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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Formic acid as an alternative reducing agent for the catalytic nitrate reduction in aqueous media

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Journal of Environmental Sciences 2013年第8期25卷 1696-1702页

作者： eun-kyoung choi Kuy-hyun Park ho-bin Lee Misun Cho Samyoung Ahn Department of Environmental Education Sunchon National University

Formic acid was used for the nitrate reduction as a reductant in the presence of Pd：Cu/γ-alumina catalysts. The surface characteristics of the bimetallic catalyst synthesized by wet impregnation were investigated by SEM, TEM-EDS. The metals were not distributed homogeneously on the surface of catalyst, although the total contents of both metals in particles agreed well with the theoretical values. Formic acid decomposition on the catalyst surface, its influence on solution pH and nitrate removal efficacy was investigated. The best removal of nitrate （50 ppm） was obtained under the condition of 0.75 g/L catalyst with Pd：Cu ratio （4：1） and two fold excess of formic acid. Formic acid decay patterns resembled those of nitrate removal, showing a linear relationship between kf （formic acid decay） and k （nitrate removal）. Negligible amount of ammonia was detected, and no nitrite was detected, possibly due to buffering effect of bicarbonate that is in situ produced by the decomposition of formic acid, and due to the sustained release of H2 gas.

关键词： formic acid catalytic nitrate reduction Pd:Cu/γ-alumina catalyst H2 supply

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

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Building Simulation 2022年第5期15卷 755-768页

作者： Jung Min Han eun Seuk choi Ali Malkawi Harvard University Graduate School of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard John A.Paulson School of Engineering and Applied Sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-ho choi JOO DONG PARK SeunG HEE choi eun-SU KO HYE JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

Electrochemical processing of spent nuclear fuels:An overview of oxide reduction in pyroprocessing technology

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Progress in Natural Science:Materials International 2015年第6期25卷 572-582页

作者： eun-Young choi Sang Mun Jeong Korea Atomic Energy Research Institute Department of Chemical Engineering Chungbuk National University

The electrochemical reduction process has been used to reduce spent oxide fuel to a metallic form using pyroprocessing technology for a closed fuel cycle in combination with a metal-fuel fast *** the electrochemical reduction process,oxides fuels are loaded at the cathode basket in molten LiO–LiCl salt and electrochemically reduced to the metal *** approaches based on thermodynamic calculations and experimental studies have been used to understand the electrode reaction and efficiently treat spent *** factors that affect the speed of the electrochemical reduction have been determined to optimize the process and scale-up the electrolysis *** addition,demonstrations of the integrated series of processes(electrorefining and salt distillation) with the electrochemical reduction have been conducted to realize the oxide fuel *** overview provides insight into the current status of and issues related to the electrochemical processing of spent nuclear fuels.

关键词： Pyroprocessing Electrochemical reduction Electrorefining Molten salt Spent oxide fuel

Antioxidant and anticancer activity of Artemisia princeps *** extract in HepG2 and Hep3B hepatocellular carcinoma cells

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Chinese Journal of Cancer Research 2013年第5期25卷 536-543页

作者： eun-Jeong choi Gun-Hee Kim Plant Resources Research Institute Duksung Women's University

Objective：The aim of the present study was to investigate antioxidant and the anticancerigen activity of a methanol extract from Artemisia princeps *** （APME）,a well-known traditional herbal medicine in Asia,in hepatocellular cancer ***：To evaluate the antioxidant activity of APME,reactive oxygen species （ROS） and the antioxidant enzymes,superoxide dismutase （SOD） and catalase were investigated in HepG2 cells exposed to APME （5,100,and 200 μg/mL） for 72 ***,to evaluate the anticancer activity of APME,we investigated the proliferation and apoptosis induction of HepG2 and Hep3B cells exposed to APME （1-200 μg/mL） for 24,48,and 72 ***：APME dose-dependently reduced the generation of ROS in the presence of H2O2 compared with control ***,it increased catalase and SOD ***,APME inhibited cell proliferation in a dose-and time-dependcnt manner,but at concentrations lower than 100 μg/mL,the inhibition was less dose-dependent than ***2 and Hep3B cells exposed to 5,100,and 200 μg/mL APME for 72 h underwent cell cycle arrest and *** to APME resulted in a significant increase in the number of cells in G1 phase and a decrease in the G2/M phase cell *** addition,APME induced P53 expression of HepG2 cells in a dose-dependent manner,and played a role in the downregulation of Bcl-2 and upregulation of Bax in both HepG2 and Hep3B ***：These results indicate the potential role of APME as an antioxidant and anticancerigen agent in hepatocarcinoma cell lines.

关键词： Artemisia princeps var.orientalis antioxidant anticancer hepatocellular carcinoma

Study of Partial Coefficients for Design of Semicircular Breakwaters

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China Ocean Engineering 2010年第1期24卷 29-40页

作者：郄禄文 Byung ho choi College of Civil Engineering Hebei University Department of Civil and Environmental Engineering Sungkyunkwan University300 Chunchun-dongJangan-GuSuwon

In the present study, the reliability design of semicircular breakwater is based on the verification of the rules defined by standard specifications, where partial coefficients are introduced to ensure safety. The reliability of the semicircular breakwaters has been analyzed by using the Hasofer-Lind method to determine the reliability index of structure that has correlated loads, utilizing the long-term observed wave data at a given place. The relation curve between reliability index and safety factor in the traditional design method, as well as the relationships between reliability index and partial coefficients, have been obtained. This paper proposes values of partial coefficients for the design expression of semicircular breakwaters in the cases of anti-sliding and anti-overturning.

关键词： partial coefftcient reliability index correlated variables semicircular breakwater

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： eun Young Lee Kun-ho Yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung choi eun-Jeong Won Emmanuel Hui ho-Shik Kim Young-Seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer