检索结果-南通市图书馆

All-in-one glycol chitosan nanoparticles for co-delivery of doxorubicin and anti-PD-L1 peptide in cancer immunotherapy

引用

Bioactive Materials 2023年第10期28卷 358-375页

作者： Sukyung Song Man Kyu Shim Suah Yang Jaewan Lee Wan Su Yun Hanhee cho Yujeong Moon jin Young Min eun Hee Han Hong Yeol Yoon Kwangmeyung Kim College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul03760Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Bioengineering Korea UniversitySeoul02841Republic of Korea Research Center for Bioconvergence Analysis Korea Basic Science Institute(KBSI)Cheongju28119Republic of Korea Department of Toxicology College of PharmacyChungnam National UniversityDaejeon34134Republic of Korea

Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates and undesirable outcomes to these combination therapies owing to the recycling mechanism of programmed death-ligand 1 (PD-L1) and the systemic toxicity of ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) and doxorubicin (DOX) to targeted tumor tissues for a safe and more effective synergistic immunotherapy. The PP-CNPs, which are prepared by conjugating ᴅ-form PP (NYSKPTDRQYHF) to CNPs, form stable nanoparticles that promote multivalent binding with PD-L1 proteins on the targeted tumor cell surface, resulting in effective lysosomal PD-L1 degradation in contrast with anti-PD-L1 antibody, which induces recycling of endocytosed PD-L1. Consequently, PP-CNPs prevent subcellular PD-L1 recycling and eventually destruct immune escape mechanism in CT26 colon tumor-bearing mice. Moreover, the ICD inducer, DOX is loaded into PP-CNPs (DOX-PP-CNPs) for synergistic ICD and ICB therapy, inducing a large number of damage-associated molecular patterns (DAMPs) in targeted tumor tissues with minimal toxicity in normal tissues. When the DOX-PP-CNPs are intravenously injected into CT26 colon tumor-bearing mice, PP and DOX are efficiently delivered to the tumor tissues via nanoparticle-derived passive and active targeting, which eventually induce both lysosomal PD-L1 degradation and substantial ICD, resulting in a high rate of complete tumor regression (CR: 60%) by a strong antitumor immune response. Collectively, this study demonstrates the superior efficacy of synergistic immunotherapy using all-in-one nanoparticles to deliver PP and DOX to targeted tumor tissues.

关键词： Chitosan nanoparticle Synergistic immunotherapy Immune checkpoint blockade Multivalent binding Immunogenic cell death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis

引用

Nano-Micro Letters 2022年第3期14卷 308-321页

作者： Huiyan Piao Goeun choi Xiaoyan jin Seong‑Ju Hwang Young Jae Song Sung‑Pyo cho jin‑Ho choy Intelligent Nanohybrid Materials Laboratory(INML) Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan 31116Republic of Korea College of Science and Technology Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Materials Science and Engineering College of EngineeringYonsei UniversitySeoul 03722Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea National Center for Inter‑University Research Facilities(NCIRF) Seoul National UniversitySeoul 08826Republic of Korea Graphene Research Center Advanced Institute of Convergence TechnologySuwon 16229Republic of Korea Department of Pre‑Medical Course College of MedicineDankook UniversityCheonan 31116Republic of Korea Tokyo Tech World Research Hub Initiative(WRHI) Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226‑8503Japan

The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic *** has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics *** this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step *** atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic *** addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine *** to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction *** addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).

关键词： Graphitic carbon nitride Monolayer Atomic image Electro-and photo-catalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanical properties of graphene oxide?silk fibroin bionanofilms via nanoindentation experiments and finite element analysis

引用

Friction 2022年第2期10卷 282-295页

作者： Hyeonho cho Joonho LEE Hyundo HWANG Woonbong HWANG jin-Gyun KIM Sunghan KIM School of Mechanical Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Mechanical Engineering(Integrated Engineering) Kyung Hee UniversityGyeonggi 17104Republic of Korea Department of Mechanical Engineering POSTECHPohang 37673Republic of Korea Department of Robotics&Mechatronics.Korea Institute of Machinery&Materials Daejeon 34103Republic of Korea

Understanding the mechanical properties of bionanofilms is important in terms of identifying their *** primary focus of this study is to examine the effect of water vapor annealed silk fibroin on the indentation modulus and hardness of graphene oxide-silk fibroin(GO-SF)bionanofilms through nanoindentation experiments and finite element analysis(FEA).The GO-SF bionanofilms were fabricated using the layer-by-layer *** water vapor annealing process was employed to enhance the interfacial properties between the GO and SF layers,and the mechanical properties of the GO-SF bionanofilms were found to be affected by this *** employing water vapor annealing,the indentation modulus and hardness of the GO-SF bionanofilms can be ***,the FEA models of the GO-SF bionanofilms were developed to simulate the details of the mechanical behaviors of the GO-SF *** difference in the stress and strain distribution inside the GO-SF bionanofilms before and after annealing was *** addition,the load-displacement curves that were obtained by the developed FEA model conformed well with the results from the nanoindentation *** summary,this study presents the mechanism of improving the indentation modulus and hardness of the GO-SF bionanofilms through the water vapor annealing process,which is established with the FEA simulation models.

