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Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： Jwa Hoon Kim Jeong eun Kim Yong Sang Hong sun Young Kim Kyu-pyo Kim Ki eun Choi Ji Hoon Shin Tae Won Kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

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Structural Analysis of FRIGIDA Flowering-Time Regulator

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Molecular Plant 2016年第4期9卷 618-620页

作者： Kyung-gi Hyun Jee eun Oh Jihye Park Yoo-sun Noh Ji-Joon Song Department of Biological Sciences KAIST Institute of the BioCentury KAIST Daejeon 34141 Korea School of Biological Sciences Seoul National University Seoul 151-747 Korea

Dear Editor,Flowering is a major developmental switch in the life cycle of flowering plants. FRIGIDA （FRI） activates FLOWERING LOCUS C （FLC） transcription, a major repressor of this switch regulating flow- ering time （Johanson et al., 2000）. FRI is highly conserved and many natural variations in FRI are found to affect flowering time. However, little is known about the molecular characteristics of FRI.

关键词： Flowering major developmental

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Epigenetic mechanisms involved in the neuroprotective effect of scorpion extract in a Parkinson's disease murine model based on multi-omics approach

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Journal of Traditional Chinese Medicine 2021年第3期41卷 390-396页

作者： Joong sun Kim Hye-sun Lim Byeong Cheol Moon Mary Jasmin Ang sung-Ho Kim Changjong Moon Boseok Seong Yunji jang Hyung-Yong Kim Chul Kim Herbal Medicine Resources Research Center Korea Institute of Oriental MedicineJeollanamdo 58245Republic of Korea College of Veterinary Medicine and BK21 Plus Project Team Chonnam National UniversityGwangju 61186Republic of Korea Future Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Research and Development Center Insilicogen Inc.Yonginsi 16954Republic of Korea

OBJECTIVE: To investigate whether scorpion extract elicits a neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice models, and the genes associated with the therapeutic effects using RNA sequencing(seq)***: This study investigated the changes in interaction between messenger ribonucleic acid(m RNA) expression and deoxyribonucleic acid(DNA) methylation related to the protective effects of scorpion extracts, in the substantia nigra(SN)region of a MPTP-induced Parkinson's disease(PD)***: In this model, scorpion extracts attenuated the motor impairment as demonstrated by the rotarod and open field tests. Scorpion extracts consistently attenuated the decrease of tyrosine hydroxylase(TH) positive neural cells in the SN and striatum of mice. We profiled genomewide DNA methylation using Methyl-Seq and measured the transcriptome using RNA-Seq in murine SN in the following groups: vehicle-treated MPTP-induced PD mice and scorpion extracttreated MPTP-induced PD mice. In total, 13 479 differentially expressed genes were identified in association with the anti-PD effect of the scorpion extract, mainly in the promoter and coding *** them, 47 were negatively correlated downregulated genes. Nineteen genes out of 47 downregulated genes were negatively correlated with the expression of the other 28 genes. Among these genes, SGSM1 was related to dopaminergic neurons including dopamine transporters, TH, dihydroxyphenylalanine decarboxylase, and dopamine D2 ***: This study provides insights into the anti-parkinsonian effects of scorpion extract and reveals the epigenetic targets in its therapeutic mechanism.

关键词： scorpions 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Parkinson disease DNA methylation

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Reconstruction of Rabbit Corneal Layer Composed of Corneal Fibroblasts and Corneal Epithelium on the Lyophilized Amniotic Membrane

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Chemical Research in Chinese Universities 2006年第2期22卷 150-156页

作者： AHN Jae-il jang In-keun YOON Mun-young SEO Young-kwon YOON Hee-hun KIN Jae-chan SONG Kye-yong YANG eun-kyung PARK Jung-keug Department of Chemical and Biochemical Engineering Dongguk University Seoul Korea Department of Ophthalmology Chung-Ang University Hospital Seoul Korea Department of Pathology College of Medicine Chung-Ang University Seoul Korea R & D Center Bioland Ltd. Chun-An Korea

