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Single nucleotide polymorphism(SNP)in genes of lupus:A Philippine study(SIGLA-PH)

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Rheumatology & Autoimmunity 2022年第1期2卷 22-30页

作者： michael L.Tee Cherica A.Tee Jose B.Nevado Jr Angeline Therese Santiago Aedrian A.Abrilla Carlo m.Lapid Francis A.Tablizo Joshua A.Dizon El K.B.morado eva maria Cutiongco-Dela Paz College of medicine University of the Philippines ManilaManilaPhillipines Institute of Human Genetics National Institutes of HealthUniversity of the Philippines ManilaManilaPhillipines College of medicine and Philippine General Hospital University of the Philippines ManilaManilaPhillipines Core Facility for Bioinformatics Philippine Genome CenterUniversity of the PhilippinesManilaPhillipines National Institutes of Health University of the Philippines ManilaManilaPhillipines

Background:Systemic lupus erythematosus(SLE)is a complex prototypic autoimmune disease,with a prevalence of 20–150 per 100,000,most commonly affecting women at child-bearing ***-wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes ***:This study was conducted to determine the association of selected single nucleotide polymorphisms(SNPs)from established genomic databases based on theoretical risk and protective odds ratios>2.5 ormong ***:We analyzed data from 310 SLE patients and 318 *** identified eight significant SNPs namely rs9271100,rs9271366,rs9272105,rs9275328,rs2647087,rs12734338,rs17885098,and rs3883013 to be associated with an increased risk of developing SLE among ***:Eight SNPs were found to be associated with the development of SLE among *** to previous genetic studies in lupus patients,majority of the SNPs were found in the major histocompatibilty complex genes in the HLA *** study identified two unique SNPs that will be validated as potential diagnostic markers for *** findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.

关键词： genetics lupus SLE SNP susceptibility

N-Graphene Nanowalls via Plasma Nitrogen Incorporation and Substitution: The Experimental Evidence

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Nano-micro Letters 2020年第4期12卷 92-108页

作者： Neelakandan mSanthosh Gregor Filipič eva Kovacevic Andrea Jagodar Johannes Berndt Thomas Strunskus Hiroki Kondo masaru Hori Elena Tatarova UrošCvelbar Jožef Stefan Institute Jamova cesta 391000 LjubljanaSlovenia Jožef Stefan International Postgraduate School Jamova cesta 391000 LjubljanaSlovenia GREmI CNRS-University of Orleans 14 rue d’Issoudun45067 Orleans Cedex 2France Institute for materials Science Christian Albrechts University KielKaiserstr224143 KielGermany Department of Electrical Engineering and Computer Science University of NagoyaFuro‑cho Chikusa‑kuNagoyaAichi 464‑8603Japan Instituto de Plasmas e Fusão Nuclear Instituto Superior TécnicoUniversidade de Lisboa1049 LisbonPortugal

Incorporating nitrogen(N)atom in graphene is considered a key technique for tuning its electrical ***,this is still a great challenge,and it is unclear how to build N-graphene with desired nitrogen *** is a lack of experimental evidence to explain the influence and mechanism of structural defects for nitrogen incorporation into graphene compared to the derived DFT ***,this gap is bridged through a systematic study of different nitrogen-containing gaseous plasma post-treatments on graphene nanowalls(CNWs)to produce N-CNWs with incorporated and substituted *** structural and morphological analyses describe a remarkable difference in the plasma–surface interaction,nitrogen concentration and nitrogen incorporation mechanism in CNWs by using different nitrogen-containing *** conductivity measurements revealed that the conductivity of the N-graphene is strongly influenced by the position and concentration of C–N bonding *** findings open up a new pathway for the synthesis of N-graphene using plasma post-treatment to control the concentration and configuration of incorporated nitrogen for application-specific properties.

