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Science Letters:Human-centered modeling for style-based adaptive games

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 530-534页

作者： Chee-onn WONG Jongin KIM eunjung han Keechul JUNG Human-Centered Interfaces Lab Department of Digital Media Soongsil UniversitySeoul 156743 Korea

This letter proposes a categorization matrix to analyze the playing style of a computer game player for a shooting game genre. Our aim is to use human-centered modeling as a strategy for adaptive games based on entertainment measure to evaluate the playing experience. We utilized a self-organizing map (SOM) to cluster the player's style with the data obtained while playing the game. We further argued that style-based adaptation contributes to higher enjoyment, and this is reflected in our experiment using a supervised multilayered perceptron (MLP) network.

关键词： Player modeling Categorization matrix Adaptive games Human-centered modeling Data clustering

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4-1BB-4-1BBL cis-interaction contributes to the survival of selfreactive CD8^(+)T cell

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Cellular & Molecular Immunology 2023年第9期20卷 1077-1080页

作者： eunjung Cho Rohit Singh Chungyong han Seon-Hee Kim Kwang H.Kim Bo-Mi Park Dong Hoon Shin Seongeun han Young H.Kim Byoung S.Kwon Ki Taek Nam Beom K.Choi Immuno-oncology Branch Division of Rare and Refractory CancerNational Cancer CenterGoyang 10408Republic of Korea Severance Biomedical Science Institute Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulRepublic of Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408Republic of Korea Department of Biomedical Laboratory Science Catholic Kwandong UniversityGangneung 25601Republic of Korea Biomedicine Production Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea Anticancer Resistance Branch Division of Rare and Refractory CancerResearch InstituteNational Cancer CenterGoyang 10408Republic of Korea Eutilex Co. Ltd.Geumcheon-guSeoul 08594Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA Innobationbio Co. Ltd.Mapo-guSeoul 03929Republic of Korea

4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of... 详细信息

关键词： interaction activation knowledge

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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong han eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

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一个有效的基于身份的群密钥协商协议

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河北科技师范学院学报 2009年第1期23卷 41-43页

作者：曹靖邢雪蜂孙国欣韩佳河北科技师范学院计算机系河北秦皇岛066004 大庆石油学院秦皇岛分院网络中心

针对Bae Eun Jung协议需要2轮广播的问题,提出了一个有效的基于身份的群密钥协商协议。新协议适于动态群,当群中有用户加入或退出时仅需计算2次MB协议,而且消息广播只用了1轮。与Bae eunjung协议相比,降低了通信量。

关键词：基于身份密码系统群密钥协商动态群

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