Many researchers have employed the cryopreserved amniotic membrane（CAM） and corneal epithelial cells in the treatment of a severely damaged burned cornea, with corneal epithelial cells cultured on an amniotic membrane （AM）. The lyophilized amniotic membrane（LAM） has a higher graft take and a longer shelf life; it is easier to store and safer because of gamma irradiation. Two Teflon rings（ Ahn＇s supporter） were made for culturing the cells on the LAM, and were then used to support the LAM. To reconstruct a corneal layer composed of corneal fibroblasts and epithelium, the corneal fibroblasts were first cultivated on the stromal side of LAM for five days, foUowed by epithelial cells culture on the epithelial side, by using the air-liquid interface culture. The reconstructed corneal layer composed of corneal fibroblasts and corneal epithelial cells has a much healthier basal layer of corneal epithelium than the reconstructed corneal epithelium, which was got by using only corneal epithelial cells, and resembles the epithelium of normal corneas, without the horny layer. Thus, the reconstruction of the corneal layer by using a LAM is considered to be a good in vitro model, not only for its application in toxicological test kits, but also for transplantation in patients with a severely damaged cornea.

关键词： Lyophilized amniotic membrane Corneal layer Corneal fibroblast Corneal epithelium

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Function of flavonoids on different types of programmed cell death and its mechanism:a review

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The Journal of Biomedical Research 2019年第6期33卷 363-370页

作者： Preethi Vetrivel Seong Min Kim Venu Venkatarame Gowda Saralamma Sang eun Ha eun Hee Kim Tae sun Min Gon Sup Kim Research Institute of Life Science and College of Veterinary Medicine Gyeongsang National UniversityJinju 52828Korea Department of Nursing Science International University of KoreaJinju 52833Korea Faculty of Biotechnology SARIJeju National UniversityJeju 63243Korea

Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the *** cell death(PCD)is a crucial component of several development and defense *** is also important in terms of aging which avoids the accumulation of cellular damage by maintaining cell *** on the execution of cell death and its role in destruction,PCD is categorized into several *** major different forms of PCD in animals are apoptosis,autophagy and necrosis,which can be distinct in morphological *** intense investigations of cell death have given close insight showing other important types of cellular destruction and their pivotal roles in treating disease conditions like *** have been acquired a great interest for disease therapies and chemoprevention through activation of several PCD *** significant potential of natural flavonoids in the induction of distinct signaling cascades is being a massive approach for targeting uncontrolled cell *** these reasons,understanding PCD mechanisms is a promising approach for the interventions in treating ***,it is intriguing that understanding the different forms of PCD mechanism induced by flavonoids with more accurate descriptions on the biochemical and cellular processes are gaining more significance in cancer ***,we provide a brief overview on the different types of PCD and aim to discuss the functional role of flavonoids in promoting different types of cell death as well as an extensive brief review on their mechanism of action has been highlighted.

关键词： programmed cell death apoptosis necrosis autophagy anoikis

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N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

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Journal of Central South University 2013年第8期20卷 2226-2232页

作者： SHON Ho sun HWANG Kyung Kuk BAE jang Whan KIM Kyung Ah LEE Jong Yun RYU Keun Ho Database and Bioinformatics Laboratory School of Electrical & Computer Engineering also PSM of School of Medicine Chungbuk National University Department of Medicine School of Medicine Chungbuk National University Department of Biomedical Engineering School of Medicine Chungbuk National University Department of Informatics and Convergence Chungbuk National University Cheongju

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

关键词： non ST-segment elevation myocardial infarction NT-ProBNP cardiovascular disease

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Machining characteristics of complex prism pattern on electroplated roll by copper

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中国有色金属学会会刊：英文版 2009年第B09期19卷 288-294页

作者： Tae-Jin JE Sang-Cheon PARK Kang-Won LEE Yeong-eun YOO Doo-sun CHOI Kyung-Hyun WHANG Myung-Chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

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Caruncle excision to treat epiphora caused by caruncle swelling in patients with active Graves' ophthalmopathy:case series

