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Chinese Expert Consensus on the diagnosis and Treatment of.Adult dermatomy.sitis (2022)#

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International Journal of.dermatology.and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui y. deng d.-Q. Gao X.-H. He y.-L. Kang X.-J. Jin H.-Z. Li C.-X. Li f. Li H.-J. Liao W.-J. liu X.-M. lu Q.-J. lu y. Pan M. Pan W.-H. Shu X.-M. Sun Q. Tang K.-y. Tao J. Wang y. Xiao T. Zhang f.-R. Zhang H.-L. department of.dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China department of.dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China department of.dermatology China-Japan Friendship Hospital Beijing 100029 China department of.dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China department of.dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China department of.dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China department of.dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China department of.dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China department of.dermatology First Medical Center PLA General Hospital Beijing 100853 China department of.dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China department of.dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China department of.dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital f.r Skin diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China department of.dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China department of.dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China department of.Rheumatology China-Japan Friendship Hospital Beijing 100029 China department of.dermatology Qilu Hospital of Shandong Universit

dermatomy.sitis, an idiopathic inf.ammatory.my.pathy. is characterized.b. distinctive skin manif.stations, proximal muscle weakness, and multiple organ involvement and can be accompanied.b. malignancies. To provide a ref.rence f.r dermatologists and clinicians in other relevant f.elds of.clinical practice, experts f.om the dermatology.branch of.the China International Exchange and Promotion Association f.r Medical and Health Care and the National Clinical Research Center f.r dermatologic and Immunologic diseases developed this consensus on the diagnosis and treatment of.adult dermatomy.sitis using Chinese and international literature and expert advice. © 2024 Wolters Kluwer Health. All rights reserved.

关键词： adult clinical protocols dermatomy.sitis diagnosis expert consensus treatment

STCf.conceptual design report (Volume 1): Phy.ics & detector

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f.ontiers of.phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.bai y.bai O.bakina A.barny.kov V.blinov V.bobrovnikov d.b.drov A.bogomy.gkov A.bondar I.boy.o Z.H.bu f.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao d.y.Chen H.Chen H.X.Chen J.f.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.f.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.dai L.y.dai X.C.dai d.dedovich A.denig I.denisenko J.M.dias d.Z.ding L.y.dong W.H.dong V.druzhinin d.S.du y.J.du Z.G.du L.M.duan d.Epif.nov y.L.f.n S.S.f.ng Z.J.f.ng G.f.dotovich C.Q.f.ng X.f.ng y.T.f.ng J.L.f. J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo f.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.b.He S.Q.He X.G.He y.L.He Z.b.He Z.X.Heng b.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.b.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li d.y.Li f.Li G.Li G.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin d.X.Lin X.S.Lin b.J.liu C.W.liu d.liu f.liu G.M.liu H.b.liu J.liu J.J.liu J.b.liu K.liu K.y.liu K.liu L.liu Q.liu S.b.liu T.liu X.liu y.W.liu y.liu y.L.liu Z.Q.liu Z.y.liu Z.W.liu I.Logashenko y.Long C.G.lu J.X.lu N.lu Q.f.Lü y.lu y.lu Z.lu P.lukin f.J.luo T.luo X.f.luo y.H.luo H.J.Ly. X.R.Ly. J.P.Ma P.Ma y.Ma y.M.Ma f.Maas S.Malde d.Matvienko Z.X.Meng R.Mitchell A.Nef.diev y.Nef.dov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Py.ta b.b.Qi y.Q.Qi W.b.Qian y.Qian C.f.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.f.Redmer H.y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of.Nuclear Phy.ics Novosibirsk 630090Russia CAS Key.Laboratory.of.Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University.of.Geosciences Wuhan 430074China China University.of.Mining and Technology Xuzhou 221116China École Poly.echnique f.dérale de Lausanne(EPf.) LausanneSwitzerland f.dan University Shanghai 200433China Goethe University.f.ankf.rt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute f.r Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hef.i University.of.Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Higher School of.Economy.11 Pokrovsky.bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University.of.Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University.of.Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of.Advanced Science f.cilities Shenzhen 518107China Institute of.High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of.Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of.Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of.Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm f.cility.STCf.is an electron–positron collider proposed.b. the Chinese particle phy.ics *** is designed to operate in a center-of.mass energy.range f.om 2 to 7 GeV with a peak luminosity.of.0.5×10^(35) cm^(–2)·s^(–1) or *** STCf.will produce a data sample about a f.ctor of.100 larger than that of.the presentτ-charm f.ctory.the bEPCII,providing a unique platf.rm f.r exploring the asy.metry.of.matter-antimatter(charge-parity.violation),in-depth studies of.the internal structure of.hadrons and the nature of.non-perturbative strong interactions,as well as searching f.r exotic hadrons and phy.ics bey.nd the Standard *** STCf.project in China is under development with an extensive R&d *** document presents the phy.ics opportunities at the STCf.describes conceptual designs of.the STCf.detector sy.tem,and discusses f.ture plans f.r detector R&d and phy.ics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCf.detector conceptual design

