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Cytoreductive 外科和 hyperthermic intraperitoneal chemoperfusion : 亚利桑那早经验的大学

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World journal of Gastrointestinal Surgery 2012年第6期4卷 135-140页

作者： Ioannis T Konstantinidis Christine Young Vassiliki L Tsikitis Ellyn Lee evan S Ong Department of Surgery The University of Arizona College of Medicine1501 N.Campbell Av.PO Box 245131TucsonAZ 85724-5131United States Department of Medicine The University of Arizona College of Medicine1501 N.Campbell Av.PO Box 245131TucsonAZ 85724-5131United States

AIM:To evaluate the safety and effectiveness of our new cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemoperfusion(HIPEC)***:Retrospective review of patients with gastrointestinal malignancies who were suitable candidates for CRS and HIPEC between 12/1/2009 and 10/1/*** clinicopathologic data were reviewed with a special focus on the surgical outcome and the postoperative morbidity and ***:Fourteen patients were *** age was 64 years;seven were *** primary tumors were:colonic(29%),appendiceal(36%),peritoneal mesothelioma(14%),gastric(7%),adenocarcinoma of unknown primary(7%),and gastrointestinal stromal tumor(7%).Eleven patients(79%)received CRS/HIPEC,three for *** patients that did not undergo CRS/HIPEC had an average peritoneal cancer index(PCI)of *** eight patients that underwent curative CRS/HIPEC had an average PCI of 10 and a completeness of cytoreduction score of 0(87.5%) or 1(12.5%).Postoperative morbidity was 36%;the worst adverse event was Grade 3 *** rate was 0%.CONCLUSION:CRS with HIPEC is safe and feasible at tertiary institutions with fledgling *** is an accurate predictor of surgical outcomes.

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemoperfusion Peritoneal carcinomatosis Early outcomes

A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease

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World journal of Nephrology 2013年第4期2卷 129-135页

作者： Keng-Thye Woo Hui-Lin Choong Kok-Seng Wong Han-Kim Tan Marjorie Foo Fook-Chong Stephanie evan jC Lee Vathsala Anantharaman Grace SL Lee Choong-Meng Chan Department of Renal Medicine Singapore General Hospital Department of Clinical Research Singapore General Hospital Department of Nephrology National University of Singapore

AIM: To assess the efficacy of combined Aliskiren and Losartan vs high dose Losartan and Aliskiren alone in chronic kidney disease(CKD).METHODS: This is a retrospective study of 143 patients with non-diabetic CKD comparing combined Aliskiren(150 mg/d) with Losartan(100 mg/d) therapyvs High dose Angiotensin receptor blockers(ARB)(Losartan 200 mg/d) and the third group Aliskiren(150 mg/d) alone. This study involved only patient medical records. Entry criteria included those patients who had been treated with the above drugs for at least 36 mo within the 5 years period; other criteria included proteinuria of 1 g or more and or CKD Stage 3 at the start of the 36 mo period. The study utilised primary renal end points of estimated Glomerular Filtration Rate(e GFR) 5.5 mmol/L) was 14.2%(7/49) in the Combined Aliskiren and ARB group, 8.7%(4/46) in the Aliskiren alone group and 6.3%(3/48) in the High dose ARB group(P < 0.001). CONCLUSION: This study in non-diabetic CKD patients showed that Combination therapy with Aliskiren and ARB was effective but was not safe as it was associated with a high prevalence of hyperkalaemia.

关键词：糖尿病患者治疗方法临床分析

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WEGROW幼儿园室内设计

城市环境设计 2019年第2期 252-259页

作者： Otilia Pupezeanu jeremy Babel Bart Ramakers Douglass Alligood Erik Berg Kreider evan Saarinen Filip Milovanovic Florencia Kratsman Francesca Portesine Il Hwan Kim jakob Lange ji Young Yoon Kristoffer Negendahl josiah Poland Mengzhu jiang Ryan Yang Stephen Kwok Terrence Chew Tore Banke Tracy Sodder Dave Burk Laurian Ghinitoiu 运小红

在纽约曼哈顿切尔西社区的WeWork总部,BIG和WeWork合作打造了第一所WeGrow学校,展示了他们对创造力开发的执着信念。该设计为3到9岁的儿童匠心打造1万平方英尺(约929平方米)的学习天地。交互的学习空间有意识地引导一种不同的教育方式,... 详细信息