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1691-1693页

作者： Yoon Jin Kong Sang Youn Han Jin Sook Yoon sun Young jang Department of Ophthalmology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of Medicine Department of Ophthalmology Kim's Eye HospitalMyung-Gok Eye Research InstituteKonyang University College of Medicine Department of Ophthalmology Severance HospitalInstitute of Vision ResearchYonsei University College of Medicine

Dear Editor,Iam Yoon Jin Kong from the Department of Ophthalmology,Soonchunhyang University Bucheon Hospital,Bucheon,***,we describe a series of three patients with active Graves＇ophthalmopathy（GO）who presented wit... 详细信息

关键词： ophthalmopathy Caruncle excision to treat epiphora caused by caruncle swelling in patients with active Graves

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Electrostabilized homogeneous dispersion of boron nitride nanotubes in wide-range of solvents achieved by surface polarity modulation through pyridine attachment

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Nano Research 2020年第2期13卷 344-352页

作者： Mi Se Chang Min-sun jang Sangsun Yang Jihun Yu Taehoon Kim Sedong Kim Hyomin Jeong Chong Rae Park Jae Won Jeong Powder/Ceramic Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan.guChangwon 51508Republic of Korea Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National University Seoul 08826Republic of Korea Composites Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan-guChangwon 51508Republic of Korea Dept.of Energy and Mech.Eng Gyeongsang National UniversityCheondaegukchi-Gil 38Tongyeong 53064Republic of Korea

Boron nitride nanotubes(BNNTs)show exceptional physical properties including high mechanical strength and thermal conductivity;however,their applications have been restricted due to limited dispersibility in processing ***,a novel BNNT dispersion method with exceptional dispersibility in a wide range of solvents has been demonstrated by surtace polarity modulation through short-molecule pyridine *** atoms in pyridine are selectively bonded to electron-deficient boron atoms of the BNNT surface through Lewis acid-base reaction,which changes the surface polarity of BNNTs from neutral to ***-dispersing pyridine-attached BNNTs(Py-BNNTs)create a thick and stable electronic double layer(EDL),resulting in uniform dispersion of BNNTs in solvents with an exceptional solubility parameter range of 18.5-48 MPa^1/*** uniform dispersion of BNNTs is maintained even after the mixing with diverse ***,composites incorporating uniformly-distributed BNNTs have been realized,and extraordinary property enhancements have been *** thermal conductivity of 20 wt.%Py-BNNT/epoxy composite has been significantly improved by 69.6%and the tensile strength of 2 wt.%Py-BNNT/PVA has been dramatically improved by 75.3%.Our work demonstrates a simple and facile route to dispersing BNNTs in diverse solvents,consequently leading to selective utlization of BNNT dispersed solvents in various application fields.

关键词： boron nitride nanotube one-dimensional nanomaterials surface polarity modulation electrostabilization boron nitride nanotube composite

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Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma

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World Journal of Gastroenterology 2017年第32期23卷 5936-5944页

作者： Kwangil Yim Daeyoun David Won In Kyu Lee Seong-Taek Oh eun sun Jung sung Hak Lee Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Uijeongbu St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate a novel grading system to predict lymph node metastasis(LNM) in patients with submucosal invasive colorectal carcinoma(SICRC).METHODS We analyzed the associations between LNM and various clinicopathological features in 252 patients with SICRC who had undergone radical surgery at the Seoul Saint Mary's hospital between 2000 and *** LNM was observed in 31 patients(12.3%). The depth and width of the submucosal invasion, lymphatic invasion, tumor budding, and the presence of poorly differentiated clusters(PDCs) were significantly associated with the incidence of LNM. Using multivariate analysis, the receiver operating characteristic curvewas calculated and the area under curve(AUC) was used to compare the ability of the different parameters to identify the risk of LNM. The most powerful clinicopathological parameter for predicting LNM was lymphatic invasion(difference AUC = 0.204), followed by the presence or absence of tumor budding(difference AUC = 0.190), presence of PDCs(difference AUC = 0.172) and tumor budding graded by the Ueno method(difference AUC = 0.128). CONCLUSION Our results indicate that the tumor budding and the depth multiplied by the width measurements of submucosal invasion can provide important information for patients with SICRC.

关键词： Colorectal cancer Neoplasm invasion Lymph node Metastasis

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