关键词： Graphene Graphene nanowalls Plasma post-treatment Nitrogen incorporation Raman spectroscopy Vacancy defects

macrofaunal communities of threatened subtidal maёrl seabeds on Tenerife (Canary Islands, north-east Atlantic Ocean) in summer

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Acta Oceanologica Sinica 2012年第1期31卷 98-105页

作者： Rodrigo Riera Juan Domingo Delgado myriam Rodríguez Óscar monterroso eva Ramos Centro de Investigaciones medioambientales del Atlántico(CImA SL) C/Arzobispo Elías Yanes Área de Ecología Departamento de Sistemas FísicosQuímicos y Naturales.Facultad de Ciencias ExperimentalesUniversidad Pablo de Olavide

This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. maerl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types （Cymodocea, Caulerpa, sabellid field, garden eel and maerl beds）. Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables （granulometry, organic matter, nitrogen and phosphates） and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on maerl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale.

关键词： macrofauna Polychaetes Amphipods molluscs soft-bottoms subtidal Tenerife Canary Islands

Amyloid fragments and their toxicity on neural cells

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Regenerative Biomaterials 2019年第2期6卷 121-127页

作者： eva Bystrenova Zuzana Bednarikova marianna Barbalinardo Cristiano Albonetti Francesco Valle Zuzana Gazova Institute of Nanostructured materials I.S.m.N–C.N.R. via Gobetti101Bologna 40129Italy Department of Biophysics Institute of Experimental Physics SASWatsonova 47Kosice 04353Slovakia

The formation of amyloid fibrils from soluble proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human *** was converted from its soluble native state into highly organized amyloid *** treatment was used to break amyloid fibrils to fibrillar fragments–*** force microscopy and fluorescence microscopy was employed to characterize the morphology of the amyloid assemblies and neural cells–amyloid *** results demonstrate that prefibrillar intermediated and their mixture with proteins exhibit toxicity,although native proteins and fibrils appear to have no effect on number of *** findings confirm that innocuous hen lysozyme can be engineered to produce both cytotoxic fibrillar fragments and non-toxic mature amyloid *** work further strengthens the claim that amyloid conformation,and not the identity of the protein,is key to cellular toxicity and the underlying specific cell death mechanism.

关键词： amyloid fibrils protein aggregation neural cells atomic force microscopy fluorescence microscopy

Septic arthritis of the hand: From etiopathogenesis to surgical treatment

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World Journal of Orthopedics 2022年第11期13卷 993-1005页

作者： Konstantin V Lipatov Arthur Asatryan George melkonyan Aleksandr D Kazantcev Ekaterina I Solov’eva Irina V Gorbacheva Alexander S Vorotyntsev Andrey Y Emelyanov General Surgery Department Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia General Surgery Department State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115142Russia General Surgery Department The Hospital for War Veterans N3Moscow 129336Russia General Surgery Department I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia

BACKGROUND Septic arthritis of the hand,which is the second most common after damage of the knee joint,remains one of the leading causes of temporary *** inflammation can cause dysfunction of the joint,and in the most severe cases,the need for amputation of the finger may *** results of their treatment today,especially from a functional point of view,cannot be considered *** surgical treatment is extremely important in septic arthritis of the hand,as it helps to prevent cartilage destruction and the development of *** To explore the features of the course of septic arthritis of the hand as well as approaches to surgical treatment and its results,depending on the nature of the damage to the articular *** The results of the treatment of 170 patients with septic arthritis of the hand,which were treated in the period of 2020-2021,were *** of the interphalangeal and metacarpophalangeal joints(mCP)of fingers 1,2,and 3 was more often noted in 147(81.6%)*** most common cause of arthritis was a penetrating injury as a result of household trauma(101,59.4%),animal bite(30,17.6%),and clenched fist injury(15,8.8%).Septic arthritis with contiguous osteomyelitis was observed in 98(54.4%)*** treatment was completed with drainage and irrigation of the *** mobilization was used to restore *** patients with osteomyelitis,it was aimed at the formation of *** was not ***-term results of treatment were assessed in 142(83.5%)patients within 1 mo to 12 mo after discharge from the hospital[the median was 7 mo(IQR:4-9)].RESULTS The most commonly isolated organism was Staphylococcus aureus(35.3%).The median treatment delay in patients without osteomyelitis was 5 d(IQR:4-7);for septic arthritis with contiguous osteomyelitis,it was 14 d(IQR:5-21).Radiography for osteomyelitis within 2 wk was uninformative:41.2%of diagnoses.A single surgical treatment was

