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Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek

World Journal of Transplantation 2024年第2期14卷 148-154页

作者： Vasileios Koutlas Eirini Tzalavra Vasileios Tatsis Charalampos Pappas Stavroula Vovlianou Stefanos Bellos Anila Duni Eleni Stamellou Konstantinos I Tsamis Michail Mitsis evangelia dounousi Department of Surgery and Kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACKGROUND Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(KTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument Kidney Transplant Questionnaire 25(KTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four KTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the KTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the KTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： Kidney Transplant Questionnaire 25 Kidney transplantation Kidney transplant recipients Health-related quality of life Quality of life

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Trends of nanotechnology in type 2 diabetes mellitus treatment

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 62-76页

作者： Yannis V.Simos Konstantinos Spyrou Michaela Patila Niki Karouta Haralambos Stamatis Dimitrios Gournis evangelia dounousi Dimitrios Peschos Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Biotechnology Laboratory Department of Biological Applications and TechnologiesUniversity of IoanninaIoannina 45110Greece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Nanomedicine and Nanobiotechnology Research Group University of IoanninaIoannina 45110Greece

There are several therapeutic approaches in type 2 diabetes mellitus(T2DM).When diet and exercise fail to control hyperglycemia,patients are forced to start therapy with antidiabetic ***,these drugs present several drawbacks that can affect the course of *** major disadvantages of current oral modalities for the treatment of T2DM are mainly depicted in the low bioavailability and the immediate release of the drug,generating the need for an increase in frequency of *** conjugation with the manifestation of adverse side effects,patient compliance to therapy is *** the past few years nanotechnology has found fertile ground in the development of novel delivery modalities that can potentially enhance anti-diabetic regimes *** efforts have been targeted towards two main vital steps:(a)to protect the drug by encapsulating it into a nano-carrier system and(b)efficiently release the drug in a gradual as well as controllable ***,only a limited number of studies published in the literature used in vivo techniques in order to support *** we discuss the current disadvantages of modern T2DMmarketed drugs,and the nanotechnology advances supported by in vivo in mouse/rat models of glucose *** generation of drug nanocarriers may increase bioavailability,prolong release and therefore reduce dosing and thus,improve patient *** novel approach might substantially improve quality of life for *** ofmetal nanoformulations as indirect hypoglycemic agents is also discussed.

关键词： Type 2 diabetes mellitus Nanotechnology Hyperglycemia Controlled release In vivo

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Cardiovascular disease: Risk factors and applicability of a risk model in a Greek cohort of renal transplant recipients

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World Journal of Transplantation 2017年第1期7卷 49-56页

作者： Nikolaos-Andreas Anastasopoulos evangelia dounousi Evangelos Papachristou Charalampos Pappas Eleni Leontaridou Eirini Savvidaki Dimitrios Goumenos Michael Mitsis Department of Medicine School of Health Sciences University of Ioannina Renal Transplant Unit University Hospital of Ioannina School of Health Science University of Patras Department of Nephrology and Transplantation Patras University Hospital Department of Nephrology University Hospital of Ioannina

AIM To investigate the incidence and the determinants of cardiovascular morbidity in Greek renal transplant recipients(RTRs) expressed as major advance cardiac event(MACE) rate. METHODS Two hundred and forty-two adult patients with a functioning graft for at least three months and availabledata that were followed up on the August 31, 2015 at two transplant centers of Western Greece were included in this study. Baseline recipients' data elements included demographics, clinical characteristics, history of comorbid conditions and laboratory parameters. Follow-up data regarding MACE occurrence were collected retrospectively from the patients' records and MACE risk score was calculated for each patient. RESULTS The mean age was 53 years(63.6% males) and 47 patients(19.4%) had a pre-existing cardiovascular disease(CVD) before transplantation. The mean estimated glomerular filtration rate was 52 ± 17 mL /min per 1.73 m2. During follow-up 36 patients(14.9%) suffered a MACE with a median time to MACE 5 years(interquartile range: 2.2-10 years). Recipients with a MACE compared to recipients without a MACE had a significantly higher mean age(59 years vs 52 years, P < 0.001) and a higher prevalence of pre-existing CVD(44.4% vs 15%, P < 0.001). The 7-year predicted mean risk for MACE was 14.6% ± 12.5% overall. In RTRs who experienced a MACE, the predicted risk was 22.3% ± 17.1% and was significantly higher than in RTRs without an event 13.3% ± 11.1%(P = 0.003). The discrimination ability of the model in the Greek database of RTRs was good with an area under the receiver operating characteristics curve of 0.68(95%CI: 0.58-0.78).CONCLUSION In this Greek cohort of RTRs, MACE occurred in 14.9% of the patients, pre-existing CVD was the main risk factor, while MACE risk model was proved a dependable utility in predicting CVD post RT.

