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Journal of Cancer Metastasis and Treatment 2019年第11期4卷 12-22页

作者： Claudia Tulotta b.ewa Snaar-Jagalska IbL Animal Sciences & Health Institute of Biology LeidenLeiden UniversityLeidenCC 2333the Netherlands

Cell-to-cell communication guarantees homeostasis in a multi-cellular organism. Cancer-to-microenvironment communication sustains malignant growth and dissemination. Whereas the accumulation of mutations is at the origin of malignant cell transformation and neoplasia onset, the interaction between cancer and the surrounding stroma, specifically immune cells, influences the balance between tumour regression and tumour progression. To study how the interaction between cancer and stromal cells is disadvantageous or beneficial for tumour progression, the use of a transparent in vivo model bears important research potentials. Zebrafish has been increasingly used as animal model to study tumour biology. The use of transparent zebrafish embryos, with fluorescent endothelial and immune cells, allows the visualization of cell-to-cell interaction, among host cells themselves and between zebrafish stroma and implanted human cancer cells. Here, we summarise our findings on the role of CXCR4 signalling in tumour progression, considering its signature both on cell autonomous and host dependent mechanisms. Finally, we address the translational impact of targeting CXCR4 signalling in cancer and the tumour microenvironment for the treatment of metastatic cancer.

关键词： CXCR4 cancer metastasis neutrophils zebrafish immunotherapy

Effect of scots pine forest management on soil properties and carabid beetle occurrence under post-fire environmental conditions——a case study from Central Europe

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Forest Ecosystems 2020年第3期7卷 366-377页

作者： ewa błońska bartłomiej bednarz Magdalena Kacprzyk Wojciech Piaszczyk Jarosław Lasota Department of Ecology and Forest Silviculture Faculty of ForestryUniversity of Agriculture in KrakowAl.29-go Listopada 4631-425KrakówPoland Department of Forest Ecosystems Protection Faculty of ForestryUniversity of Agriculture in KrakowAl.29-go Listopada 4631-425KrakówPoland

background: Fires have a fundamental impact on phytocoenoses and, depending on the size of the fire, can have a positive or negative effect. The role of fires in the formation of the species composition of plants, restoration of stands and changes in soil properties is well studied. However, the long-term relationship between forest management methods, soil properties and epigeic entomofauna assemblages in post-fire areas is still not clear. The effects of Scots pine stand management methods on biochemical soil properties and ground beetle assemblages in the largest post-fire area in Central Europe after the second World were investigated. The study was conducted in the Rudy Raciborskie Forest district in southern Poland. The soil properties and epigeic beetle community structure were analysed. The research covered areas with natural and artificial pine regeneration, which were subjected to various care ***: The tendency for higher accumulations of organic matter in the soil of stands that underwent natural regeneration was proven. The stimulating role of soil organic carbon on the activity of dehydrogenases in the soil of naturally renewed areas with silvicultural treatment(NRAT) was noted. Regardless of the manner of stand regeneration, the activity of β-glucosidase was higher in the areas in which breeding treatments were ***, managed forest stands presented a higher abundance of carabid beetles than stands without treatment practices. Thirteen epigeic beetle species from the families Geotrupidae, Carabidae, Curculionidae,Cerambycidae and Silphidae were captured, with beetles from the first two families being the most numerous. Rare epigeal carabid species in the fauna of Poland and Europe, such as Carabus glabratus(Paykull) and Carabus auronitens Fabr., found appropriate habitat conditions for survival in the post-fire areas. Compared with the other areas, in the NRAT area, there were better stand and soil properties and more fea

关键词： Stand treatment strategy Forest regeneration Enzyme activity Soil organic carbon Epigeic beetle assemblage structure

Unique Factorization of Compositive Hereditary Graph Properties

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Acta Mathematica Sinica,English Series 2012年第2期28卷 267-280页

作者： Izak bROERE ewa DRGAS-bURCHARDT Department of Mathematics University of Johannesburg Department of Mathematics and Applied Mathematics University of PretoriaPretoria0002South Africa Faculty of Mathematics Computer Science and Econometrics University of Zielona Góra

A graph property is any class of graphs that is closed under isomorphisms, A graph property P is hereditary if it is closed under taking subgraphs; it is compositive if for any graphs

关键词： Graph property hereditary compositive property unique factorization minimal forbid-den graphs reducibility

The break-up tendency of long rod projectiles

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Defence Technology（防务技术） 2016年第2期12卷 177-187页

作者： ewa LIDéN Andreas HELTE FOI Swedish Defence Research Agency

A model for the tendency of fragmentation of a long rod projectile subjected to armour components in add-on armours such as reactive armour and active protection systems is presented. The model is based on studies of the interaction between a cylindrical streamlined projectile and moving thin plates(backwards moving like the front plate in a reactive armour panel and forwards moving like the rear plate in a reactive armour panel).The assumption behind the model is that the sliding force, with velocity vslidebetween the projectile and the plate, gives rise to a transverse velocity vtransof the projectile segment it passes, which will deflect the projectile segment. This deflection is assumed to be a major reason for the fractures that can emerge along the projectile. The velocity, geometry and material of the projectile and the plate are of importance for the fragmentation of the projectile and the dimensionless parameterδ? = v trans vslideexpresses how these parameters influence the break-up tendency. Experiments and simulations have verified that the identifiedδ?-parameter predicts an increased amount of fragmentation of the projectile with increasing value of this parameter.

