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Hepatocellular carcinoma,decompensation,and mortality based on hepatitis C treatment:A prospective cohort study

World Journal of Gastroenterology 2022年第30期28卷 4182-4200页

作者： Gwang Hyeon Choi eun Sun jang Young Seok Kim Youn Jae Lee In Hee Kim Sung Bum Cho Han Chu Lee Jeong Won jang Moran Ki Hwa Young Choi Dahye Baik Sook-Hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907JeonbukSouth Korea Department of Internal Medicine Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea Cancer Control and Population Health Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408South Korea

BACKGROUND Prospective studies of the long-term outcomes of patients with hepatitis C virus(HCV)infection after treatment with interferon-based therapy(IBT)or directacting antivirals(DAA)are limited in many Asian *** To elucidate the incidences of hepatocellular carcinoma(HCC)and death/transplantation based on treatment with IBT or DAA,to compare the outcomes of the sustained virologic response(SVR)to IBT and DAA,and to investigate outcome-determining factors after *** This cohort included 2054 viremic patients(mean age,57 years;46.5%male;27.4%with cirrhosis)prospectively enrolled at seven hospitals between 2007 and *** were classified as the untreated group(n=619),IBT group(n=578),and DAA group(n=857).Outcomes included the incidences of HCC and death/*** incidences of the outcomes for each group according to treatment were calculated using an exact method based on the Poisson distribution.A multivariate Cox regression analysis was performed to determine the factors associated with HCC or death/transplantation,followed by propensity score matching to confirm the *** During a median of 4.1 years of follow-up,HCC and death/transplantation occurred in 113 and 206 patients,respectively,in the entire *** with the untreated group,the incidences of HCC and death/transplantation were significantly lower in the IBT group[adjusted hazard ratio(aHR)0.47,95%CI:0.28-0.80 and aHR 0.28,95%CI:0.18-0.43,respectively]and the DAA group(aHR 0.58,95%CI:0.35-0.96,and aHR 0.19,95%CI:0.20-0.68,respectively).Among 1268 patients who attained SVR with IBT(n=451)or DAA(n=816),the multivariable-adjusted analysis showed no differences in the risks of HCC(HR 2.03;95%CI:0.76-5.43)and death/transplantation(HR 1.38;95%CI:0.55-3.49)between the two *** was confirmed by a propensity score-matching *** factors for HCC after SVR were age,genotype 1,and the presence of *** Treatment and achieving SVR

关键词： Hepatitis C virus Direct-acting antiviral Sustained virologic response Hepatocellular carcinoma Mortality

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Grain flow rate sensing for a 55 kW full-feed type multi-purpose combine

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 206-210页

作者： Moon-Chan Choi Kyu-Ho Lee Bo-eun jang Yong-Joo Kim Sun-Ok Chung Jong-Soon Lee Su-Kyeong Kim Department of Biosystems Machinery Engineering Chungnam National UniversityDaejeon34134Korea R&D Center Daedong Industrial Co.LtdChangyeongKorea R&D Center TongYang Co.LtdGongjuKorea

Real time sensing of crop yield is critical for a successful implementation of precision *** monitoring system is an optional component of a 55 kW multi-purpose combine harvester,developed in Korea,for both domestic and global markets,especially Asian countries where field sizes are relatively *** aim of the present study was to fabricate and evaluate the performance of a grain flow sensor suitable to the mid-sized full-feed type combine for rice,soybean,and ***,commercially available non-contact type sensing modules(optical,ultrasonic,laser,and microwave modules)were chosen for alternative candidates,to be further tested in a laboratory *** the laboratory tests,the ultrasonic module was selected as a potential approach and the performance was improved by increasing the number of modules and their ***,the improved grain flow sensor was evaluated during field harvesting *** tests with the improved grain flow sensor showed a good potential for rice(R^(2)=0.85,RMSE=126.14 g/s),soybean(R^(2)=0.78,RMSE=43.87 g/s),and barley(R^(2)=0.83,RMSE=37.39 g/s).Further research would be necessary for improvement and commercialization,through various signal processing and field tests under different field and crop conditions.

