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Multiscale structural analysis inspired by exceptional load cases concerning the immersed tunnel of the Hong Kong-Zhuhai-Macao Bridge

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Underground Space 2018年第4期3卷 252-267页

作者： Hui Wang eva Binder Herbert Mang Yong Yuan Bernhard Pichler Institute for Mechanics of Materials and Structures TU Wien–Vienna University of TechnologyKarlsplatz 13/202A-1040 ViennaAustria College of Civil Engineering Tongji UniversityShanghaiChina

This paper contains an assessment of the added value of multiscale material models for concrete in the context of macroscopic struc-tural analysis of(steel-reinforced)concrete *** examples are *** are inspired by the possibility of car accidents inside the immersed tunnel of the Hong Kong-Zhuhai-Macao Bridge(HZMB).The first example deals with vehicles crashing into the tunnel *** high-dynamic strengthening effect of concrete is studied based on an engineering mechanics *** structural nature of the dynamic strength increase factor(DIF)is demonstrated by means of high-dynamic strength values measured on mortar cylinders of different ***,the evolution of the DIF as a function of hardening of concrete at material ages beyond 28 days is studied.A validated multiscale model for concrete renders a customized analysis for the specific concrete used for the aforementioned tunnel *** is found that the DIF decreases with progressive hardening of concrete at material ages beyond 28 *** second example is inspired by tunnel fires as may happen after car *** study refers to thermal stresses in steel-reinforced concrete beams sub-jected to sudden *** thermal expansion coefficient of the concrete of the tunnel is quantified by means of a multiscale *** is used as input for linear thermo-mechanical Finite-Element simulations of steel-reinforced concrete *** essential macroscopic simulation results are temperature distributions and associated stress *** are employed for top-down quantification of micro-scopic stress states inside the cement paste and the *** allows for quantifying two sources of microstructural stress fluctu-ations:(i)the macro-to-micro stress concentration and(ii)the mismatch of microscopic thermal expansion *** both examples,the multiscale models for concrete have increased the informative content of the structural simulations.

关键词： Concrete linings High-dynamic strength Thermal stresses

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Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第2期11卷 184-193页

作者： Benjamin Singh eva M.Zopf Erin J Howden Gallipoli Medical Research Foundation Greenslopes Private HospitalGreenslopesQLD 4120Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityMelbourneVIC 3000Australia Baker Heart and Diabetes Institute MelbourneVIC 3004Australia

Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer ***:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer *** mean differences(SMDs)were calculated to assess effects on physical activity and health-related *** analyses were conducted to assess whether the effects differed by interventions and cancer *** of bias was assessed using the Cochrane risk of bias ***:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 *** trials(n=25,71%)involved pedometer-based physical activity ***(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily *** to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with *** how these devices can be implemented for longer-term use with other intervention components remains an area for future research.

关键词： Activity tracker Cancer Exercise Physical activity Wearable

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From variome to phenome:Pathogenesis,diagnosis and management of ectopic mineralization disorders

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World Journal of Clinical Cases 2015年第7期3卷 556-574页

作者： eva YG De Vilder Olivier M Vanakker Center for Medical Genetics Ghent University Hospital Department of Ophthalmology Ghent University Hospital

Ectopic mineralization- inappropriate biomineralization in soft tissues- is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality. Further, pathologic mineralization is seen in several rare genetic disorders, which often present life-threatening phenotypes. These disorders are classified based on the mechanisms through which the mineralization occurs: metastatic or dystrophic calcification or ectopic ossification. Underlying mechanisms have been extensively studied, which resulted in several hypotheses regarding the etiology of mineralization in the extracellular matrix of soft tissue. These hypotheses include intracellular and extracellular mechanisms, such as the formation of matrix vesicles, aberrant osteogenic and chondrogenic signaling, apoptosis and oxidative stress. Though coherence between the different findings is not always clear, current insights have led to improvement of the diagnosis and management of ectopic mineralization patients, thus translating pathogenetic knowledge(variome) to the phenotype(phenome). In this review, we will focus on the clinical presentation, pathogenesis and management of primary genetic soft tissue mineralization disorders. As examples of dystrophic calcification disorders Pseudoxanthoma elasticum, Generalized arterial calcification of infancy, Keutel syndrome, Idiopathic basal ganglia calcification and Arterial calcification due to CD73(NT5E) deficiency will be discussed. Hyperphosphatemic familial tumoral calcinosis will be reviewed as an example of mineralization disorders caused by metastatic calcification.