关键词：长杆弹破裂反应装甲趋势模型主动防护系统横向速度无量纲参数附加装甲

(De) Constructing Sentences

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外国语 2013年第1期36卷 2-15页

作者： ewa Dabrowska Northumbria University UK

Lexically specific units,i.e.,formulaic frames(Where's Daddy? What's Mummy doing?) and frames with slots(***'s NP? Do you want to VP?) are known to play a central role in language *** such mechanisms also account for adult production? I argue that the types of representations and production mechanisms that constructivist language researchers have postulated for children can also explain the basic mode of adult language use,*** *** adult language in such terms not only captures the continuity between child and adult usage,but also helps to explain how speakers are able to produce and understand language as fast as they do: using preconstructed chunks saves processing ***,adults also have more abstract linguistic ***,however,are acquired relatively late in acquisition,largely as a result of experience with written texts,and may not be acquired by all speakers.

关键词：语言学语言理论语言规划分类

Satyrization and satyrization-resistance in competitive displacements of invasive mosquito species

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Insect Science 2016年第2期23卷 162-174页

作者： Irka ewa bargielowski Leon Philip Lounibos Florida Medical Entomology Laboratory University of Florida Vero Beach Florida USA

Competitive displacements or reductions of resident populations of insects, often effected by a related species, may be caused by a variety of mechanisms. Satyrization is a form of mating interference in which males of one species mate with females of another species, significantly decreasing their fitness and not generating hybrids. Satyriza- tion has been established to be the probable cause of competitive displacements of resident mosquitoes by invasive species, especially of Aedes aegypti by Aedes albopictus, two important vectors of dengue and chikungunya viruses. Mathematical models predict that even low levels of asymmetric mating interference are capable of producing competitive displacements or reductions. Couplings of virgin Ae. aegypti females with Ae. albopictus males effectively sterilize these females through the monogamizing actions of male ac- cessory gland products, but the converse interspecific mating does not impact the future reproduction ofAe. albopictus females. Populations ofAe. aegypti exposed to satyrization quickly evolve resistance to interspecific mating, which is believed to ameliorate repro- ductive interference from, and promote co-existence with, Ae. albopictus. The evolution of satyrization resistance among Ae. aegypti in laboratory cages is accompanied by fitness costs, such as reduced fecundity and slower receptivity to conspecific males. Cage exper- iments and field observations indicate that Ae. albopictus males are capable of satyrizing females of other species of the Stegomvia subgenus, potentially leading to competitive displacements, and possible extinctions, especially of endemic species on islands. Exam- ination of other examples of reproductive interference in insects reveals few parallels to the mechanism and outcomes of satyrization by Ae. albopictus. We conclude by posing the hypothesis that satyrization may favor the ecological success of Ae. albopictus, and suggest many lines for future research on this phenomenon.

关键词： Aedes aegypti Aedes albopictus mating interference reproductive interfer-ence satyrization

Decreased serum prohepcidin concentration in patients with polycythemia vera

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2009年第11期10卷 791-795页

作者： Justyna KWAPISZ ewa ■EKANOWSKA Joanna JASINIEWSKA Department of Pathophysiology Nicolaus Copernicus University in ToruńCollegium Medicum in Bydgoszcz

Objective： Iron deficiency is a common complication in patients with polycythemia vera （PV）. Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precursor, and other iron status pa- rameters in the serum of PV patients. Methods： The study was performed in 60 patients （F/M 26/34） aged 38-84 （66＋ 10） years. The control group consisted of 20 healthy volunteers, age and sex matched. The following parameters were determined in blood serum samples： prohepcidin concentration, iron content, unsaturated iron binding capacity （UIbC）, total iron binding capacity （TIbC）, transferrin saturation （TfS）, and concentrations of ferritin and soluble transferrin receptor （sTfR）. Results： All PV patients showed significantly lower levels of prohepcidin, higher levels of sTIR and TIbC compared to the control group. 40% of the patients from the study group showed concentrations of ferritin below the normal range and significantly lower levels of serum iron and TfS, and significantly higher levels of sTIR, UIbC and TIbC in comparison with the rest of the study group. In this group of patients, prohepcidin concentrations were significantly lower than those in other patients. Conclusion： The results indicate that PV patients suffer from iron metabolism disorders. The decreased serum level ofprohepcidin in PV patients may be a result of iron deficiency.

