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Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2691-2692页

作者： Cristina Municio eva carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neurobiology of Alzheimer’s disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain

Lactoferrin is an antimicrobial prote in characterized by the exertion of many protective functions,including antibacterial,antifungal,antiviral,and antiparasitic properties,as well as anti-inflammatory and immunomodulatory activities(Kruzel et al.,2017).Lactoferrin is one of the major proteins present in exocrine secretions,including saliva,and is therefore associated with host defense against oral pathogens and control of the oral *** recent years,it has become clear that alterations in the oral microbiome may contribute to opportunistic pathogen infections in the brains of Alzheimer’s disease(AD)patients and thus participate in or contribute to the development of this neurodegenerative disease(Sureda et al.,2020).Pathogenic oral microbes can affect neurological processes by entering brain tissue through various pathways and directly damaging the central nervous *** the central nervous system,oral microbes may trigger an immune response that increases amyloidβ(Aβ)production and may even trigger the Aβcascade to promote the onset of AD,as we discuss in our previous study supporting the“infectious hypothesis”in AD(González-Sánchez et al.,2020).

关键词： Alzheimer infections protective

Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?

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Neural Regeneration Research 2024年第9期19卷 1967-1972页

作者： Laura Carrero DesireéAntequera Cristina Municio eva carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain

Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic ***,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional ***,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.

关键词： Alzheimer’s disease amyloid circadian rhythm neurodegeneration retina

Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

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Neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria Cunha Alves eva carro Joana Figueiro-Silva Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatology and Subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life Science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA *** review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

Language Education Optimization: A New Human-Based Metaheuristic Algorithm for Solving Optimization Problems

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1527-1573页

作者： Pavel Trojovsky Mohammad Dehghani eva Trojovská eva Milkova Department of Mathematics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic

In this paper,based on the concept of the NFL theorem,that there is no unique algorithm that has the best performance for all optimization problems,a new human-based metaheuristic algorithm called Language Education Optimization(LEO)is introduced,which is used to solve optimization *** is inspired by the foreign language education process in which a language teacher trains the students of language schools in the desired language skills and *** is mathematically modeled in three phases:(i)students selecting their teacher,(ii)students learning from each other,and(iii)individual practice,considering exploration in local search and exploitation in local *** performance of LEO in optimization tasks has been challenged against fifty-two benchmark functions of a variety of unimodal,multimodal types and the CEC 2017 test *** optimization results show that LEO,with its acceptable ability in exploration,exploitation,and maintaining a balance between them,has efficient performance in optimization applications and solution *** efficiency in optimization tasks is compared with ten well-known metaheuristic *** of the simulation results show that LEO has effective performance in dealing with optimization tasks and is significantly superior andmore competitive in combating the compared *** implementation results of the proposed approach to four engineering design problems show the effectiveness of LEO in solving real-world optimization applications.

关键词： Optimization language education exploration exploitation metaheuristic algorithm

Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling

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Neural Regeneration Research 2022年第6期17卷 1172-1182页

作者： Bart Nieuwenhuis Richard eva John van Geest Center for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK

Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous *** in the central nervous system fail to regenerate,meaning that injuries or diseases that cause loss of axonal connectivity have life-changing *** 2008,genetic deletion of PTEN was identified as a means of stimulating robust regeneration in the optic *** is a phosphatase that opposes the actions of PI3-kinase,a family of enzymes that function to generate the membrane phospholipid PIP_(3) from PIP_(2)(phosphatidylinositol(3,4,5)-trisphosphate from phosphatidylinositol(4,5)-bisphosphate).Deletion of PTEN therefore allows elevated signaling downstream of PI3-kinase,and was initially demonstrated to promote axon regeneration by signaling through *** recently,additional mechanisms have been identified that contribute to the neuron-intrinsic control of regenerative *** review describes neuronal signaling pathways downstream of PI3-kinase and PIP3,and considers them in relation to both developmental and regenerative axon *** briefly discuss the key neuron-intrinsic mechanisms that govern regenerative ability,and describe how these are affected by signaling through *** highlight the recent finding of a developmental decline in the generation of PIP_(3) as a key reason for regenerative failure,and summarize the studies that target an increase in signaling downstream of PI3-kinase to facilitate regeneration in the adult central nervous ***,we discuss obstacles that remain to be overcome in order to generate a robust strategy for repairing the injured central nervous system through manipulation of PI3-kinase signaling.