关键词： Ectopic mineralization Pseudoxanthoma elasticum Pseudoxanthoma elasticum-like syndrome Generalized arterial calcification of infancy Keutel syndrome Idiopathic basal ganglia calcification Arterial calcification due to CD73 deficiency Hyperphosphatemic familial tumoral calcinosis Etiology Phenotype

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CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer

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World Journal of Gastroenterology 2018年第42期24卷 4738-4749页

作者： Sara Cabrero-de las Heras eva Martínez-Balibrea Program Against Cancer Therapeutic Resistance Catalan Institute of OncologyGermans Trias i Pujol health research institute Program of Predictive and Personalized Cancer Medicine Germans Trias i Pujol health research institute

Colorectal cancer(CRC) is the third most common cancer in men and the second most common cancer in women,worldwide. In the early stages of the disease, biomarkers predicting early relapse would improve survival *** metastatic patients, the use of predictive biomarkers could potentially result in more personalized treatments and better outcomes. The CXC family of chemokines(CXCL1 to 17) are small(8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These chemokines signal through chemokine receptors(CXCR) 1 to *** studies have reported that these chemokines and receptors have a role in either the promotion or inhibition of cancer, depending on their capacity to suppress or stimulate the action of the immune system, *** general terms, activation of the CXCR1/CXCR2 pathway or the CXCR4/CXCR7 pathway is associated with tumor aggressiveness and poor prognosis; therefore,the specific inhibition of these receptors is a possible therapeutic strategy. On the other hand, the lesser known CXCR3 and CXCR5 axes are generally considered to be tumor suppressor signaling pathways, and their stimulation has been suggested as a way to fight *** pathways have been studied in tumor tissues(using immunohistochemistry or measuring mRNA levels)or serum [using enzyme-linked immuno sorbent assay(ELISA) or multiplexing techniques], among other sample types. Common variants in genes encoding for the CXC chemokines have also been investigated as possible biomarkers of the disease. This review summarizes themost recent findings on the role of CXC chemokines and their receptors in CRC and discusses their possible value as prognostic or predictive biomarkers as well as the possibility of targeting them as a therapeutic strategy.

关键词： Biomarkers Treatment Chemotherapy Oxaliplatin Irinotecan Immunotherapy Colorectal cancer CXC chemokines Immune system Bevacizumab

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Confounding response of macrofauna from a confluence of impacts: brine and sewage pollution

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Acta Oceanologica Sinica 2013年第10期32卷 74-81页

作者： Rodrigo Riera Fernando Tuya Myriam Rodríguez óscar Monterroso eva Ramos Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Arzobispo Elías Yanes 4438206 La LagunaTenerifeCanary IslandsSpain BIOGES University of Las Palmas de G.C.35017 Las Palmas de Gran CanariaCanary IslandsSpain

Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of sub- tidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria （Canary Islands, NE Atlantic Ocean）. Samples were collected in two surveys （May 2008 and January 2009） at three distances （0, 15, and 30 m） away from the discharge point. Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys. In May 2008, lower abundances were observed at 0 m （53.89±46.82 ind.） than at 15 m （120±91.7 ind.） and 30 m （283.89±189.33 ind.） away from the dis- posal point. In January 2009, however, higher abundances were observed at 0 m （131.33±58.69 ind.） than at 30 m （100±24.44 ind.） and 15 m （84.78±58.39 ind.） away from the disposal point. Significant differ- ences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys. The effect of proximity from the disposal point was confounded by changes in sedimen- tary composition between surveys, which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point. As a result, confounding driver- s of macrofaunal assemblage structure, here, changes in sediment composition, accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage.

