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Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding

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World Journal of Gastroenterology 2018年第44期24卷 5025-5033页

作者： Jeong-Ju Yoo Young Chang eun Ju Cho Ji eun Moon Sang Gyune Kim Young Seok Kim Yun Bin Lee Jeong-Hoon Lee Su Jong Yu yoon Jun Kim Jung-Hwan yoon Department of Gastroenterology and Hepatology Soonchunhyang University school of Medicine Bucheon 14584 South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul 03080 South Korea Department of Biostatistics Clinical Trial Center Soonchunhyang University Bucheon Hospital Bucheon 14584 South Korea

AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic *** This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting （IPW） method. The primary outcome was the mortality of patients within 6 *** A total of 173 patients received urgent endoscopy （ i.e. , ≤ 12 h after admission）, and 101 patients received non-urgent endoscopy （〉 12 h after admission）. The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before （P = 0.266） and after IPW （P = 0.639）. The length of hospital stay was statistically different between the urgent group and non-urgent group （P = 0.033）; however, there was no significant difference in the in-hospital mortality rate between the two groups （8.1%vs 7.9%, P = 0.960）. In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality （hazard ratio, 1.297; 95% confdence interval, 0.806-2.089; P = 0.284）.CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.

关键词： Cirrhosis Endoscopy Upper gastrointestinal bleeding Gastroesophageal varices Timing

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Spatial and spectral measurement of laser-driven protons through radioactivation

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Nuclear Science and Techniques 2023年第12期34卷 30-39页

作者： Yin‑Ren Shou Xue‑Zhi Wu Gwang‑eun Ahn Seung Yeon Kim Seong Hoon Kim Hwang Woon Lee jin Woo yoon Jae Hee Sung Seong Ku Lee Xue‑Qing Yan Il Woo Choi Chang Hee Nam Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea School of Physics Peking UniversityBeijing 100871China Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

The simultaneous measurement of the spatial profile and spectrum of laser-accelerated protons is important for further optimization of the beam qualities and *** report a detailed study regarding the underlying physics and regular procedure of such a measurement through the radioactivation of a stack composed of aluminum,copper,and CR-39 plates as well as radiochromic films(RCFs).After being radioactivated,the copper plates are placed on imaging plates(IPs)to detect the positrons emitted by the reaction products through contact *** spectrum and energy-dependent spatial profile of the protons are then obtained from the IPs and confirmed by the measured ones from the RCFs and CR-39 *** also discuss the detection range,influence of electrons,radiation safety,and spatial resolution of this ***,insights regarding the extension of the current method to online measurements and dynamic proton imaging are also provided.

关键词： Laser-driven proton acceleration Proton-induced nuclear reaction Radioactivation measurement Contact imaging

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Topically administered bevacizumab had longer standing anti-angiogenic effect than subconjunctivally injected bevacizumab in rat corneal neovacularization

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 588-591页

作者： Jae Yong Kim Dong yoon Kim eun-Soon Kim Myoung Joon Kim Hungwon Tchah Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIMTo compare the effect of topically administered and subconjunctivally injected bevacizumab on experimental corneal neovascularization in rats for two weeks after treatment.

关键词： corneal neovascularization bevacizumab topical and subconjunctival administration

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Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

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Liver Research 2018年第4期2卷 209-215页

作者： yoon Kwang Lee Jung eun Park Mikang Lee James P.Hardwick Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA Department of Food Science and Human Nutrition Chonbuk National UniversityDeokjin-guJeonjuRepublic of Korea

Peroxisome proliferator-activated receptor gamma(PPARγor PPARG)is a ligand-activated transcription factor belonging to the nuclear hormone receptor *** plays a master role in the differentiation and proliferation of adipose *** has two major isoforms,PPARγ1 and PPARγ2,encoded from a single gene using two separate promoters and alternative *** them,PPARγ2 is most abundantly expressed in adipocytes and plays major adipogenic and lipogenic roles in the ***,it has been shown that PPARγ2 is also expressed in the liver,specifically in hepatocytes,and its expression level positively correlates with fat accumulation induced by pathological conditions such as obesity and *** of the hepatic Pparg gene ameliorates hepatic steatosis induced by diet or genetic *** activation of Pparg in the liver induces the adipogenic program to store fatty acids in lipid droplets as observed in *** how the hepatic Pparg gene expression is regulated will help develop preventative and therapeutic treatments for non-alcoholic fatty liver disease(NAFLD).Due to the potential adverse effect of hepatic Pparg gene deletion on peripheral tissue functions,therapeutic interventions that target PPAR g for fatty liver diseases require fine-tuning of this gene's expression and transcriptional activity。

