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Health beliefs toward lung cancer screening among Chinese American high-risk smokers:Interviews based on Health Belief Model

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International Journal of Nursing Sciences 2022年第3期9卷 378-388页

作者： Fang Lei Wei-Ti Chen Mary-Lynn Brecht Zuo-Feng Zhang eunice lee School of Nursing University of MinnesotaTwin CitiesMinneapolisMNUnited States School of Nursing University of California at Los AngelesLos AngelesCAUnited States Fielding School of Public Health University of California at Los AngelesLos AngelesCAUnited States

Objective This study aims to explore health beliefs toward lung cancer screening with low dose computed tomography among Chinese American high-risk *** Guided by the Health Belief Model,semi-structured individual interviews were conducted with Chinese American high-risk smokers via *** questionnaires on demographic information,history of smoking and lung cancer screening were collected via email or phone before the interview,depending on participants’*** analysis was used to extract meaningful and significant themes in the *** comparison analysis and process coding were used to categorize and code *** Data saturation was reached after interviewing 12 *** American high-risk smokers perceived a low susceptibility to lung cancer,since they believed various protective factors of lung cancer(e.g.,doing exercise,healthy diet,etc.)reduced their risk of getting lung *** the participants perceived a high severity of lung *** acknowledged lung cancer would have a huge impact on their *** benefits of lung cancer screening were accurate in most aspects although minor confusions were still noticed among this *** barriers varied on participants’,physicians’,and institutional ***-risk Chinese American smokers had little confidence to screening for lung *** to action for them to screening for lung cancer included recommendations from health care providers,support from family members and friends,and information shared on Chinese-based social *** Misconceptions and barriers to screening for lung cancer existed widely among Chinese American high-risk *** programs and targeted health education should be implemented to promote lung cancer screening among this population.

关键词： Asian Americans Early detection of cancer Health belief model Lung neoplasms Smokers

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中链脂肪酸及其衍生物有利于动物肠道健康

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国外畜牧学（猪与禽） 2021年第5期41卷 19-20页

作者：张弦(译) 王晶晶(校) eunice lee 江西农业大学不详

畜牧业正在研究不同种类的抗生素替代品,其中包括中链脂肪酸及其衍生物。研究表明,在动物日粮中添加中链脂肪酸可以改善动物肠道的微生物组成。

关键词：中链脂肪酸及其衍生物抑菌活性肠道健康

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二语习得视角下对外汉语语法教学中的“形式”与“意义”——以马来语为例

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国际汉语学报 2018年第2期9卷 201-209页

作者：李静文北京大学对外汉语教育学院

在汉语作为第二语言教学领域中,语法教学的过程应从“形式”到“意义”还是“意义”到“形式”、如何处理好二者之间的关系等问题一直是讨论的焦点,但至今仍未达致共识。学界已有讨论多以学习者的语言水平或语言教学的方法为切入点,而... 详细信息

在汉语作为第二语言教学领域中,语法教学的过程应从“形式”到“意义”还是“意义”到“形式”、如何处理好二者之间的关系等问题一直是讨论的焦点,但至今仍未达致共识。学界已有讨论多以学习者的语言水平或语言教学的方法为切入点,而本文则选择从二语习得的角度探讨这个问题。从这个角度,我们认为形式和意义孰先孰后讲解的问题,应该要根据母语和目的语语法结构的差异程度以及语言迁移对二语习得的影响,区别对待。

关键词：语法形式语法意义二语习得马来语语法结构差异

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英语媒介语在面向非英语母语者汉语教学中的支架作用

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国际汉语教学研究 2023年第2期 65-73,86页

作者：刘元满李静文北京大学对外汉语教育学院启历学校香港英国国际学校薄扶林校区中国香港

非英语母语国家的汉语学习者有不少将英语作为第二语言,汉语是其正在学习的第三语言。在汉语目的语环境下,特别是多国别混班教学中师生双方都会将英语作为共通的媒介语使用。本研究通过考察学界对英语媒介语的看法,师生对英语的接受程度... 详细信息

非英语母语国家的汉语学习者有不少将英语作为第二语言,汉语是其正在学习的第三语言。在汉语目的语环境下,特别是多国别混班教学中师生双方都会将英语作为共通的媒介语使用。本研究通过考察学界对英语媒介语的看法,师生对英语的接受程度,以及英语在教师教学、教材编写、学生学习中的功能表现,提出英语媒介语可作为对非英语母语者进行汉语教学的支架使用,其具有可选性,使用原则为适时提供、适度运用、适时撤除。

关键词：英语媒介语非英语母语者汉语教学支架

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Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review

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World Journal of Gastroenterology 2020年第2期26卷 219-245页

作者： eunice Xiang-Xuan Tan Min-Xian Wang Junxiong Pang Guan-Huei lee National University Health System Singapore 119228Singapore Centre for Infectious Disease Epidemiology and Research Saw Swee Hock School of Public HealthNational University of SingaporeSingapore 119077Singapore National University of Singapore Singapore 119077Singapore