关键词： Polycythemia vera (PV) Iron metabolism Prohepcidin Hepcidin

Succinite, baltic Amber:A Chemical Masterpiece of Nature

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宝石和宝石学杂志（中英文） 2023年第4期25卷 69-87页

作者： ewa Wagner-Wysiecka Department of Chemistry and Technology of Functional Materials Faculty of ChemistryGdańsk University of TechnologyNarutowicza Street 11/1280-233 GdańskPoland Advanced Materials Center Faculty of ChemistryGdańsk University of TechnologyNarutowicza Street 11/1280-233 GdańskPoland International Amber Association Warzywnicza Street 180-838 GdańskPoland

Succinite,baltic amber,is one of the most appreciated fossil *** beauty has fascinated people since prehistoric *** is a substance,and also gemstone,whose uniqueness is due to its compelling,though still not fully understood,physicochemical *** this article,some facts about the physical and chemical properties of succinite in order to find an answer for questions about the unique properties of this resin,such as color,transparency,texture etc.,are *** properties are among the factors that determine the choice of baltic amber as a *** known properties of succinite,but also some less obvious features,have been linked to the organic and inorganic chemical composition and structural factors,including the sophisticated supramolecular structure masterfully created by *** of the properties of succinite used as a jewelry stone are discussed as a reflection of changes in its physicochemical *** this light,some methods that can be used to identify succinite(i.e.,infrared spectroscopy and nuclear magnetic resonance spectroscopy)and their relevance to the classification of fossil resins are briefly *** article highlights an important point:only by understanding the chemical and physical nature of the material we able to identify,modify and effectively use the goods that have been given to us by mother nature.

关键词： baltic amber succinite chemical composition property

A dopamine and noradrenaline reuptake inhibitor （bupropion） does not alter exercise performance of bank voles

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Current Zoology 2016年第3期62卷 307-315页

作者： ewa JAROMIN Edyta Teresa SADOWSKA Pawet KOTEJA Institute of Environmental Sciences Jagiellonian University Gronostajowa 7 Krakow 30-387 Poland

Physical performance is determined both by biophysical and physiological limitations and behav- ioral characteristic, specifically motivation. We applied an experimental evolution approach com- bined with pharmacological manipulation to test the hypothesis that evolution of increased aerobic exercise performance can be triggered by evolution of motivation to undertake physical activity. We used a unique model system： bank voles from A lines, selected for high swim-induced aerobic metabolism （VO2swim）, which achieved a 61% higher mass-adjusted VO2swim than those from un- selected C lines. because the voles could float on the water surface with only a minimum activity, the maximum rate of metabolism achieved in that test depended not only on their aerobic capacity, but also on motivation to undertake intensive activity. Therefore, we hypothesized that signaling of neurotransmitters putatively involved in regulating physical activity （dopamine and noradrenaline） had changed in response to selection. We measured VO2swim after intraperitoneal injections of sa- line or the norepinephrine and dopamine reuptake inhibitor bupropion （20 mg/kg or 30 mg/kg）. Additionally, we measured forced-exercise VO2 （VO2max）. In C lines, VO2swim （mass-adjusted mean ± standard error （SE）： 4.0 ± 0.1 mLO2/min） was lower than VO2max （5.0 ± 0.1 mLO2/min）, but in A lines VO2swim （6.0 ± 0.1 mLO2/min） was as high as VO2max （6.0 ± 0.1 mLO2/min）. Thus, the selection effectively changed both the physiological-physical performance limit and mechanisms responsible for the willingness to undertake vigorous locomotor activity. Surprisingly, the drug had no effect on the achieved level of VO2swim. Thus, the results did not allow firm conclusions concerning involvement of these neurotransmitters in evolution of increased aerobic exercise performance in the experimental evolution model system.

关键词： exercise performance motivation physical activity selection experiment.

Diffusion Carbide Layers, Formed on the Surface of Steel in the Vacuum Titanizing Process

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材料热处理学报 2004年第05B期25卷 646-648页

作者： KASPRZYCKA ewa SENATORSKI Jan NAKONIECZNY Aleksander bAbUL Tomasz Institute of Precision Mechanics Warsaw PolandInstitute of Precision Mechanics Warsaw PolandInstitute of Precision Mechanics Warsaw PolandInstitute of Precision Mechanics Warsaw Poland

Diffusion layers produced on carbon steel surface in vacuum titanizing process were investigated. Studies of layers thickness, their morphology, titanium, carbon and iron concentration depth profiles in the diffusion zone of titanized layers were carried out. The effect of process parameters such as time and temperature on the kinetics of layer growth on steel surface was investigated. Tribocorrosion resistance of titanized layers was determined.

关键词：扩散层热化学处理真空镀钛耐蚀性抗磨损性