements; ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss.

关键词： Enlarged vestibular aqueduct Hearing loss Computed

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老年病的药物治疗

老年病的药物治疗

Monte Carlo Simulation of first-Order Diffusion-Limited Reaction within Three-Dimensional Porous Pellets

作者： T.g.·贾奇(T.g. Judge) f.I.·凯尔德(f.I. Caird)

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Chinese Journal of Chemical Engineering 2003年第4期11卷 472-476页

作者：郭向云 and f.J.Keil State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 China Hamburg University of Technology Chemical Reaction Engineering Eissendorfer Str. 38 D-21071 HamburgGermany

The Monte Carlo method was employed to simulate diffusion and reaction processes within three-dimensional porous catalyst pellets. The porous pellets used were represented by a Menger sponge and a uniform-pore structure respectively. Results obtained from the fractal pellet showed an intermediate low-slope asymptote in the logarithmic plot of reaction rate and reaction probability. However, the low-slope one did not appear when the reaction occurred within the uniform pellet. Moreover, it was certified that the fractal structure not only generated a new asymptote, but also reduced diffusion resistance of reactants and products.

关键词： Monte Carlo method reaction-diffusion fractal structure low-slope asymptote concentration distribution

Effects of UV irradiation on cell viability,anthocyanin,and flavonoid contents of callus-cultured Malva neglecta cells

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Effects of UV irradiation on cell viability,anthocyanin,and ...

Processes governing the Retention of Phosphorus and Nitrogen in Nyashishi Wetland

International Conference on Life Science and Technology（ICLST 2011）

作者： f.Khatami f.ghanati Department of Plant biology Faculty of Biological ScienceTarbiat Modares University （TMU） TehranIran

Callus cultures from leaf explants of Malva neglecta were initiated in vitro,and their capacity to produce UV absorbing compounds was *** objective of this study was to evaluate the effects of UV-B and UV-C on UV absorbing compounds （e.g.,flavonoid,anthocyanin,tannin） of calluscultured Malva neglecta *** calli were exposed to different doses of UV irradiation as follows: 144,288,432,576,720,864,1296,and 1728 j/m2 for UV-B and 204,408,612,816,1020,1284,1836,and 2448 j/m2 for *** results showed that the flavonoids and anthocyanins were increased significantly,compared with the control *** addition,tannin such as catechin was increased by longer exposure to UV-C and UV-B,compared to *** viability percent of cells under UV treatment decreased,compared with those of the control cells.

关键词： Anthocyanin flavonoide Malva neglecta Tannin Ultraviolet irradiation

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Open Journal of Ecology 2014年第3期4卷 124-134页

作者： Baraka C. Sekadende John f. Machiwa fredrick f. Mwanuzi College of Engineering Science and Technology Dar es Salaam Tanzania Tanzania fisheries Research Institute Kigoma Tanzania University of Dar es Salaam Dar es Salaam Tanzania

One of the important functions of the wetland is the retention of catchment nutrients and improving lacustrine water quality. This study analyzed how much nutrients were retained in the Nyashishi wetland, southern part of Lake Victoria, and went further to analyze the processes which were responsible in the reduction of nutrients. Three major processes were analysed in this study, namely nutrients uptake by three macrophyte species (Eichhornia crassipes, Cyperus papyrus and Typha domingensis) dominating the Nyashishi wetland, nitrification and denitrification processes. The study demonstrated high nutrients retention especially phosphorus nutrients of which up to 98% were retained. In some occasions, particularly for nitrogen nutrients, there was 0% retention especially during wet season. In some other instances, the inflow exceeded the outflow meaning that, more nutrients were generated by the wetland itself. Among the three processes analyzed, nutrients uptaken by macrophytes were more efficient in reducing nutrients in wetland water. Biological nitrification and denitrification which are believed to be the major pathway for ammonia removal in both natural and constructed wetlands were less important in this study. Among the macrophyte species, Eichhornia crassipes demonstrated higher uptake rate than the other two species possibly due to its high turnover rate. This ability can be exploited in removing excess nutrients from runoff by frequent harvesting of the mature plants.

关键词： Phosphorus Nitrogen Nitrification Denitrification Nutrients Uptake

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金属真空弧离子源引出强流离子束的数值模拟

核技术 2006年第2期29卷 97-101页

作者：向伟 Spdtke P Hollinger R galonska M Heymach f 中国工程物理研究院电子工程研究所绵阳621900 gesellschaft für Schwerionenforschung mbH-gSI

为了引出更高强度、更高亮度的铀离子束,以满足重离子研究中心(gesellschaft fur Schwerionenforschung mbH,gSI)重离子同步加速器的需求,本文用三维的计算机程序KOBRA3-INP对金属真空弧离子源(Metal vapor vacuum arc ion source,MEVVA)引出强流铀离子束在引出系统和后加速系统中的动力学特性进行了研究,讨论了离子源发射束流密度对引出束性能的影响。结果表明,束流损失主要发生在引出系统和后加速系统之间的漂移区;在假设漂移区束流被空间电荷中和的情况下,模拟结果和实验结果符合;在发射束流密度为180-230 mA／cm2范围内,经后加速的束流强度变化不大。

关键词：金属真空弧离子源强流铀离子束后加速系统数值模拟