关键词： Cardiovascular disease Major advance cardiac event Risk factors Risk model Kidney Transplantation

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Electrocardiographic characteristics of pediatric and adolescent football players

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Sports Medicine and Health Science 2024年第2期6卷 179-184页

作者： Maria Doumparatzi Panagiota Sotiriou Asterios Deligiannis evangelia Kouidi Sports Medicine Laboratory School of Physical Education and Sports ScienceAristotle University of ThessalonikiThermiGR57001Greece

Electrocardiographic characteristics of children and adolescents present differences compared to *** aim of our work was to study electrocardiograms(ECGs)of football male players from childhood to late adolescence and examine if the ECG parameters are influenced by systematic *** thousand fifty-four football players participated and formed four *** A included 89 players aged 5–7 years,group B 353 players aged 8–11 years,group C consisted of 355 football players 12-15 yearsold and group D of 257 players with 16–18 years of *** participants underwent preparticipation screening,including 12-lead surface *** rate(HR),PR,RR,QRS,QT,QTc intervals,QT dispersion(QTdisp)and QRS axis were *** ECGs were evaluated according to the current preparticipation cardiac screening guidelines,that refer to athletes aged 12–35 years and do not include pediatric *** percent of the participants presented an ECG *** D obtained the lowest values of HR,QTc and the highest of PR,RR,QRS,QT intervals and QTdisp,whereas no differences in QRS axis were *** Right Bandle Branch Block(RBBB)was the most frequent ECG peculiarity,detected in 7.3%of the *** of training were statistically significantly correlated to HR,PR,RR,QRS and QT *** conclusion,guidelines for ECG interpretation of athletes in childhood,early and late adolescence are needed.

关键词： Exercise Children Adolescents Electrocardiogram Soccer

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Multi-Elemental Chemostratigraphy,Sequence Development,Depositional History,and Environmental Importance of Early Eocene Red Beds(Kuldana Formation)in NW Himalayas,Pakistan

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Journal of Earth Science 2024年第2期35卷 349-375页

作者： Amir Shahzad George Kontakiotis Thierry Adatte Khawaja Shoaib Ahmed Muhammad Tayyib Riaz Hammad Tariq Janjuhah evangelia Besiou Institute of Geology University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Historical Geology-Paleontology Faculty of Geology and GeoenvironmentSchool of Earth SciencesNational and Kapodistrian University of AthensPanepistimiopolisZografou15784Greece Institute of Earth Sciences(ISTE) University of LausanneLausanneCH-1015Switzerland Department of Geology Shaheed Benazir Bhutto UniversitySheringalPeshawar18050Pakistan

The Eocene Kuldana Formation(KF)in the Yadgar area of Pakistan,comprises a diverse range of sedimentary facies,including variegated red beds of shales,mudstones,and sandstones,as well as interbedded limestone and *** this study,we conducted an integrated micropaleontological,sedimentological,mineralogical,and geochemical investigation to determine the depositional setting,biochronology,provenance,and paleoclimate of the *** study identified six lithofacies and six microfacies,which indicate a variety of environments ranging from floodplains and channels to the margins and shallow marine *** nannofossil biostratigraphy places the KF in the Early Eocene,more precisely the NP10 zone(Ypresian),and the fossil zone of benthic foraminifera classifies the study section as the Shallow Benthic Zone SBZ-8(Middle Ilerdian 2).In terms of petrography,the KF sandstone was classified as litharenite and feldspathic litharenite,while the QtFL diagram suggests a recycled *** proxies indicate an oxidizing environment,a high-to-low regular sedimentation rate,moderate-to-intense chemical weathering in the source region,and a warm-humid to dry climate during the deposition of ***,the findings suggest that the deposition of KF marks the end of Neo-Tethys due to the Early Eocene Indian–Kohistan collision and that the uplifting of the Himalayas provided the source for the deposition of KF in the foreland *** study provides new insights into the depositional environment,biochronology,provenance,and paleoclimate of KF,and highlights the potential for red beds as reliable indicators of oxygenation levels in proximity to mineral deposits.

关键词： sedimentary microfacies Paleocene–Eocene thermal maximum stratigraphic correlations paleoenvironmental reconstruction nannofossils paleontology

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Acute bacterial sternoclavicular osteomyelitis in a long-term renal transplant recipient

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World Journal of Transplantation 2016年第2期6卷 442-446页

作者： evangelia dounousi Anila Duni Sofia Xiromeriti Charalambos Pappas Kostas C Siamopoulos Nephrology Department University Hospital of Ioannina

Kidney transplantation is the treatment of choice for a significant number of patients with end-stage renal disease. Although immunosuppression therapy improves graft and patient's survival, it is a major risk factor for infection following kidney transplantation altering clinical manifestations of the infectious diseases and complicating both the diagnosis and management of renal transplant recipients(RTRs). Existing literature is very limited regarding osteomyelitis in RTRs. Sternoclavicular osteomyelitis is rare and has been mainly reported after contiguous spread of infection or direct traumatic seeding of the bacteria. We present an interesting case of acute, bacterial sternoclavicular osteomyelitis in a long-term RTR. Blood cultures were positive for Streptococcus mitis, while the portal entry site was not identified. Magnetic resonance imaging of the sternoclavicluar region and a three-phase bone scan were positive for sternoclavicular osteomyelitis. Eventually, the patient was successfully treated with Daptomycin as monotherapy. In the presence of immunosuppression, the transplant physician should always remain alert for opportunistic pathogens or unusual location of osteomyelitis.