关键词： graphene oxide silk fibroin layer-by-layer(LbL) nanoindentation finite element analysis(FEA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acute respiratory distress syndrome and severe pneumonitis after atezolizumab plus bevacizumab for hepatocellular carcinoma treatment:A case report

引用

World Journal of Gastrointestinal Oncology 2023年第5期15卷 892-901页

作者： Su Hyeon cho Ga Ram You Chan Park Sang-Geon cho Jong eun Lee Sung Kyu choi Sung Bum cho Jae Hyun Yoon Department of Gastroenterology and Hepatology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology and Hepatology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Nuclear Medicine Chonnam National University HospitalHwasun 58128South Korea

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide and has a high ***,the treatment options for advanced HCC are limited to tyrosine kinase inhibitors,such as sorafenib and *** previous regimens have an insufficient efficacy,the combination therapy of atezolizumab and bevacizumab(Ate/Bev)has been investigated,which showed an improvement in progression-free and overall ***,the adverse events of this combination therapy in advanced HCC have not been ***,we report a novel case of an unresectable HCC and acute respiratory distress syndrome(ARDS)after a combination therapy of Ate/*** SUMMARY An 82-year-old male visited our outpatient clinic for an incidentally detected liver *** magnetic resonance imaging and enhanced chest computed tomography(CT)were performed,which showed arterial hyperenhancement with washout in delayed phase suggesting HCC,and a well-defined metastatic solid nodule,respectively.F-18 fluorodeoxyglucose positron emission tomography(PET)-CT exhibited multiple hypermetabolic lesions in the iliac bone,lumbar vertebrae,and *** of the high burden of the intrahepatic tumor,transarterial radioembolization was initially performed;after 37 d,a combination therapy of Ate/Bev was *** patient visited the emergency department three days after Ate/Bev treatment complaining of *** was diagnosed with severe pneumonitis based on *** administering oxygen via a high-flow nasal cannula,the P/F ratio was only 74;therefore,the patient was diagnosed with ARDS based on the overall examination *** tidal volume with high positive end-expiratory pressure,sedative agents combined with a neuromuscular blocker,and a systemic steroid were promptly applied to manage the ***,the patient did not recover from the hypoxia and expired 31 h after being *** Clinicians should be aware of severe pneumonitis due to the immune-

关键词： Hepatocellular carcinoma Systemic therapy Adverse events Pneumonitis Atezolizumab Acute respiratory distress syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells

引用

Bone Research 2023年第2期11卷 354-367页

作者： eun Jung Lee Kyoung jin Lee Seungpil Jung Kyong Hwa Park Serk In Park Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoulRepublic of Korea The BK21 Graduate Program Department of Biomedical SciencesKorea University College of MedicineSeoulRepublic of Korea Division of Breast and Endocrine Surgery Department of SurgeryKorea University Anam HospitalSeoulRepublic of Korea Division of Oncology and Hematology Department of Internal MedicineKorea University Anam HospitalSeoulRepublic of Korea Vanderbilt Center for Bone Biology Vanderbilt University School of MedicineNashvilleTNUSA

Myeloid-derived suppressor cells(MDSCs)are bone marrow(BM)-derived immunosuppressive cells in the tumor microenvironment,but the mechanism of MDSC mobilization from the BM remains *** investigated how BM stromal cell activation by PTH1R contributes to MDSC ***1R activation by parathyroid hormone(PTH)or PTH-related peptide(PTHrP),a tumor-derived counterpart,mobilized monocytic(M-)MDSCs from murine BM without increasing immunosuppressive *** vitro cell-binding assays demonstrated thatα4β1 integrin and vascular cell adhesion molecule(VCAM)-1,expressed on M-MDSCs and osteoblasts,respectively,are key to M-MDSC binding to *** PTH1R activation,osteoblasts express VEGF-A and IL6,leading to Src family kinase phosphorylation in *** inhibitors suppressed PTHrP-induced MDSC mobilization,and Src activation in M-MDSCs upregulated two proteases,ADAM-17 and MMP7,leading to VCAM1 shedding and subsequent disruption of M-MDSC tethering to ***,our data provide the molecular mechanism of M-MDSC mobilization in the bones of tumor hosts.

