检索结果-南通市图书馆

Phylogeny of Culex theileri virus flavivirus in Spain, Myanmar, Portugal and Turkey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2019年第5期12卷 216-223页

作者： Eleonora Cella Domenico Benvenuto Daniele Donati francesco Garilli Silvia Angeletti Stefano Pascarella Massimo Ciccozzi Unit of Medical Statistics and Molecular Epidemiology,University Campus bio-Medico of Rome School of Nursing,faculty of Medicine,Department of.biomedicine and Prevention,Tor Vergata University faculty of Medicine,University Campus bio-Medico of Rome Unit of Clinical Laboratory Science,University Campus bio-Medico of Rome Department of.biochemical Sciences'A.rossi fanelli',University of Rome'La Sapienza' Unit of Medical Statistics and Molecular Epidemiology University Campus Bio-Medico of Rome School of Nursing Faculty of Medicine Department of Biomedicine and Prevention Tor Vergata University faculty of Medicine University Campus Bio-Medico of Rome Unit of Clinical Laboratory Science University Campus Bio-Medico of Rome Department of.biochemical Sciences"A.rossi fanelli" University of Rome "La Sapienza"

Objective: To study the genetic diversity of Culex theileri flavivirus and the spread of this virus among Spain, Portugal and ***: A database consisting of 55 sequences of the NS5/3'UTR region of Culex theileri flavivirus group downloaded from GenBank were aligned and manual edited with *** est v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset was investigated by the likelihood mapping ***: The phylogenetic tree showed three *** sequences clusterd together with Turkish sequences, Spain and Portugal strains grouped together and two Turkish sequences grouped *** pressure analysis showed a moderate percentage of sites(22.5%) under pervasive negative selection and only 1% under pervasive positive *** sites subject to selective pressure in CTfV RdRp NS5 fragments have been located onto the predicted three-dimensional ***: Phylogenetic and evolutionary analysis can be an important tool for understanding the evolutionary impact of the probable contemporary existence between nonpathogenic and pathogenic flaviviruses among these vectors.

关键词： Culex virus flaviviridae Phylogenetic analysis Evolution

Synthesis and characterization of lanthanum bonded agar-carbomer hydrogel:a promising tool for biomedical research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2011年第3期29卷 259-264页

作者： filippo rossi Marco Santoro Tommaso Casalini Giuseppe Perale Dipartimento di Chimica Materialied Ingegneria Chimica"G.Natta"Politecnico di MilanoVia Mancinelli7

Agar-Carbomer（branched poly（acrylic acid）） hydrogel,an injectable bio-resorbable scaffold with a controlled nanostructure specifically designed for neural cell housing,was developed together with a new protocol for building three dimensional biohybrid cell/hydrogel *** order to overcome classic structural analysis inconveniences due to the high water amount,which affects instruments results and reliability,agar-Carbomer hydrogels were synthesized by microwave-assisted block copolymerization together with La3＋ *** glycol,glycerol and buffered saline solution were used as cross-linking agents and solvent,*** properties were not affected by the presence of lanthanum,and were checked via swelling and rheological ***,the presence of La3＋ within the polymeric network was characterized by thermogravimetric analysis,environmental scanning electron microscopy and fourier transformed infrared *** results showed that the rare earth presented uniform distribution in the hydrogel network due to the formation of chemical bonds after polymerization without being modified its luminescence emission spectrum that allowed hydrogel *** results made the obtained host-guest system a useful tool for analytical research studies concerning regenerative medical applications that could also be potentially taken up with in vivo experiments.

关键词： hydrogel acrylic acid agarose lanthanum luminescence drug delivery rare earths

Applying the electroforming process to bio-inspired architecture： The case of Castelbuono Estate Winery

在线全文

学校读者我要写书评

暂无评论

frontiers of Architectural Research 2013年第4期2卷 435-444页

作者： Stefano rossi Mauro Peilizzari Department of Industrial Engineering University of Trento Trento 38123 Italy ferrari f.lli Lunelli spa via del Ponte di Ravina 15 Trento 30123 Italy

Inaugurated in June 2012, the Carapace at Castelbuono Estate Winery in Italy is a highly interesting example of.biomorphic architecture. The structure, an artistic creation of world-renowned sculptor Arnatdo Pomodoro, is reminiscent of a tortoise shell that conveys a sense of protection： the Carapace structure guards wine barriques in the same way that the tortoise carapace protects the animal. Zoomorphic aspects are further exhibited by symbots on the roof, which remind observers of cuttlefish bone, a recurring element in the artistic production of Maestro Pomodoro. The roof was constructed by assembly of single copper plates with a rough surface in accordance with the design of the artist. Therefore, determining the appropriate production process was crucial. Etectroforming was selected as the method to achieve a challenging architectural goal.

