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Characterization of fusarium Oxysporum Isolates Obtained from Wax Gourd and Chieh-qua in China by Pathogenicity, RAMs and Sequence Analysis of the rdNA Internal Transcribed Spacers (ITS1 and ITS2)

作者： (南非)E. d.·普莱希斯

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分子植物育种 2007年第2期5卷 271-272页

作者： d.S. Xie　 X.M. He　 Q.W. Peng Vegetable Research Institute Guangdong Academy of Agricultural Science Guangzhou 510640 China

Wax gourd (Benincasa hispida Thumb. Cogn) is called white gourd, winter melon, Chinese preserving melon, Chinese squash, and don kwa. It has been cultivated in China for over 2 300 years. It probably

关键词：镰刀霉病原序列分析白葫芦

HPTLC Phytochemical Screening and Hydrophilic Antioxidant Activities of Apium graveolensL., Cleome gynandraL., and Hibiscus sabdariffaL. Used for diabetes Management

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American Journal of Analytical Chemistry 2021年第1期12卷 15-28页

作者： Moumouni Koala Alphonsine Ramde-Tiendrebeogo Noufou Ouedraogo Sylvain Ilboudo Boukaré Kaboré félix B. Kini Sylvin Ouedraogo Institut de Recherche en Sciences de la Santé Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Laboratoire de Chimie Organique et Physique Appliquées (L.C.O.P.A.) Université Joseph KI-ZERBO UFR/SEA Département de Chimie Ouagadougou Burkina Faso Unité Mixte Internationale Environnement-Santé-Société (UMI 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB-P&ocirc le Burkina Ouagadougou Burkina Faso

diabetes mellitus is a socially significant disease characterized by chronic hyperglycemia and metabolic disorders of proteins, carbohydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in bioactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa from Burkina faso were investigated for their phytochemical profile and antioxidant activities. The high-performance thin-layer chromatography profile revealed flavonoids, tannins, and sterols in these herbaceous. The Hibiscus sabdariffa methanolic extract exhibited the highest total phenolic (138.4 ± 0.5 mg GAE/g dW) and flavonoid (52.8 ± 0.6 mg RuE/g dW) contents comparatively to Cleome gynandra and Apium graveolens. Hibiscus sabdariffa methanolic extract also presented the highest antioxidant activity (IC50 = 0.31 ± 0.002 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl (dPPH) radical scavenging capacity assay. A high correlation between flavonoid contents and hydrophilic antioxidant activities (r = 0.99) was observed, indicating that flavonoids contribute significatively to these herbaceous antioxidant properties. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa constitute a natural source of phenolic compounds that could be exploited in diabetes mellitus management.

关键词： diabetes Mellitus Medicinal Plants flavonoids Contents Hydrophilic Antioxidant Activity HPTLC Screening

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美国政党和选举

美国政党和选举

A CLINICAL STUdY Of CEREBROSPINAL fEVER WITH SPECIAL REfERENCE TO THE dISEASE IN SHANGHAI

作者： H.f.·戈斯内尔(H.f. Gosnoll) R.G.·斯莫尔卡(R.G. Smolka)

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Chinese Medical Journal 1934年第6期048卷 515-535页

作者： f.d.ZAU S.M.C.Isolation Hospital for Chinese Shanghai.

1.A report of 1,673 cases of cerebrospinal fever treated at theMunicipal Chinese Isolation Hospital between 1924 and 1933 is *** in this is a number of tables and graphs showing yearly admis-sions of the cases;their distribution according to age,sex and season;the frequency in occurrence of some symptoms and signs as well as ofvarious complications;the death rate according to age,sex and season;the results of treatment by various special methods as well as byantimeningococcus serum of different brands;and the length of periodspent in the hospital for both cured and fatal *** the distribution of cases,it was found that March,Apriland May at least in this part of China are always the worst months ofthe year for the infection;that the period between 16 to 20 years of ageis the most favorable one for meningitic attack;that males are morepredisposed to the disease than females;and that people living in dustyplaces are more liable to be infected with meningococcus *** relationship of dust,cold, pre-existing infection and con-tact with the patients to cerebrospinal fever is briefly *** symptomatology of the disease,it was found that headache,restlessness and pain at the back of the neck are important early mani-festations of the infection while vomiting,fever,purpura,Kernig’ssign,*** not of so much *** stiffness and loss ofconsciousness are late signs of the *** infants the presence ofany bulging of the fontanelle coupled with a history of vomiting andconvulsions is strong evidence of meningitic *** diagnosis of any case of cerebrospinal fever must he con-firmed by examination of the spinal fluid as it is often impossible todifferentiate it from other forms of meningitis by symptoms *** with infant patients,a condition described as 'Ascarid men-ingitis' should ahvays be kept in mind and santonin treatment shouldbe resorted to without delay if the stools contain ova of ascarislumb

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fundamental Investigations in the design of five-Axis Nanopositioning Machines for Measurement and fabrication Purposes

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Nanomanufacturing and Metrology 2021年第3期4卷 156-164页

作者： Ralf Schienbein florian fern Rene Theska Shraddha Supreeti Roland fuBl Eberhard Manske department of Mechanical Engineering Institute of Design and Precision Engineering.Technical University of Ilmenau.IlmenauGermany Institute of Process Measurement and Sensor Technology Department of Mechanical EngineeringTechnical University of IlmenauIlmenauGermany Electronics Technology Group Department of Electrical Engineering and Information TechnologyTechnical University of IlmenauIlmenauGermany

The majority of nanopositioning and nanomeasuring machines(NPMMs)are based on three independent linear movements in a Cartesian coordinate *** in combination with the specific nature of sensors and tools limits the addressable part *** enhancement of an NPMM is introduced by the implementation of rotational movements while keeping the precision in the nanometer *** this purpose,a parameter-based dynamic evaluation system with quantifiable technological parameters has been set up and employed to identify and assess general solution concepts and adequate *** taken show high potential for three linear movements of the object in combination with two angular movements of the *** influence of the additional rotation systems on the existing structure of NPMMs has been investigated further *** series on the repeatability of an NPMM enhanced by a chosen combination of a rotary stage and a goniometer setup are *** a result of these test series,the necessity of in situ position determination of the tool became very *** tool position is measured in situ in relation to a hemispherical reference mirror by three fabry-Perot *** optimization has been used to enhance the overall system structure with regard to reproducibility and long-term *** have been experimentally investigated by use of a retroreflector as a tool and the various laser interferometers of the *** knowledge gained has been formed into general rules for the verification and optimization of design solutions for multiaxial nanopositioning machines.

关键词： Multiaxial nanopositioning and nanomanufacturing Ultra-precision machine designs 5-Axis operation Ultraprecision rotations

A 3d Human Liver Model of Nonalcoholic Steatohepatitis

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 359-370页

作者： Marion duriez Agnes Jacquet Lucile Hoet Sandrine Roche Marie-dominique Bock Corinne Rocher Gilles Haussy Xavier Vigé Zsolt Bocskei Tamara Slavnic Valérie Martin Jean-Claude Guillemot Michel didier Aimo Kannt Cécile Orsini Vincent Mikol Anne-Céline Le fèvre Translational Sciences Sanofi1 Avenue Pierre BrossoletteChilly-MazarinFrance IT&M STATS Groupe IT&MNeuilly-sur-SeineFrance Non Clinical Biostatistics SanofiVitry sur SeineFrance diabetes and Cardiovascular Research SanofiIndustriepark HöchstFrankfurtGermany Institute of Experimental Pharmacology Medical Faculty MannheimUniversity of HeidelbergMannheimGermany

Background and Aims: To better understand nonalcoholic steatohepatitis (NASH) disease progression and to evaluate drug targets and compound activity, we undertook the devel-opment of an in vitro 3d model to mimic liver architecture and the NASH environment. Methods:We have developed an in vitro preclinical 3d NASH model by coculturing primary hu-man hepatocytes, human stellate cells, liver endothelial cells and Kupffer cells embedded in a hydrogel of rat collagen on a 96-well plate. A NASH-like environment was induced by ad-dition of medium containing free fatty acids and tumor ne-crosis factor-α. This model was then characterized by biochemical, imaging and transcriptomics analyses. Results:We succeeded in defining suitable culture conditions to main-tain the 3d coculture for up to 10 days in vitro, with the lowest level of steatosis and reproducible low level of inflammation and fibrosis. NASH disease was induced with a custom me-dium mimicking NASH features. The cell model exhibited the key NASH disease phenotypes of hepatocyte injury, steatosis, inflammation, and fibrosis. Hepatocyte injury was highlighted by a decrease of CYP3A4 expression and activity, without loss of viability up to day 10. Moreover, the model was able to stimulate a stable inflammatory and early fibrotic environ-ment, with expression and secretion of several cytokines. A global gene expression analysis confirmed the NASH induc-tion. Conclusions:This is a new in vitro model of NASH dis-ease consisting of four human primary cell-types that exhibits most features of the disease. The 10-day cell viability and cost effectiveness of the model make it suitable for medium throughput drug screening and provide attractive avenues to better understand disease physiology and to identify and characterize new drug targets.

关键词： 3d liver model Human primary cells Key features of NASH

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气相法生产氮化钛和碳化钛粉

稀有金属材料与工程 1987年第4期 41-45页

作者： d. d Harbuck,张正德美国矿务局盐湖市研究中心

矿务局研究了一种生产细粒度氮化钛、碳化钛和碳氮化钛粉末的工艺。因为这些粉末具有高硬度和耐磨性,所以它能够代替碳化钨在某些切削工具方面的应用。氮化钛和碳化钛粉末能够与镍粘结在一起。本研究探讨了在氮气氛中,750—1050℃(1382... 详细信息

矿务局研究了一种生产细粒度氮化钛、碳化钛和碳氮化钛粉末的工艺。因为这些粉末具有高硬度和耐磨性,所以它能够代替碳化钨在某些切削工具方面的应用。氮化钛和碳化钛粉末能够与镍粘结在一起。本研究探讨了在氮气氛中,750—1050℃(1382—1922f°)温度下用镁或钠蒸气还原四氯化钛生产氮化钛的方法。在氮气氛中添加甲烷,能够形成碳化碳和碳氮化钛,获得了高达98%的四氯化钛还原效率。X射线衍射分析表明,这种粉末不含有显著杂质。由于反应是在气相中进行的,因而获得了小于1μm的粉末。

关键词：粉末甲烷沼气烷烃气相反应均相反应氮化物氮化合物还原剂气相法杂质含量 XRd

德国社会民主党史第2卷三月革命及其后果 1848-1863 第1版

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