关键词： MMP7 suppressor regulated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential risk of 23 site-specific incident cancers and cancer-related mortality among patients withmetabolic dysfunction-associated fatty liver disease:a population-based cohort study with 9.7 million Korean subjects

引用

Cancer Communications 2023年第8期43卷 863-876页

作者： Goh eun Chung Su Jong Yu Jeong-Ju Yoo Yuri cho Kyu-na Lee Dong Wook Shin Yoon Jun Kim Jung-Hwan Yoon Kyungdo Han eun Ju cho Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoulRepublic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Gastroenterology and Hepatology Soonchunhyang University Bucheon HospitalBucheonGyeonggi-doRepublic of Korea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangGyeonggi-doRepublic of Korea Department of Biomedicine&Health Science Catholic University of KoreaSeoulRepublic of Korea Department of Family Medicine/Supportive care center Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Clinical Research Design and Evaluation/Department of Digital Health Samsung Advanced Institute for Health ScienceSeoulRepublic of Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoulRepublic of Korea

Introduction:Although an association between metabolic dysfunctionassociated fatty liver disease(MAFLD)and cardiovascular disease or overall mortality has been reported,it is unclearwhether there is an association between MAFLD and cancer incidence or *** aimed to investigate the differential risk of all-and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver ***:Using the Korean National Health Insurance Service database,we stratified the participants into three groups:(1)single-etiology MAFLD(SMAFLD)or MAFLD of pure metabolic origin;(2)mixed-etiology MAFLD(M-MAFLD)or MAFLD with additional etiological factor(s)(i.e.,concomitant liver diseases and/or heavy alcohol consumption);and(3)*** steatosis and fibrosiswere defined using the fatty liver index and the BARDscore,*** proportional hazards regression was performed to estimate the risk of cancer ***:Among the 9,718,182 participants,the prevalence of S-MAFLD and M-MAFLD was 29.2%and 6.7%,*** the median 8.3 years of follow-up,510,330(5.3%)individuals were newly diagnosed with cancer,and 122,774(1.3%)cancer-related deaths occurred among the entire *** with the non-MAFLD group,the risk of all-cancer incidence and mortality was slightly higher among patients in the S-MAFLD group(incidence,adjusted hazard ratio[aHR]=1.03;95%confidence interval[CI]:1.02−1.04;mortality,aHR=1.06;95%CI:1.04−1.08)and highest among patients with M-MAFLD group(incidence,aHR=1.31;95%CI:1.29−1.32;mortality,aHR=1.45;95%CI:1.42−1.48,respectively).The M-MAFLD with fibrosis group(BARD score≥2)showed the highest relative risk of all-cancer incidence(aHR=1.38,95%CI=1.36–1.39),followed by the M-MAFLD without fibrosis group(aHR=1.09,95%CI=1.06–1.11).Similar trends were observed for cancer-related ***:MAFLD classification,by applying additional etiologies other than pure metabolic origi

关键词： cancer etiology metabolic mortality steatosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Massive hemothorax following internal jugular vein catheterization under ultrasound guidance:A case report

引用

World Journal of Clinical Cases 2022年第17期10卷 5776-5782页

作者： Hyun Kang Soo Young cho eun Ha Suk Wan Ju Joon Yong choi Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Hemothorax is a rare but life-threatening complication of central venous *** reports suggest that ultrasound guidance may reduce complications however,it does not guarantee safety CASE SUMMARY A 75-year-old male patient was admitted for laparoscopic radical *** ultrasound guidance,right internal jugular vein catheterization was successfully achieved after failure to aspirate blood from the catheter in the first *** hypotension developed after surgical positioning and persisted until the end of the operation,lasting for about 4 *** the recovery room,a massive hemothorax was identified on chest radiography and computed *** patient recovered following chest tube drainage of 1.6 L *** Hemothorax must be suspected when unexplained hemodynamic instability develops after central venous catheterization despite ultrasound *** the proper use of ultrasound is important.

关键词： Central venous catheterization Hemothorax Ultrasound guidance Internal jugular vein Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rapid hemostasis of the residual inguinal access sites during endovascular procedures:A case report

引用

World Journal of Clinical Cases 2022年第34期10卷 12684-12689页

作者： Hyangkyoung Kim Kwangjin Lee Sungsin cho jin Hyun Joh Department of Vascular Surgery Kyung Hee University Hospital at GangdongSeoul 05278South Korea Department of Surgery Kyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND In endovascular procedures including total percutaneous endovascular aneurysm repair(pEVAR),percutaneous access through the common femoral artery is most commonly ***-site bleeding is a major concern in percutaneous ***,we present a case of successful control of continuous oozing using a vascular closure device(VCD)and the application of Surgicel(Johnson&Johnson,United States)over the access *** SUMMARY An 82-year-old man presented with an unruptured abdominal aortic aneurysm measuring 83 mm×75 *** patient had a medical history of atrial fibrillation and was receiving rivaroxaban(15 mg/d).Routine pEVAR was performed using the preclose technique with ProGlide(Abbott,Santa Clara,CA,United States).Significant amount of bleeding was observed at the end of the procedure after the deployment of the closure device at the access site.A sheet of Surgicel was applied to the suture thread using a surgical *** was applied to the surface of the artery along the access tract using a pusher,and hemostasis was immediately *** This simple technique is an excellent adjunct to control residual bleeding from the access site following VCD use.