BACKGROUND Acute liver failure(ALF)and acute-on-chronic liver(ACLF)carry high short-term mortality rate,and may result from a wide variety of *** exchange has been shown in a randomized control trial to improve survival in ALF especially in patients who did not receive a liver *** cohort studies demonstrated potential improvement in survival in patients with *** To assess utility of plasma exchange in liver failure and its effect on mortality in patients who do not undergo liver *** Databases MEDLINE via PubMed,and EMBASE were searched and relevant publications up to 30 March,2019 were *** were included if they involved human participants diagnosed with liver failure who underwent plasma exchange,with or without another alternative non-bioartificial liver assist *** Three hundred twenty four records were reviewed,of which 62 studies were found to be *** the 262 records screened,211 studies were ***-one articles were assessed for eligibility,for which 7 were ***-nine studies were included for ALF only,and 9 studies for ACLF *** studies included both ALF and ACLF patients.A total of 44 publications were *** the included publications,2 were randomized controlled trials,14 cohort studies,12 case series,16 case *** of three ALF studies which looked at survival rate or survival days reported improvement in outcome with plasma *** two out of four studies where plasma exchange-based liver support systems were compared to standard medical treatment(SMT)for ACLF,a biochemical improvement was *** in the non-transplanted patients was improved in all four studies in patients with ACLF comparing plasma exchange vs *** the aforementioned studies,plasma exchange based therapy in ACLF compared to SMT improved survival in non-transplanted patients at 30 and 90-d with a pooled OR of 0.60(95%CI 0.46-0.77,P<0.01).CONCLUSION The level of ev

关键词： Acute-on-chronic liver failure Acute liver failure Plasmapheresis Plasma exchange Liver failure

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The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation

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Journal of Molecular Cell Biology 2022年第6期14卷 14-29页

作者： Soonhwa Song Joon Kyu Park Sang Chui Shin Jae-Jin lee Seung Kon Hong In-Kang Song Bokyung Kim Eun Joo Song Kong-Joo lee eunice EunKyeong Kim Graduate School of Pharmaceutical Sciences College of PharmacyEwha Womans UniversitySeoul 03760Republic of Korea Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Technology Support Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Fas-associated factor 1 (FAF1) is a scaffolding protein that plays multiple functions, and dysregulation of FAF1 is associated withmany types of diseases such as cancers. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UAS, and UBX), eachdomain interacting with a specific partner. In particular, the interaction of UBL1 with heat shock protein 70 (Hsp70) is associatedwith tumor formation, although the molecular understanding remains unknown. In this study, the structural analysis revealed thatHis160 of FAF1 is important for its interaction with Hsp70. The association of Hsp70 with FAF1 is required for the interaction withIQGAP1. FAF1 negatively regulates RhoA activation by FAF1–Hsp70 complex formation, which then interacts with IQGAP1. Thesesteps play a key role in maintaining the stability of cell-to-cell junction. We conclude that FAF1 plays a critical role in the structureand function of adherens junction during tissue homeostasis and morphogenesis by suppressing RhoA activation, which induces theactivation of Rho-associated protein kinase, phosphorylation of myosin light chain, formation of actin stress fiber, and disruptionof adherens junction. In addition, depletion of FAF1 increased collective invasion in a 3D spheroid cell culture. These results provideinsightinto how the FAF1–Hsp70 complex acts as a novelregulator ofthe adherens junction integrity. The complex can be a potentialtherapeutic target to inhibit tumorigenesis and metastasis.

关键词： human Fas-associated factor 1(FAF1) heat shock protein 70(Hsp70) adherens junction RhoA activation IQGAP1 X-ray crystallography FAF1–Hsp70 complex

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Case Study of Middle East Respiratory Syndrome (MERS-CoV) Outbreak in South Korea and Future Implications

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Advances in Infectious Diseases 2020年第2期10卷 76-89页

作者： Woo Hyung lee David Ahn Kunmin Kim Peter S. Park Seog In Moon Hark Joon lee David Park Hyun Seung Shin eunice Kang Daniel Choo David S. Chung Biotechnology School of Science Hong Kong University of Science of Technology Hong Kong China Department of Economics William & Mary Williamsburg VA USA Department of Chemistry and Biochemistry University of California San Diego CA USA Department of Biology College of Art and Science Biology Cornell University Ithaca NY USA Department of Biology Amherst College Amherst MA USA Department of Biology Washington University St. Louis MO USA College of Art and Science Biology Emory University Atlanta GA USA Division of Biomedical Informatics University of Virginia Charlottesville VA USA Youth with Talents Fairfax VA USA School of Medicine University of Virginia Charlottesville VA USA

The Middle East Respiratory Syndrome (MERS-CoV) is a potentially fatal respiratory viral infection that has had outbreaks in the Middle East and Asia region starting in 2012. As recent as 2015, MERS had outbreaks in South Korea, resulting in 36 deaths among 186 infected patients. The purpose of this thesis is to gain an in-depth understanding of how this viral infection behaves in outbreaks and how it is spread around the globe. To gain insight, real time analysis was performed under a case study methodology based on pooled data from the Ministry of Health & Welfare of South Korea. We calculated a striated mortality rate based on gender, age, and the presence of pre-existing health conditions ranging from heart, lung, and kidney diseases. We found that MERS outbreak follows the pattern of a point source outbreak, largely spurred by the patient-referral system under the universal healthcare system in South Korea. The purpose of this case is to discuss the benefits and challenges of such patient referral system, and to offer a possible solution in improving transparency between healthcare providers and the government under a universal healthcare system to prevent future outbreaks.

