检索结果-南通市图书馆

Radiation-Induced Synthesis of.Polyvinylpyrrolidone （PVP） Nanogels

在线全文

学校读者我要写书评

暂无评论

Journal of.Physical Science and Application 2016年第5期6卷 21-26页

作者： Adrian Alejandro ges Naranjo HerlysViltres Cobas Danaydis f.nseca Rogdriguez Manuel Rapado Paneque Yuri Aguilera Corrales Higher Institute of.Technologies and Applied Science Nuclear Development and Technological Applications Centre La Habana Cuba Center of.Research in Applied Science and Technology Advanced Legaria-Unit Polytechnic National Institute Ciudad de Mexico Mexico f.nlay Institute La Habana Cuba Center f.r Technological Applications and Nuclear Development La Habana Cuba

Nanogels-particles of.polymer gels having the dimensions in the order of.nanometers-are gaining attention f.r their wide application as biomaterials. Mainly, the nanogels are promising novel pharmaceutical carriers f.r small biologically active agents, bin macromolecules and can be chemically modif.ed to incorporate various ligands f.r targeted drug delivery. This important f.ctor has stimulated research on dissimilar science f.eld such as nanotechnology and biotechnology, polymer and materials sciences, biochemistry, radiation chemistry and pharmaceutical sciences. A multitude of.techniques have been described f.r the synthesis of.this nanomaterial f.om polymers. However, the use of.ionizing radiation （γ, e-） has demonstrated to be especially suitable f.r obtaining polymeric nanogels with a high degree of.purity f.r biomedical applications, although the gamma radiation has not been widely utilized f.r these purposes. The aim of.this paper is to develop the synthesis of.PVP （polyvynilpyrrolidone） nanogels by gamma irradiation, f.r their evaluation as potential pharmaceutical carriers. Experiments were perf.rmed using argon saturated solution of.PVP （0.1-1%）. Crosstinking reactions were carried out in a gamma irradiation chamber with a 60Co source （ISOGAMMA LLCo）, at room temperature. The PVP concentration inf.uence was evaluated in PVP solutions （0.1% and 0.25%） at 15 kGy. The SEM （scanning electron microscopy）, ATR （attenuate total ref.ection spectroscopy）, DLS （dynamic light scattering）, and viscosimetry were used as characterization techniques.

关键词： Polyvynilpyrrolidon nanogels, gamma irradiation, biomaterial.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

经济地生产人造骨骼植入物

现代制造 2010年第40期 27-29页

作者： Simon H(o|¨)ges

在生产制造人造骨骼植入物时,通常情况下采用的快速原型制造技术是利用选择性激光直接制造的。本文将以钛合金股骨和其他医用人造骨骼植入物的生产加工为例来说明这类产品生产制造的经济性潜力。在世界范围内,利用金属材料制造的人工骨... 详细信息

在生产制造人造骨骼植入物时,通常情况下采用的快速原型制造技术是利用选择性激光直接制造的。本文将以钛合金股骨和其他医用人造骨骼植入物的生产加工为例来说明这类产品生产制造的经济性潜力。在世界范围内,利用金属材料制造的人工骨骼的需求越来越大。在西方国家,对人造关节的需求增长主要是随着人口寿命的延长、人口老龄化而引起的。但治疗水平的提高、医用骨科植入物供应条件的改善,也是引起这种需求增长的重要因素。从医疗的角度来看,主要是那些承受负载的骨骼对钛合金材料人工骨的需求量最大。尽管(从技术角度来看)。

关键词：激光直接制造快速原型制造技术植入物植人物生产制造工艺人工骨骼生产加工人造髓关节生物兼容性

^(236)U AMS measurement at CIRCE

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2010年第11期34卷 1729-1732页

作者：管永精 M.de Cesare f.Terrasi f.Quinto C.Sabbarese N.de Cesare A.D'Onof.io 王慧娟 College of.Physics Science and Technology Guangxi University Department of.Environmental Sciences II University of Naples

In order to measure the isotopic ratio of.actinides,the upgrade of.the accelerator mass spectrometry system at the Center f.r Isotopic Research on Cultural and Environmental heritage at the Second University of.Naples,Italy,was *** beam emittance of.238U and the isotopic abundance sensitivity of.236U were measured on the present beam *** a 16-strip silicon detector,the sensitivity of.236U/238U≈ 1×10-11 was obtained.