Amplitude analy.is of.the decay. d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Phy.ics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Af.dulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.bai O.bakina I.balossino y.ban H.-R.bao V.batozskay. K.begzsuren N.berger M.berlowski M.bertani d.b.ttoni f.bianchi E.bianco A.bortone I.boy.o R.A.briere A.brueggemann H.Cai X.Cai A.Calcaterra G.f.Cao N.Cao S.A.Cetin J.f.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.b.Chen y.Q.Chen Z.J.Chen Z.y.Chen S.K.Choi X.Chu G.Cibinetto f.Cossio J.J.Cui H.L.dai J.P.dai A.dbey.si R.E.de boer d.dedovich C.Q.deng Z.y.deng A.denig I.deny.enko M.destef.nis f.de Mori b.f.ng S.S.f.ng W.X.f.ng y.f.ng y.Q.f.ng R.f.rinelli L.f.va f.f.ldbauer G.f.lici C.Q.f.ng J.H.f.ng y.T.f.ng K.f.scher M.f.itsch C.d.f. J.L.f. y.W.f. H.Gao y.N.Gao yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck b.ding X.X.ding y.ding y.ding J.dong L.y.dong M.y.dong X.dong M.C.du S.X.du Z.H.duan P.Egorov y.H.f.n J.f.ng JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.b.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao f.A.Harris K.K.He K.L.He f.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou b.y.Hu H.M.Hu J.f.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain f.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.b.Ji X.L.Ji y.y.Ji X.Q.Jia Z.K.Jia d.Jiang H.b.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang y.Jiang J.b.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nay.stanaki X.L.Kang X.S.Kang M.Kavatsy.k b.C.Ke V.Khachatry.n A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf.M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithof. M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.M.Li f.Li G.Li H.Li H.b.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.y.Li y Institute of.High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780 BochumGermany budker Institute of.Nuclear Phy.ics Sb RAS(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of.Advanced Science and Technology Beijing 100190China China University.of.Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University.Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan f.dan University Shanghai 200433China GSI Helmholtzcentre f.r Heavy.Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University.of.Science and Technology Luoyang 471003China Henan University.of.Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of.Technology.Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INf. Laboratori Nazionali di f.ascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INf. Laboratori Nazionali di f.ascati INFN Sezione di PerugiaI-06100PerugiaItaly INf. Laboratori Nazionali di f.ascati University of PerugiaI-06100PerugiaItaly INf. Sezione di f.rrara INFN Sezione di FerraraI-44122FerraraItaly INf. Sezione di f.rrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of.Modern Phy.ics Lanzhou 730000China Institute of.Phy.ics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity.of.2.93 f.^(−1)taken at the center-of.mass energy.s=3.773 GeV with the bESIII detector,a joint amplitude analy.is is perf.rmed on the decay. d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The f.t f.actions of.individual components are obtained,and large interf.rences among the dominant components of.the decay. d^(0)→a_(1)(1260)π,d^(0)→π(1300)π,d^(0)→ρ(770)ρ(770),and d^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even f.actions of.d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(sy.t.))%and(68.9±1.5_(stat).±2.4_(sy.t.))%,*** branching f.actions of.d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(sy.t.))%and(0.951±0.025_(stat.)±0.021_(sy.t.))%,*** amplitude analy.is provides an important model f.r the binning strategy.in measuring the strong phase parameters of.d^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the b^(−)→dK^(−)decay.

