检索结果-南通市图书馆

Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model:Microarray analysis

World Journal of Gastroenterology 2021年第15期27卷 1616-1629页

作者： Monia Cecati Matteo Giulietti Alessandra righetti Berina Sabanovic francesco Piva Department of Specialistic Clinical and Odontostomatological Sciences Polytechnic University of MarcheAncona 60126Italy

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of death among cancers,it is characterized by poor prognosis and strong *** the PDAC microenvironment,stromal cells release different extracellular components,including *** CXCL12 is a chemokine promoting the communication between tumour and stromal *** different splicing isoforms of CXCL12 are known(α,β,γ,δ,ε,θ)but their role in PDAC has not yet been *** To investigate the specific role ofα,β,andγCXCL12 isoforms in PDAC *** We used hTERT-HPNE E6/E7/KRasG12D(Human Pancreatic Nestin-Expressing)cell line as a pancreatic pre-tumour model and exposed it to theα,β,andγCXCL12 *** altered expression profiles were assessed by microarray analyses and confirmed by Real-Time polymerase chain *** functional enrichment analyses have been performed by Enrichr tool to highlight Gene Ontology enriched *** addition,wound healing assays have been carried out to assess the phenotypic changes,in terms of migration ability,induced by theα,β,andγCXCL12 *** Microarray analysis of hTERT-HPNE cells treated with the three different CXCL12 isoforms highlighted that the expression of only a few genes was ***,theαandβisoforms showed an alteration in expression of different genes,whereasγisoform affected the expression of genes also common withαandβ***βisoform altered the expression of genes mainly involved in cell cycle *** addition,all isoforms affected the expression of genes assay confirmed that CXCL12 enhanced the migration ability of hTERT-HPNE *** the CXCL12 splicing isoforms,theγisoform showed higher induction of migration thanαandβ*** Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC ***,more investigations are needed to confirm these preliminary observations.

关键词： CXCL12 Splicing isoforms Pancreatic cancer Microarray Migration Wound healing assay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anomalies Observed in VLf and Lf Radio Signals on the Occasion of the Western Turkey Earthquake(M_(W)=5.7)on May 19,2011

引用

International Journal of Geosciences 2012年第4期3卷 856-865页

作者： Pier francesco Biagi f.avia righetti Tommaso Maggipinto Luigi Schiavulli Teresa Ligonzo Anita Ermini Iren Adelina Moldovan Adrian Septimiu Moldovan Hugo Goncalves Silva Mourad Bezzeghoud Michael E.Contadakis Dimitrios N.Arabelos Thomas D.Xenos Aydin Buyuksarac Department of Physics University of BariBariItaly Department of Industrial Engineering University of Tor VergataRomeItaly National Institute of Earth’s Physics Seismological DepartmentBucharestRomania AZEL-Designing Group S.R.L. BucharestRomania Geophysical Centre of Evora and Physics Department ECTUniversity of EvoraEvoraPortugal Department of Surveying&Geodesy University of ThessalonikiThessalonikiGreece Department of Geophysics Canakkale Onsekiz Mart UniversityCanakkaleTurkey

Since 2009 a network of VLf (20 - 60 kHz) and Lf (150 - 300 kHz) radio receivers is operating in Europe in order to study the disturbances produced by the earthquakes on the propagation of these signals. In 2011 the network was formed by nine receivers, of which three are located in Italy and one is in Austria, Greece, Portugal, Romania, Russia and Turkey. On May 19, 2001 an earthquake (Mw = 5.7) occurred in western Turkey, that is inside the “sensitive” area of the network. The radio data collected during April-May 2011 were studied using the Wavelet spectra, the Principal Component Analysis and the Standard Deviation trends as different methods of analysis. Evident anomalies were revealed both in the signals broadcasted by the TRT transmitter (180 kHz) located near Ankara and in a VLf signal coming from a transmitter located in Western Europe and collected by the receiver TUR of the network located in eastern Turkey. Evident precursor phases were pointed out. Some differences in the efficiency of the three analysis methods were revealed.

关键词： Earthquake Precursors European Radio Network Radio Signal Analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：