关键词： Septic arthritis Osteomyelitis Hand Surgical treatment Neoarthrosis

P-T path of metamorphism and U-Pb monazite and zircon age of the Kitoy terrane: Implication for Neoarchean collision in SW Siberian Craton

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Geoscience Frontiers 2020年第6期11卷 1915-1934页

作者： Vasiliy P.Sukhorukov Valentina B.Savel’eva Yingde Jiang Zhiyong Li V.S.Sobolev Institute of Geology and mineralogy SB RAS 3 Koptyuga Av.Novosibirsk630090Russia Novosibirsk State University 2 Pirogova St.Novosibirsk630090Russia Institute of the Earth Crust SB RAS 128 Lermontova St.Irkutsk664033Russia State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

The first data on P-T metamorphic conditions coupled with U-Pb monazite and zircon age obtained for the Neoarchean Kitoy granulite-gneiss terrane(SW Siberian Craton).Alumina gneisses of the Kitoy terrane indicate two-staged metamorphic *** first stage of regional metamorphism(m1)occurred at high-amphibolite facies conditions at T=780-800℃ and P=8-9 *** second stage(m2)belongs to mT-HT/LP type of metamorphism with the wide temperature interval 600-750℃ and pressure 2-4 *** age peaks were established on the basis of U-Pb monazite and zircon dating in garnet-anthophyllite *** of them correspond to the Neoarchean age:the age of m1 falls into the interval of ca.2489-2496 ma,the age of m2-ca.2446-2456 *** high-temperature metamorphism of the Kitoy block and nearly coeval granitoid magmatism can be an evidence for the Neoarchean collision in SW Siberian craton.

关键词： Siberian craton Neoarchean Kitoy terrane metamorphism P-T path

Clinical Judgment Development: Six Steps to Establish Professional Identity and Role-Specific Competencies in Caring for a Sexual Assault Survivor

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Health 2022年第1期14卷 23-37页

作者： Rose eva Constantino Larissa C. Allen Vivian Hui Kelly m. Nitowski Brayden Kameg Amy S. Bowser Rebecca Burkart Betty Braxter Department of Health and Community Systems School of Nursing University of Pittsburgh Pittsburgh Pennsylvania USA School of Nursing University of Pittsburgh Pittsburgh Pennsylvania USA

Background: Clinical judgment is a specific role that establishes a professional identity. The purpose of this paper is to prepare nursing students to make better judgments in the clinical setting and realign learning and teaching. methods: We used six steps to arrive at a competent clinical judgment suggested by the National Council State Board of Nursing (NSCBN) as a clinical judgment model 1) recognizing cues, 2) analyzing cues, 3) prioritizing hypotheses, 4) generating solutions, 5) taking an action, and 6) evaluating outcomes during the head-to-toe examination of the patient. Results: The primary outcomes are stabilization of the hemodynamics of the patient and prevention of further blood loss. Fluids are being given to help keep the vascular volume from being depleted, but they cannot solve the underlying problem. Continued assessment, intervention, and monitoring of vital signs through the course of the hospital stay ending with the patient’s discharge. Discussion: Survivors of sexual assault are unique for a nurse to provide care. The nurse needs to assess, intervene, monitor, and pay attention to detail of the 6 steps to clinical judgment, resulting in positive outcomes for their patient. Conclusions: Forensic nursing is a field of nursing that focuses on sexual assault survivor care and works to make the aftermath of their tragic situation easier to cope with. Strengthening clinical judgment skills could remedy significant mistakes made by novice forensic nurses. Critical thinking and clinical ethical reasoning are the building blocks of clinical judgment.

