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A promising resilience parameter for breeding:the use of weight and feed trajectories in growing pigs

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2363-2382页

作者： Wim Gorssen Carmen Winters Roel Meyermans Lea Chapard Katrijn Hooyberghs Steven Janssens Abe Huisman Katrijn peeters Han Mulder Nadine Buys Center for Animal Breeding and Genetics Department of BiosystemsKU LeuvenKasteelpark Arenberg 30–Box 24723001 LeuvenBelgium. Laboratory for Biological Psychology KU LeuvenTiensestraat 102‑Box 37143000 LeuvenBelgium. Hendrix Genetics P.O.Box 1145830 AC BoxmeerThe Netherlands. Research Animal Breeding and Genomics Wageningen UniversityP.O.Box 3386700 AH Wageningenthe Netherlands

Background Increasing resilience is a priority in modern pig breeding.Recent research shows that general resilience can be quantified via variability in longitudinal data.The collection of such longitudinal data on weight,feed intake and feeding behaviour in pigs has been facilitated by the development of technologies such as automated feeding stations.The goal of this study was to investigate resilience traits,which were estimated as deviations from longitudinal weight,feed intake and feeding behaviour data during the finishing phase.A dataset with 324,207 records between the age of 95 and 155 days on 5,939 Pietrain pigs with known pedigree and genomic information was used.We provided guidelines for a rigid quality control of longitudinal body weight data,as we found that outliers can significantly affect results.Gompertz growth curve analysis,linear modelling and trajectory analyses were used for quantifying resilience traits.Results To our knowledge,this is the first study comparing resilience traits from longitudinal body weight,feed intake and feeding behaviour data in pigs.We demonstrated that the resilience traits are lowly to moderately heritable for deviations in body weight(h2=2.9%–20.2%),in feed intake(9.4%–23.3%)and in feeding behaviour(16.2%–28.3%).Additionally,these traits have good predictive abilities in cross-validation analyses.Deviations in individual body weight and feed intake trajectories are highly correlated(rg=0.78)with low to moderate favourable genetic correlations with feed conversion ratio(rg=0.39–0.49).Lastly,we showed that some resilience traits,such as the natural logarithm of variances of observed versus predicted body weights(lnvarweight),are more robust to lower observation frequencies and are repeatable over three different time periods of the finishing phase.Conclusions Our results will help future studies investigating resilience traits and resilience-related traits.Moreover,our study provides first results on standardization of quality control and efficient data sampling fro

关键词： Deviations Genetics Gompertz growth curves Heritability Pigs Predictive ability Resilience Trajectory analysis

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Electronic properties of 2H-stacking bilayer MoS_(2)measured by terahertz time-domain spectroscopy

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frontiers of physics 2023年第5期18卷 161-171页

作者： Xingjia Cheng Wen Xu Hua Wen Jing Zhang Heng Zhang Haowen Li francois M.peeters Qingqing Chen Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Micro Optical Instruments Inc. Shenzhen 518118China School of Physics and Astronomy and Yunnan Key Laboratory of Quantum Information of Yunnan Province Yunnan UniversityKunming 650091China Department of Physics University of AntwerpGroenenborgerlaan 171B-2020 AntwerpenBelgium

Bilayer (BL) molybdenum disulfide (MoS_(2)) is one of the most important electronic structures not only in valleytronics but also in realizing twistronic systems on the basis of the topological mosaics in moiré superlattices. In this work, BL MoS_(2) on sapphire substrate with 2H-stacking structure is fabricated. We apply the terahertz (THz) time-domain spectroscopy (TDS) for examining the basic optoelectronic properties of this kind of BL MoS_(2). The optical conductivity of BL MoS_(2) is obtained in temperature regime from 80 K to 280 K. Through fitting the experimental data with the theoretical formula, the key sample parameters of BL MoS_(2) can be determined, such as the electron density, the electronic relaxation time and the electronic localization factor. The temperature dependence of these parameters is examined and analyzed. We find that, similar to monolayer (ML) MoS_(2), BL MoS_(2) with 2H-stacking can respond strongly to THz radiation field and show semiconductor-like optoelectronic features. The theoretical calculations using density functional theory (DfT) can help us to further understand why the THz optoelectronic properties of BL MoS_(2) differ from those observed for ML MoS_(2). The results obtained from this study indicate that the THz TDS can be applied suitably to study the optoelectronic properties of BL MoS_(2) based twistronic systems for novel applications as optical and optoelectronic materials and devices.

