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Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang Hong Hee-eun jeong Hee-won Kang Hyunjung Kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho cha Chongtae Kim Myeongwoo Jung Seungyeon Ryu Sukyoung Han Wook Kim eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

Binary interaction of typhoons Soulik and Cimaron in 2018—Part Ⅰ:Observational characteristics and forecast error

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Tropical Cyclone Research and Review 2021年第1期10卷 32-42页

作者： eun-jeong cha Sug-gyeong Yun Il-Ju Moon Dong-Hoon Kim Meso-scale Research Team Convergence Meteorological Research DepartmentNational Institute of Meteorological SciencesKorea Meteorological AdministrationSeogwipoRepublic of Korea Typhoon Research Center Jeju National UniversityJejuRepublic of Korea Artificial Intelligence Convergence Research Center Inha UniversityIncheonRepublic of Korea

To understand structural changes and forecast error,a case study of binary typhoons in the western North Pacific(WNP)of 2018 was investigated using best track and reanalysis *** was generated on August 16 and Cimaron was generated on August 18,*** 19 th typhoon Soulik and 20 th typhoon Cimaron co-existed from August 18 to 24 and approached each *** was located on the western side and Cimaron was located on the eastern side of the *** were located approximately 1300 km from each other at 00 UTC August *** Soulik structure began changing around August 22 and became weak and slow,while Cimaron maintained its intensity,size,and moving *** observational evidence is likely caused by the binary interaction between two typhoons within a certain distance and environmental steering flow,such as the location of the North Pacific high and strong jet stream of the northern flank of the North Pacific *** was initially forecasted to make landfall and reach Seoul;however,its track changed from northward to northeastward from August 21 to 23 according to both official guidance and unified model(UM).Four global numerical weather prediction models forecasted different tracks of *** and JGSM forecasted a northward track whereas ECMWF and GFS showed a northeastward track for 12 UTC August 21 through 12 UTC August *** latter models were similar to the best *** track forecast error and spread of Soulik were larger than those of *** mean absolute error of the maximum wind speed of Soulik was similar to the average of total typhoons in 2018.

关键词： Typhoon Soulik Cimaron Binary typhoon interaction Structure change Forecast track Intensity error

Evaluating the role of large language models in inflammatory bowel disease patient information

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World Journal of Gastroenterology 2024年第29期30卷 3538-3540页

作者： eun jeong Gong chang Seok Bang Department of Internal Medicine Hallym University College of MedicineChuncheon 24253Gangwon-doSouth Korea

This letter evaluates the article by Gravina et al on chatGPT’s potential in providing medical information for inflammatory bowel disease *** promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and *** that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease chat generative pre-trained transformer Large language model Artificial intelligence

Metabolic relationships between marine red algae and algae‑associated bacteria

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Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： Kyung Hyun Kim jeong Min Kim Ju Hye Baek Sang eun jeong Hocheol Kim Hwan Su Yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

Third assessment on impacts of climate change on tropical cyclones in the Typhoon Committee Region——Part Ⅰ:Observed changes, detection and attribution

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Tropical Cyclone Research and Review 2020年第1期9卷 1-22页

作者： Tsz-Cheung Lee Thomas R.Knutson Toshiyuki Nakaegawa Ming Ying eun jeong cha Hong Kong Observatory Hong KongChina Geophysical Fluid Dynamics Laboratory/NOAA PrincetonNJUSA Meteorological Research Institute/Japan Meteorological Agency TsukubaJapan Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina National Typhoon Center Korea Meteorological AdministrationJejuRepublic of Korea

Published findings on climate change impacts on tropical cyclones(TCs)in the ESCAP/WMO Typhoon Committee Region are *** focus on observed TC changes in the western North Pacific(WNP)basin,including frequency,intensity,precipitation,track pattern,and storm *** from an updated survey of impacts of past TC activity on various Members of the Typhoon Committee are also *** TC datasets continue to show substantial interdecadal variations in basin-wide TC frequency and intensity in the *** has been encouraging progress in improving the consensus between different datasets concerning intensity trends.A statistically significant northwestward shift in WNP TC tracks since the 1980s has been *** is low-to-medium confidence in a detectable poleward shift since the 1940s in the average latitude where TCs reach their peak intensity in the WNP.A worsening of storm inundation levels is believed to be occurring due to sea level rise-due in part to anthropogenic influence-assuming all other factors ***,we are not aware that any TC climate change signal has been convincingly detected in WNP sea level extremes *** also consider detection and attribution of observed changes based on an alternative Type II error avoidance perspective.

关键词： Tropical cyclones Typhoons Climate change Typhoon Committee Western North Pacific

Third assessment on impacts of climate change on tropical cyclones in the Typhoon Committee Region-Part Ⅱ:Future projections

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Tropical Cyclone Research and Review 2020年第2期9卷 75-86页

作者： eun jeong cha Thomas R.Knutson Tsz-Cheung Lee Ming Ying Toshiyuki Nakaegawa National Typhoon Center Korea Meteorological AdministrationJejuRepublic of Korea Geophysical Fluid Dynamics Laboratory/NOAA PrincetonNJUSA Hong Kong Observatory Hong KongChina Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Meteorological Research Institute/Japan Meteorological Agency TsukubaJapan

This paper assesses published findings on projections of future tropical cyclone(TC)activity in the ESCAP/WMO Typhoon Committee Region under climate change *** assessment also estimates the projected changes of key TC metrics for a 2℃anthropogenic global warming scenario for the western North Pacific(WNP)following the approach of a WMO Task Team,together with other reported findings for this *** projections of TC genesis/frequency,most models suggest a reduction of TC frequency,but an increase in the proportion of very intense TCs over the WNP in the ***,some individual studies project an increase in WNP TC *** studies agree on a projected increase of WNP TC intensity over the 21 st *** available projections for TC related precipitation in the WNP indicate an increase in TC related precipitation rate in a warmer *** warming may also lead to changes in TC prevailing tracks.A further increase in storm surge risk may result from increases in TC *** most confident aspect of forced anthropogenic change in TC inundation risk derives from the highly confident expectation of further sea level rise,which we expect will exacerbate storm inundation risk in coastal regions,assuming all other factors equal.

关键词： Tropical cyclones Climate change Westerm North Pacifie Typhoon Comitte Projections

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo Lee chang-Lim You chae-eun Yun Hyeon-Ju jeong eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid eun jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics