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Psychological impact of the COVId-19 pandemic on individuals with serious mental disorders: A systematic review of the literature

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World Journal of Psychiatry 2021年第12期11卷 1387-1406页

作者： eva Fleischmann Nina dalkner Frederike T Fellendorf eva Z Reininghaus department of Psychiatry and Psychotherapeutic Medicine Medical University of GrazGraz 8036Austria

BACKGROUNd The coronavirus disease 2019(COVId-19)pandemic is having a great impact on individuals from all over the world,particularly on individuals with mental *** studies found more pronounced psychiatric symptoms,notably symptoms of depression and *** To assess the situation of patients with serious mental illness(SMI:Affective disorders and schizophrenia)regarding their mental health outcome during the *** A systematic search using the databases PubMed and MEdLINE was conducted,employing the key words“COVId-19”,“SARS-CoV-2”,“psychiatric/mental disorder/illness”,“affective/mood disorder”,“bipolar disorder”,“(major)depression”,“schizoaffective disorder”,and“schizophrenia”.Studies that had been published up until January 9,2021 were *** of studies in languages other than English and German was mostly taken from their English *** The literature search concluded in the finding of 36 studies containing relevant clinical data.A general impairment of the mental health of individuals with SMI could be detected,particularly in individuals with affective disorders,as compared to those with *** to healthy controls,symptoms of anxiety,depression,and stress were more pronounced in individuals with *** factors found that impacted their mental health were age,resilience,and socioeconomic environment,especially the shortage of mental health services,lack of social support,and inadequate information about *** In light of these results,mental health services should be reinforced,notably the use of telemental health ***,supplying individuals with SMI with adequate information about the COVId-19 pandemic and increasing their resilience is *** researching the impact of the COVId-19 pandemic on individuals with SMI,standardization as well as follow-up studies are needed to enable better comparability and understanding.

关键词： COVId-19 pandemic Serious mental illness Affective disorders Bipolar disorder Major depressive disorder Schizophrenia

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Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian Reena desai david J.Handelsman Jeffrey d.Zajac Mathis Grossmann Rachel A.davey department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

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Structure and dynamics of the Isoprenoid Pathway Network

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Molecular Plant 2012年第2期5卷 318-333页

作者： eva Vranova diana Coman Wilhelm Gruissem department of Biology Plant Biotechnology ETH Zurich Universitatstrasse 2 8092 Zurich Switzerland

Isoprenoids are functionally and structurally the most diverse group of plant metabolites reported to date. They can function as primary metabolites, participating in essential plant cellular processes, and as secondary metabolites, of which many have substantial commercial, pharmacological, and agricultural value. Isoprenoid end products participate in plants in a wide range of physiological processes acting in them both synergistically, such as chlorophyll and carotenoids during photosynthesis, or antagonistically, such as gibberellic acid and abscisic acid during seed germination. It is therefore expected that fluxes via isoprenoid metabolic network are tightly controlled both temporally and spatially, and that this control occurs at different levels of regulation and in an orchestrated manner over the entire isoprenoid metabolic network. In this review, we summarize our current knowledge of the topology of the plant isoprenoid pathway network and its regulation at the gene expression level following diverse stimuli. We conclude by discussing agronomical and biotechnological applications emerging from the plant isoprenoid metabolism and provide an outlook on future directions in the systems analysis of the plant isoprenoid pathway network.

关键词： isoprenoids flux metabolites network pathway.

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Post-pyloric feeding

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World Journal of Gastroenterology 2009年第11期15卷 1281-1288页

作者： eva Niv Zvi Fireman Nachum Vaisman department of Gastroenterology Hillel Yaffe Medical Center Hadera 38100 Israel The Unit of Clinical Nutrition Tel Aviv Sourasky Medical Center Tel Aviv 6974444 Israel

Postpyloric feeding is an important and promising alternative to parenteral nutrition. The indications for this kind of feeding are increasing and include a variety of clinical conditions, such as gastroparesis, acute pancreatitis, gastric outlet stenosis, hyperemesis (including gravida), recurrent aspiration, tracheoesophageal fistula and stenosis in gastroenterostomy. This review discusses the differences between pre- and postpyloric feeding, indications and contraindications, advantages and disadvantages, and provides an overview of the techniques of placement of various postpyloric devices.