关键词： macrofauna amphipoda polychaeta brine sewage Canary Islands

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Wheat streak mosaic virus： incidence in field crops, potential reservoir within grass species and uptake in winter wheat cultivars

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Journal of Integrative Agriculture 2017年第3期16卷 523-531页

作者： Jana Chalupniková Jiban Kumar Kundu Khushwant Singh Pavla Bartaková eva Beoni Division of Crop Protection and Plant Health Crop Research Institute Prague 16106 Czech Republic Department of Experimental Plant Biology Faculty of Science Charles University in Prague Prague 12843 Czech Republic

Wheat streak mosaic virus（WSMV）has become a re-emerging pathogen in cereal crops in the Czech *** was first reported in the former Czechoslovakia in the early 1980s,and then no record of the virus was documented until *** incidence of the virus was recorded in recent years in several winter wheat fields and many grass ***,we surveyed the incidence of WSMV in cereal *** results demonstrated the existence of the virus in winter wheat and volunteer wheat during each year of the monitoring period,which spanned from 2013–*** the range of infected samples was low（6.4%of the total tested samples）,a high incidence of well-distributed virus was *** at least six fields,the virus reached severe and potentially epidemic *** accordance with our previous report detailing WSMV infection of native grasses,we tested several grass species commonly grown in the Czech *** found that some grass species acted as experimental hosts and possible reservoirs of the virus;these included Anthoxanthum odoratum（sweet vernal grass）,Arrhenatherum elatius（false oat-grass）,Lolium multiflorum（Italian rye-grass）,Bromus japonicus（Japanese chess）,Echinochloa crus-galli（barnyard grass）,Holcus lanatus（meadow soft grass）and Holcus mollis（creeping soft grass）.Some of these grass species are also important weeds of cereals,which may be the potential source of WSMV infection in cereal *** widely used winter wheat cultivars were tested in the field after artificial inoculation with WSMV to evaluate virus titre by ***,the tested cultivars had a low virus titre,which is associated with mild disease symptoms and may provide a good level of crop resistance to WSMV.

关键词： WSMV survey grass species cereal crops

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Rapid determination of iron oxide content in magnetically modified particulate materials

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Particuology 2016年第3期14卷 114-117页

作者： Ivo Safarik Leona Nydlova Kristyna Pospiskova eva Baldikova Zdenka Maderova Mirka Safarikova Department of Nanobiotechnology Institute of Nanobiology and Structural Biology ofGCRC Na Sadkach 7 370 05 Ceske Budejovice Czech Republic Regional Centre of Advanced Technologies and Materials Palacky University Slechtitelu 27 783 71 Olomouc Czech Republic Department of Nanobiotechnology Biology Centre CAS Na Sadkach 7 370 05 Ceske Budejovice Czech Republic Department of Applied Chemistry Faculty of Agriculture University of South Bohemia Branisovska 1457 370 05 Ceske Budejovice Czech Republic

Magnetically responsive composite materials have been used in interesting applications in various areas of bioscience, biotechnology, and environmental technology. In this work, a simple method to determine the amount of magnetic iron oxide nano- and microparticles attached to magnetically-modified partic- ulate diamagnetic materials has been developed using a commercially available magnetic permeability meter, The procedure is fast and enables dry particulate magnetically modified materials to be analysed without any modification or pretreatment. We show that the magnetic permeability can be measured for materials containing up to 20% magnetic iron oxide, The magnetic permeability measurements are highly reproducible.

关键词： Magnetic permeability meter Magnetic iron oxides Magnetically modified materials

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Long-term changes in biological soil crust cover and composition

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Ecological Processes 2013年第1期2卷 54-63页

作者： eva Dettweiler-Robinson Jeanne M Ponzetti Jonathan D Bakker Department of Biology University of New MexicoMSC0320201 University of New MexicoAlbuquerqueNM 98131U.S.A. 2914 Central St.SE OlympiaWA 98501U.S.A. School of Environmental and Forest Sciences University of WashingtonBox 354115SeattleWA98195-4115U.S.A.

