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Behavioral assessment of hippocampal function following dietary intervention

Food Science and Human Wellness 2018年第3期7卷 229-233页

作者： Klaus W.Lange ewelina stollberg Yukiko Nakamura Joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Pattern separation keeps items distinct in memory and is mediated by the hippocampus.A relationship between hippocampal function and diet quality has been suggested by findings in both humans and *** the present study,rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids,reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids(“Western”diet).Spatial pattern separation(or local discrimination)performance of these animals was compared with that of rats fed a standard diet.A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task,with rats of the“Western”group performing fewer *** present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a“Western”*** studies should determine which components of this diet induce the memory impairments related to the *** translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated.

关键词： Memory Hippocampus Western diet Fatty acids Sugar

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Alterations of attention and impulsivity in the rat following a transgenerational decrease in dietary omega-3 fatty acids

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Food Science and Human Wellness 2018年第1期7卷 49-56页

作者： Joachim Hauser ewelina stollberg Andreas Reissmann Ivo Kaunzinger Klaus W.Lange Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system *** present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar *** this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient *** addition,a group of previously untreated dams was fed an omega-3 sufficient *** male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSRTT).The present data show that the deficiency of omega-3 PUFAs over generations led to substantial changes in attentional processes and impulsive *** impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention *** there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive *** conclusion,transgenerational dietary changes in the availability of omega-3 PUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 PUFAs play a role in cognitive and behavioral *** present findings offer a promising approach in the investigation of the role of omega-3 PUFAs in a variety of cognitive and behavioral domains.

关键词： Omega-3 fatty acid Polyunsaturated fatty acids Attention Impulsivity Activity Rat Neurodevelopmental disorders Psychiatric disorders

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