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5-Bromo-2'-deoxyuridine labeling:historical perspectives,f.ctors inf.uencing the detection,toxicity,and its implications in the neurogenesis

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neural Regeneration Research 2024年第2期19卷 302-308页

作者： Joaquín martí-Clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine 5-bromo-2′-deoxyuridine(BrdU)is an exogenous marker of.DnA *** the introduction of.monoclonal antibodies against BrdU,an increasing number of.methodologies have been used f.r the immunodetection of.this synthesized bromine-tagged base analogue into replicating *** labeling is widely used f.r identif.ing neuron precursors and f.llowing their f.te during the embryonic,perinatal,and adult neurogenesis in a variety of.vertebrate species including birds,reptiles,and *** to BrdU toxicity,its incorporation into replicating DnA presents adverse consequences on the generation,survival,and settled patterns of.*** may lead to f.lse results and misinterpretation in the identif.cation of.prolif.rative *** this review,I will indicate the detrimental ef.ects of.this nucleoside during the development of.the central nervous system,as well as the reliability of.BrdU labeling to detect prolif.rating ***,it will show f.ctors inf.uencing BrdU immunodetection and the contribution of.this nucleoside to the study of.prenatal,perinatal,and adult *** adult neurogenesis will also be *** is my hope that this review serves as a ref.rence f.r those researchers who f.cused on detecting cells that are in the synthetic phase of.the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult neurogenesis human adult neurogenesis labeling pitf.lls prenatal neurogenesis prolif.ration S-phase suturing S-phase toxicity

Weather inf.uenced nestling growth of.an insectivorous but not a granivorous grassland passerine in Argentina

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Avian Research 2024年第2期15卷 156-162页

作者： martín Alejandro Colombo Adrian Jauregui Luciano n.Segura Laboratorio de Ecología de Aves.Institute“Dr.Raúl A.Ringuelet”(ILPLA)-UnLP/COnICET Boulevard 1201437La PlataB1900Buenos AiresArgentina

nestling growth of.birds can be af.ected by weather *** general,it is expected that higher temper-atures f.vor growth by improving f.od availability and nestling metabolism,while rain hinders it by reducing f.raging ***,most of.these patterns have been described in insectivorous cavity-nesting birds in temperate *** tested these predictions in two neotropical grassland ground-nesting birds with contrasting nestling diets and theref.re potentially dif.erent responses to *** measured nestlings of.the Hellmayr’s Pipit(Anthus hellmayri,an insectivorous passerine)and the Grassland Yellow-f.nch(Sicalis luteola,which f.eds its nestlings exclusively with seeds)during three breeding seasons(2017-2020)in central-eastern *** took measurements of.tarsus and body mass,modeled growth curves using nonlinear mixed-ef.ects models,and evaluated the ef.ects of.minimum daily temperature and precipitation during the growth period and the 30 days prior to *** pipits(60 nestlings f.om 21 nests),minimum temperatures during the growth period were positively associated with tarsus and body mass ***,there was a positive association between precipitation during the pre-hatching period and tarsus ***,none of.the weather variables analyzed had signif.cant ef.ects on nestling growth of.f.nches(131 nestlings f.om 35 nests).Dietary contrast between species may explain the dif.erent *** activity and abundance can be af.ected by weather variations within the span of.a breeding season,whereas seeds may depend on conditions f.om previous years,making the ef.ects harder to *** with reduced asymptotic size can have reduced chances of.***,pipit populations could be impacted if.they experience cold and dry conditions during their breeding season,which is of.major relevance in the current context of.climate change.

关键词： f.nches Grassland birds neotropical birds Pipits Precipitation Temperature

Alpha7 nicotinic receptors as potential theranostic targets f.r experimental stroke

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neural Regeneration Research 2024年第5期19卷 939-940页

作者： Maider Garbizu Laura Aguado Abraham martín Achucarro Basque Center f.r neuroscience LeioaSpain CIC biomaGUnE Basque Research and Technology AllianceSan SebastianSpain Ikerbasque Basque f.undation f.r Science BilbaoSpain

Inf.ammatory ref.ex and cholinergic anti-inf.ammatory pathway:Innate immune system triggers a local inf.ammatory response f.llowing an injury or a pathogen ***,this inf.ammatory response is limited by rapid,localized,and adaptive anti-inf.ammatory responses which are crucial f.r maintaining ***,the loss of.these responses converts a limited and protective inf.ammatory response into an excessive and harmf.l ***-inf.ammatory responses are integrated into the central nervous system,since the central nervous system accumulates inf.rmation about harmf.l events,activates def.nses,and builds memory f.r *** the same time,it has been demonstrated that hypothalamic neuronal signaling can be altered by inf.ammation in peripheral ***,immune cells release neuropeptides and neurotransmitters such as acetylcholine(ACh),the main neurotransmitter of.the parasympathetic autonomic nervous system,evidencing the communication between the immune and nervous systems(Tracey,2002).