在纽约曼哈顿切尔西社区的WeWork总部,BIG和WeWork合作打造了第一所WeGrow学校,展示了他们对创造力开发的执着信念。该设计为3到9岁的儿童匠心打造1万平方英尺(约929平方米)的学习天地。交互的学习空间有意识地引导一种不同的教育方式,伴随21世纪儿童的成长,更好地培养孩子们的情感和心智。这样一个多功能空间可以让孩子们在其中自由活动,从周围环境和彼此之间学习到

关键词：游戏空间 WEGROW 幼儿园

5岁以下儿童补充维生素A对预防死亡、疾病及失明的系统回顾和荟萃分析

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英国医学杂志中文版 2011年第6期14卷 360-360页

作者： Mayo－Wilson evan Imdad Aamer Herzer Kurt Yakoob Mohammad Yawar Bhutta Zulfiqar A 高志杰(译者) Centre for Evidence－Based Intervention Department of Social Policy and Intervention University of Oxford Barnett House Oxford OX1 2ER UK Division of Women and Child Health Aga Khan University Hospital Stadium Road PO Box 3500 74800 Karachi Pakistan 首都儿科研究所附属儿童医院神经科

目的研究补充维生素A与6个月至5岁儿童死亡率和发病率的减少是否相关。方法系统回顾和荟萃分析，由2名研究者独立筛选文献，数据经双方提取，不同点通过讨论解决，主要进行死亡、疾病、视力及副作用的荟萃分析。数据来源于Cochrane中心... 详细信息

目的研究补充维生素A与6个月至5岁儿童死亡率和发病率的减少是否相关。方法系统回顾和荟萃分析，由2名研究者独立筛选文献，数据经双方提取，不同点通过讨论解决，主要进行死亡、疾病、视力及副作用的荟萃分析。数据来源于Cochrane中心注册的对照研究，包括Cochrane图书馆、Medline、Embase、GlobalHealth、Latin American和Caribbean HealthSciences，metaRegister of Controlled Trials和African Index Medicus。数据检索至2010年4月前已发表或待发表的各种语言的文献。入选标准为对口服合成维生素A的6个月至5岁儿童的随机对照研究，研究儿童患有疾病（包括腹泻、麻疹及HIV），排除住院以及食物强化或B胡萝卜素儿童。结果包括215633名儿童的43项研究人选。其中17项研究（194483名儿童）显示全因死亡率减少了24％，其比值比为0．76，95％可信区间（95％CI）0．69～0．83。7项研究报道与腹泻相关的死亡率减少了28％，其比值比为0．72（95％C10．57—0．91）。维生素A的补充与腹泻减少的比值比为0．85（95％C10．82—0．87）、与麻疹、视力问题包括夜盲和眼球干燥症减少的比值比分别为0．50（95％C10．37—0．67）、0．32（95％C10．21～0．50）和0．31（95％C10．22—0．45）。3项研究报道在补充维生素A的48小时内呕吐增加的风险为2．75（95％CI1．81～4．19）。结论补充维生素A在一定范围内与儿童的死亡率、发病率及视力问题的大幅减少有关，且这一结论不能由偏倚来解释。在6个月至59个月的儿童中已无需进行补充维生素A的安慰剂对照研究，但是有必要进一步比较不同剂量和不同给药方式（如强化）的区别。就目前得到的数据而言，所有可能缺乏维生素A的儿童均应得到补充，尤其是中低收入的国家。

关键词：缺乏维生素A 儿童死亡率荟萃分析系统回顾疾病 Cochrane图书馆 Cochrane中心 Medline

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超级高铁

城市环境设计 2019年第2期118卷 260-267页

作者： Erik Berg Kreider Adi Krainer Ashton Stare Cheyenne Vandevoorde Cristian Lera Daniele Pronesti Derek Wong Domenic Schmid evan Wiskup Francesca Portesine Hugo Soo Kristian Hindsberg Lam Le Nguyen Lasse Kristensen Linda Halim Maureen Rahman Ovidiu Munteanu Pei Pei Yang Ryan Duval Stephen Steckel Terrence Chew Thomas Christoffersen Tore Banke Veronica Moretti Yehezkiel Wiliardy 曲鸿

BIG的创始合伙人比亚克评价说:"通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们... 详细信息

BIG的创始合伙人比亚克评价说:"通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们对时空的习惯认知,我们脑海中对城市版图的理解也将随之改变。"

关键词：传送器目的地 portal

肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)

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中华神经外科疾病研究杂志 2010年第1期9卷 22-22页

作者： Maria Stella Carro Wei Keat Lim Mariano javier Alvarez Robert j. Bollo evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone

The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.

