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基于多叶调强准直器的调强放疗系统的运行与剂量学验证

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中华放射医学与防护杂志 2008年第1期28卷 60-62页

作者：王佳 Dobler B Lohr f.Wenz f.任秋实上海交通大学生命科学技术学院 200240 Department of.Radiation Oncology Mannheim Medical Center University of Heidelberg Germany

调强放疗（IMRT）是一种采用强度不均匀并且可调节的射线照射目标靶区的适形放疗方法。基于多叶调强准直器（multileaf.intensity—modulating coilimator，MIMiC）的IMRT是一种动态放疗方法，同时MIMiC形成的扇形柬在治疗床定位装置Aut... 详细信息

调强放疗（IMRT）是一种采用强度不均匀并且可调节的射线照射目标靶区的适形放疗方法。基于多叶调强准直器（multileaf.intensity—modulating coilimator，MIMiC）的IMRT是一种动态放疗方法，同时MIMiC形成的扇形柬在治疗床定位装置AutoCRANE的辅助下还可实现层进式治疗。然而由于MIMiC不均匀强度动态照射，增加了调强射野照射剂量的不确定性，实施过程中任何环节出现差错都会引起极大的治疗误差。因此为保证这一技术临床实施的安全与可靠，笔者在德国曼海姆医学中心放射肿瘤治疗中心围绕Peacock系统的运行过程进行验证，探讨IMRT计划的剂量验证方法并对测量结果进行分析。

关键词：调强放疗剂量学验证准直器运行系统 MIMiC 肿瘤治疗中心射线照射

热休克蛋白65与βhCG多表位融合蛋白疫苗的抗黑色素瘤研究

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药物生物技术 2015年第5期22卷 382-386页

作者：杨洁程乾陆峥李曼曼袁玉婷曹荣月徐州医学院江苏省肿瘤生物治疗重点实验室江苏徐州221002 中国药科大学生命科学与技术学院微基因药物实验室江苏南京210009

选取HSP65-X10-βhCGCTP37融合蛋白作为免疫原,观察其对小鼠黑色素瘤B16-f.0的体内抑制作用,以及对荷瘤小鼠生存期的影响,并对其抗肿瘤的作用机理进行初步探讨。以制备的HSP65-X10-βhCGCTP37蛋白免疫C57BL/6J小鼠,2 w免疫1次,共4次。第... 详细信息

选取HSP65-X10-βhCGCTP37融合蛋白作为免疫原,观察其对小鼠黑色素瘤B16-f.0的体内抑制作用,以及对荷瘤小鼠生存期的影响,并对其抗肿瘤的作用机理进行初步探讨。以制备的HSP65-X10-βhCGCTP37蛋白免疫C57BL/6J小鼠,2 w免疫1次,共4次。第4次免疫后的第2 w,进行肿瘤攻击实验。HSP65-X10-βhCGCTP37激发的免疫应答对于小鼠黑色素瘤的攻击起到了有效的保护作用,与PBS阴性对照组比较,实验组小鼠的平均肿瘤重量显著降低(P<0.05);并有效延长了荷瘤鼠的生存期;小鼠的黑色素移植瘤的肿瘤病理切片结果显示,疫苗对肿瘤细胞的体内生长有明显的抑制作用,核分裂减少,淋巴细胞浸润增加,有灶性坏死。HSP65-X10-βhCGCTP37蛋白疫苗能有效地抑制小鼠黑色素瘤的生长。

关键词：人绒毛膜促性腺激素热休克蛋白65 蛋白疫苗黑色素瘤病理切片生存期考察

无创性皮层刺激对慢性卒中患者熟练运动功能的影响

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 9-10页

作者： Hummel f. Celnik P. Giraux P. L.G. Cohen 郭俊 Human Cortical Physiology Section NINDS NIH BethesdaMD 20817 United States Dr.

Stroke is a leading cause of.adult motor disability. Despite recent progress, recovery of.motor f.nction af.er stroke is usually incomplete. This double blind , Sham-controlled, crossover study was designed to test the hypothesis that non -invasive stimulation of.the motor cortex could improve motor f.nction in the p aretic hand of.patients with chronic stroke. Hand f.nction was measured using th e Jebsen-Taylor Hand f.nction Test (JTT),a widely used, well validated test f.r f.nctional motor assessment that ref.ects activities of.daily living. JTT measu red in the paretic hand improved signif.cantly with non-invasive transcranial direct current stimulat ion (tDCS), but not with Sham, an ef.ect that outlasted the stimulation period, was present in every single patient tested and that correlated with an increment in motor cortical excitability within the af.ected hemisphe- re, expressed as increased recruitment curves(RC) and reduced short-interval intracortical inhibition. These results document a benef.cial ef.ect of.non-inv asive cortical stimulation on a set of.hand f.nctions that mimic activities of.d aily living in the paretic hand of.patients with chronic stroke, and suggest tha t this interventional strategy in combination with customary rehabilitative trea tments may play an adjuvant role in neurorehabilitation.