关键词： Endovascular procedures Punctures Hemostasis Hemostatic techniques Femoral artery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influences of etiology and endoscopic appearance on the long-term outcomes of gastric antral vascular ectasia

引用

World Journal of Clinical Cases 2022年第18期10卷 6050-6059页

作者： Hyo jin Kwon Si Hyung Lee Joon Hyun cho Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Gastric antral vascular ectasia(GAVE)has diverse associations and presumed causes,which include liver cirrhosis,chronic kidney disease,and autoimmune *** heterogeneity of underlying disorders suggests that the pathogenesis of GAVE may be *** To compare the clinical features and long-term outcomes of GAVE according to endoscopic patterns and *** The medical records and endoscopic images of 23 consecutive patients diagnosed with GAVE by endoscopy at Yeungnam University Hospital from January 2006 to December 2020 were retrospectively *** were allocated to cirrhosis(16 patients)and non-cirrhosis groups(7 patients).GAVE subtypes,as determined by endoscopy,were categorized as punctate(a diffuse,honeycomb-like appearance,17 patients)or striped(a linear,watermelon-like appearance,6 patients).RESULTS All GAVE patients with cirrhosis(16/16,100%)had a punctate pattern by endoscopy,whereas the majority of patients(6/7,85.7%)without cirrhosis had a striped pattern(P<0.001).Overt GAVE bleeding(10/23,43%)was significantly more common in the non-cirrhosis group than in the cirrhosis group(6/7,85.7%vs 4/16,25.0%;P=0.019),and more common in the striped group than in the punctate group(5/6,83.3%vs 5/17,29.4%;P=0.052).However,mean numbers of admissions due to GAVE bleeding and argon plasma coagulation(APC)sessions to address overt bleeding were similar in the cirrhosis and non-cirrhosis groups and in the punctate and striped *** patients with GAVE bleeding were successfully treated by APC,and no patient died from GAVE-related blood loss during a median follow-up of 24 *** Punctate-type GAVE is strongly associated with liver cirrhosis,and GAVE patients without cirrhosis tend to be more prone to overt ***,the presence of cirrhosis and endoscopic patterns did not influence long-term clinical courses or outcomes in cases of overt bleeding.

关键词： Gastric antral vascular ectasia Cirrhosis Endoscopy Gastrointestinal bleeding Argon plasma coagulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

How has the disease course of pediatric ulcerative colitis changed throughout the biologics era?A comparison with the IBSEN study

引用

World Journal of Gastroenterology 2022年第28期28卷 3666-3681页

作者： Yiyoung Kwon eun Sil Kim Yon Ho choe Mi jin Kim Department of Pediatrics Samsung Medical CenterSeoul 06351South Korea Department of Pediatrics Kangbuk Samsung Medical CenterSeoul 03181South Korea

BACKGROUND In Korea,infliximab was approved for use in children with ulcerative colitis(UC)in October *** To compare the clinical course of UC before and after the introduction of biological agents,and to compare with the IBSEN *** Patients under 18 years of age,who were diagnosed with UC and followed from January 2003 to October 2020,were included in the *** A(n=48)was followed for at least 2 years between January 2003 and October 2012,and Group B(n=62)was followed for at least 2 years between November 2012 and October *** compared endoscopic remission,drug composition,relapse rate,steroidfree period,and the quality of life of each *** plotted the clinical course of the included patients using the pediatric UC activity index score,and compared our patients with those in the IBSEN *** After 2 years of treatment,colonoscopy evaluation revealed different outcomes in the two treatment *** was confirmed in 14 patients(29.2%)of Group A,and in 31 patients(50.0%)of Group B(P<0.012).The median cumulative corticosteroid-free period was 3.0 years in Group A and 4.4 years in Group ***-free period of Group B was significantly longer than that of Group A(P<0.001).There was a statistically significant difference between the two groups in evaluation of the relapse rate during the observation period(P<0.001).The plotted clinical course graphs of Group A showed similar proportions to the graphs in the IBSEN ***,in Group B,the proportion of patients corresponding to curve 1(remission or mild severity after initial high activity)was high at 76%(47/62).CONCLUSION The incidence of relapse has decreased and the steroid-free period has increased after the introduction of the biological *** clinical course also showed a different pattern from that of IBSEN *** active use of biological agents may change the long-term disease course in moderate to severe pediatric UC.

关键词： Colitis Ulcerative Children Infliximab Relapse Steroid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：