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Exploring the Relationship between Adiponectin and Blood Pressure in Nigerian Children

Open Journal of Endocrine and Metabolic Diseases 2022年第2期12卷 9-19页

作者： Chisom Adaobi Nri-Ezedi Henry Chima Okpara Kenneth Nchekwube Okeke ezinne ifeyinwa nwaneli Emeka Stephen Edokwe Sylvia Tochukwu Echendu Thomas Obiajulu Ulasi Department of Paediatrics Faculty of Medicine Nnamdi Azikiwe University Awka Nigeria Department of Chemical Pathology Faculty of Medicine Nnamdi Azikiwe University Awka Nigeria Life International Hospital Awka Nigeria

Background: Adiponectin possesses essential physiological functions that protect against the onset of cardiovascular and metabolic diseases. Although several studies have discussed the association between adiponectin and Blood Pressure (BP) in adults and older adolescents. To the best of our knowledge, this is the first study to explore the relationship between adiponectin and BP among children in Africa. Significance: This novel discovery is expected to serve as a benchmark for future local studies in examining the role of adiponectin in cardiovascular disorders among Africans. Method: A cross-sectional study was conducted among 86 healthy children aged 4 to 11 years with normal BMI. BP values were measured and percentiles derived from the 2017 revised clinical practice guidelines of the American Academy of Paediatrics. Fasting blood adiponectin values were determined with ELISA, and the level of statistical significance was set at p Result: 86 children were comprised of 42 (48.8%) males and 44 (51.2%) females. The mean age of all subjects was 7.5 ± 2.3 years, while that of fasting adiponectin was 4.8 ± 2.1 ng/dl. There were no significant differences in the age, Body Mass Index, BP and adiponectin concentrations across gender. 69 (80.2%) participants had normal BP while 5 (5.8%) and 12 (14.0%) had elevated BP and stage 1 hypertension. Mean adiponectin values for normal BP, elevated BP and stage 1 hypertension were 5.1 ± 2.1 ng/ml, 3.3 ± 1.2 ng/ml and 4.1 ± 1.9 ng/ml respectively (p-value = 0.039). A significant negative correlation was observed between adiponectin and systolic BP independent of age, sex, and BMI. Although a negative correlation was noted between adiponectin and diastolic blood pressure, this was not statistically significant. Conclusion: Adiponectin correlates negatively with systolic BP in young Nigerian children independent of age, Body Mass Index and gender. More studies are indicated to investigate this relationship in association with vital m

关键词： Adiponectin Blood Pressure Cardiovascular Diseases Nigeria Atherosclerosis Hypertension

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Sociodemographic Factors for Vitamin D Levels in Children with Acute Respiratory Infection

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Open Journal of Pediatrics 2021年第4期11卷 759-769页

作者： Esther Ngozi Umeadi Sylvia Tochukwu Echendu Chinyelu Uchenna Ufoaroh Ernest Ndukaife Anyabolu ezinne ifeyinwa nwaneli Wilson Chukwuneke Igwe Chijioke E. Ezeudu Ekene Agatha Emeka Joy Chinelo Ebenebe Ifeoma Egbuonu Department of Pediatrics Nnamdi Azikiwe University Nnewi Nigeria Department of Medicine Nnamdi Azikiwe University Nnewi Nigeria Department of Medicine Chukwuemeka Odumegwu Ojukwu University Awka Nigeria

Background and Objectives: Childhood acute respiratory infection is a public health problem with significant morbidity and mortality in developing countries. The present study was to assess the sociodemographic determinants of vitamin D levels in patient with acute respiratory infections (ARIs) receiving care in Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Southeast Nigeria. Methodology: This was a cross-sectional study, conducted in Nnewi, Nigeria, on 250 children with ARI. Sociodemographic data were collected and serum vitamin D levels of the subjects were assayed. The association between sociodemographic variables and vitamin D was evaluated using multivariate logistic regression analysis. Results: A total of 250 children with ARI aged 1 - 59 months were enrolled in this study, with slight male preponderance (57.2%). About 60% of the population was less than 2 years. The majority (85.6%) of the subjects had adequate vitamin D levels (≥20 ng/dL). The mean serum vitamin D level in the subjects was (52.2 ± 25.6 ng/mL). Multivariate logistic regression showed that only gender was significantly related to vitamin D levels with males found to have a lower risk of vitamin D deficiency. {OR = 0.05

关键词： Vitamin D Deficiency Under-Five Children Acute Respiratory Infection Gender

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