关键词： protective invasion Alpha

Brent *** Texas Intermediate in the US petro derivatives price f.rmation

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Petroleum Science 2024年第1期21卷 729-739页

作者： Alejandro Almeida Antonio A.Golpe Juan Manuel martín-Alvarez Jose Carlos Vides Universidad Internacional de La Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of.Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of.Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of.two types of.crude oil prices(WTI and Brent crude oil)and their ref.ned products over *** the turbulent months of.2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the f.ll sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the ref.ned ***,when attending to each regime,results derived f.om the f.rst and third regimes are quite similar to the f.ll sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it inf.uenced the distillate ***,our model can let us determine the price-setters and price-f.llowers in the price f.rmation mechanism through ref.ned *** results possess important considerations to policymakers and the market participants and the price f.rmation.

关键词： Crude oil prices Spatial panel model Ref.ned products Price f.rmation

Plant cell wall-mediated disease resistance:Current understanding and f.ture perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres Marina martın-Dacal Diego Jose Berlanga Patricia f.rnandez-Calvo Elena Gomez-Rubio Sonsoles martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their f.nction as structural barriers,plant cell walls are essential elements f.r the adaptation of.plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen inf.ction,wounding,or other stresses leads to the release of.wall molecules,such as carbohydrates(glycans),that f.nction as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of.pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released f.om the walls and extracellular layers of.microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specif.c ECD-PRRs triggering PTI *** number of.oligosaccharides DAMPs/MAMPs identif.ed that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly f.cused on receptors of.the LysM-PRR f.mily,which are involved in the perception of.various molecules,such as chitooligosaccharides f.om f.ngi and lipo-chitooligosaccharides(i.e.,nod/MYC f.ctors f.om bacteria and mycorrhiza,respectively)that trigger dif.erential physiological ***,additional f.milies of.plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KInASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of.structural basis of.glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive f.nction recovery in Tg2576 mice

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neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso Josémartínez-Hernández Alejandro martín-Belmonte Rocío Alf.ro-Ruiz Miriam f.rnández Ana Esther Moreno-martínez Mar Cuadrado-Tejedor Ana García-Osta Raf.el Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy f.r neurological Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of.Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of.amyloid-β(Aβ)and neurof.brillary tangles are the main pathological characteristics of.Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the f.ctors that lead to this cognitive resilience to AD of.ers promising prospects f.r identif.ing new therapeutic *** hypothesis f.cuses on the contribution of.resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive perf.rmance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of.Aβ42 in both experimental groups,western blot analysis revealed dif.erences in tau pathology in the pre-synaptic supernatant *** f.rther investigate the density of.synapses in the hippocampus of.16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** f.ndings indicated a decrease in the density of.excitatory synapses in the stratum radiatum of.the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of.impaired and resilient Tg2576 transgenic AD mice,we uncovered dif.erences in the subcellular localization of.glutamate ***,the density of.GluA1,GluA2/3,and mGlu5 in spines and dendritic shaf.s of.CA1 pyramidal cells in impaired Tg2576 mice was signif.cantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of.GluA2/3 in resilient Tg2576 mice was signif.cantly increased in spines but not in dendritic shaf.s compared with impaired Tg2576 and non-transgenic *** subcellular f.ndings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

Assessment of.CO_(2)storage prospect based on physical properties of.Rio Bonito f.rmation rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richardson M.Abraham-A Stephanie San martín Cañas Isabella f.S.Miranda Colombo C.G.Tassinari Institute of.Energy and Environment(IEE) University of São Paulo(USP)Brazil Research Centre f.r Greenhouse Gas Innovation(RCGI) University of Sãao Paulo(USP)Brazil