关键词： Postpyloric feeding Nasojejunal feeding Nasojejunal tube Jejunostomy Nasoenteric tube Percutaneous endoscopic gastrostomy-jejunostomytube Percutaneous endoscopic jejunostomy

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Reliability and Feedback of Multiple Hop Wireless Networks

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International Journal of Automation and computing 2007年第2期4卷 125-134页

作者： N. eva Wu Sudha Thavamani department of Electrical and Computer Engineering Binghamton UniversityBinghamtonNY 13902-6000USA

This paper analyzes fault-tolerance over the entire design life of a class of multiple-hop wireless networks, where cooperative transmission schemes are used. The networks are subject to both node failure and random channel fading. A node lifetime distribution is modeled with an increasing failure rate, where the node power consumption level enters the parameters of the distribution. A method for assessing both link and network reliabilities projected at the network＇s design life is developed. Link reliability is enhanced through use of redundant nodes. The number of redundant nodes is restricted by the cooperative transmission scheme used. The link reliability is then used to establish a re-transmission control policy that minimizes an expected cost involving power, bandwidth expenditures, and packet loss. The benefit and cost of feedback in network operations are examined. The results of a simulation study under specific node processing times are presented. The study quantifies the effect of loop closure frequency, acknowledgment deadline, and nodes＇ storage capacity on the performance of the network in terms of network lifetime, packet loss rate, and false alarm rate. The study concludes that in a network where energy is severely constrained, feedback must be applied judiciously.

关键词： Fault-tolerance network reliability energy efficiency packet loss rate discrete event simulation feedback optimal control.

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A case of interstitial pneumonitis in a patient with ulcerative colitis treated with azathioprine

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World Journal of Gastroenterology 2007年第2期13卷 316-319页

作者： Ferenc Nagy Tamas Molnar eva Makula Ildiko Kiss Peter Milassin eva Zollei Laszlo Tiszlavicz Janos Lonovics First department of Medicine University of Szeged Faculty of Medicine Szeged Hungary department of Radiology University of Szeged Faculty of Medicine Szeged Hungary Medical Intensive Care Unit University of Szeged Faculty of Medicine Szeged Hungary Institute of Pathology University of Szeged Faculty of Medicine Szeged Hungary

The early hypersensitivity reaction and late bone marrow depression are well-known side-effects of azathioprine, whereas interstitial pneumonia is a rare complication. A 40-year old male patient had been treated with azathioprine in consequence of extensive ulcerative colitis for 10 years. He then complained of 7 d of fever, cough and catarrhal signs, without symptoms of active colitis. Opportunistic infections were ruled out. The chest X-ray, CT and lung biopsy demonstrated the presence of interstitial inflammation. Azathioprine therapy was discontinued as a potential source of the pulmonary infiltrate. In response to steroid therapy, and intensive care, the pulmonary infiltrate gradually decreased within 4 wk. Three months later, his ulcerative colitis relapsed, and ileo-anal pouch surgery was performed. In cases of atypical pneumonia, without a proven infection, azathioprine-associated interstitial pneumonitis may be present, which heals after withdrawal of the drug.

关键词： Inflammatory bowel disease Ulcerative colitis Azathioprine Interstitial pneumonitis

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Heat Transfer Model with Two Heat Transfer Coefficients Along a M ultiperforated Plate-Application to Combustion Chamber Wall Cooling

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Journal of Thermal Science 2003年第4期12卷 363-366页

作者： Brice Petre eva dorignac Jean Jacques Vullierme Laboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCELaboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCELaboratoire d'Etudes Thermiques U.M.R C.N.R.S 6608-ENSMA BP 40109 86961 Futuroscope Chasseneuil Cedex FRANCE

Walls' cooling of aeronautic propeller combustion chamber is performed with the injection, through the combustion chamber wall, of a part of the air coming from compressors placed upstream. Measurements of the wall thermal fields are made by infrared thermography along the injection wall. This injection wall is pierced by 9 rows of 8 holes (α=90°) in staggered configuration (p/d=s/d=6). We propose a model using two heat transfer coefficients to represent the convective exchanges. The results are non-dimensioned and presented in comparison with the case without holes. The use of this model allows us to define 4 zones. Those 4 zones exist for the 5 blowing rates.