关键词： bESIII d^(0)meson decay. amplitude analy.is CP-even f.action

determination of.the number of.(3686)events taken at bESⅢ

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Chinese Phy.ics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Af.dulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.bai O.bakina I.balossino y.ban H.-R.bao V.batozskay. K.begzsuren N.berger M.berlowski M.bertani d.b.ttoni f.bianchi E.bianco A.bortone I.boy.o R.A.briere A.brueggemann H.Cai X.Cai A.Calcaterra G.f.Cao N.Cao S.A.Cetin J.f.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.b.Chen y.Q.Chen Z.J.Chen Z.y.Chen S.K.Choi G.Cibinetto f.Cossio J.J.Cui H.L.dai J.P.dai A.dbey.si R.E.de boer d.dedovich C.Q.deng Z.y.deng A.denig I.deny.enko M.destef.nis f.de Mori b.ding X.X.ding y.ding y.ding J.dong L.y.dong M.y.dong X.dong M.C.du S.X.du y.y.duan Z.H.duan P.Egorov y.H.f.n J.f.ng J.f.ng S.S.f.ng W.X.f.ng y.f.ng y.Q.f.ng R.f.rinelli L.f.va f.f.ldbauer G.f.lici C.Q.f.ng J.H.f.ng y.T.f.ng M.f.itsch C.d.f. J.L.f. y.W.f. H.Gao X.b.Gao y.N.Gao yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.b.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han f.Hanisch X.Q.Hao f.A.Harris K.K.He K.L.He f.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou b.y.Hu H.M.Hu J.f.Hu S.L.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain f.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.b.Ji X.L.Ji y.y.Ji X.Q.Jia Z.K.Jia d.Jiang H.b.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang y.Jiang J.b.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nay.stanaki X.L.Kang X.S.Kang M.Kavatsy.k b.C.Ke V.Khachatry.n A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf.M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.M.Li f.Li G.Li H.b.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of.High Energy.Phy.ics Beijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780BochumGermany budker Institute of.Nuclear Phy.ics Sb RAS(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of.Advanced Science and Technology Beijing 100190China China University.of.Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University.Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan f.dan University Shanghai 200433China GSI Helmholtzcentre f.r Heavy.Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University.of.Science and Technology Luoyang 471003China Henan University.of.Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of.Technology.Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INf. Laboratori Nazionali di f.ascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INf. Sezione di f.rrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of.Modern Phy.ics Lanzhou 730000China Institute of.Phy.ics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number of.(3686)events collected.b. the bESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by.counting inclusiveψ(3686)hadronic *** uncertainty.is sy.tematic and the statistical uncertainty.is ***,the numbers of.(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number of.(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events bESⅢdetector

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-y. liu Ruizhi yang 不详 Key.Laboratory.of.Particle Astrophy.cs&Experimental Phy.ics division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of.Chinese Academy.of.Sciences Beijing 100049China TIANf. Cosmic Ray.Research Center ChengduChina Institute of.f.ontier and Interdisciplinary.Science Shandong UniversityQingdao 266237China School of.Astronomy.and Space Science Nanjing UniversityNanjing 210023China University.of.Science and Technology.of.China Hefei 230026China

We report the detection of.aγ-ray.bubble spanning at least 100deg2 in ultra-high energy.UHE)up to a f.w PeV in the direction of.the star-f.rming region Cy.nus X,imply.ng the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola f.rm with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is f.und f.tting the gamma-ray.energy.spectrum of.the bubble *** sources,“hot spots”correlated with very.massive molecular clouds,and a quasi-spherical amorphousγ-ray.emitter with a sharp central brightening are observed in the *** the core of.0.5°,spatially.associating with a region containing massive Ob association(Cy.nus Ob2)and a microquasar(Cy.nus X-3),as well as previously.reported multi-TeV sources,an enhanced concentration of.UHEγ-ray. is observed with 2 photons at energies above 1 *** general f.ature of.the bubble,the morphology.and the energy.spectrum,are reasonably.reproduced.b. the assumption of.a particle accelerator in the core,continuously.injecting protons into the ambient medium.