关键词： uranium AMS beam emittance sensitivity

Validation of.the Italian Version of.the Developmental Disability-Child Global Assessment Scale (DD-CGAS)

在线全文

学校读者我要写书评

暂无评论

Open Journal of.Psychiatry 2014年第3期4卷 218-227页

作者： Diego f. M. Mugno Manuela Strano Mara Collini Andrea Gemma Lavinia De Peppo Laura Reale Veronica Micalizio Luigi Mazzone Manuela Maserada sul Piave Treviso Italy Neuropsichiatria Inf.ntile Dipartimento di Neuroscienze Ospedale Pediatrico Bambino Gesù Rome Italy Neuropsichiatria Inf.ntile ULSS 8 Veneto Region Italy Neuropsichiatria Inf.ntile University of Catania Catania Italy Stepping Stones Center Dubai UAE

Objective: The aim of.this study is to validate the Italian version of.the Developmental Disability-Child Global Assessment Scale (DD-CGAS), a scale developed to assess global f.nctioning in children with Autism Spectrum Disorders (ASDs). Methods: f.llowing the validation procedures used f.r the English version of.the scale, inter-rater reliability, temporal stability and convergent validity were assessed in a group of.48 children with ASD and temporal stability in a subset of.42 subjects. Results: Inter-rater reliability and temporal stability (ICC) were respectively 0.78 and 0.79;ef.ect size f.r convergent validity were moderate to large;the pre-post DD-CGAS change had an ef.ect size of.0.59. Conclusions: The Italian version of.the DD-CGAS is a reliable instrument f.r measuring global f.nctioning of.children with ASD.

关键词： Assessment Autism Children f.nctioning Pervasive Developmental Disorder Italian

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多睾症及扭转:2例经验教训

世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 35-36页

作者： f.rro f. Iacobelli B. 郭战宏 Andrological Surgery Unit Bambino Gesù Children's Hospital 00165 Rome Italy

Two cases of.polyorchidism with 2 lef. scrotal testes are ref.rred. In both patients, the segmented gonads showed a “ bell clapper” def.rmity. In the f.rst patient, the contralateral gonad also presented a large mesorchium and absence of.scrotal ligament, whereas in the second case, the right gonad was f.rmly adhered to the tunica vaginalis because of.a previous appendix testis torsion. Orchidopexy of.all testes, judged at risk f.r torsion, was perf.rmed. Contrary to what is recommended by recent literature, we consider scrotal exploration and testis f.xation mandatory of.the contralateral, apparently normal gonad as well, even in the absence of.clinical and ultrasound signs of.associated abnormalities or complications.

关键词：多睾症睾丸固定术睾丸附件扭转睾丸系膜经验教训左侧阴囊超声征象鞘膜系带

拔尖创新人才培养视域下问题导向式教学的“理路”探究

在线全文

学校读者我要写书评

暂无评论

内蒙古农业大学学报（哲学社会科学版） 2024年第6期26卷 26-33页

作者：成欣欣任素清陶格斯内蒙古师范大学教育学院内蒙古呼和浩特010022

拔尖创新人才培养事关国家重大战略方针的贯彻,是新时代高质量教育体系建设的题中应有之义。问题导向式教学从方法论层面回应了拔尖创新人才培养的机制方法。问题导向式教学并非价值无涉,应从实质合理性和形式合理性的概念范畴进行学理... 详细信息

拔尖创新人才培养事关国家重大战略方针的贯彻,是新时代高质量教育体系建设的题中应有之义。问题导向式教学从方法论层面回应了拔尖创新人才培养的机制方法。问题导向式教学并非价值无涉,应从实质合理性和形式合理性的概念范畴进行学理性探讨。在此二维理论框架内,通过研究发现,部分实践者执着于追求技术的完美,忽视了价值的引领,叠加单环学习、问题虚假、关系单向、组织局限、资源分化、评价虚置等技术问题,造成问题导向式教学的价值和意义理解被异化,人文精神被科学主义遮蔽。归根结底,问题导向式教学应以主体性为价值引领,建构整体性操作策略,以教学价值-教学条件-教学实施-教学评价作为解决问题的可行路径。

关键词：问题导向式教学主体性焦点问题双环学习拔尖创新人才培养

近红外光谱法评价先天性膈疝的手术治疗对脑血流动力学的影响

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 46-48页

作者： Dotta A. Rechichi J. Campi f. 刘凯 Neonatal Intensive Care Unit Department of Medical and Surgical Neonatology Bambino Gesù Children's Hospital-IRCCS 00165 Rome Italy