关键词： terahertz time-domain spectroscopy bilayer MoS_(2) optoelectronics

The fat and the furious:fatty acids fuel hyperproliferative germinal center B cells

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Cellular & Molecular Immunology 2020年第8期17卷 794-796页

作者： Rens peeters Annemiek B.van Spriel Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboudumcNijmegenThe Netherlands

The germinal center(GC)reaction is considered the cornerstone of our humoral immune response.Localized in specialized follicles inside secondary lymphoid organs,germinal center B cells(GCBCs)execute a pivotal task.following an infection,the number of GCBCs is rapidly expanded,and subsequently GCBCs differentiate into specialized antibody-secreting factories.This intricate process is driven by the positive selection of GCBCs via the B-cell receptor with the highest affinity for the respective antigen.During this period of extensive proliferation,GCBCs are among the fastest dividing cells in our body.It has been established that cell proliferation requires tremendous amounts of energy and building blocks.However,there remains a paucity of evidence to explain how proliferating GCBCs meet these metabolic demands.In their latest publication in Nature Immunology,Weisel et al.provided new insights that may have a far-reaching impact on the evolution of the immunometabolism field.

关键词： metabolism organs specialized

Safety of active auditory implants in magnetic resonance imaging

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Journal of Otology 2021年第3期16卷 185-198页

作者： Guy fierens Nina Standaert Ronald peeters Christ Glorieux Nicolas Verhaer Laboratory of Soft Matter and Biophysics Department of Physics and AstronomyKU LeuvenCelestijnenlaan 200DB-3001HeverleeBelgium Cochlear Technology Centre Schali€enhoevedreef 20IB-2800MechelenBelgium KU Leuven Department of NeurosciencesResearch Group Experimental OtorhinolaryngologyHerestraat 49B-3000LeuvenBelgium University Hospitals Leuven Department of OtorhinolaryngologyHerestraat 49B-3000LeuvenBelgium University Hospitals Leuven Department of RadiologyHerestraat 49B-3000LeuvenBelgium

Magnetic resonance imaging(MRI)has become the gold standard for the diagnosis of many pathologies.Using MRI in patients with auditory implants can however raise concerns due to mutual interactions between the implant and imaging device,resulting in potential patient risks.Several implant manufacturers have been working towards more MRI safe devices.Older devices are however often labelled for more stringent conditions,possibly creating confusion with patients and professionals.With this myriad of different devices that are implanted in patients for lifetimes of at least 20 years,it is crucial that both patients and professionals have a clear understanding of the safety of their devices.This work aims at providing an exhaustive overview on the MRI safety of active auditory implants.The available industry standards that are followed by manufacturers are outlined and an overview of the latest scientific developments focusing on the last five years is provided.In addition,based on the analysis of the adverse events reported to the food and Drug Administration(fDA)and in literature within the past ten years,a systematic review of the most commonly occurring issues for patients with auditory implants in the MRI environment is provided.Results indicate that despite the release of more MRI conditional active hearing implants on the market,adverse events still occur.An extensive overview is provided on the MRI safety of active auditory implants,aiming to increase the understanding of the topic for healthcare professionals and contribute to safer scanning conditions for patients.

