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Median arcuate ligamentum syndrome:Four case reports

World Journal of Clinical Cases 2022年第6期10卷 1991-1997页

作者： Ji eun kim Poong Lyul Rhee Division of Gastroenterology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Median arcuate ligamentum syndrome(MALS)is a disease entity with unclear *** it is not considered in advance,the clinical diagnosis of the disease is very difficult because patients complain of digestive discomfort including ***,this characteristic is not specific to *** have been no studies to assist in making a quick *** aim of this case series was to recognize that MALS must be considered as a differential factor in the cause of abdominal *** SUMMARY We described cases in which four patients complained of abdominal pain over a long period but in whom a diagnosis of MALS could not be *** the gastroenterologist does not take into account abdominal pain in advance,the patient is considered an asymptomatic gallstone patient and has their gallbladder removed despite imaging *** patient may also be considered a psychiatric patient and may be administered psychiatric drugs over a long *** all four cases in this report,the patients experienced abdominal *** three cases,the diagnosis was possible by the clinician’s judgment considering both clinical symptoms and imaging techniques shortly after the onset of ***,in one case that lasted over 20 years,a clear diagnosis was not *** after complaining of colicky pain and performing a cholecystectomy,the diagnosis was made only after the symptoms *** all four cases,the symptoms were relieved by *** MALS is a rare disease and it is easy to miss because it is not malignant,but patients can suffer from pain over a long *** the accurate diagnosis of a patient complaining of abdominal pain,the diagnosis must be *** addition,as there are asymptomatic patients,patients who need treatment should be carefully selected,and improvement with medical treatment can be ***-scale studies are also needed.

关键词： Median arcuate ligamentum syndrome Abdominal pain Missed diagnosis Neuromodulator Celiac artery compression Case report

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nhalation of Sevoflurane and Desflurane Can Not Affect QT Interval, Corrected QT, Tp-Te/QT or Tp-Te/JT in Children

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Chinese Medical Journal 2018年第6期131卷 739-740页

作者： Ji-Hyun Lee eun-Hee kim Young-eun Jang Jin-Tae kim Hee-Soo kim Department of Anesthesiology and Pain Medicine Seoul National University Hospital Seoul 03080 Korea

To the Editor： Sevoflurane and desflurane are tile most common general anesthetics used in children. Previous study has shown that these agents can affect the electrocardiogram （ECG） markers,i^i leading to fatal ventricular arrhythmia. The followings were identified as useful indices for predicting and estimating the occurrence of a fatal arrhythmia： the interval between the peak and the end of T wave （Tp-Te） the ratio of the Tp-Te interval to the QT interval （[Tp-Te/QT]）, and the JY interval （JT）, which is measured from the end of the QRS complex to Te.

关键词： QT 孩子心电图代理人 QRS 建筑群心律学习

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Design study of a radio-frequency quadrupole for high-intensity beams

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Chinese Physics C 2017年第7期41卷 142-150页

作者： Jungbae Bahng eun-San kim Bong-Hyuk Choi Department of Physics Kyungpook National University Daegu 41566 Republic of Korea Department of Accelerator Science Graduate School Korea University Sejong campus Sejong 30019 Republic of Korea Institute for Basic Science Daejeon 34047 Republic of Korea

The Rare isotope Accelerator Of Newness（RAON） heavy-ion accelerator has been designed for the Rare Isotope Science Project（RISP） in Korea. The RAON will produce heavy-ion beams from 660-MeV-proton to200-MeV/u-uranium with continuous wave（CW） power of 400 k W to support research in various scientific *** system consists of an ECR ion source, LEBTs with 10 ke V/u, CW RFQ accelerator with 81.25 MHz and 500 ke V/u, a MEBT system, and a SC linac. In detail, the driver linac system consists of a Quarter Wave Resonator（QWR） section with 81.25 MHz and a Half Wave Resonator（HWR） section with 162.5 MHz, Linac-1, and a Spoke Cavity section with 325 MHz, Linac-2. These linacs have been designed to optimize the beam parameters to meet the required design goals. At the same time, a light-heavy ion accelerator with high-intensity beam, such as proton,deuteron, and helium beams, is required for experiments. In this paper, we present the design study of the high intensity RFQ for a deuteron beam with energies from 30 ke V/u to 1.5 MeV/u and currents in the m A range. This system is composed of an Penning Ionization Gauge ion source, short LEBT with a RF deflector, and shared SC Linac. In order to increase acceleration efficiency in a short length with low cost, the 2nd harmonic of 162.5 MHz is applied as the operation frequency in the D^＋RFQ design. The D^＋RFQ is designed with 4.97 m, 1.52 bravery factor. Since it operates with 2nd harmonic frequency, the beam should be 50% of the duty factor while the cavity should be operated in CW mode, to protect the downstream linac system. We focus on avoiding emittance growth by the space-charge effect and optimizing the RFQ to achieve a high transmission and low emittance growth. Both the RFQ beam dynamics study and RFQ cavity design study for two and three dimensions will be discussed.