关键词： multiperforation cooling heat transfer coefficients infrared thermography.

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Food preference of the rove beetle, Atheta coriaria Kraatz （Coleoptera： Staphylinidae） under laboratory conditions

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Insect Science 2007年第1期14卷 53-56页

作者： eva M. BIRKEN RAYMONd A. CLOYd department of Natural Resources and Environmental Sciences University of Illinois Urbana Illinois USA

A study, involving laboratory choice tests, was conducted to determine the feeding behavior, based on food preference, of the adult and larval stage of the rove beetle, Atheta coriaria Kraatz when presented with both fresh moistened oatmeal and second instar fungus gnat, Bradysia sp. nr. coprophila （Lintner） larvae in Petri dishes. Rove beetles used in this study came from a laboratory-reared colony. A rating scale from 1 to 5, based on percent missing （1 = 0 to 10%, 2 = 11 to 30%, 3 = 31 to 50%, 4 = 51 to 75%, and 5 = 76 to 100%）, was used to objectively assess the amount of oatmeal and number of fungus gnat larvae consumed by each rove beetle adult and larva. In all the choice tests, A. coriaria adults and larvae preferred to feed on fungus gnat larvae （78% and 69%, respectively） significantly more so than oatmeal （9% and 5%, respectively） based on the amount of oatmeal and number of fungus gnat larvae consumed after 4 and 6 hours. There were relatively minimal differences in the amount of food consumed for both adults and larvae after 4 and 6 hours. The results of this study indicate that oatmeal may be an inexpensive supplemental food source, during the rearing process, which will not inhibit the effectiveness of rove beetles to control fungus gnat larvae when released into greenhouses.

关键词： Atheta coriaria biological control choice tests feeding behavior fungus gnats

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Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries

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Neural Regeneration Research 2020年第9期15卷 1639-1649页

作者： Yanjun Xie Kevin J.Schneider Syed A.Ali Norman d.Hogikyan eva L.Feldman Michael J.Brenner department of Otolaryngology-Head and Neck Surgery University of Michigan Medical SchoolAnn ArborMIUSA department of Neurology University of Michigan Medical SchoolAnn ArborMIUSA

The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing

关键词： axon degeneration cranial neuropathy facial nerve facial paralysis motoneuron nerve regeneration peripheral nerve recurrent laryngeal nerve synkinesis vocal fold paralysis

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Normalized evaluation of the performance,capacity and availability of catalogue services:a pilot study based on INfrastruture for SPatial InfoRmation in Europe

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International Journal of digital Earth 2016年第4期9卷 325-341页

作者： Tomáš Řezníka Radoslav Chudý eva Mičietová department of Geography Masaryk UniversityBrnoThe Czech Republic department of Cartography Geoinformatics and Remote SensingComenius UniversityBratislavaThe Slovak Republic

Geographic information has a great potential to be re-used when supported by mechanisms for its *** all,the quality of a catalogue service is the key feature supporting users in the discovery *** far,there have been in existence various methodologies dealing with the normalized evaluation of quality with respect to catalogue *** biggest weakness seems to be in the depth of quality testing,*** influences are beyond the scope of evaluation of these methodologies with respect to quality in catalogue *** this study,the quality of 45 catalogue services across Europe was verified with the proposed normalized evaluation methodology originating from documents within the INfrastruture for SPatial InfoRmation in Europe(INSPIRE)*** paper discusses the(statistical)influence of factors that may significantly change the results of catalogue service *** proposals for improving the existing INSPIRE normalized evaluation procedure are applicable for any spatial data infrastructure and/or digital Earth component using the Open Geospatial Consortium Catalogue Service for the Web as a basis.

关键词： metadata quality evaluation spatial data infrastructures INSPIRE Catalogue Service for the Web

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