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Treating acute low back pain with acupuncture:A randomized controlled study protocol to compare the effectiveness between distal and local acupoints

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 351-356页

作者： Singleung Chan Shukyan lam Sinyin Ho Wanyi Au Poyi lin Waiming Chan Taking Yu Shungchi Tam Bacon f.l.ng linda l.D.Zhong Pok Oi Hospital Hong Kong Baptist University Chinese Medicine Clinic Cum Training and Research CentreHong Kong 999077China Chinese Medicine Department Hong Kong Hospital AuthorityHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China School of Biological Sciences Nanyang Technological University637551Singapore

Objective To compare the efficacy of using“distal acupoints only”vs.“local acupoints mainly combined with distal acupoints”in cases of acute low back pain(AlBP).Methods A total of 102 eligible patients aged 18–65 years with AlBP lasting less than 6 weeks will be randomized in a 1:1 ratio to the distal acupoints only group(DPOG)and the local acupoints mainly combined with the distal acupoints group(lPMG).During a 4-week treatment period,patients in the DPOG will receive acupuncture at distal acupoints only(Houxi[SI 3]and Yaotongxue[EX-UE 7])twice a week,while those in the lPMG group will receive acupuncture at local acupoints(mainly Shenshu[Bl 23]and Dachangshu[Bl 25])combined with distal points(Weizhong[Bl 40]).The patients in both groups will be evaluated at every session of treatment,and the follow-up will be performed for 3 *** primary outcome measure will be the change in AlBP intensity,assessed using visual analogue scale scores before and after *** secondary outcome measure will be the evaluation of functional disability using the Oswestry Disability *** This study compares the DPOG and lPMG to explore the feasibility of the DPOG in the treatment of AlBP.

关键词： Acupuncture Acute low back pain Motion style acupuncture Activating qi acupuncture Distal acupoints local acupoints

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High mechanical strengths and ductility of stainless steel 304l fabricated using selective laser melting

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Journal of Materials Science & Technology 2019年第2期35卷 388-394页

作者： Q.B.nguyen Z.Zhu f.l.ng B.W.Chua S.M.l.Nai J.Wei Singapore Institute of Manufacturing Technology Institute of Research and Development Duy Tan University

Achieving not only high mechanical strengths but also high ductility is recently established using an additive manufacturing technique called selective laser melting. In the present study, stainless steel 304 l fully dense samples were successfully printed using the 3 D systems – ProX 300 printing machine. The ductility and tensile yield strength were almost two and three times higher compared to those of ASTM cast's alloy. Honey comb like nano-cellular structure with different orientation was observed in the fine grains(~4μm) due to fast cooling rate. In addition, the formation of martensite phase in random grains is also a contributor to the strengths. furthermore, negative residual stresses in the build and horizontal directions were detected and assisted further increase in the tensile strength. fractography revealed the ductile feature of plastic deformation and the crack openings at unmelted particles or pores.

关键词： Additive manufacturing Stainless steel Powder Selective laser melting

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Microstructure and mechanical behavior of laser aided additive manufactured low carbon interstitial fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)multicomponent alloy

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Journal of Materials Science & Technology 2021年第18期77卷 38-46页

作者： Y.Chew Z.G.Zhu f.Weng S.B.Gao f.l.ng B.Y lee G.J.Bi Singapore Institute of Manufacturing Technology 73 Nanyang Drive637662Singapore School of Mechanical Aerospace Engineering Nanyang Technological University50 N any ang Avenue639798Singapore

laser aided additive manufacturing(lAAM)was used to fabricate bulk fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)interstitial multicomponent alloy using pre-alloyed *** room temperature yield strength(σ_y),ultimate tensile strength(σ_(UTS))and elongation(ε_(UTS))were 645 MPa,917 MPa and 27.0%*** asbuilt sample consisted of equiaxed and dendritic cellular structures formed by elemental *** cellular structures together with oxide particle inclusions were deemed to strengthen the *** other contributing components include dislocation strengthening,friction stress and grain boundary *** highε_(UTS)was attributed to dislocation motion and activation of both twinning and transformation-induced plasticity(TWIP and TRIP).Tensile tests performed at-40℃and-130℃demonstrated superior tensile strength of 1041 MPa and 1267 MPa ***,almost no twinning was observed in the fractured sample tested at-40℃and-130℃.Instead,higher fraction of strain-induced hexagonal close-packed(HCP)εphase transformation of 21.2%were observed for fractured sample tested at-40℃,compared with 6.3%in fractured room temperature sample.

关键词： Multicomponent alloys laser aided additive manufacturing Additive manufacturing Microstructure Mechanical property

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Education of Critical Appraisal Skills and Research Ethics of Chinese Medicine Practitioners

Education of Critical Appraisal Skills and Research Ethics o...

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第十四届全国中药和天然药物学术研讨会

作者： Bacon f.l.ng Eric T.C.Ziea Hospital Authority

＜正＞A base-line evaluation of the critical appraisal skills of Chinese Medicine Practitioners in the local context reviewed 27%of them were confused about the types of research study design and over half of them wer...

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Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei long ng Viktor Shkolnikov Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

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Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi ng Mian Cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 f,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and lRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

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Cognition and movement in neurodegenerative disorders:a dynamic duo

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Neural Regeneration Research 2024年第10期19卷 2101-2102页

作者： Marit f.l.Ruitenberg Department of Health Medical and NeuropsychologyLeiden UniversityLeidenthe Netherlands leiden Institute for Brain and Cognition Leidenthe Netherlands

People with neurodegenerative disorders often experience problems across a variety of functional domains,including cognition,movement,and psychosocial *** classification of these disorders is based on the phenotypical manifestations that represent the most prominent clinical *** example,Parkinson's disease and Huntington's disease are typically regarded as movement disorders,whereas Alzheimer's disease(AD) and other dementias are regarded as cognitive disorders.

关键词： disorders Huntington degenerative

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Stability and Generalization of Hypergraph Collaborative Networks

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Machine Intelligence Research 2024年第1期21卷 184-196页

作者： Michael K.ng Hanrui Wu Andy Yip Institute of Data Science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural networks have been shown to be very effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural networks to hypergraph neural networks to exploit more com-plex *** particular,the hypergraph collaborative networks yield superior results compared to other hypergraph neural net-works for various semi-supervised learning *** collaborative network can provide high quality vertex embeddings and hyperedge embeddings together by formulating them as a joint optimization problem and by using their consistency in reconstructing the given *** this paper,we aim to establish the algorithmic stability of the core layer of the collaborative network and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in collaborative networks,for instance,how the data and hypergraph filters should be scaled to achieve uniform stability of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hypergraphs vertices hyperedges collaborative networks graph convolutional neural networks(CNNs) stability generalization guarantees

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Perspectives in human brain plasticity sparked by glioma invasion:from intraoperative(re)mappings to neural reconfigurations

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Neural Regeneration Research 2024年第5期19卷 947-948页

作者： Sam ng Hugues Duffau Guillaume Herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of functional Genomics University of MontpellierCNRSINSERMMontpellierFrance Praxiling laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative *** term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences

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Three-dimensional numerical analysis of plant-soil hydraulic interactions on pore water pressure of vegetated slope under different rainfall patterns

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3696-3706页

作者： Haowen Guo Charles Wang Wai ng Qi Zhang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall ***,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further *** address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding *** series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall *** rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the *** computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return *** extreme rainfalls with advanced(PA),bimodal(PB)and uniform(PU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(PD)and uniform(PU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).for the long duration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and slope stability may not be sufficient.

关键词： Root-soil interactions Rainfall patterns Slope stability Three-dimensional(3D)

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