关键词： heavy-ion accelerator RFQ accelerator high intensity RFQ beam dynamics RFQ cavity design

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Effects of Polymeric Stabilizers on the Synthesis of Gold Nanoparticles

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Journal of Materials Science & Technology 2014年第2期30卷 107-111页

作者： eun Jung kim Jeong Hyun Yeum Jin Hyun Choi Department of Advanced Organic Materials Science and Engineering Kyungpook National University Department of Bio-fibers and materials Science Kyungpook National University

Gold nanoparticles （AuNPs） stabilized with sodium alginate （SA）, glycol chitosan （GC）, polyvinyl alcohol （PVA）, and polyethyleneimine （PEI） were synthesized in aqueous solutions at room temperature. Different sizes and size distributions of AuNPs were obtained according to the polymeric stabilizers. The mean particle diameters of AuNPs synthesized with GC and PVA as stabilizers were about 5.1 and 5.3 nm, respectively, while those of AuNPs stabilized with SA and PEI were 8.4 and 10.8 nm, respectively. When SA was used, relatively large particles aggregated to form large clusters. In the case of GC, a number of small particles built up large clusters. When PVA was used, the size and the number of nanoperticles were estimated small with a low weight content of Au. For this reason, the PVA-stabilized AuNPs formed clusters with a small hydrodynamic size. The AuNPs synthesized in the aqueous solution of PEI without a reducing agent, sodium borohydride, were uniform in size and formed the smallest nanoclusters （67.4 nm）. In this case, the highest Au content was obtained. Sufficiently grown nanoparticles with a high Au content and a limited hydrodynamic size are considered to be suitable for a variety of applications.

关键词： Gold nanoparticles Sodium alginate Glycol chitosan Polyvinyl alcohol Polyethyleneimine

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Efficient page layout analysis on small devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 800-804页

作者： eun-jung HAN Chee-onn WONG Kee-chul JUNG Kyung-ho LEE eun-yi kim Department of Naval Architecture and Ocean Engineering Inha University Human-Centered Interfaces Lab Department of Digital MediaSoongsil University Internet and Media Engineering Konkuk University

Previously we have designed and implemented new image browsing facilities to support effective offiine image contents on mobile devices with limited capabilities： low bandwidth, small display, and slow processing. In this letter, we fulfill the automatic production of cartoon contents fitting small-screen display, and introduce a clustering method useful for various types of cartoon images as a prerequisite stage for preserving semantic meaning. The usage of neural networks is to properly cut the various forms of pages. Texture information that is useful for grayscale image segmentation gives us a good clue for page layout analysis using the multilayer perceptron （MLP） based x-y recursive algorithm. We also automatically frame the segment MLP using agglomerative segmentation. Our experimental results show that the combined approaches yield good results of segmentation for several cartoons.

关键词： Efficient page layout analysis MLP-based segmentation Mobile devices Image segmentation Neural network

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CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage (Brassica rapa)

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Horticulture Research 2023年第6期10卷 135-143页

作者： Ye-Rin Lee Muhammad Irfan Siddique Do-Sun kim eun Su Lee Koeun Han Sang-Gyu kim Hye-eun Lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

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Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice

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Journal of Traditional Chinese Medicine 2019年第6期39卷 818-825页

作者： Se-eun Lee Hyungwoo kim Chang-Hyun kim Chiyeon Lim Suin Cho Department of Korean Medicine School of Korean MedicineYangsan Campus of Pusan National UniversityYangsan 50612Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea

OBJECTIVE:To investigate the effects and molecular targets of Schisandrae Fructus(SF)methanol extract(SFme)in mice with hyperlipidemia induced by high fat ***:We observed changes in body weight,blood serum content of total cholesterol,high-density lipoprotein(HDL)-cholesterol,and *** extent of accumulation of lipid peroxide due to lipid metabolism disorder also evaluated by measuring malondialdehyde(MDA)*** addition,after getting gene expression in hepatic tissues,target protein of SFme was identified using a protein interaction ***:SFme significantly decreased total cholesterol and triglyceride levels without alteration of body weight in mice,and the livercontent of MDA was statistically decreased by *** expression changes of cyclindependent kinase 1(Cdk1)and leucine-rich repeat kinase 2(Lrrk2)were restored by ***:The effect of SFme on the highfat-diet induced hyperlipidemia via decreasing total cholesterol and triglyceride levels may involve the expression of Cdk1 and Lrrk2 proteins.