The physical properties of.the rock units associated with the Rio Bonito f.rmation are presented in this study with the f.cus on modelling reservoir quality based on petrophysics-derived parameters to evaluate CO_(2)storage *** involves the modelling of.the reservoir depths,thicknesses,f.ow zone indicators(f.I),and ef.ective permeability(Kef.)and presenting the CO_(2)storage ef.iciency f.ctors peculiar to the rock units of.the study *** results presented by this study f.r the stated objectives are not quite common in the *** values range f.om 200 mD to higher than 2000 mD,and f.I values are generally above 1.0 mm and up to 13.0 mm within the portions covered by the drilled *** sandstone units recorded are up to 20 m thick in some *** Kef. and f.I models indicate the sandstone reservoirs as permeable units to support the injection and circulation of.CO_(2)within the potential reservoir units of.the Rio Bonio f.rmation across São Paulo *** f.om some points in the southeastern part of.the study location,where the Rio Bonito are delineated at depths less than 800 m(minimum CO_(2)storage depth based on best practices),other portions are deeper,ranging f.om 950 m to 3500 ***-bedded layers will af.ect the integrity of.the rocks as CO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m in some ***,hybrid CO_(2)reservoir units are f.asible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on CO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will signif.cantly control the CO_(2)storage ef.iciency of.the study *** studies f.aturing a detailed geophysical exploration of.the site to conf.rm the availability and saturations of.preexisting f.uid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Ef.ective permeability f.uid transmissibility CO_(2)storage prospect Reservoir quality Overburden integrity f.ow zones

Sex-dependent resilience to extreme drought events: implications f.r climate change adaptation of.a South American endangered tree species

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Ecological Processes 2024年第02期13卷 48-60页

作者： Sergio Piraino martín Ariel Hadad Yanina Antonia Ribas-f.rnández f.del Alejandro Roig Laboratorio de Dendrocronología e Historia Ambiental (IAnIGLA COnICET ) f.cultad de Ciencias Agrarias Universidad Nacional de Cuyo Laboratorio de Dendrocronología de Zonas áridas (CIGEOBIO COnICET ) Gabinete de Geología Ambiental (INGEO UNSJ) Hémera Centro de Observación de la Tierra Facultad de Ciencias Universidad Mayor

Background Recent changes in climatic trends are resulting in an increased f.equency and intensity of.extreme events, with unknown ef.ect on ecosystem dynamics in the near f.ture. Extreme drought episodes are recognized as disturbance f.ctors capable of.modif.ing f.rest dynamics and tree growth. Within this context, dioecious tree species may be impacted by climatic extremes, af.ecting male/f.male proportions and, consequently, reproductive processes and species persistence. Theref.re, there is an urgent need f.r species-specif.c assessments of.growth tolerance to extreme dry spells in dioecious tree species, to establish ef.ective conservation strategies f.r these particular natural resources. Araucaria araucana(araucaria), an endangered dioecious Patagonian tree species, has recently undergone decay and mortality episodes in response to increasing dry climatic conditions. While sex-dependent tolerance to extreme drought episodes has been assessed in the species' humid distribution range, there is still a lack of.inf.rmation on the gender-based resilience of.trees growing in the drier environments of.the species' *** We reconstructed, through dendrochronological methods, the sex-dependent response of.105 araucaria individuals(55 f.male and 50 male trees) to f.ve regional extreme dry spells employing a set of.dif.erent indices. Resistance, recovery period, and average growth reduction of.standardized tree-ring growth were examined, analysing the ef.ect of.biotic(sex, pre-drought stem tree growth) and abiotic(local climatic conditions bef.re, during, and af.er extreme climatic episodes) f.ctors on tree *** Sex inf.uences only the species resistance to climatic disturbance, with male individuals showing lower tolerance to extreme drought events. Pre-drought radial growth rates and local meteorological conditions preceding, during, and f.llowing extreme dry spells strongly modulated araucaria radial growth resilience regardless of.tree s

关键词： Araucaria Climate change Dendrochronology Extreme drought event Resilience

Output f.edback adaptive super twisting sliding mode control f.r quadrotor UAVs

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Control Theory and Technology 2024年第1期22卷 92-105页

作者： Oscar Salas-Peña Jesus DeLeón-Morales Susana V.Gutiérrez-martínez École Centrale de nantes-LS2n UMR 6004 CNRS44300NantesFrance f.cultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this paper, a sliding mode control with adaptive gain combined with a high-order sliding mode observer to solve the tracking problem f.r a quadrotor UAV is addressed, in presence of.bounded external disturbances and parametric uncertainties. The high order sliding mode observer is designed f.r estimating the linear and angular speed in order to implement the proposed scheme. f.rthermore, a Lyapunov f.nction is introduced to design the controller with the adaptation law, whereas an analysis of.f.nite time convergence towards to zero is provided, where suf.icient conditions are obtained. Regarding previous works f.om literature, one important advantage of.proposed strategy is that the gains of.control are parameterized in terms of.only one adaptive parameter, which reduces the control ef.ort by avoiding gain overestimation. numerical simulations f.r tracking control of.the quadrotor are given to show the perf.rmance of.proposed adaptive control–observer scheme.

关键词： Adaptive super twisting controller High-order sliding modes observer UAV