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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： f.Mannacio f.di marzo M.Gaiotti C.M.Rizzo M.Venturini Italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-contact underwater explosion phenomena(UNDEX)have been studied for decades and several numerical methods have been proposed in literature,its effects on military structures,especially composite ones,are even nowadays matter of *** early design phases,it is not always possible to verify the shock resistance of hull structures modelling the whole phenomenon,in which fluid,gas and solid properties must be properly set in a fully coupled fluid-structure interaction(fSI)numerical *** ones are extremely complex to set,computationally demanding and certainly not suitable for everyday design *** this paper,a simplified finite element(fE)model,easy to use in an early design phase,is ***,the structure and the fluid are *** this approximation,the fluid behaviour is simplified,using special finite elements,available in a commercial software *** choice reduces the computational time and numerical efforts avoiding the problem of combining computational fluid dynamics(CfD)and fE domains and equations in a fully coupled fluid-structure interaction model.A typical parallel body block of a minesweeper is modelled,using two-dimensional multi-layered shell elements to properly account for the composite materials *** the fluid instead,three dimensional volumetric elements,directly coupled to the structural elements,are *** addition,the same calculation is performed,modelling separately fluid in the CfD environment and structures in the finite element ***,realizing a fully coupled fluid-structure interaction *** results obtained by applying both numerical models are compared with the structural response measured on board of a composite ship during a full-scale shock *** simplified proposed procedure provides results in satisfactory agreement with experiments,allowing the validation of the *** are discussed and differences with the real phenomenon and fully coupled CfD+

关键词： Underwater explosions Shock resistance Composites fluid-structure interaction Experimental analysis Numerical simulation Vulnerability Preliminary design

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PROSTAMIDES ANANDAMIDE CYCLOOXY- GENASE-2 METABOLITES: METABOLISM AND TRANSPORT STUdiES

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国际眼科杂志 2003年第1期3卷 104-104页

作者： V.di marzo D.f.Woodward Consiglio Nazionale Delle Ricerche ItalyA1lergan Inc. Irvine CA USA

The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and f2alpha and their synthetic analog Bimatoprost have been described, but little has been reported on their metabolism and pharmacology, except that they do not appear to activate prostanoid or cannabinoid receptors. These studies were performed to determine if prostamides exhibit simi-

关键词：前列腺素乙醇酰胺环氧合酶-2 代谢物转运药学性质

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