关键词： Schisandra hyperlipidemias Obesity Cardiovascular diseases CDC2 protein kinase

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Toward Data-Driven Digital Therapeutics Analytics:Literature Review and Research Directions

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 42-66页

作者： Uichin Lee Gyuwon Jung eun-Yeol Ma Jin San kim Heepyung kim Jumabek Alikhanov Youngtae Noh Heeyoung kim Korea Advanced Institute of Science and Technology Daejeon 34141Republic of Korea Inha University Incheon 402-751Republic of Korea KENTECH Naju-siRepublic of Korea

With the advent of digital therapeutics(DTx),the development of software as a medical device(SaMD)for mobile and wearable devices has gained significant attention in recent *** DTx evaluations,such as randomized clinical trials,mostly focus on verifying the effectiveness of DTx *** acquire a deeper understanding of DTx engagement and behavioral adherence,beyond efficacy,a large amount of contextual and interaction data from mobile and wearable devices during field deployment would be required for *** this work,the overall flow of the data-driven DTx analytics is reviewed to help researchers and practitioners to explore DTx datasets,to investigate contextual patterns associated with DTx usage,and to establish the(causal)relationship between DTx engagement and behavioral *** review of the key components of datadriven analytics provides novel research directions in the analysis of mobile sensor and interaction datasets,which helps to iteratively improve the receptivity of existing DTx.

关键词： Causal inference data-driven analytics framework digital therapeutics(DTx) mobile and wearable data technical and behavioral engagement

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Prognostic value of single-nucleotide polymorphisms for extranodal natural killer/T-cell lymphoma:the identification of risk factors in the molecular era

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Cancer Communications 2021年第11期41卷 1232-1233页

作者： Sang eun Yoon Won Seog kim Division of Hematology-oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Extranodal naturalkiller/T-cell lymphoma(ENKTL)is a distinct subtype of non-Hodgkin lymphoma(NHL)with aggressive clinical course and is closely associated with Epstein Barr virus(EBV)infection[1].Due to the unique feature that majority of ENKTL patients have involvement of the upper aerodigestive tract(UADT),the commonly used international prognostic index(IPI)system for NHL is not applicable for ENKTL as most of the patients would be divided into the low-risk group[2].Thus,an optimal prognostic system for ENKTL remains *** models particularly constructed for ENKTL have been reported and several potential risk factors such as regional lymph node involvement,nasal type disease,primary tumor invasiveness,and EBV-DNA,were identified as independent prognostic factors[3–5].

关键词： involvement killer lymphoma

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Numerical modeling of sedimentation control scenarios in the approach channel of the Nakdong River Estuary Barrage,South Korea

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International Journal of Sediment Research 2016年第3期31卷 257-263页

作者： Un Ji eun-Kyung Jang Gwonhan kim Hydro Science and Engineering Research Institute Korea Institute of Civil Engineering and Building Technology

The effects of sedimentation reduction at the Nakdong River Estuary Barrage(NREB) in Korea were quantitatively analyzed with respect to different sediment control methods using the calibrated and validated two-dimensional *** countermeasures of sediment dredging,sediment flushing,channel geometry change,and a combination of flushing and channel geometry change were examined for the approach channel of the *** flood event and channel geometries of the 3.8 km section upstream of the NREB surveyed before and after dredging in 2007 were used for modeling *** a result,the half of sediments dredged in 2007 could be eliminated naturally by floods without *** numerical simulation of sediment flushing indicated that the deposition height decreased in the entire simulation section with the minimum and maximum reductions from 0.3 in to1.3 m in deposition *** channel contraction method produced quantitatively the largest amount of sedimentation reduction and sediment flushing and dredging *** reduction by a combination of flushing and channel contraction was up 10%compared to the individual method of channel contraction.

关键词： Channel contraction Nakdong River Estuary Barrage Sediment dredging Sediment flushing Sedimentation reduction

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