关键词： Infectious Diseases Respiratory Viral Infections Public Health Disease Prevention

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Sexually Transmitted Diseases at Monkey Bay Community Hospital in Mangochi, Malawi;an Analysis of Characteristics of Common Sexually Transmitted Diseases

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Advances in Infectious Diseases 2020年第4期10卷 243-252页

作者： David S. Chung Min Jung Koh Sung Hwan Chough Seog In Moon Gene K. lee Ivy Kim Yujin Kim Jae Hee Kim Lorie Kim Hyunjin Kim eunice Kang Fatsani Manase Thomas Nyirenda School of Medicine University of Virginia Charlottesville VA USA Youth with Talents Fairfax VA USA School of Medicine Georgetwon University Washington DC USA College of Dentistry NYU New York NY USA Clinical Research Education and Management Service Lilongwe Malawi

We present the characteristics of the commonly diagnosed sexually transmitted infections (STI) at a clinic of Monkey Bay community hospital by a retrospective study. We conducted an audit of patients’ hospital records from a STIs clinic at Monkey Bay community hospital in Mangochi District (Malawi) covering a period from January 2019 to June 2019 (18 months). Data was tabulated in excel and analyses were made based on sex, age, male circumcision status, pregnancy and the pattern of STIs diagnosed within the chosen study period. A total number of 659 clients presented at STI clinic of Monkey Bay community hospital between January 2018 and June 2019. Out these clients, 409 (62%) were females and 250 (38%) were males. Most of the patients were in the age range of 25 years or above (447, 68%). Majority of the patients were HIV negative (523, 79%). Out of the 250 males, 113 (45%) were circumcised. Among female patients 56 of the 409 (14%) were pregnant. The most common presentations for all cases put together were lower abdominal pain (253, 38%), then urethral discharge (189, 29%), abnormal vaginal discharge (141, 21%), genital ulcer disease (64, 10%), in that order. Syphilis, genital warts, inguinal bubo and scrotal swelling were less common. The most common presentation in males was urethral discharge (178, 71%), while in females it was lower abdominal pain (214, 52%). Our audit showed that in Mangochi (Malawi) sexually transmitted diseases of various types are more common among young adults, females and uncircumcised men. There was no much difference in the percentage of STI’s between HIV positive and HIV negative people. These results point to an alarmingly high level of risky sexual behaviors among sexually active age groups in this part of Malawi, a country which still has one of the highest HIV prevalence in sub-Saharan Africa. This calls for continued and better research and control for transmission of STIs in the district.

关键词： Sexually Transmitted Infections (STIs) Mangochi Malawi

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Developmental staging of male murine embryonic gonad by SAGE analysis

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Journal of Genetics and Genomics 2009年第4期36卷 215-227页

作者： Tin-Lap lee Yunmin Li Diana Alba Queenie R Vong Shao-Ming Wu Vanessa Baxendale Owen M. Rennert Yun-Fai Chris Lau Wai-Yee Chan Section on Developmental Genomics Laboratory of Clinical Genomics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 USA Department of Medicine VA Medical Center University of California San Francisco CA 94121 USA Department of Pediatrics Biochemistry Molecular & Cellular Biology Georgetown University Washington DC 20007 USA

Despite the identification of key genes such as Sry integral to embryonic gonadal development, the genomic classification and identification of chromosomal activation of this process is still poorly understood. To better understand the genetic regulation of gonadal development, we performed Serial Analysis of Gene Expression （SAGE） to profile the genes and novel transcripts, and an average of 152,000 tags from male embryonic gonads at E10.5 （embryonic day 10.5）, E11.5, E12.5, E13.5, E15.5 and E17.5 were analyzed. A total of 275,583 non-singleton tags that do not map to any annotated sequence were identified in the six gonad libraries, and 47,255 tags were mapped to 24,975 annotated sequences, among which 987 sequences were uncharacterized. Utilizing an unsupervised pattern identification technique, we established molecular staging of male gonadal development. Rather than providing a static descriptive analysis, we developed algorithms to cluster the SAGE data and assign SAGE tags to a corresponding chromosomal position; these data are displayed in chromosome graphic format. A prominent increase in global genomic activity from E10.5 to E17.5 was observed. Important chromosomal regions related to the developmental processes were identified and validated based on established mouse models with developmental disorders. These regions may represent markers for early diagnosis for disorders of male gonad development as well as potential treatment targets.

关键词： SAGE transcriptome male gonads gene tag novel transcripts cluster analysis chromosome transcription hotspot

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Testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian Journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P lee Mara Y Roth Jean-Jacques Nya-Ngatchou Kat Lin Thomas J Walsh Stephanie T Page Alvin M Matsumoto William J Bremner John K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events （0.5%） required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis

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