关键词： Cosmic ray. γ-ray. Interstellar medium Star cluster

Theoretical and experimental cocry.tal screening of.temozolomide with a series of.phenolic acids, promising cocry.tal cof.rmers

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Chinese Chemical Letters 2024年第5期35卷 407-417页

作者： Hongmei y. baoxi Zhang Meiju liu Cheng Xing Guorong He Li Zhang Ningbo Gong yang lu Guanhua du beijing Key.Laboratory.of.Poly.orphic drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China beijing City.Key.Laboratory.of.drug Target Identif.cation and drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The virtual cocry.tal screening approach based on molecular electrostatic potential surf.ce(MEPS)maps is a f.st and f.asible computational method to estimate the probability.of.cocry.tal f.rmation by.calculating the dif.erence in the interaction site pairing energies of.monomers and that of.their assemblies prior to experimental *** this paper,we report 12 cocry.tal f.rms of.temozolomide with mono-,di-,and trihy.roxy.benzoic acids,namely.3-hy.roxy.,2,4-dihy.roxy.,2,5-dihy.roxy.,2,6-dihy.roxy.,3,4-dihy.roxy.,and 3,4,5-trihy.roxy.benzoic acids,as well as benzoic acid,as pharmaceutical cof.rmers f.r the f.rst time.10 single cry.tals out of.the 12 cocry.tal f.rms were obtained and unequivocally.determined.b. single-cry.tal X-ray.dif.raction,which clarif.ed spatial arrangements,molecular conf.rmations,and supramolecular *** f.rther gains some insights into the sites of.hy.rogen bonding interactions f.r exploring combination patterns in these *** stability.of.TMZ was successf.lly.achieved.b. cocry.tallization with these acids.

关键词： Virtual Cocry.tal Temozolomide Supramolecular sy.thon Phenolic acid Stability

Optimization of.perf.rmance of.the KM2A f.ll array.using the Crab Nebula

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Chinese Phy.ics C 2024年第6期48卷 169-178页

作者：曹臻 f.Aharonian 安琪阿西克古白云翔包逸炜 d.b.stieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 d.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 d.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 d.Ruf.olo A.Sáiz d.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 y..V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key.Laboratory.of.Particle Astrophy.cs&Experimental Phy.ics division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of.Chinese Academy.of.Sciences Beijing 100049China Tianf. Cosmic Ray.Research Center Chengdu 610000China d.b.in Institute f.r Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut f.r Nuclear Phy.ics P.O.Box 10398069029 HeidelbergGermany State Key.Laboratory.of.Particle detection and Electronics China University.of.Science and Technology.of.China Hefei 230026China School of.Phy.ical Science and Technology.School of.Inf.rmation Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of.Astronomy.and Space Science Nanjing UniversityNanjing 210023China Center f.r Astrophy.ics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key.Laboratory.of.dark Matter and Space Astronomy.Key.Laboratory.of.Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-dao Lee Institute&School of.Phy.ics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key.Laboratory.f.r Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key.Laboratory.of.Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of.Phy.ics and Astronomy.Zhuhai)&School of.Phy.ics(Guangzhou)&Sino-f.ench Institute of.Nuclear Engineering and Technology.Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of.Phy.ics and Astronomy Yunnan UniversityKunming 650091China département de Phy.ique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of.f.ontier and Interdisciplinary.Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The f.ll array.of.the Large High Altitude Air Shower Observatory.LHAASO)has been in operation since July.*** its kilometer-square array.KM2A),we optimized the selection criteria f.r very.high and ultrahigh energy.-ray. using data collected f.om August 2021 to August 2022,resulting in an improvement in signif.cance of.the detection in the Crab Nebula of.approximately.15%,compared with that of.previous *** the implementation of.these new selection criteria,the angular resolution was also signif.cantly.improved.b. approximately.10%at tens of.*** aspects of.the f.ll KM2A array.perf.rmance,such as the pointing error,were also calibrated using the Crab *** resulting energy.spectrum of.the Crab Nebula in the energy.range of.10-1000 TeV are well f.tted.b. a log-parabola model,which is consistent with the previous results f.om LHAASO and other experiments.

关键词： γ-ray Crab Nebula signif.cance

Structure-based design of.pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jiny. Zhao Sulin Zhang lu liu y.min Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia y.n Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao dai Zhen Ge Shulei Hu Changy.e y. Jiang Wang dakota Ma Mingy.e Zheng Haitao yang Gengf. Xiao Zihe Rao lu lu Leike Zhang f.ng bai y.o Zhao Shibo Jiang Hong liu drug discovery.and design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University.of.Chinese Academy.of.Sciences Beijing 100049China Key.Laboratory.of.Medical Molecular Virology.MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China shanghai Institute f.r Advanced Immunochemical Studies and School of.Lif. Science and Technology ShanghaiTech UniversityShanghai 201210China State Key.Laboratory.of.Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of.Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of.Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center f.r Inf.ctious disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory.disease caused.b. coronavirus inf.ction remains a global health *** several SARS-CoV-2-specif.c vaccines and direct-acting antivirals are available,their ef.cacy.on emerging coronaviruses in the f.ture,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage f.ture outbreak of.emerging *** L(CTSL)and calpain-1(CAPN1)are host cy.teine proteases which play.crucial roles in coronaviral entrance into cells and inf.ction-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identif.ed as potent dual target inhibitors against CTSL and *** X-ray.cry.tal structures of.human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of.a-ketoamide groups of.14a and 14b to C25 of.CTSL and C115 of.*** showed potent and.b.oad-spectrum anticoronaviral activities in vitro,and it is worth noting that they.exhibited low nanomolar potency.against SARS-CoV-2 and its variants of.concern(VOCs)with ECso values ranging f.om 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they.exhibited anticoronaviral activity.through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and f.vorable saf.ty.in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency.against SARS-CoV-2 Xbb 1.16 variant inf.ction in a K18-hACE2 transgenic mouse *** 14b also showed ef.ective antiviral activity.against HCoV-OC43 inf.ction in a mouse model with a f.nal survival rate of.60%.f.rther evaluation showed that 14a and 14b exhibited excellent antiinf.ammatory.ef.ects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

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bone Research 2024年第1期12卷 122-136页

作者： Nan-y. Zou Ran liu Mei Huang y.-Rui Jiao Jie Wei yangzi Jiang Wen-Zhen He Min Huang y.-Li Xu Ling liu y.-Chen Sun Mi yang Qi Guo y.n Huang Tian Su y. Xiao Wei-shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang luo Chang-Jun Li department of.Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China department of.Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China department of.Epidemiology.and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key.Laboratory.of.Joint degeneration and Injury ChangshaHunan 410008China Key.Laboratory.of.Aging-related.b.ne and Joint diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of.biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina department of.Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center f.r Geriatric disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of.decreased.b.ne regenerative potential with aging,but the causes of.SSPC senescence remain *** this study.we revealed that macrophages in calluses secrete prosenescent f.ctors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs f.acture *** injection of.human rGCA in y.ung mice induced SSPC senescence and delay.d f.acture *** deletion of.Gca in monocy.es/macrophages was suf.icient to rejuvenate f.acture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-b2 receptor and activates Arg2-mediated mitochondrial dy.f.nction,resulting in cellular *** of.Plxnb2 in SSPCs impaired f.acture *** of.GCA-neutralizing antibody.enhanced f.acture healing in aged ***,our study.revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary.senescence,and GCA neutralization represents a promising therapy.f.r nonunion or delay.d union in elderly.individuals.

关键词： healing union senescence