关键词： Analyze Cues Clinical Judgment evaluate Outcomes Generate Solutions Prioritize Hypotheses Recognize Cues

Dilute carbon in H_(3)S under pressure

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npj Computational materials 2022年第1期8卷 806-814页

作者： Xiaoyu Wang Tiange Bi Katerina P.Hilleke Anmol Lamichhane Russell J.Hemley eva Zurek Department of Chemistry State University of New York at BuffaloBuffaloNYUSA Department of Physics University of Illinois ChicagoChicagoILUSA Departments of Physics Chemistryand Earth and Environmental SciencesUniversity of Illinois ChicagoChicagoUSA

Recently,room temperature superconductivity was measured in a carbonaceous sulfur hydride material whose identity remains ***,first-principles calculations are performed to provide a chemical basis for structural candidates derived by doping H3S with low levels of *** stabilizes unusual bonding configurations about the carbon atoms,which can be six-fold coordinated as CH_(6) entities within the cubic H_(3)S framework,or four-fold coordinated as methane intercalated into the H-S lattice,with or without an additional hydrogen in the *** doping breaks degenerate bands,lowering the density of states at the Fermi level(NF),and localizing electrons in C-H *** levels of CH_(4) doping do not increase N_(F) to values as high as those calculated for Im3m-H_(3)S,but they can yield a larger logarithmic average phonon frequency,and an electron–phonon coupling parameter comparable to that of R3m-H_(3)*** implications of carbon doping on the superconducting properties are discussed.

关键词： doping phonon carbon

myxomycete diversity in the Tarim basin and eastern Tian-Shan,Xinjiang Prov.,China

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Fungal Diversity 2013年第2期59卷 91-108页

作者： martin Schnittler Yuri K.Novozhilov eva Carvajal Frederick W.Spiegel Institute of Botany and Landscape Ecology Ernst Moritz Arndt University GreifswaldGrimmer Str.8817487 GreifswaldGermany V.L.Komarov Botanical Institute of the Russian Academy of Sciences Prof.Popov St.2197376 St.PetersburgRussia Royal Botanic Garden(CSIC) Plaza de Murillo2Madrid 28014Spain Department of Biological Sciences University of ArkansasSCEN 6011FayettevilleAR 72701USA

We report the results of a survey for myxomycetes in the Chinese province of Xinjiang,covering the northern part of the Tarim basin and the eastern Tian-Shan *** in the hyperarid Tarim basin focused on monospecific Tugai forests;these are park-like stands of the phreatophyte Populus *** a transect from the Tarim basin to the mountains,trees vanish outside the basin,but reoccur at ca.1,400 m elevation as monospecific forests of Picea schrenkiana;the second focal area of the *** a total of 362 substrate samples(245 from the Tarim basin,177 from the mountains)we obtained 477 determinable records of myxomycetes,plus a total of 206 field collections,the latter almost exclusively from the spruce forests in the *** the 80 taxa recorded 53 are represented by field collections,and 32 were found in moist chamber cultures;with a very low overlap in species assemblages found in the field and in *** receiving less than 50 mm annual precipitation,corticolous myxomycetes were common in the Tugai forests,with Physarum pseudonotabile ***.,Didymium anellus,Echinostelium colliculosum and Protophysarum phloiogenum as the most common *** to the Tarim basin(21 taxa)the mountains were much richer in myxomycetes(75 taxa),although the diversity recovered from cultures was comparable(21 vs.28 taxa).most species from the mountains fruited on decaying spruce,often collected under or even inside the logs due to the extremely dry *** results suggest first that there is no lower limit of annual precipitation for myxomycetes,as long as at least some days with nightly dew fall allow these organisms to complete their life ***,the two examples of surprisingly diverse myxomycete assemblages from monospecific forests demonstrate,that species richness of this group is not necessarily connected with plant diversity of the *** survey is the most eastern of a large-scale study of myxomycete diversity throughout m

关键词： Amoebozoa Distribution moist chamber culture myxogastria Plasmodial slime molds