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The Correlation between N-Terminal Pro-Brain Natriuretic Peptide and Diastolic Function in Asymptomatic Patients at Risk of Developing Heart Failure

The Correlation between N-Terminal Pro-Brain Natriuretic Pep...

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作者： evan jim gunawan 重庆医科大学

学位级别：硕士

Objective: to identify the correlation between N-terminal pro-brainnatriuretic peptide （NT-proBNP） with diastolic function in asymptomaticpatients at risk of developing heart failure, and the role of NT-proBNP inidentifying diastolic dysfunction. Methods: eighty patients （age45–70years） were selected based onhistory of hypertension, diabetes mellitus, and coronary artery *** with at least one risk factor for HF were selected in this *** were enrolled in this study from January to July2011in FirstAffiliated Hospital of Chongqing Medical University. Left ventricular （LV）diastolic function was measured by conventional Doppler and TissueDoppler imaging （TDI） echocardiography of mitral annulus. PlasmaNT-proBNP concentration was measured by immunoassay. Results: There were36men and44women in this study. The mean age ofpatients was58.8years old. Hypertension was present in78/80patients（97.5%）;diabetes in32/80patients （40%）;and coronary artery disease in 25/80（31.3%）. In transmitral pulsed-wave Doppler velocity measurement,there was no significant difference of NT-proBNP between normal andimpaired relaxation （mild diastolic dysfunction）. Patients withpseudonormal filling （262.2±55.63pg/ml） and restrictive like pattern（781.5±152pg/ml） had significantly higher NT-proBNP level （p＜0.0005）.In TDI measurement, patients were grouped into3groups based on E/E’ratio ＜8（group1）, E/E’ ratio8-15（group2）, E/E’ ratio＞15（group3）. TheNT-proBNP level in group1was47.54±34.08pg/ml, group2was94.98±78.88pg/ml, and group3was781.5±152pg/ml. There was goodcorrelation between NT-proBNP and E/E’lateral （r=063;p＜0.0005）. Conclusion: NT-proBNP level increases as left ventricular diastolicfunction decreases, and there was good correlation between NT-proBNPwith E/E’ ratio. Patient with moderate-severe diastolic dysfunction hadhigher NT-proBNP level. NT-proBNP cannot be used for identification ofmild diastolic dysfunction in patient at risk of developing heart failure.

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Investigation of experimental observables in search of the chiral magnetic effect in heavy-ion collisions in the STAR experiment

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Chinese Physics C 2022年第1期46卷 129-145页

作者： Subikash Choudhury Xin Dong jim Drachenberg James Dunlop ShinIchi Esumi Yicheng Feng evan Finch Yu Hu Jiangyong Jia Jerome Lauret Wei Li Jinfeng Liao Yufu Lin Mike Lisa Takafumi Niida Robert Lanny Ray Masha Sergeeva Diyu Shen Shuzhe Shi Paul Sorensen Aihong Tang Prithwish Tribedy Gene Van Buren Sergei Voloshin Fuqiang Wang Gang Wang Haojie Xu Zhiwan Xu Nanxi Yao Jie Zhao Fudan University Shanghai200433 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Abilene Christian University AbileneTexas 79699 Brookhaven National Laboratory UptonNew York 11973 University of Tsukuba TsukubaIbaraki 305-8571 Purdue University West LafayetteIndiana 47907 Southern Connecticut State University New HavenConnecticut 06515 State University of New York Stony BrookNew York 11794 Rice University HoustonTexas 77251 Physics Department and Center for Exploration of Energy and Matter Indiana University2401 N Milo B.Sampson LaneBloomingtonIN 47408 College of Physics and Technology Guangxi Normal UniversityGuilin541004 Central China Normal University WuhanHubei 430079 Ohio State University ColumbusOhio 43210 University of Texas AustinTexas 78712 University of California Los AngelesCalifornia 90095 Department of Physics McGill University3600 University StreetMontrealQCH3A 2T8 Wayne State University DetroitMichigan 48201 Huzhou University HuzhouZhejiang 313000

The chiral magnetic effect(CME)is a novel transport phenomenon,arising from the interplay between quantum anomalies and strong magnetic fields in chiral *** high-energy nuclear collisions,the CME may survive the expansion of the quark-gluon plasma fireball and be detected in *** the past two decades,experimental searches for the CME have attracted extensive interest at the Relativistic Heavy Ion Collider(RHIC)and the Large Hadron Collider(LHC).The main goal of this study is to investigate three pertinent experimental approaches:the$\gamma$correlator,the R correlator,and the signed balance *** exploit simple Monte Carlo simulations and a realistic event generator(EBE-AVFD)to verify the equivalence of the core components among these methods and to ascertain their sensitivities to the CME signal and the background contributions for the isobar collisions at the RHIC.

关键词： chiral magnetic effect anisotropic flow heavy-ion collisions quark-gluon plasma

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Plasma Accumulations of Vitamin B6 from an Oral Dose in a New Reversible Model for Mouse Gut Injury and Regeneration

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Food and Nutrition Sciences 2013年第9期4卷 908-917页

作者： Pilar jiménez Damián Cordoba-Diaz Patricia Cabrero Mónica Aracil Manuel J. Gayoso Manuel Garrosa Manuel Cordoba-Diaz Tomás Girbés Biología Celular Histología y Farmacología Facultad de Medicina and INCYL (Instituto de Neurociencias de Castilla y León) Universidad de Valladolid Valladolid Spain. Farmacia y Tecnología Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética- Edificio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain

Chemically based rodent models are used to assess the positive effects promoted by foods and gut microbiota on gut health. Lectins with enzymatic activity, such as type 2 ribosome-inactivating proteins, might also prove useful for exploring these issues. Sub-lethal doses of the lectin nigrin from Sambucus nigra L. to mice promoted reversible derangement of gut epithelium by induction of apoptosis of transit amplifying cells of the small intestine crypts in a time-dependent course. The present work seeks to study vitamin B6 accumulation in plasma from an oral bolus in a mouse nigrin model. 24 h after sub-lethal nigrin b treatment, there was clear body weight reduction associated to a notable increase in evan’s blue stain accumulation in excised small intestine, an increase in myeloperoxidase activity, and a near 50% reduction in plasma accumulation of vitamin B6. Histological analysis of small intestine sections of nigrin b-treated animals also revealed significant derangement of intestinal crypts. Seventy two hours after nigrin b treatment, stain uptake decreased and vitamin B6 accumulation was almost restored despite villi derangement. Large intestine crypts were scarcely or not at all affected. Eight days after nigrin b treatment, vitamin B6 uptake and intestinal crypt structure had fully recovered. The nigrin b mice model supports the view that, under these conditions, the carrier-mediated vitamin B6 uptake component of the small intestine crypts is probably the most active when the vitamin is administered orally as a bolus. The findings provide insights into the suitability of the present mice model for nutritional or drug absorption studies in conditions of partially altered or injured intestinal mucosa.

关键词： Vitamin B6 Nigrin b Ribosome-Inactivating Protein Sambucus Ricin Intestines Mice Model

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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