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Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats

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Journal of Integrative Medicine 2021年第3期19卷 243-250页

作者： f.dele ntchapda fernand C.Tchatchouang David Miaffo Barthelemy Maidadi Lorella Vecchio Rodrigue E.Talla Christian Bonabe Paul f.Seke Etet Theophile Dimo Department of Biological Sciences University of NgaoundereNgaoundereAdamawa RegionCameroon Department of Life and Earth Sciences Higher Teachers’Training CollegeUniversity of MarouaExtreme North RegionCameroon Center for Sustainable Health and Development GarouaNorth RegionCameroon Department of Physiological Sciences and Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of NgaoundereGarouaNorth RegionCameroon Department of Animal Biology and Physiology University of Yaoundé1YaoundeCentre RegionCameroon

Objective:Ipomoea batatas(L.)*** a food plant used in African traditional medicine to treat cardiovascular diseases and related *** assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of *** leaves in a rat model of diet-induced ***:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four ***,rats were treated once daily(per os)with *** extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four *** treatment,animals were observed for another four weeks and then *** were excised and processed for histopathological studies,and blood glucose level and lipid profile were ***:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard *** of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic ***:Our findings suggest that *** leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine.

关键词： Hypercholesterolemic rat Ipomoea batatas Atherosclerotic plaques High-density lipoprotein cholesterol Low-density lipoprotein cholesterol Very low-density lipoprotein cholesterol

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