关键词：电刺激轻瘫康复治疗内抑制刺激时间交叉研究治疗效应

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伦敦市新的创意平台——温室

景观设计 2008年第6期 36-41页

作者： Pedro f. Marcelino Gany Ash f.ecuk Rissom Ioana Marinescu Nick Guttridge 武秀伟（翻译）不详 Ash Saknla建筑师事务所

从20世纪80年代开始，自由形式艺术机构就纷纷在伦敦许多小型场地上开展“艺术存于心中”的城市重建工程，以其独特的使命感为艺术及创新产业提供服务，近来来，该机构在环境改造方面扮演着越来越重要的角色，在伦敦的各个角落许多宏伟... 详细信息

从20世纪80年代开始，自由形式艺术机构就纷纷在伦敦许多小型场地上开展“艺术存于心中”的城市重建工程，以其独特的使命感为艺术及创新产业提供服务，近来来，该机构在环境改造方面扮演着越来越重要的角色，在伦敦的各个角落许多宏伟的重建计划被实施，其中包括未来奥运场地的重建工程，新的创意空间是该机构更好地开展创造性工作的必备条件，该项目是该机构的新家，地处伦敦东部的Hackeny区，能够满足这种需要，设计师及建筑师正聚集到该创意空间中.

关键词：创意空间伦敦市温室重建工程环境改造机构艺术

贝多芬两首小提琴与乐队浪漫曲作品40号作品50号小提琴与钢琴谱

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慢性丙型肝炎感染者的LKM1自身抗体:一项分子模拟研究

丛书名：音乐伴奏CD系列乐谱

2005年

作者：（德）贝多芬（Ludwig Van Beethoven）曲伊格尔·奥依斯特拉赫（Igor Oistrach）小提琴编订曼弗雷德·费希纳（Manf.ed f.chner）钢琴缩编

本书录了贝多芬《G大调浪漫曲》、《f.调浪漫曲》，并附有CD1张。

ISBN: (纸本)7103030820

本书录了贝多芬《G大调浪漫曲》、《f.调浪漫曲》，并附有CD1张。

关键词：小提琴浪漫曲德国选集

来源：畅想之星图书光盘版（南... 评论

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 49-50页

作者： Marceau G. Lapierre P. Béland K. f. Alvarez 张欣 Service de Gastroenté rologie Hé patologie et Nutrition Hpital Sainte-Justine 3175 Cte Ste-CatherineMontré al Que. H3T 1C5 Canada Dr.

Anti-liver-kidney microsome type 1 (LKM1) autoantibodies directed against the cytochrome P450 2D6 (CYP2D6) are considered specif.c markers of.type 2 autoimmune hepatitis, but are also f.und in 5% of.sera f.om patients chronically inf.cted by hepatitis C virus (HCV). Molecular mimicry between HCV proteins and CYP2D6 has been proposed to explain the emergence of.these autoantibodies. Anti LKM1 autoantibodies f.om hepatitis C-inf.cted patients were af.inity-purif.ed against immobilized CYP2D6 protein and used to screen a phage display library. CYP2D6 conf.rmational epitopes were identif.ed using phage display analysis and the identif.cation of.statistically signif.cant pairs (SSPs). Cross-reactivity between CYP2D6 and HCV protein candidates was tested by immunoprecipitation. Nineteen dif.erent clones were isolated, and their sequencing resulted in the mapping of.a conf.rmational epitope to the region of.amino acids 254- 288 of.CYP2D6. Candidate HCV proteins f.r molecular mimicry included: core, E2, NS3 and NS5a. Af.inity-purif.ed autoantibodies f.om HCV+ /LKM1+ patients immunoprecipitated either NS3, NS5a, or both, and these reactivities were specif.cally inhibited by immobilized CYP2D6. In conclusion, HCV+ /LKM1 + sera recognize a specif.c conf.rmational epitope on CYP2D6 between amino acids 254 to 288, the region that contains the major linear epitope in type 2 autoimmune hepatitis patients. Cross-reactivity due to molecular mimicry at the B-cell level was shown between the CYP2D6 and the HCV NS3 and NS5a proteins and could explain the presence of.anti-LKMl in patients chronically inf.cted with HCV. f.rther investigation of.the role played by this molecular mimicry in HCV-inf.cted patients may lead to more specif.c strategies f.r diagnosis and treatment.