关键词： bio-inspired architec-ture biomorphic structure Artistic design Copper electroforming

The role of green manure nitrogen use by corn and sugarcane crops in Brazil

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences 2013年第12期4卷 89-108页

作者： Edmilson José Ambrosano Heitor Cantarella Gláucia Maria Bovi Ambrosano f.bio Luis ferreira Dias fabrício rossi Paulo Cesar Ocheuze Trivelin Takashi Muraoka APTA Regional Center South PolePiracicabaBrazil APTA Agronomic Institute of Campinas(IAC)CampinasBrazil Department of Social Dentistry State University of Campinas(UNICAMP)PiracicabaBrazil College of Animal Science and food Engineering University of São Paulo(USP)PirassunungaBrazil Center for Nuclear Energy in Agriculture(CENA/USP) PiracicabaBrazil

Three assays were developed from April 3, 1995 to October 10, 2005. The work with corn was conducted in a greenhouse, using velvet bean (Mucuna aterrima) and sunn hemp (Crotalaria juncea) as green manure with 15N labeling of either shoots or roots, in two soils with contrasting textural classes. The mineralization of N from legume plants incorporated into the two soils was investigated too. This work included two green manures: velvet bean and sunn hemp, and the common bean (Phaseolus vulgaris) residues. Nitrogen from the velvet bean accounted for a greater proportion of the soil inorganic N;shoots were responsible for most of N accumulated. Common bean residues caused immobilization of inorganic N. The leguminous species added were intensively and promptly mineralized, preserving the soil native nitrogen. One hundred days after emergence of the corn, velvet bean provided higher accumulation of nitrogen in the soil, higher absorption by corn plants and accumulation in the aerial part. The green manure decomposition was more intense in the medium textured soil. In this soil, highest nitrogen losses were also observed. The sugarcane (Saccharum spp.) was cultivated for five years in the field and was harvested three times;15N recovery was evaluated in the first two harvests. The combination of inorganic fertilizer and green manure resulted in higher sugarcane yields than either N source applied separately;however, in the second cutting the yields were higher where sunn hemp was used than in plots with ammonium sulfate. The recovery of N by the first two consecutive harvests accounted for 19% to 21% of the N applied as sunn hemp and 46% to 49% of the N applied as ammonium sulfate. Very little inorganic N was present in the 0-40 cm soil layer with both N sources.

关键词： Saccharum spp. biological Nitrogen fixation 15N Isotope Technique N-Mineralization Mineral Nitrogen

Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2019年第1期39卷 318-333页

作者： Jean-françois rossi Patrice Céballos Zhao-Yang Lu Institut Sainte Catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance Département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie Cellulaire CHU Saint-Eloi34295 MontpellierFrance

Cancer cell growth is associated with immune surveillance ***,restoring the desired immune response against cancer cells remains a major therapeutic *** to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision *** of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative *** recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor *** aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse *** effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive *** these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body *** aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and *** precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.

关键词： Precision therapy Immunotherapy NK lymphocytes T-lymphocytes Dendritic cells Vaccination Cancer

Safety,immunogenicity,efficacy,and acceptability of COVID-19 vaccination in people with multiple sclerosis:a narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 284-288页

作者： fioravante Capone Mariagrazia rossi Alessandro Cruciani francesco Motolese f.bio Pilato Vincenzo Di Lazzaro Neurology Neurophysiology and Neurobiology UnitDepartment of MedicineCampus Bio-Medico of Rome UniversityRomeItaly

In the last two years,a new seve re acute res piratory syndrome coronavirus(SARS-CoV)infection has spread worldwide leading to the death of *** ccination represents the key factor in the global strategy against this pandemic,but it also poses several problems,especially for vulnerable people such as patients with multiple scle *** this review,we have briefly summarized the main findings of the safety,efficacy,and acceptability of Coronavirus Disease 2019(COVID-19)vaccination fo r multiple sclerosis *** the acceptability of COVID-19 vaccines has progressively increased in the last year,a small but significant part of patients with multiple sclerosis still has relevant concerns about vaccination that make them hesitant about receiving the COVID-19 ***,available data suggest that the COVID-19 vaccination is safe and effective in multiple scle rosis patients,even though some pharmacological treatments such as anti-CD20 therapies or sphingosine I-phosphate receptor modulato rs can reduce the immune response to ***,COVID-19 vaccination should be strongly recommended for people with multiple scle rosis and,in patients treated with anti-CD20 therapies and sphingosine I-phosphate receptor modulato rs,and clinicians should evaluate the appropriate timing for vaccine *** studies are necessary to understand the role of cellular immunity in COVID-19 vaccination and the possible usefulness of booster *** the other hand,it is mandatory to learn more about the reasons why people refuse *** would help to design a more effective communication campaign aimed at increasing vaccination coverage among vulnerable people.

