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Hepatitis B virus mutations potentially conferring adefovir/ tenofovir resistance in treatment-naive patients

World Journal of Gastroenterology 2009年第6期15卷 753-755页

作者： Rebecca Pastor Franois Habersetzer Samira Fafi-Kremer Michel Doffoёl Thomas F Baumert Jean-Pierre Gut Franoise Stoll-Keller evelyne schvoerer Laboratoire de Virologie CHRU de Strasbourg3 Rue Koeberlé67000 StrasbourgFrance Service d'Hépato-gastroentérologie Nouvel Hpital Civil1 Place de l'Hpital67091 StrasbourgFrance Inserm U 748 Strasbourg3 Rue Koeberlé67000 StrasbourgFrance Université Louis Pasteur Facultéde Médecine4 Rue Kirschleger67084 StrasbourgFrance

Anti-hepatitis B virus(HBV)therapy leads to the emer- gence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants with primary antiviral resistance may be important for treatment choice. We studied two patients with chronic HBV infection by sequencing the HBV polymerase *** had adefovir-and tenofovir-related mutations in the viral polymerase,although they had never been treated. These mutations were rtV214A/rtN238T in one patient and rtA194T in the ***,mutations in untreated patients deserve cautious *** data indicate that mutations that can theoretically confer adefovir or tenofovir resistance may emerge in treatmentnaive patients.

关键词：乙肝病毒变异体感染治疗方法

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Clinical impact of hepatitis B and C virus envelope glycoproteins

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World Journal of Gastroenterology 2013年第5期19卷 654-664页

作者： Hélène Jeulin Aurélie Velay John Murray evelyne schvoerer Virology Laboratory Centre Hospitalier Universitaire de NancyVandoeuvre-lès-NancyF-54511France EA RHEM 4369 Universitéde LorraineF-54000 NancyFrance School of Mathematics and Statistics University of New South WalesSydneyNSW 2052Australia The Kirby Institute University of New South WalesSydneyNSW 2052Australia

Chronic infection by either hepatitis B virus(HBV)or hepatitis C virus(HCV)share epidemiological characteristics with risks for development of severe complications such as liver cirrhosis and hepatocellular *** and HCV also share a high genetic variability. Among highly variable regions,viral genes encoding surface proteins(hepatitis B surface antigen,E1/E2 HCV glycoproteins)play key roles in the stimulation of the host-related immune response and viral entry into *** segments of HBV envelope proteins(preS1,"a"determinant)are crucial in the entry process into permissive *** entry is a complex multistep process involving multiple cell cofactors (glycosaminoglycans,low density lipoprotein receptor, SR-B1,CD81,claudin-1,occludin,EGFR,EphA2)in the interaction with HCV E1/E2 envelope *** vitro both viruses can be controlled by antibody-me-diated neutralization targeting viral envelope,also essential in preventing HBV infection in vivo as observed through successful vaccination using HBs *** preventive vaccination and/or therapeutic pressure can influence HBV and HCV *** HBV,the patterns of antiviral drug resistance in chronic hepatitis are complex and the original pol/S gene overlap has to be taken into ***-induced HBV mutations in pol could indeed generate S mutants with subsequent modified antigenicity or increased cancer *** of HBV and HCV envelope proteins combining high exposure to selective pressures and crucial functional roles require investigation in the context of diagnostic,vaccination and treatment *** this editorial a synthesis is performed of HBV and HCV envelope properties at the entry step and as antigenic proteins,and the subsequent clinical impact.

关键词： Hepatitis B Hepatitis C Viral envelope glycoproteins Clinical outcome

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