关键词：丙型肝炎感染 LKM1 分子模拟自身抗体噬菌体展示细胞色素特异性标记核心蛋白免疫沉淀物

皮肤黏膜巴西芽生菌病:法国奎亚那确诊的首例病例(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 29-30页

作者： Sarazin f. Sainte-Marie D. Demar M. P.Couppie 刘燕 'Service de Dermatologie Centre Hospitalier de Cayenne BP 6006 Cayenne Cedex French Guiana

Introduction. Paracoccidio-domycosisis a deep mycosis due to a dimorphic f.ngus: Paracoccidioides brasiliensis. The principle endemic country is Brazil. We describe the f.rst case of.paracoccidio-domycosis, in its cutaneous-mucosal f.rm, diagnosed in f.ench Guiana. Observation. A 20 year-old Brazilian man, having mover to f.ench Guiana a f.w months earlier, presented with multiple disseminated cutaneous lesions, predominating on the f.ce, and composed of.multiple nodules and two ulcerations. The clinical examination also revealed voluminous superf.cial lymph nodes and ulcerations of.the pharynx and larynx. Direct examination, anatomopathology and culture of.cutaneous biopsies revealed specif.c images of.Paracoccidioides brasiliensis. HIV serology was negative. Treatment combining cotrimoxazole and itraconazole eliminated the lesions in one month. Discussion. Because the patient had just moved to Guiana, this observation probably corresponded to an imported disease. The principle dif.erential diagnosis was leishmaniosis.

关键词：巴西芽生菌病皮肤黏膜亚那播散型双相型真菌皮损消退依曲康唑多形性利什曼病病理解剖学

阿尔茨海默病APOE基因表达和脑内淀粉样蛋白沉积之间是否相关

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 36-37页

作者： Lambert J.-C. Mann D. Richard f. 方伯言 Unité INSER M 508 Institut Pasteur de Lille 1 rue du professeur Calmette 59019 Lille CédexFrance Dr.

Background: It has been proposed that, independent of.the 4 allele, APOE prom oter polymorphisms (- 491 A/T and 219 G/T) may be risks f.ctor f.r Alzheimer’ s disease by modulating APOE expression. Objective: To measure the level of.APOE expression in Alzheimer’ s disease. Methods: Brains were obtained at necropsy f.om 114 patients with early and late onset sporadic Alzheimer’ s disease in Gr eater Manchester (UK) during years 1986 to 2001. Total RNA was extracted f.om 84 brains. Purif.ed lymphocytes were obtained f.om f.esh blood f.om 16 probable Al zheimer cases f.om Lille (f.ance). APOE and β - actin gene expression was dete rmined by reverse transcriptase polymerase chain reaction in brain and lymphocyt es. Results: An inverse correlation between APOE expression level and Aβ loads was observed. As previously described and extended to 114 cases here, an associ ation between the - 219 TT genotype and a higher level of.parenchymal Aβ .depo sition was f.und, irrespective of.APOE  4 allele status. This ef.ect was more pronounced in older individuals, whereas higher Aβ load appeared more closely related to 4inthe younger age group (cut of. point at the median age at death (7 2.5 years). The - 219 TT genotype was associated with a decrease in APOE expres sion. There was a 60% decrease in APOE expression in lymphocytes f.om probable Alzheimer cases v controls (p=0.01). Conclusions: In the oldest individuals, re duced APOE expression, modulated in part by - 219 G/T polymorphism, may inf.uen ce risk and constitute a determinant Aβ load in Alzheimer’ s disease.

关键词：阿尔茨海默病 APOE基因淀粉样蛋白沉积基因表达脑标本死亡年龄试验样本多态性负相关

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病例报道:巨大的“T”形横结肠重复畸形

世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 50-51页

作者： Trotovek B. Hribernik M. GvardijaniD. Jelenc f. 李丹 Institute of.Anatomy Medical Faculty University of Ljubljana SI-1000 Ljubljana Slovenia

A case of.long diverticular colonic duplication producing acute abdominal pain in a 6-year-old girl is presented. Physical examination showed no signs of.acute abdomen at the initial presentation. Af.er a pain-f.ee interval, there was a sudden onset of.severe abdominal pain and a large tumor in the lower abdomen was observed. A plain x-ray showed an enormously dilated colonic pouch f.lled with gas. Excision of.the T-shaped duplication and small part of.the transverse colon was successf.l. Because of.extensive f.brotic changes in the colon near the opening of.duplication, a resection margin of.at least 2 cm is recommended.

关键词：结肠重复畸形腹部巨大肿块病例报道急性腹部疼痛切除手术阳性体征体格检查 X线平片急腹症缓解期