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中国农业科学 2007年第12期40卷 2667-2678页

作者：王兰芬 BALFOURIERF 郝晨阳 exbrayat-vinsonf 董玉琛盖红梅张学勇中国农业科学院作物科学研究所/农业部作物品种资源与生物技术重点实验室/国家农作物基因资源与基因改良重大科学工程 INRA UMR Améliorationet Santédes Plantes234 avenuedu Brézet63100 Clermont-FerrandFrance

【目的】在分子水平上回答欧洲和东亚小麦品种的遗传关系和多样性差异;同时对Genomic-SSR(gSSR)和EST-SSR(eSSR)多态性水平进行比较分析。【方法】利用38个Genomic-SSR引物对和44对EST-SSR引物对分析371份欧洲小麦品种和363份东亚品种... 详细信息

【目的】在分子水平上回答欧洲和东亚小麦品种的遗传关系和多样性差异;同时对Genomic-SSR(gSSR)和EST-SSR(eSSR)多态性水平进行比较分析。【方法】利用38个Genomic-SSR引物对和44对EST-SSR引物对分析371份欧洲小麦品种和363份东亚品种。【结果】共检测到865个等位变异,每个引物对的等位变异数为1～50,平均为10.42;多态性信息含量(PIC)为0～0.91,平均为0.53;欧洲和东亚品种分别检测到730、716个等位变异,特有等位变异分别为150、135,平均遗传丰富度分别为8.80和8.61,遗传多样性指数分别为0.46和0.52。欧洲和东亚小麦品种在聚类图上明显地划分为两大类群;每个国家或大区聚类结果与其地理分布基本一致,即相邻国家或地区的品种亲缘关系更近一些。近一半基因座的等位变异频率及其分布在欧洲与东亚材料间存在明显差异。通过标记/性状关联分析,在4B、5A、6A、7B染色体上发现6个影响穗粒数、千粒重、株高、抽穗期、有效分蘖等重要农艺性状的基因座,其中个别基因座优势等位变异差异可能与东亚、欧洲品种的分化密切相关。中国20世纪50～80年代育成品种在大的聚类上明显靠近欧洲材料、而远离中国50年代以前的育成品种和地方品种,这与中国的育种实际相吻合。基于Genomic-SSR和基于EST-SSR的聚类图整体趋势是一致的,但由前者估算的遗传距离远高于后者,因此,一般的SSR较功能基因SSR更易发生变异,由育种选择所引起的分化更快。【结论】在中国今后的小麦育种中,需要通过杂交、回交,对欧洲品种的一些重要基因座等位变异(基因)进行置换,方有可能实现"洋为中用"的目的。

关键词：小麦遗传多样性 gSSR eSSR 地理分化关联分析

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Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

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World Journal of Gastroenterology 2021年第31期27卷 5272-5287页

作者： Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie Clerc Claire Piccotti Anne Deloraine Catherine exbrayat Site de l'Ain Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-AlpesBourg-en-Bresse 01000France Site de Seine-Saint-Denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-FranceBondy 93146France Sites Savoie&Haute Savoie Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesChambery 73000France Site de Drome Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesValence 26000France Site Isere&Drome-Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesMeylan 38240France

BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been *** To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening *** This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December *** between test_((-1))and test_((0))was>1year and test_((-1))result was negative(<150 ngHb/mL).The severity of colorectal lesions diagnosed at test_((0))was described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression *** The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of *** risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to

关键词： Colorectal cancer screening Fecal immunochemical test Fecal hemoglobin concentration Colorectal lesion severity

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Expression Patterns of CAPN1 and CAPN8b Genes during Embryogenesis in Xenopus laevis

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CellBio 2013年第4期2卷 211-216页

作者： Lucie Abrouk-Vérot Claire Brun Jean-Marie exbrayat Université de Lyon UMRS 449 Biologie Générale Université Catholique de Lyon Reproduction et Développement Comparé Ecole Pratique des Hautes Etudes Lyon France

Calpains are a superfamily of Ca2+-dependent cysteine proteases, implicated in various cellular processes and thus probably necessary in all the stages of cell life. The first extended report of quantification of total RNAs within the developmental stages of Xenopus laevis was described in this study. Decreases of total RNAs were positively associated with waves of apoptotic cell death (onset of gastrulation, and morphogenesis). Using qPCR, the temporal expression pattern of CAPN1 and CPAN8b (XCL-2) were characterized during the Xenopus laevis embryogenesis. Transcripts of the CAPN1 and CAPN8 genes were detectable from gastrula stage and their levels oscillated throughout development. The expression of the CAPN1 (mu/I) gene was observed in earliest stage, indicating a maternal origin, while expression of the CAPN8b gene was detectable after midblastula transition. The levels of the two transcripts then started to rise again obviously as a result of zygotic expression (stage 11). The CAPN1 gene expression was particularly expressed at tailbud stage, while the CAPN8 transcripts were found at gastrula, neurula and tailbud stages. This is the first report of quantification of mRNAs CAPN8b and CAPN1 (mu/I) within the developmental stages of Xenopus laevis by qPCR.

关键词： Calpain Embryonic Development Cell Death Xenopus laevis

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Apoptosis in amphibian development

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Advances in Bioscience and Biotechnology 2012年第6期3卷 669-678页

作者： Jean-Marie exbrayat Elara N. Moudilou Lucie Abrouk Claire Brun Université de Lyon UMRS 449 Biologie générale Université catholique de Lyon Reproduction et développement comparé Ecole Pratique des Hautes Etudes 25 rue du Plat F-692088 Lyon Cedex 02 France

Amphibians and more particularly X. laevis are models often used for studying apoptosis during embryonic development. Using several methods, searchers determined the localization of programmed cell deaths (PCD). Several experimental methods also have been used to understand the regulatory mechanisms of apoptosis, throughout development, contributing to elucidate the general action of several genes and proteins. Apoptosis occurs very early, with a first program under control of maternal genes expressed before MBT, in order to eliminate damaged cells before gastrulation, and a second program at the onset of gastrulation. PCD is also observed during neurulation. Then, apoptotic cells are observed in amphibian organogenesis and metamorphosis. Results of these researches showed both importance of PCD for embryonic development, and the complexity of its regulation. Results obtained can be useful to understand others aspects of the importance of apoptosis, particularly pathological aspects.

关键词： PCD Apoptosis Development Metamorphosis Amphibian Xenopus

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Comparison of Genetic Diversity Level between European and Asian Wheat Germplasm,Using SSR Markers

Comparison of Genetic Diversity Level between European and A...

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第二届植物分子育种国际会议

作者： F.exbrayat-Vinson Valérie Roussel F.Balfourier INRA UMR1095 Amélioration et Santé des PlantesF-63100 Clermont-FerrandFrance INRA UMR1095 Amélioration et Santé des PlantesF-63100 Clermont-FerrandFrance INRA UMR1095 Amélioration et Santé des PlantesF-63100 Clermont-FerrandFrance

＜正＞In order to compare genetic diversity level between contrasted wheat germplasm （Triticum. aestivum）, 371 accessions collected from 21 European countries plus 363 accessions , mainly collected from China, were

关键词： T. aestivum Genetic diversity Geographical structure Microsatellites markers

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叶落归根第一版

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1981年

作者：（英）爱克斯帕莱亚（exbrayat）陈轸尧译

这是一本诙谐、讽刺性推理小说。

ISBN: (纸本)10215·41

这是一本诙谐、讽刺性推理小说。

关键词：长篇小说现代英国

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