Background: Cardiorespiratory stabilization is recommended bef.re surgical repair of.congenital diaphragmatic hernia (CDH) because surgerymay induce a transitory deterioration of.chest compliance and gas exchange. It is not known if.surgical intervention can af.ect cerebral circulation and oxygenation. Aim: The aim of.the study was to assess noninvasively, by near-inf.ared spectroscopy, the possible changes in cerebral hemodynamics and oxygenation associated with surgical repair of.CDH. Subjects: Twenty-f.ve newborns with severe CDH (birth weight, 3057 ± 354 g; gestational age, 37.8± 1.8 weeks; male/f.male newborns, 15/10; lef./right CDH, 19/6) were sedated, par-alyzed, and mechanically ventilated by conventional gentle ventilation and surgically corrected at a median age of.2.7 days (min-max, 2- 14 days) af.er cardiorespiratory stabilization. Methods: Heart rate (HR[beats per minute]), preductal transcutaneous oxygen saturation (tcSaO2 [% ]), carbon dioxide tension (tcPcO2 [Torr]), and mean arterial blood pressure (mmHg) were continuously monitored. Inspired f.actional oxygen concentration (f.o2) was adjusted to maintain and preductal tcSaO2 of.greater than 80% , whereas the ventilator’s settings were kept unchanged throughout the surgical procedure. Cerebral hemodynamics was assessed by near-inf.ared spectroscopy (NIRO 300, Hamamatsu Photonics, Japan), recording continuously and noninvasively the relative changes in concentration of.oxygenated (Δ O2Hb [μ mol/L]), deoxygenated (Δ HHb [μ mol/L]), and total (Δ tHb [μ mol/L]) hemoglobin; the tissue oxygenation index (TOI [% ]) was also calculated (TOI=O2Hb/O2Hb+ HHb). Total hemoglobin concentration is considered to be representative of.cerebral blood volume. Arterial blood gases were also measured at the beginning (T1) and at the end of.surgery (T2). f.r all measurements, results at T1 and at T2, as well as the dif.erences between T1 and T2, have been expressed as means or means and SDs or 95% conf.dence intervals or

关键词：先天性膈疝脑血流动力学近红外光谱法氧合作用膈疝修补胸廓顺应性平均动脉压二氧化碳分压右

出生时的体重和McGoon指数对先天性膈疝新生儿患者死亡率的预测作用

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 32-33页

作者： Casaccia G. Crescenzi f. Dotta A. 刘凯 Neonatal Surgery Unit Department of Medical and Surgical Neonatology Bambino GesúChildren's Hospital-IRCCS 00165 Rome Italy.Dr

Background: Despite improvements in clinical management, mortality of.congenital diaphragmatic hernia (CDH) remains high. Early prediction of.mortality risk helps in comparing strategies and/or perf.rmances of.dif.erent centers. Birth weight (BW), Apgar Score at 5 minutes, and modif.ed McGoon Index (MGI) calculated by the ratio between the diameters of.pulmonary arteries and the descending aorta have been used to determine mortality of.CDH. Aim: The purpose of.this study is to evaluate the relationship between early detectable variables and survival in newborns with CDH intubated at birth, managed with “gentle”ventilation and delayed surgery. Methods: All medical records of.patients af.ected by highrisk CDH and treated with a standardized protocol at Bambino gesúChildren’s Hospital, Rome, Italy, between January 2002 and September 2004 were reviewed. Prenatal diagnosis, gestational age, BW, sex, side of.hernia, and MGI were recorded on admission. The relationship with mortality of.each variable was evaluated by univariate analysis. Subsequently, a predictive model of.mortality was developed using a logistic regression: the explanatory variables, BW, and MGI were dichotomized in high (HBW and HMGI) and low (LBW and LMGI) according to the best cutof. f.und with receiver-operating characteristic curves. Results: Thirty-f.ur newborns with CDH, treated with a standardized protocol, were studied. The main characteristics of.the 34 patients were BW, 2886 g (1500-3620 g); gestational age, 37.7 weeks (32-42 weeks); male/f.male, 22/12; right/lef., 8/26; prenatal diagnosis, 29; MGI, 1.31 (0.9-1.85). Only BW and MGI were signif.cantly (P f. values were 2755 g f.r BW (sensitivity, 70%; specif.city, 74%) and 1.25 f.r MGI (sensitivity, 73%; specif.city, 78%). Using these limits, BW and MGI resulted independently associated with mortality in the multivariate analysis. Using the 4 possible combinations, the LBW

关键词：新生儿患者先天性膈疝预测作用死亡率出生时指数体重 Apgar评分死亡危险率主动脉直径

多发性硬化症时体液病理改变与治疗性血浆置换疗效间的关系

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 2-3页

作者： Keegan M. Kinig f. mCclelland R. C. f.Lucchinetti 郭俊 Dr.Department of.Neurology Mayo Clin-icCollege of Medicine Rochester MN 55905 United States

Early, active multiple sclerosis lesions show f.ur immunopathological patterns of.demyelination. Although these patterns dif.er between patients, multiple active lesions f.om a given patient have an identical pattern, which suggests pathogenic heterogeneity. Therapeutic plasma exchange (TPE) has been successf.lly used to treat f.lminant demyelinating attacks unresponsive to steroids. We postulated that patients with pattern II would be more likely to improve af.er TPE than those with other patterns since pattern II lesions are distinguished by prominent immunoglobulin deposition and complement activation. We retrospectively studied 19 patients treated with TPE f.r an attack of.f.lminant CNS inf.ammatory demyelinating disease. All patients with pattern II (n=10), but none with pattern I (n=3) or pattern III (n=6), achieved moderate to substantial f.nctional neurologicalimprovement af.er TPE (p f.vourably to TPE than are patients with patterns I or III.

关键词：多发性硬化症治疗性血浆置换脱髓鞘性疾病免疫病理中枢神经系统免疫球蛋白暴发性补体激活异质性