关键词： Non-alcoholic fatty liver disease(NAFLD) High fat diet(HFD) Adipogenesis Gene expression Peroxisome proliferator-activated receptor gamma(PPARγ)

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Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： Jeong Suk Koh yoon Joo Kim Da Hyun Kang Jeong eun Lee Song-I Lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

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Paradoxical vocal fold motion masquerading as post-anesthetic respiratory distress:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2349-2354页

作者： Jongyoon Baek Dae-Lim Jee yoon Seok Choi Sang Woo Kim eun Kyung Choi Department of Anesthesiology and Pain Medicine Yeungnam University College of MedicineDaegu 42415South Korea Department of Otorhinolaryngology-Head and Neck Surgery Yeungnam University College of MedicineDaegu 42415South Korea Department of Neurosurgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Functional vocal cord disorders can be a differential diagnosis for postoperative upper airway obstruction requiring urgent ***,this may be unfamiliar to anesthesiologists who would favor inappropriate airway intervention and increased *** SUMMARY A 61-year-old woman underwent cervical laminectomy,followed by laparoscopic cholecystectomy 10 mo *** adequate reversal of neuromuscular blockade,the patient experienced repetitive respiratory difficulty with inspiratory stridor after *** the second operation,the patient was diagnosed with paradoxical vocal fold motion(PVFM)by an otolaryngologist based on the clinical features and fiberoptic bronchoscopy results,and the patient was successfully *** PVFM should be considered a differential diagnosis if a patient presents with stridor after general anesthesia.

关键词： Anesthesiology Vocal fold Paradoxical motion Postoperative respiratory distress Case report

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Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

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Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho Jung-Hwan yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee eun Ju Cho Jeong-Hoon Lee Su Jong Yu yoon Jun Kim Chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

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Zeolitic imidazolate framework-67 derived Al-Co-S hierarchical sheets bridged by nitrogen-doped graphene:Incorporation of PANI derived carbon nanorods for solid-state asymmetric supercapacitors

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Journal of Energy Chemistry 2022年第11期31卷 429-445,I0012页

作者： Emad S.Goda Bidhan Pandit Sang eun Hong Bal Sydulu Singu Seong K.Kim Essam B.Moustafa Kuk Ro yoon Kuk Ro yoon Organic Nanomaterials Lab Department of ChemistryHannam UniversityDaejeon 34054Republic of Korea Gas Analysis and Fire Safety Laboratory Chemistry DivisionNational Institute for Standards136Giza 12211Egypt Department of Materials Science and Engineering and Chemical Engineering Universidad Carlos Ⅲ de MadridAvenida de La Universidad 3028911 LeganésMadridSpain Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Hannam University1646 Yuseongdae-roYuseong-guDaejeon 34054Republic of Korea Mechanical Engineering Department Faculty of EngineeringKing Abdulaziz UniversityP.O.Box 80204Jeddah 22254Saudi Arabia