关键词： Bacterial infections Immunosuppression Renal transplantation Osteomyelitis

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Historical pearls of the European medical school related to the acute articular rheumatism from the Renaissance to the 20^(th) century

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History & Philosophy of Medicine 2024年第4期6卷 24-28页

作者： evangelia Mourellou Gregory Tsoucalas Department of the History of Medicine and Medical Deontology School of MedicineUniversity of CreteHeraklion 71003Greece

Acute articular rheumatism(AAR)primarily affects children aged 5 to 15,causing fever and non-suppurative arthritis,and can lead to severe heart problems such as mitral stenosis and aortic *** of early years by Hippocrates and Galen were expanded in a in the 19^(th) century by Jean-Baptiste Bouillaud,who linked AAR to heart *** exploration of the historical development of AAR can be beneficial to further medical *** period between Renaissance and mid-20^(th) century unveiled a series of hallmarks in diagnosis,symptomatology,feverous attacks and *** research method,a documentary research related to the *** great importance concerning AAR’s understanding are Hippocrates’early descriptions,Jerome Cardan’s Renaissance distinction between“morbus articularis”and podagral(gout),and Jean-Baptiste Bouillaud’s 19^(th)-century linkage of AAR to heart ***,contributions from Théodore-Hermann Meynet,Louis Bard,and Edmond Weill were pivotal in clarifying the clinical and cardiac aspects of the *** 19^(th) century new diagnostic factors like visceral lesions and clearer understanding of chemical and mineral drugs supplied novel *** the 20^(th) century,research in the United States confirmed the streptococcal cause of AAR,marking an advancement of great significance in the understanding the cause of AAR,as well as its *** since the ancient times AAR has been *** nominations described the disease,while gradually physicians understood the causes and the nature of the disease,as philosophical physiology gave space to clinical anatomy and medical science of the mechanized *** made during the last centuries aided in AAR further *** comprehension of the evolution of AAR is crucial in order to appreciate its current medical perspective and treatment.

关键词： Jean-Baptiste Bouillaud podagral gout streptococcus heart lesion

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Enhancing the clinical relevance of haemorrhage prediction models in trauma

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Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.Wohlgemut Max E.R.Marsden Erhan Pisirir evangelia Kyrimi Rebecca S.Stoner William Marsh Zane B.Perkins Nigel R.M.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

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Burril-Bernard Crohn(1884-1983)and the disease which bears his name

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History & Philosophy of Medicine 2024年第4期6卷 16-23页

作者： Georgios Androutsos Konstantinos Laios Pavlos Lytsikas-Sarlis evangelia Mourellou Constantinos Georgios Zografos Gregory Tsoucalas Marianna Karamanou School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of History of Medicine and Medical Ethics School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Graduate School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of the History of Medicine and Medical Deontology School of MedicineUniversity of CreteHeraklion 71003Greece Surgery Department School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece

Background:Crohn’s disease,described by *** Crohn and his colleagues in 1932,continues to be of great research and clinical *** was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and *** though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still ***:This article reviews both historical and contemporary perspectives on Crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded *** refers to notable contributions from medical figures,such as *** and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being ***:This article highlights the evolution of Crohn’s disease from a distinct condition to a more heterogeneous ***,it refers to advancements made in medical research,such as the identification of CARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic ***:Even though significant progress has been made since the initial description of Chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great *** ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of Crohn’s disease.

关键词： regional ileitis granulomatous inflammation endoscopic evaluation historical figures

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Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes

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World Journal of Experimental Medicine 2024年第1期14卷 13-21页

作者： Charalampos Milionis Ioannis Ilias Anastasia Lekkou evangelia Venaki Eftychia Koukkou Department of Endocrinology Diabetesand Metabolism‘Elena Venizelou’General HospitalAthens 11521Greece

Gestational diabetes is typically diagnosed in the late second or third trimester of *** is one of the most common metabolic disorders among expectant mothers,with potential serious short-and long-term complications for both maternal and offspring health.C-peptide is secreted from pancreatic beta-cells into circulation in equimolar amounts with *** is a useful biomarker to estimate the beta-cell function because it undergoes negligible hepatic clearance and consequently it has a longer half-life compared to *** induces increased insulin resistance due to physiological changes in hormonal and metabolic *** compensation by islet beta-cells results in *** standard oral glucose tolerance test at 24-28 wk of gestation sets the *** evidence from prospective studies indicates a link between early pregnancy C-peptide levels and the risk of subsequent gestational *** C-peptide levels and surrogate glycemic indices at the beginning of pregnancy could prompt appropriate strategies for secondary prevention.

关键词： C-peptide Gestational diabetes Secondary prevention Pregnancy Clinical laboratory techniques

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