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Stressful life events,psychosocial health and general health in preschool children before age 4

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World Journal of Pediatrics 2023年第3期19卷 243-250页

作者： Jie Luo Amy van Grieken Shuang Zhou Yuan fang Hein raat Department of Public Health Erasmus MCDr.Molewaterplein 403015 GD RotterdamThe Netherlands Department of Maternal and Child Health School of Public HealthPeking UniversityBeijingChina

Background The impact of stressful life events(SLEs)in early childhood is often *** aimed to examine longitudinal associations between SLEs and psychosocial and general health in preschool *** Twelve SLEs occurring before the age of 24 months were assessed and categorized by frequency(no events,1-2 SLEs,and>2 SLEs)and overall tension(no events,low,and high)(n=1431).Psychosocial and general health were meas-ured three times at the age of 24,36 and 45 *** associations were examined by logistic regression models using generalized estimating equations to handle repeated *** Half(48.4%)of the families experienced SLEs,and 23.8%perceived high-tension SLEs before the children were aged 24 *** differences were observed in the association between SLEs and psychosocial *** to girls without SLEs,girls who experienced>2 SLEs[OR=3.31,95%confidence interval(CI)2.05-5.35]or high-tension SLEs(OR=3.01,95%CI 2.07-4.39)had higher odds of psychosocial problems from 24 to 45 *** odds ratios in boys were 2.10(95%CI 1.36-3.24)and 1.47(95%CI 1.06-2.03),***,only girls'risk of psychosocial problems increased after experiencing 1-2 SLEs(OR=2.15,95%CI 1.54-3.00)or low-tension SLEs(OR=1.90,95%CI 1.31-2.74).Regarding general health,children who experienced>2 SLEs(OR=1.96,95%CI 1.21-3.18)and high-tension SLEs(OR=1.60,95%CI 1.12-2.28)had higher odds of poor general health from 24 to 45 *** The findings emphasized that young children's psychosocial and general health can be impacted by experienc-ing SLEs in early *** and adequate support for families experiencing SLEs are needed to minimize the potential negative effect of SLEs on child health,particularly in girls.

关键词： Child health Preschool children Stressful life event

factors of heavy social media use among 13-year-old adolescents on weekdays and weekends

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World Journal of Pediatrics 2023年第4期19卷 378-389页

作者： Yue-Yue You Junwen Yang-Huang Hein raat Amy van Grieken The Generation R Study Group Erasmus Medical CenterDr.Molewaterplein 403015 GDRotterdamthe Netherlands Department of Public Health Erasmus Medical CenterDr.Molewaterplein 403015 GDRotterdamthe Netherlands

Background few studies have investigated which factors were related to adolescents'social media *** study aimed to evaluate which factors were associated with heavy social media use on weekdays and weekends among 13-year-old *** We analyzed data from 3727 children from the Generation R Study,a population-based cohort study in the *** of demographic factors(child age,sex,ethnic background,and family situation),socioeconomic posi-tion(parental educational level,parental employment status,and net household income),screen-based behaviors(computer playing and TV viewing),and the home environment(communication,supervision,and restriction)with adolescents'heavy social media use(≥2 hours/day)were assessed separately on weekdays and *** logistic regression analysis was *** The prevalence of heavy social media use was 37.7%on a weekday and 59.6%on a weekend *** a girl,liv-ing in a one-parent family,and more time spent playing on the computer were associated with heavy social media use on weekdays and weekends(all Pf heavy social media use(all Pfamily,or having a longer computer playing time were associated with heavy social media use on weekdays and *** studies are needed to understand the factors associated with heavy social media use and the impact of heavy social media use on child health.

关键词： School-aged children Screen-based behaviors Social-cultural home environment Social media use Socioeconomic position

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang f U Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

维普期刊数据库

Early detection of emotional and behavioral problems in childhood and integrated care pathways;application of the BITSEA and SDQ in The Netherlands,Europe

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Early detection of emotional and behavioral problems in chil...

Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review

心理疾患的早期识别与干预——第三届心理健康学术年会

作者： Hein raat Cathelijne Mieloo Ingrid Kruizinga Wilma Jansen Erasmus University Medical Center(dept.of Public Health)

The prevalence of psychosocial problems among preschool and school children is high in *** detection and treatment of emotional and behavioral problems may have a positive effect on ***,currently many cases are being *** has been strongly suggested to implement and to evaluate the test properties and impact of two parent questionnaires that may be helpful to assess emotional and behavioral problems of young *** are:

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Infectious Diseases of Poverty 2020年第2期9卷 90-91页

作者： Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein raat Huan Zhou West China School of Public Health and West China fourth Hospital Sichuan UniversityChengduChina 不详

Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December *** of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 *** World Health Organization has declared it a Public Health Emergency of International ***:A scoping review was conducted following the methodological framework suggested by Arksey and O'*** this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this *** research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the *** the findings and statements in this review regarding the outbreak are based on published information as listed in the ***:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese *** articles initially focused on causes,but over time there was an increase of the articles related to prevention and *** thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been *** symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and *** measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce *** date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive ***:There has been a rapid surge in research in response to the outbreak of *** t

关键词： COVID-19 Epidemiology Causes Prevention and control Review

Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo febrylian f.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

维普期刊数据库

friedrich Ackermann’s scientific research program

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Geo-Spatial Information Science 2023年第2期26卷 141-150页

作者： Wolfgang förstner Department of Photogrammetry UniversityBonnGermany

We sketch friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image *** research program,with its core being statistical estimation theory,has decisively influenced photogrammetry since the 60s,is still fully alive,and a challenge for today’s methods of image *** describe(1)Lakatos’concept of a scientific research program,with its negative and positive heuristics and(2)Ackermann’s research program,clearly made explicit in his PhD,with its mathematical model,the ability to predict theoretical precision and reliability,the potential of analyzing rigorous and approximate method,and the role of *** development of aerotriangulation,later augmented by image matching techniques,is closely connected to Ackermann’s successful attempts to integrate basic research and practical applications.

关键词： friedrich Ackermann scientific research program aerotriangulation image matching role of theory and application