Metal sulfides have been widely enticed as battery-type electrodes in supercapacitor devices because of their maximal theoretical ***,their lower conductivity and ion transport kinetics can largely restrict their rate performance,hence the practical usage in fields of demanding high power ***,the design of new electrodes with higher energy and power densities remains a highly challenging *** the best of our knowledge,a novel hierarchical composite of Al-CoS_(2) on nitrogendoped graphene(NG)is prepared based on a zeolite imidazole framework using a simple and scalable hydrothermal *** this hybrid,ultrathin Al-CoS_(2) nanosheet arrays are vertically orientated on the NG framework to limit self-aggregation,hence increasing the electrical property and cycle stability of *** is investigated that the Al/Co feeding ratio plays a crucial role in controlling the obtained hierarchical structure of Al-Co-S sheets and their electrode ***,Al^(3+) can influence remarkably the morphology and electrochemical property of the resultant graphene *** effective synergism is noticed between the redox Al-CoS_(2) and NG resulting in fast electron transfer and chargingdischarging ***,when the as-developed composite is utilized as a positive electrode at an applied current density of 1 A/g,a specific capacitance of 1915.8 F/g is attained with ultra-long cycle stability(96%,10,000 cycles)and an excellent retention rate(~89%).As a consequence,when a solid-state asymmetric supercapacitor(ASC)device is made by combining an Al-CoS_(2) @NG hybrid with a negative electrode made of polyaniline(PANI)derived carbon nanorods(PCNRs),it demonstrates remarkable specific capacitance(188 F/g),energy density(66.9 Wh/kg),and cyclic stability of 92%after 10,000 *** may open the pathway for the application of the next-generation supercapacitors in the future.

关键词： Hierarchical sheets MOFs Al-doped CoS_(2) Nitrogen-doped graphene Solid-state supercapacitor

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NaF-FeF2 nanocomposite： New type of Na-ion battery cathode material

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Nano Research 2017年第12期10卷 4388-4397页

作者： Insang Hwang Sung-Kyun Jung eun-Suk Jeong Hyunchul Kim Sung-Pyo Cho Kyojin Ku Hyungsub Kim Won-Sub yoon Kisuk Kang Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Seoul 08826 Republic of Korea Department of Energy Science (DOES) Sungkyunkwan University Suwon 16419 Republic of Korea National Center for Inter-University Research Facilities Seoul National University Seou108826 Republic of Korea Neutron Science Division HANARO Korea Atomic Energy Research Institute Daejeon 34057 Republic of Korea Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul National University Seou108826 Republic of Korea

Na-ion batteries （NIBs） are considered one of the most attractive alternatives for Li-ion batteries （LIBs） because of the natural abundance of Na and the similarities between the NIB technology and the well-established LIB technology. However, the discovery of high-performance electrode materials remains a key factor in the success of NIBs. Herein, we propose a new type of cathode material for NIBs based on a nanocomposite of an alkali metal fluoride （NaF） and a transition metal fluoride （FeF2）. Although neither of these components is electrochemically active with Na, the nanoscale mixture of the two can deliver a reversible capacity of -125 mAh/g in the voltage range of 1.2--4.8 V vs. Na/Na＋ via an Fe2＋/Fe3＋ redox couple. X-ray absorption spectroscopy reveals that the reversible Na storage is aided by the F-ions due to the decomposition of NaF, which are absorbed on the surface of FeF2, promoting the redox reaction of Fe and triggering the gradual transformation of the mother structure （FeF2） into a new （FeFB-like） host structure for the Na ions. This unique Na-ion storage phenomenon, which is reported for the first time, will introduce an avenue for designing novel cathode materials for NIBs.

关键词： nanocomposite Na-ion batteries NaF FeF2 cathode

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Thermal energy harvesting circuit with maximum power point tracking control for self-powered sensor node applications

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Frontiers of Information Technology & Electronic Engineering 2018年第2期19卷 285-296页

作者： eun-Jung yoon Jong-Tae PARK Chong-Gun YU Department of Electronics Engineering Incheon National University

We present a simple implementation of a thermal energy harvesting circuit with the maximum power point tracking（MPPT） control for self-powered miniature-sized sensor nodes. Complex start-up circuitry and direct current to direct current（DC-DC） boost converters are not required, because the output voltage of targeted thermoelectric generator（TEG） devices is high enough to drive the load applications directly. The circuit operates in the active/asleep mode to overcome the power mismatch between TEG devices and load applications. The proposed circuit was implemented using a 0.35-μm complementary metal-oxide semiconductor（CMOS） process. Experimental results confirmed correct circuit operation and demonstrated the performance of the MPPT scheme. The circuit achieved a peak power efficiency of 95.5% and an MPPT accuracy of higher than 99%.

关键词： Thermoelectric energy Energy harvesting Maximum power point tracking (MPPT) control Self-powered system Sensor node

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