关键词： MRI Safety Active hearing implant Adverse events Systematic review Cochlear implant Radiology

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Shedding Light on Large-Scale Chromatin Reorganization in Arabidopsis thaliana

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Molecular Plant 2012年第3期5卷 583-590页

作者： Martijn van Zanten federico Tessadori Anton J.M. peeters Paul fransz Molecular Plant Physiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands Department of Plant Breeding and Genetics Max Planck Institute for Plant Breeding Research Carl-von-Linne＇-weg 10 50829 Cologne Germany Cardiac Development and Genetics Group Hubrecht Institute for Developmental Biology and Stem Cell Research Uppsalalaan 8 3584 CT Utrecht The Netherlands Plant Ecophysiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands Nuclear Organization Group Swammerdam Institute for Life Sciences University of Amsterdam Kruislaan 318 1098 SM Amsterdam The Netherlands

Plants need to respond quickly and appropriately to various types of light signals from the environment to optimize growth and development. The immediate response to shading, reduced photon flux （low light）, and changes in spectral quality involves changes in gene regulation. In the case of more persistent shade, the plant shows a dramatic change in the organization of chromatin. Both plant responses are controlled via photoreceptor signaling proteins. Re- cently, several studies have revealed similar features of chromatin reorganization in response to various abiotic and biotic signals, while others have unveiled intricate molecular networks of light signaling towards gene regulation. This opinion paper briefly describes the chromatin （de）compaction response from a light-signaling perspective to provide a link be- tween chromatin and the molecular network of photoreceptors and E3 ubiquitin ligase complexes.

关键词： light signaling chromatin compaction molecular network Arabidopsis

Digestive oncologist in the gastroenterology training curriculum

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World Journal of Gastroenterology 2011年第9期17卷 1109-1115页

作者： Chris Jacob Johan Mulder Marc peeters Annemieke Cats Anna Dahele Jochim Terhaar sive Droste Department of Gastroenterology and Hepatology VU University Medical Center Department of Oncology Antwerp University Hospital Antwerp Department of Gastroenterology and Hepatology Netherlands Cancer Institute

Until the late 1980s, gastroenterology (GE) was considered a subspecialty of Internal Medicine. Today, GE also incorporates Hepatology. However, Digestive Oncology training is poorly defined in the Hepatogastroenterology (HGE)-curriculum. Therefore, a Digestive Oncology curriculum should be developed and this document might be a starting point for such a curriculum. HGE-specialists are increasingly resisting the paradigm in which they play only a diagnostic and technical role in the management of digestive tumors. We suggest minimum endpoints in the standard HGE-curriculum for oncology, and recommend a focus year in the Netherlands for Digestive Oncology in the HGE-curriculum. To produce welltrained digestive oncologists, an advanced Digestive Oncology training program with specific qualifications in Digestive Oncology (2 years) has been developed. The schedule in Belgium includes a period of at least 6 mo to be spent in a medical oncology department. The goal ofthese programs remains the production of well-trained digestive oncologists. HGE specialists are part of the multidisciplinary oncological teams, and some have been administering chemotherapy in their countries for years. In this article, we provide a road map for the organization of a proper training in Digestive Oncology. We hope that the World Gastroenterology Organisation and other (inter)national societies will support the necessary certifications for this specific training in the HGE-curriculum.

关键词：消化系统肿瘤培训课程胃肠病学肿瘤学消化道肿瘤国家管理肿瘤组织附件

Comparison of Diaton transpalpebral tonometer with applanation tonometry in keratoconus

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 395-398页

作者： Robert PL Wisse Natalie peeters Saskia M Imhof Allegonda van der Lelij Utrecht Corneal Research Group Department of Ophthalmology University Medical Center Utrecht Utrecht 3508 GA The Netherlands