关键词： COVID-19 multiple sclerosis SARS-CoV-2 vaccination vaccine

Evaluation of in vitro cell and blood compatibility and in vivo analgesic activity of plant-derived dietary supplements

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2019年第3期17卷 213-220页

作者： Stefania Lamponi Anna Maria Aloisi Claudia Bonechi Marco Consumi AlessANDro Donati Gemma Leone Claudio rossi Gabriella Tamasi Luana GhiANDai Ersilia ferrini Paolo fiorenzani Ilaria Ceccarelli Agnese Magnani Department of.biotechnology Chemistry and PharmacyUniversity of Siena Union B.I.O.S.r.l. Labor Chimica S.r.l. Department of Medicine Surgery and NeurosciencesUniversity of Siena

Objective: In vitro cell and blood compatibility of three dietary supplements, comprised of multiple plant extracts, Pneumo Go(PG), Green active(GA) and Equistasi(Eq), and their main component, the phytocomplex Matrix U.B.ò(Union bio S.r.l.)(M), were evaluated. Moreover, preliminary in vivo tests were performed on GA in order to assess its ability to reduce pain in an animal ***: Cell compatibility was determined using fibroblasts(NIH3T3) and primary adult human microvascular endothelial cells(HMVECad) and the neutral red uptake test. Blood compatibility was evaluated by analyzing blood parameters after incubation of the products with sodium citrate anticoagulated whole blood. Thrombin time was determined by adding thrombin to aliquots of human plasma containing the samples. Clotting time was revealed by an automatic coagulometer. The in vivo analgesic effect of GA was evaluated in Wistar rats using the formalin ***: M and PG reduced the percentage of viable NIH3T3 cells, indicating their interference in the cell cycle. GA and Eq stimulated fibroblast proliferation and neutralized the toxic effect of M. M and PG reduced HMVECad cell viability. GA and Eq did not affect cell viability as well as negative control. The hemocompatibility tests indicated that all the samples did not interfere with fibrinogen. The in vivo test carried out in male rats showed a significant analgesic effect of GA in all formalin-induced pain ***: No hemotoxicity and good cell compatibility were found for all the tested samples. GA and Eq were the best candidates for further biocompatibility testing. Moreover, GA reduced pain in the animal model.

关键词： Plant extracts fibroblasts Endothelial cells Cytotoxicity Cytocompatibility Haemocompatibility Pain reduction In vivo animal model

from Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of Transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

Magnetic resonance imaging differential diagnosis of brainstem lesions in children

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2016年第1期8卷 1-20页

作者： Carlo Cosimo Quattrocchi Yuri Errante Maria Camilla rossi Espagnet Stefania Galassi Sabino Walter Della Sala Bruno Bernardi Giuseppe fariello Daniela Longo Department of Medicine and Surgery Università Campus Bio-Medico di Roma Department of NESMOS Sant’ Andrea HospitalUniversità La Sapienza Unit of Neuroradiology Bambino Gesù Children’s Research Hospital IRCCS fatebenefratelli S. Pietro Hospital

Differential diagnosis of brainstem lesions,either isolated or in association with cerebellar and supra-tentorial lesions,can be challenging. Knowledge of the structural organization is crucial for the differential diagnosis and establishment of prognosis of pathologies with involvement of the brainstem. familiarity with the location of the lesions in the brainstem is essential,especially in the pediatric population. Magnetic resonance imaging(MRI) is the most sensitive and specific imaging technique for diagnosing disorders of the posterior fossa and,particularly,the brainstem. High magnetic static field MRI allows detailed visualization of the morphology,signal intensity and metabolic content of the brainstem nuclei,together with visualization of the normal development and myelination. In this pictorial essay we review the brainstem pathology in pediatric patients and consider the MR imaging patterns that may help the radiologist to differentiate among vascular,toxico-metabolic,infectiveinflammatory,degenerative and neoplastic processes. Helpful MR tips can guide the differential diagnosis: These include the location and morphology of lesions,the brainstem vascularization territories,gray and white matter distribution and tissue selective vulnerability.

关键词： Brainstem Pediatrics Differential diagnosis Neuroradiology Magnetic resonance