关键词： axon cytoskeleton axon regeneration axon transport cell signaling central nervous system growth cone neuroprotection PI3-kinase PI3K PTEN trafficking transcription translation

Utilization of fly ash from coal-fired power plants in China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 681-687页

作者： eva SELIC Jan-Dirk HERBELL Waste Management Engineering Department of Mechanical Engineering University of Duisburg-Essen Duisburg 47057 Germany

The rapidly increasing demand for energy in China leads to the construction of new power plants all over the country. Coal, as the main fuel resource of those power plants, results in increasing problems with the disposal of solid residues from combustion and off gas cleaning. This investigation describes chances for the utilization of fly ash from coal-fired power plants in China. After briefly comparing the situation in China and Germany, the status of aluminum recycling from fly ash and the ad- vantages for using fly ash in concrete products are introduced. Chemical and physical analyses of Chinese fly ash samples, e.g., X-ray diffraction (XRD), ICP (Inductive Coupled Plasma) and particle size analysis, water requirement, etc. are presented. Rea- sonable amounts of aluminum were detected in the samples under investigation, but for recovery only sophisticated procedures are available up to now. Therefore, simpler techniques are suggested for the first steps in the utilization of Chinese fly ash.

关键词： Fly ash utilization Aluminum recycling Concrete Chemical and physical analyses

Characterisation of the granular dynamics at the interface between a pipe and a granular flow in a rotating drum

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Particuology 2024年第3期86卷 117-125页

作者： Francois Rioual Paule Emmanuelle eva Gbehe Research Unit FRISE National Research Institute for Agriculture Food and the Environment1 Rue Pierre Gilles De Gennes92160AntonyFrance

A new mobile bed heat exchanger is presented in this work which is composed of a flowing granular material in a rotating drum and a cylindrical pipe with potential interest in different energy applications as cooling,heating or heat recovery *** optimal design of the device requires a characterisation of the phenomena involved at the interface between the granular flow and the *** process is modelled by the discrete element method and a global classification of the flow patterns around the pipe is presented with respect to the three main control parameters of the problem:the Froude number,the diameter ratio and the relative filling height of the *** second part is devoted to the characterisation of the structure of the flow at the interface(velocity field,density field)in particular in a so-called Biflow regime where granular motion occurs above as well as below the pipe which is favourable to transfer by convection.A typical behavior at the interface with the pipe consists of a zone I with high velocities of particles at the top of the pipe,a second zone with quasistatic particles or low velocity particles at the front and at the bottom of the pipe and a last zone ll of depletion of particles at the back of the *** Froude number has a limited effect on the features of this structure on the first layer in the range of Froude numbers considered whereas the relative height is a more determinant parameter to control the relative magnitude of velocities in zone I and zone Il as well as the extent of the depletion *** first hydrodynamical characterisation can shed light on the dynamical regimes with improved transfer between the particles and the pipe boundary.

关键词： Granular flow Transfer Heat exchange Mobile bed Boundary condition

Predicting the output error of the suboptimal state estimator to improve the performance of the MPC-based artificial pancreas

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Control Theory and Technology 2023年第4期21卷 541-554页

作者： Martin Dodek eva Miklovičová Institute of Robotics and Cybernetics Faculty of Electrical Engineering and Information TechnologySlovak University of Technology in BratislavaIlkovičova 3Bratislava81219Slovakia

The error of single step-ahead output prediction is the information traditionally used to correct the state estimate while exploiting the new measurement of the system ***,its dynamics and statistical properties can be further studied and exploited in other *** is known that in the case of suboptimal state estimation,this output prediction error forms a correlated sequence,hence it can be effectively predicted in real *** a suboptimal scenario is typical in applications where the process noise model is not known or it is ***,the paper deals with the problems of analytical and empirical modeling,identification,and prediction of the output error of the suboptimal state estimator for the sake of improving the output prediction accuracy and ultimately the performance of the model predictive *** improvements are validated on an empirical model of type 1 diabetes within an in-silico experiment focused on glycemia prediction and implementation of the MPC-based artificial pancreas.

关键词： Suboptimal state estimation Prediction Autoregressive model Moving average model Model predictive control Diabetes mellitus Artificial pancreas

FTC of hidden Markov process with application to resource allocation in air operation

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Journal of Systems Engineering and Electronics 2011年第1期22卷 12-21页

作者： Neng eva Wu Matthew Charies Ruschmann Department of Electrical and Computer Engineering Binghamton UniversityState University of New York

This paper investigates the feedback control of hidden Markov process（HMP） in the face of loss of some observation *** control action facilitates or impedes some particular transitions from an inferred current state in the attempt to maximize the probability that the HMP is driven to a desirable absorbing *** control problem is motivated by the need for judicious resource allocation to win an air operation involving two opposing *** effectiveness of a receding horizon control scheme based on the inferred discrete state is *** to loss of sensors that help determine the state of the air operation is achieved through a decentralized scheme that estimates a continuous state from measurements of linear models with additive *** discrete state of the HMP is identified using three well-known detection *** sub-optimal control policy based on the detected state is implemented on-line in a closed-loop,where the air operation is simulated as a stochastic process with SimEvents,and the measurement process is simulated for a range of single sensor loss rates.

关键词： hidden Markov process(HMP) decentralization information fusion fault tolerant estimation air operation receding horizon control(RHC).