AIM： To Investigate the added value of using a Diaton transpalpebral tonometer （DT） to measure lOP in keretoconus. Most type of tonometers use corneal applanation or biomechanical resistance to measure intraocular pressure （lOP）; however, these factors can be altered by keratoconus. Specifically, we examined whether DT can detect false-negative low Goldmann applanation tonometry （AT） measurements. METHODS： Patients with keratoconus were recruited from our tertiary academic treatment center. Measurements included AT and DT （in random order） and Scheimpflug imaging. An age- and gender-matched group of control subjects with no history of corneal disease or glaucoma was also recruited. RESULTS： In total, 130 eyes from 66 participants were assessed. In the keratoconus group, mean AT was 11.0± 2.6, mean DT 11±5.5 （P =0.729）and the two measures were correlated significantly（P=0.006, R=0.323）. However, a Bland-Altman plot revealed a wide distribution and poor agreement between both measurements. Previous corneal crosslinking, corneal pachymetry, and Krumeich classification had no effect on measured IOP. CONCLUSION： Measurements obtained using a Diaton tonometer are not affected by corneal biomechanics; however, its poor agreement with Goldmann AT values calls into question the added value of using a Diaton tonometer to measure lOP in keratoconus.

关键词： Diaton Goldmann applanation tonometry transpalpebral tonometry keratoconus Bland-Altman plot

On Improving Accuracy of finite-Element Solutions of the Effective-Mass Schr¨odinger Equation for Interdiffused Quantum Wells and Quantum Wires

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Communications in Theoretical Physics 2016年第1期65卷 105-113页

作者： D.B.Topalovi V.V.Arsoski S.Pavlovic N.A.Cukaric M.Z.Tadic f.M.peeters School of Electrical Engineering University of Belgrade P.O. Box 35-54 11120 Belgrade Serbia Vinca Institute of Nuclear Sciences University of Belgrade P.O. Box 522 11001 Belgrade Serbia Department of Physics University of Antwerp Groenenborgerlaan 171 B-2020 Antwerp Belgium

We use the Galerkin approach and the finite-element method to numerically solve the effective-mass Schr¨odinger equation.The accuracy of the solution is explored as it varies with the range of the numerical domain.The model potentials are those of interdiffused semiconductor quantum wells and axially symmetric quantum wires.Also,the model of a linear harmonic oscillator is considered for comparison reasons.It is demonstrated that the absolute error of the electron ground state energy level exhibits a minimum at a certain domain range,which is thus considered to be optimal.This range is found to depend on the number of mesh nodes N approximately as α_0 log_e^(α1)(α_2N),where the values of the constants α_0,α_1,and α_2are determined by fitting the numerical data.And the optimal range is found to be a weak function of the diffusion length.Moreover,it was demonstrated that a domain range adaptation to the optimal value leads to substantial improvement of accuracy of the solution of the Schr¨odinger equation.

关键词：薛定谔方程量子导线有效质量互扩散有限元解精度 Galerkin方法数值求解

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Gallium bismuth halide GaBi-X2 （X = I, Br, CI） monolayers with distorted hexagonal framework： Novel room- temperature quantum spin Hall insulators

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Nano Research 2017年第6期10卷 2168-2180页

作者： Linyang Li Ortwin Leenaerts Xiangru Kong Xin Chen Mingwen Zhao francois M. peeters Department of Physics University of Antwerp Groenenborgerlaan 171 B-2020 Antwerp Belgium International Center for Quantum Materials Peking University Beijing 100871 China School of Physics and State Key Laboratory of Crystal Materials Shandong University Jinan 250700 China

Quantum spin Hall （QSH） insulators with a large topologically nontrivial bulk gap are crucial for future applications of the QSH effect. Among these, group III-V monolayers and their halides, which have a chair structure （regular hexagonal framework）, have been widely studied. Using first-principles calculations, we formulate a new structure model for the functionalized group III-V monolayers, which consist of rectangular GaBi-X2 （X = I, Br, C1） monolayers with a distorted hexagonal framework （DHf）. These structures have a far lower energy than the GaBi-X2 monolayers with a chair structure. Remarkably, the DHf GaBi-X2 monolayers are all QSH insulators, which exhibit sizeable nontrivial band gaps ranging from 0.17 to 0.39 eV. The band gaps can be widely tuned by applying different spin-orbit coupling strengths, resulting in a distorted Dirac cone.

关键词： quantum spin Hall （QSH）insulators,first-principles calculations,GaBi-X2 （X = L Br Cl）monolayers,distorted hexagonal framework,distorted Dirac cone