关键词：脑瘤细胞分子生理学临床分析

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Plasma Accumulations of Vitamin B6 from an Oral Dose in a New Reversible Model for Mouse Gut Injury and Regeneration

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Food and Nutrition Sciences 2013年第9期4卷 908-917页

作者： Pilar jiménez Damián Cordoba-Diaz Patricia Cabrero Mónica Aracil Manuel j. Gayoso Manuel Garrosa Manuel Cordoba-Diaz Tomás Girbés Biología Celular Histología y Farmacología Facultad de Medicina and INCYL (Instituto de Neurociencias de Castilla y León) Universidad de Valladolid Valladolid Spain. Farmacia y Tecnología Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética- Edificio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain

Chemically based rodent models are used to assess the positive effects promoted by foods and gut microbiota on gut health. Lectins with enzymatic activity, such as type 2 ribosome-inactivating proteins, might also prove useful for exploring these issues. Sub-lethal doses of the lectin nigrin from Sambucus nigra L. to mice promoted reversible derangement of gut epithelium by induction of apoptosis of transit amplifying cells of the small intestine crypts in a time-dependent course. The present work seeks to study vitamin B6 accumulation in plasma from an oral bolus in a mouse nigrin model. 24 h after sub-lethal nigrin b treatment, there was clear body weight reduction associated to a notable increase in evan’s blue stain accumulation in excised small intestine, an increase in myeloperoxidase activity, and a near 50% reduction in plasma accumulation of vitamin B6. Histological analysis of small intestine sections of nigrin b-treated animals also revealed significant derangement of intestinal crypts. Seventy two hours after nigrin b treatment, stain uptake decreased and vitamin B6 accumulation was almost restored despite villi derangement. Large intestine crypts were scarcely or not at all affected. Eight days after nigrin b treatment, vitamin B6 uptake and intestinal crypt structure had fully recovered. The nigrin b mice model supports the view that, under these conditions, the carrier-mediated vitamin B6 uptake component of the small intestine crypts is probably the most active when the vitamin is administered orally as a bolus. The findings provide insights into the suitability of the present mice model for nutritional or drug absorption studies in conditions of partially altered or injured intestinal mucosa.

关键词： Vitamin B6 Nigrin b Ribosome-Inactivating Protein Sambucus Ricin Intestines Mice Model

指南双相障碍的评估与管理：NICE指南更新概要

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英国医学杂志中文版 2015年第8期18卷 469-473页

作者： Tim Kendall director, consultant psychiatrist Richard Morriss professor of psychiatry and community mental health evan Mayo-Wilson assistant scientist Elena Marcus research assistant , 张磊马燕桃 NationalCollaborating Centrefor Mental Health Royal College ofPsychiatrists LondonE1 8AA. UK: Sheffield Health and Social Care NHS Foundation Trust Sheffield S10 3TH UK psychiatry and Applied Psychology Faculty of Medicine and Health Sciences University of Nottingham Nottingham UK Department of Epidemlology Johns Hopkins Bloomberg School of Public Health Bahimore MD USA National Collaborating Centre for Mental Health University College London London UK Centre for Outcomes Research and Effectiveness University College London London UK 北京大学第六医院北京大学精神卫生研究所

本文是英国医学杂志（TheBMj）最新指南系列文章之一，新指南基于现有的最佳证据编写；着重解读对临床实践重要的建议，特别是存在不确定和争议的部分。

关键词：情感障碍指南管理评估双相

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花拉阁,新加坡

城市建筑 2010年第10期 118-121页

作者： Edward Calver Bianca Cheung Dominiki Dadatsi Loreto Flores Helen Lee Hee Seung Lee jeonghoon Lee Feng Lin jee Seon Lim Ludovico Lombardi Clara Martins Kutbuddin Nadiadi Hoda Nobakhti Annarita Papeschi Line Rahbek Hala Sheikh Zhong Tian evil Yazici Effie Kuan Sandra Riess Eleni Pavlidou Federico Dunkelberg evan Erlebacher Gorka Blas Bozana Komljenovic Sophie Le Bienvenu Kelly Lee jose M.Monfa Selahattin Tuysuz TaKang Hsu Emily Chang judith Wahle Zaha Hadid Architects Zaha Hadid with Patrik Schumacher GROSSMAX Edinburgh Engineering Acviron/Singapore

建筑基址花拉阁基址地处新加坡住宅区的关键地段,毗邻荷兰路(Holland Road)及未来规划中的MRT车站,与交通干道花拉路(Farrer Rd.)直接连通,基址周边无高层建筑。如此优越的地理及交通条件使该项目广受全城民众的关注。

关键词：基址规划长远计划新加坡直接连通花拉交通干道高层建筑