关键词： precision agriculture combine harvester yield monitoring system sensor grain flow rate

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nhalation of Sevoflurane and Desflurane Can Not Affect QT Interval, Corrected QT, Tp-Te/QT or Tp-Te/JT in Children

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Chinese Medical Journal 2018年第6期131卷 739-740页

作者： Ji-Hyun Lee eun-Hee Kim Young-eun jang Jin-Tae Kim Hee-Soo Kim Department of Anesthesiology and Pain Medicine Seoul National University Hospital Seoul 03080 Korea

To the Editor： Sevoflurane and desflurane are tile most common general anesthetics used in children. Previous study has shown that these agents can affect the electrocardiogram （ECG） markers,i^i leading to fatal ventricular arrhythmia. The followings were identified as useful indices for predicting and estimating the occurrence of a fatal arrhythmia： the interval between the peak and the end of T wave （Tp-Te） the ratio of the Tp-Te interval to the QT interval （[Tp-Te/QT]）, and the JY interval （JT）, which is measured from the end of the QRS complex to Te.

关键词： QT 孩子心电图代理人 QRS 建筑群心律学习

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Synergistic Effect between Fucoidan and Antibiotics against Clinic Methicillin-Resistant <i>Staphylococcus aureus</i>

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Advances in Bioscience and Biotechnology 2015年第4期6卷 275-285页

作者： Sung-Mi Choi eun-Jin jang Jeong-Dan Cha Department of Dental Hygiene Daegu Health College Daegu South Korea Department of Dental Technology Daegu Health College Daegu South Korea Department of Natural Products Research Institute of Jinan Red Ginseng Jinan South Korea

Fucoidan is a sulfated polysaccharide that is primarily extracted from brown seaweeds which has been broadly studied in recent years due to its numerous biological properties, including anticoagulant, antithrombotic, antitumor, and antiviral activities. In this study, fucoidan was evaluated against clinic isolated methicillin-resistant Staphylococcus aureus (MRSA) 1 - 20, either alone or with antibiotics, via broth dilution method and checkerboard and time kill assay. Minimum inhibitory concentrations (MICs)/Minimum bactericidal concentrations (MBCs) values for the fucoidan against all the tested bacteria ranged between 64 - 512/256 - 2048 microg/mL, for ampicillin 32 - 1024/64 - 1024 microg/mL and for oxacillin 8 - 64/16 - 256 microg/mL respectively. Furthermore, the MIC and MBC were reduced to one half-eighth as a result of the combination of the fucoidan with antibiotics. 2 - 6 hours of treatment with 1/2 MIC of fucoidan with 1/2 MIC of antibiotics resulted from an increase of the rate of killing in units of CFU/mL to a greater degree than was observed with alone. These results suggest that fucoidan could be employed as a natural antibacterial agent against multi-drug bacteria.

关键词： Fucoidan Antibacterial Activity Methicillin-Resistant Staphylococcus aureus Synergistic Effect Minimum Inhibitory Concentrations (MICs) Minimum Bactericidal Concentrations (MBCs)

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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World Journal of Gastroenterology 2016年第42期22卷 9427-9436页

作者： Junhyeon Cho Sang Soo Lee Yun Suk Choi Yejoo Jeon Jung Wha Chung Joo Yeong Baeg Won Keun Si eun Sun jang Jin-Wook Kim Sook-Hyang Jeong Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University College of Medicine

AIM To clarify the prevalence of occult hepatitis B virus(HBV) infection(OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma(HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus(HCV) infection. METHODS This prospective cohort study enrolled 174 patients with chronic HCV infection(chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or moredifferent viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome. RESULTS The overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively(P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response(SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development. CONCLUSION The prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

关键词： Hepatitis B virus Hepatitis C virus Disease control Oncogenesis

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ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SeunG HEE CHOI eun-SU KO HYE JUNG jang KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

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Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han eun Chul jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

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Colonic lipoma covered by hyperplastic epithelium: Case report

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World Journal of Clinical Cases 2013年第3期1卷 124-127页

作者： Ju-Ok Yeom Sun-Young Kim eun-Chul jang Ji-Youn Yu eun Deok Chang Young-Seok Cho Division of Gastroenterology Department of Internal MedicineUijeongbu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea Departement of Cilinical Pathology Uijeong-bu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea

Colonic lipomas are submucosal nonepithelial tumors covered by intact or eroded mucosa. In rare cases, alterations in the mucosa covering a lipoma include hyperplasia, adenoma, atrophy, ulceration, and necrosis. Here, we report a case of a colonic lipoma covered by hyperplastic epithelium in a 68-year-old woman. Based on the colonoscopy findings, a snare polypectomy was performed for a presumptive diagnosis of an epithelial lesion; however, the histological examination revealed a colonic submucosal lipoma with overlying hyperplastic epithelium.

关键词： Lipoma Colonic lipomas Hyperplastic Colonoscopy

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Assessing the impact of meteorological factors on malaria patients in demilitarized zones in Republic of Korea

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Infectious Diseases of Poverty 2016年第1期5卷 180-191页

作者： Se-Min Hwang Seok-Joon Yoon Yoo-Mi Jung Geun-Yong Kwon Soo-Nam Jo eun-Jeong jang Myoung-Ok Kwon Korea Human Resource Development Institute for Health&Welfare OsongRepublic of Korea Department of Preventive Medicine College of MedicineKorea UniversitySeoulRepublic of Korea Department of Preventive Medicine Armed Forces Medical CommandSeongnamRepublic of Korea Department of Health Policy and Hospital Management Graduate School of Public HealthKorea University73 Inchon-ro.Seongbuk-GuSeoul 136-705Republic of Korea Korea Armed Forces Nursing Academy 90 Jaun-roYuseong-guDaejeon 305-153Republic of Korea Korean Centers for Disease Control and Prevention OsongRepublic of Korea

Background:The trend of military patients becoming infected with vivax malaria reemerged in the Republic of Korea(ROK)in *** common explanation has been that infective Anopheles mosquitoes from the Democratic People’s Republic of Korea have invaded Republic of Korea’s demilitarized zone(DMZ).The aim of this study was to verify the relationship between meteorological factors and the number of malaria patients in the military in this ***:The authors estimated the effects of meteorological factors on vivax malaria patients from the military based on the monthly number of malaria cases between 2006 and ***,precipitation,snow depth,wind velocity,relative humidity,duration of sunshine,and cloud cover were selected as the meteorological factors to be studied.A systematic pattern in the spatial distribution of malaria cases was assessed using the Moran’s *** causality tests and cross-correlation coefficients were used to evaluate the relationship between meteorological factors and malaria patients in the ***:Spatial analysis revealed significant clusters of malaria patients in the military in Republic of Korea in 2011(Moran’s I=0.136,p-value=0.026).In the six years investigated,the number of malaria patients in the military in Paju decreased,but the number of malaria patients in the military in Hwacheon and Chuncheon *** average,maximum and minimum temperatures;wind velocity;and relative humidity were found to be predicting factors of malaria in patients in the military in *** contrast,wind velocity alone was not able to predict malaria in Hwacheon and Chuncheon,however,precipitation and cloud cover were able to predict malaria in Hwacheon and ***:This study demonstrated that the number of malaria patients in the military is correlated with meteorological *** variation in occurrence of malaria cases was principally attributed to differences in meteorological factors by regions of

关键词： Malaria Plasmodium vivax Meteorological factors

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Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma

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Cancer Communications 2024年第8期44卷 915-920页

作者： Sangyeop Hyun Youngmin Han Jae Yun Moon Young-Ah Suh Won-Gun Yun Wooil Kwon Jong-eun Lee Daeun Kim Ja-Lok Ku Jin-Young jang Daechan Park Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Molecular Science and Technology Research Center Ajou UniversitySuwonRepublic of Korea DNA Link Inc. SeoulRepublic of Korea Korean Cell Line Bank Laboratory of Cell BiologyCancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea

Patient-derived xenograft(PDX)models have been used to explore therapeutic opportunities for pancreatic ductal adenocarcinoma(PDAC)[1].Although original tumor characteristics are altered by cancer-stromal interactions... 详细信息

关键词： adenocarcinoma ductal xenograft

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