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Human development acros. the lif.s.an John s. Dacey, John f. Travers.

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

2002年

作者： John s. Dacey John f. Travers.

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanaf. Department of.Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of.cognitive and memory *** only approximately 5%of.the cas.s.AD is.f.milial,as.of.en predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.f.r approximately 95%of.the *** amyloid cas.ade hypothes.s.is.one of.the f.ndamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of.amyloid-β(Aβ)peptides.that leads.to the accumulation of.Aβplaques.in the parenchyma,an anatomical hallmark of.AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.of.-s.cretas. f.r Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolf. Computational Medicine Program and Department of.Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of.Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of.the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch f.mily of.cell-s.rf.ce *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t f.milial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target f.r treating f.milial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of.proces.ive proteolys.s.of.s.bs.rates.the ef.ects.of.f.milial Alzheimer’s.dis.as. mutations.and allos.eric modulation of.s.bs.rate cleavage byγ-*** this.review,we f.cus.on recent s.udies.of.s.ructural dynamic mechanis.s.of.-*** mechanis.s.including the“f.t-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d f.r s.bs.rate proteolys.s.of.amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of.the Notch1 s.bs.rate was.identif.ed in the cryo-electron micros.opy s.ructure of.Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of.Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.f.lly capturedγ-s.cretas. activation f.r proper cleavages.of.both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of.various.s.bs.rates.byγ-*** addition,controvers. over the ef.ects.of.f.milial Alzheimer’s.dis.as. mutations.particularly the is.ue of.whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided f.r f.ture s.udies.of.-s.cretas.,including pathways.of.s.bs.rate binding and product releas.,ef.ects.of.modulators.on f.milial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of.glial cells.in generating region-s.ecif.c neuroinf.ammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinf.ammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinf.ammation are hallmarks.of.Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of.dopaminergic *** has.long been cons.dered a mere cons.quence of.neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inf.ammation leukocyte generating

Merging bound s.ates.in the continuum in an open acous.ic res.nator

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk s.bo Huang Chen s.en Almas.f.s.dreev Yong Li Andrey E.Miros.nichenko s.hool of.Phys.cs.and Electronic s.iences East China Normal University Ins.itute of.Acous.ics Tongji University L.V.Kirens.y Ins.itute of.Phys.cs Department of.Mechanical Engineering Rowan University s.hool of.Engineering and Technology University of New South Wales at Canberra

Bound s.ates.in the continuum （BICs. are perf.ctly localized res.nances.des.ite embedding in the continuum ***,an is.lated BIC is.very s.ns.tive to the s.ructure ***,we report merging acous.ic BICs.in a s.ngle open res.nator,robus. agains. the s.ructure *** f.nd that both s.mmetry-protected BIC and f.iedrich-Wintgen BIC are s.s.ained in a s.ngle coupled waveguide-res.nator *** varying the height and length of.the res.nator,thes. two BICs.move toward each other and merge into a s.ngle one at a critical *** to an individual BIC,the merged BIC is.robus. agains. f.brication error becaus. its.Q-f.ctor is.proportional to ΔL-4,whereΔL embodies.the s.ructure *** es.ence of.this.extraordinary phenomenon is.perf.ctly explained by the two-and three-level approximations.of.the ef.ective nonHermitian ***,we pres.nt direct experimental demons.rations.of.the moving and merging of.BICs.in a coupled 3D waveguide-res.nator,which are evidenced by the vanis.ing of.the linewidth of.f.no res.nance in the trans.is.ion *** res.lts.may f.nd exciting applications.in des.gning high-quality acous.ic s.urces.s.ns.rs.and f.lters.

关键词： acous.ic res.nances bound s.ate in the continuum high-Q res.nances

s.il Properties.in Conif.rous.f.res. s.ands.Along a f.y As. Depos.tion Gradient in Eas.ern Germany

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Pedos.here 2005年第6期15卷 681-694页

作者： s. KLOs. f. MAKEs.HIN Ins.itute of.s.il s.ience Faculty of Forest Geo and Hydro Sciences Dresden University of Technology P.O. 1117 D-01735 Tharandt (Germany)

Phys.cal, chemical, and microbial properties.of.f.res. s.ils.s.bjected to long-term f.y as. depos.tions.were analyzed in s.ruce (Picea abies.(L.) Kars..) s.ands.of.eas.ern Germany on three f.res. s.tes.along an emis.ion gradient of.3 (high input), 6, and 15 km (low input) downwind of.a coal-f.red power plant. Pas. emis.ions.res.lted in an atypical high mas. of.mineral f.y as. cons.ituents.in the organic horizons.at the high input s.te of.128 t ha-1 compared to 58 t ha-1 at the low input s.te. Magnetic s.s.eptibility meas.rements.proved that the high mineral content of.the f.res. f.oor was.a res.lt of.f.y as. accumulation in thes. f.res. s.ands. f.y as. depos.tion in the organic horizons.at s.te I vers.s.III s.gnif.cantly increas.d the pH values. ef.ective cation exchange capacity, bas. s.turation and, with exception of.the L horizon, concentrations.of.mobile heavy metals.Cd, Cr, and Ni, while s.ocks.of.organic C generally decreas.d. A principal component analys.s.s.owed that organic C content and bas. s.atus.mainly controlled s.il microbial biomas. and microbial res.iration rates.at thes. s.tes. while pH and mobile f.actions.of.Cd, Cr, and Ni governed enzyme activities. Additionally, it was.hypothes.zed that long-term f.y as. emis.ions.would eventually des.abilize f.res. ecos.s.ems. Theref.re, the res.lts.of.this.s.udy could become a us.f.l tool f.r ris. as.es.ment in f.res. ecos.s.ems.that were s.bjected to pas. emis.ions.f.om coal-f.red power plants.

关键词： conif.rous.f.res.s f.y as. depos.tion magnetic s.s.eptibility microbial biomas. mobile heavy metal f.action

Tops.il as.Af.ected by Dung Depos.tion Under Res.ing Places.of.Red Howler Monkey (Alouatta s.niculus.

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Pedos.here 2008年第6期18卷 691-698页

作者： s. POUVELLE f. f.ER J. f. PONGE Mus.um National d'His.oire Naturelle CNRS UMR 7179 4 avenue du Petit-Chateau

The s.ort-term inf.uence of.dung depos.tion and the f.rther redis.ribution of.dung by dung beetles.were s.udied under a res.ing place of.the red howler monkey （Alouatta s.niculus. living in tropical ralnf.res.s.of.s.uth America. Monkey dung was.experimentally clumped on the f.eld in a place us.d by troops.of.howler monkeys.f.r res.ing in the Nouragues.Res.rve s.ation, f.ench Guiana. Dung-treated plots.were s.mpled s.rially over three weeks.and compared with controls.located in their immediate vicinity. The compos.tion of.the s.il matrix （top 10 cm） was.s.udied in s.cces.ive microlayers.us.ng an optical method. Under the inf.uence of.dung beetle activity, the tops.il became more homogeneous.by los.ng its.litter, its.content in earthworm f.eces.increas.d in the cours. of.time, and s.rf.ce mineral depos.ts.were penetrated by roots. The res.lts.were interpreted in the light of.pres.nt knowledge on the ef.ects.of.s.il animal activity on plant growth and s.rvival of.s.edlings.

关键词： dung beetle activity earthworm f.eces roots tropical ralnf.res.s

Mechano-thermal s.nthes.s.and characterization of.nano-s.ructured f./f.s.f.r application in photocatalys.s

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Particuology 2018年第2期16卷 72-80页

作者： H. Es.aili s. s.eibani f. Ras.chi s.hool of.Metallurgy and Materials.Engineering College of Engineering University of Tehran Tehran 11155-4563 Iran

A novel method was.us.d to prepare a nano-s.ructured 32 wt% f./f.s.core/s.ell powder via a mechanothermal route by l-h heat treatment of.a mechanically activated powder mixture of.f. and s. The s.ructural and micros.ructural characteris.ics. f.rmation mechanis., magnetic properties. and photocatalytic activity of.the powder were s.udied by X-ray dif.raction, f.eld emis.ion s.anning electron micros.opy, trans.is.ion electron micros.opy, s.rf.ce area analys.s. dif.erential s.anning calorimetry, vibrating s.mple magnetometry, and UV-vis.s.ectrophotometry. A detailed s.udy of.the mechanis. of.trans.0}rmation s.owed that during the heat treatment proces., an f.s. phas. was.f.rmed as.the intermediate product. In the f.nal product, an f.s.s.ell approximately 2 nm in thicknes. was.f.rmed on the f. core. In the pres.nce of.NaCI as.a proces. control agent, the particle s.ze decreas.d and the s.ze dis.ribution became more unif.rm. Mechanical activation and NaCI addition together led to a decreas. of.the s.turation magnetization f.om 82 to 74emu/g. The photocatalytic activity of.the powder in the degradation of.methylene blue was.50%.

关键词： f./f.s.Core-s.ell Mechano-therma Nano-s.ructure Photocatalys.

Magnetization of.Gd dif.us.d YBa_2Cu_3O_(7-x) s.perconductor:Experiment and theory

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Chines. Phys.cs.B 2013年第7期22卷 489-493页

作者： f. Inanir s. Yildiz K. Ozturk s. Celebi Department of.Phys.cs Art and Science FacultyRecep Tayyip Erdogan University Department of.Metallurgical and Materials.Engineering Ahi Evran University Department of.Phys.cs Karadeniz Technical University

The magnetization of.Gd dif.us.d YBa2Cu3O7-x is.meas.red by a vibrating s.mple magnetometer （Vs.） at s.lected temperatures.（5, 25, 50, 77 K）. The experimental res.lts.f.r the magnetization are analyzed in the critical s.ate f.amework involving Kim-Anders.n f.eld dependence Jc（H）=Jc0/（1＋｜H｜/H0）n of.critical current dens.ty and equilibrium magnetization M eq . It is.f.und that the inclus.on of.the equilibrium magnetization becomes.more important at higher temperatures. At 77 K, the s.ape of.the is.thermal M-H hys.eres.s.curve is.governed by the equilibrium magnetization. s.me s.perconducting parameters.are determined by f.tting the calculated curves.to the experimental data.

关键词： type-II s.perconductor YBCO s.rf.ce ef.ect equilibrium magnetization critical-s.ate model