Introduction:Communities change over time due to disturbances,variations in climate,and species *** soil crust communities are important because they contribute to erosion control and nutrient *** types may respond differently to changes in environmental conditions:single-celled organisms and bryophytes quickly recover after a disturbance,while lichens are slow growing and dominate favorable *** change in crusts has seldom been assessed using repeated *** this study,we hypothesized that changes in crust composition were related to disturbance,topographic position,and invasive ***:We monitored permanent plots in the Columbia Basin in 1999 and 2010 and compared changes in crust composition,cover,richness,and turnover with predictor variables of herbivore exclosure,elevation,heat load index,time since fire,presence of an invasive grass,and change in cover of the invasive ***:Bryophytes were cosmopolitan with high *** lichens did not change *** taxa differed by monitoring *** and total crust cover declined,and there was lower turnover outside of herbivore *** cover did not change *** that burned recently had high *** in taxon richness was correlated with presence of an invasive grass in *** in cover of the invasive grass was positively related to proportional loss and negatively related to ***:Composition and turnover metrics differed significantly over 11 years,though cover was more stable between *** study can be a baseline for assessing change in crust composition due to anthropogenic influences.

关键词： Biological soil crust Columbia basin Composition change Taxa turnover rate Fire Bromus tectorum Livestock exclosure

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Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus

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Neural Regeneration Research 2022年第3期17卷 649-654页

作者： Agnes Magyar eva Racz Clara Matesz Ervin Wolf Peter Kiss Botond Gaal Pediatrics Clinic Faculty of MedicineUniversity of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Division of Oral Anatomy Faculty of DentistryUniversity of DebrecenDebrecenHungary MTA-DE Neuroscience Research Group DebrecenHungary

Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements,posture and vegetative *** a shorter or longer period of time,the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic *** the plasticity of adult central nervous system is associated with the alteration of extracellular matrix,including its condensed form,the perineuronal net,we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth *** results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the *** reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net *** a transitory decrease,the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular *** bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular *** experimental procedures were approved by the 'University of Debrecen–Committee of Animal Welfare'(approval No.6/2017/DEMAB) and the 'Scientific Ethics Committee of Animal Experimentation'(approval ***/06/éLB/2270-10/2017;approved on June 6,2017).

关键词： brainstem brevican chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system

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Adding body load modifies the vibratory sensation of the foot sole and affects the postural control

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Military Medical Research 2019年第1期6卷 60-66页

作者： Yves Jammes eva Ferrand Corentin Fraud Alain Boussuges Jean Paul Weber School of Podiatry C2VN Inra Inserm Faculty of Medicine Aix Marseille University

Background: Heavy backpacks are often used by soldiers and firefighters. Weight carrying could reduce the speed and efficiency in task completion by altering the foot sole sensitivity and postural ***: In fifteen healthy subjects, we measured the changes in sensitivity to vibrations applied to the foot sole when standing upright or walking after load carrying(30% body weight). The participants were asked to judge different vibration amplitudes applied on the 2 nd or 5 th metatarsal head and the heel at two frequencies(25 and 150 Hz) to determine the vibration threshold and the global perceptual representation(Ψ)of the vibration amplitude(Φ)given by the Stevens power function(Ψ=k×Φ~n). Any increase in negative k value indicated a reduction in sensitivity to the lowest loads. Pedobarographic measurements, with computation of the center of pressure(COP) and its deviations, were performed during weight ***: The 25-Hz vibration threshold significantly increased after weight carrying when standing upright or *** standing with the added loads, the absolute negative k value increased for the 25 Hz frequency. After walking with the added loads, the k coefficient increased for the two vibration frequencies. Weight carrying significantly increased both the CoP surface and CoP lateral ***: Our data show that weight carrying reduces the sensory pathways from the foot sole and accentuates the center of pressure deviations.

关键词： Foot sole sensitivity Vibration Weight carrying Postural control

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