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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model

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Chinese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il Yoon Woong jin Bae Yong Sun Choi Su jin Kim U Syn ha Sung-Hoo Hong Dong Wan Sohn Sae Woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis（CBP） rat ***： The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups（n=8 in each group）.Then,drip infusion of bacterial suspension（Escherichia coli Z17O2：K1：H^-） into Sprague-Dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each ***： The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group（P〈0.05）.The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group（P〈0.05）.Conclusions： These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ***,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.

关键词： prostatitis anti-bacterial agents anthocyanins

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： Young Ju Lee jin-Woo Jung Sangchul Lee Sang Wook Lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang eun Lee Seong jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

Deep Learning Based Single Image Super-resolution:A Survey

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International Journal of Automation and computing 2019年第4期16卷 413-426页

作者： Viet Khanh ha jin-Chang Ren Xin-Ying Xu Sophia Zhao Gang Xie Valentin Masero Amir Hussain Department of Electronic and Electrical Engineering University of Strathclyde Glasgow G1 1XW UK College of Information Engineering Taiyuan University of Technology Taiyuan 030024 China School of Electronic Information Engineering Taiyuan University of Science and Technology Taiyuan 030024 China Department of Computer Systems and Telematics Engineering University of Extremadura Badajoz 06006 Spain School of Computing Edinburgh Napier University Edinburgh EH10 5DT UK School of Computer Science and Technology Anhui University Anhui 230039 China

Single image super-resolution has attracted increasing attention and has a wide range of applications in satellite imaging, medical imaging, computer vision, security surveillance imaging, remote sensing, objection detection, and recognition. Recently, deep learning techniques have emerged and blossomed, producing " the state-of-the-art” in many domains. Due to their capability in feature extraction and mapping, it is very helpful to predict high-frequency details lost in low-resolution images. In this paper, we give an overview of recent advances in deep learning-based models and methods that have been applied to single image super-resolution tasks. We also summarize, compare and discuss various models from the past and present for comprehensive understanding and finally provide open problems and possible directions for future research.

关键词： Image super-resolution convolutional neural network high-resolution image low-resolution image deep learning

Polymyxin B hemoperfusion as a feasible therapy after source control in abdominal septic shock

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World Journal of Gastrointestinal Surgery 2019年第12期11卷 422-432页

作者： jin Joo Kim Young Jun Park Ki Yoon Moon jin Hyeong Park Yong Ki Jeong eun Young Kim Division of Trauma and Surgical Critical Care Department of Surgery Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea

BACKGROUND Polymyxin B hemoperfusion(PMX-HP)has been used as a treatment for intraabdominal septic shock by absorbing and removing endotoxins of gram-negative *** To investigate the clinical efficacy of PMX-HP in patients with gram-negative septic shock who underwent abdominal *** From January 2012 to December 2018,patients who had septic shock secondary to peritonitis were *** were classified into PMX-HP treated and control groups based on postopreative intervention using *** clinical outcomes were compared using 1:1 propensity score matching methods to balance the overall distribution between the two *** After propensity score matching,40 patients were analyzed(20 patients in the PMX group and 20 patients in the control group).The scores of total Sequential Organ Failure Assessment(SOFA)score,renal SOFA and coagulation SOFA were significantly improved in the PMX group but not in the control group.(from 11.2±5.8 to 4.7±3.5 in PMX group vs 10.0±4.0 to 8.7±7.3 in control group,P=0.047 from 2.6±1.0 to 0.7±1.0 in PMX group vs 2.6±1.5 to 2.8±1.6 in control group,P=0.000,from 1.6±1.5 to 1.3±1.3 in PMX group vs 1.2±1.2 to 2.8±1.8 in control group,P=0.014,respectively).Further,the length of intensive care unit(ICU)stay was significantly shorter in PMX ***,no statistically significant difference was found in ICU mortality(50%in PMX group vs 50%in control group).CONCLUSION PMX-HP is a feasible adjunct treatment for peritonitis in ICU patients with peritonitis for improved organ impairment and to stabilize *** would be helpful to enhance clinical outcomes especially in patients with complete elimination of the source of gram-negative bacilli infection by surgical procedure accompanied with conventional treatment of sepsis.

关键词： Intraabdominal septic shock Panperitonitis Polymyxin B hemoperfusion Sepsis Toraymyxin

Effects of nanopores and sulfur doping on hierarchically bunched carbon fibers to protect lithium metal anode

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Carbon Energy 2021年第5期3卷 784-794页

作者： Ji In Jung Sunwoo Park Son ha Se Youn Cho Hyoung-Joon jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju-gunJeollabuk-doSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSouth Korea

Studies on three-dimensional structured carbon templates have focused on how to guide homogeneous lithium metal nucleation and growth for lithium metal anodes(LMAs).However,there is still insufficient evidence for a key factor to achieve their high electrochemical ***,the effects of nanopores and sulfur doping on carbon-based nanoporous host(CNH)electrode materials for LMAs were investigated using natural polymer-derived *** pore-filling behaviors of lithium metal in the nanopores of the CNH electrode materials were first observed by ex situ scanning electron microscopy analysis,where the protective lithium metal nucleation and growth process led to significantly high Coulombic efficiency(CE)of~99.4%and stable 600 *** addition,a comparison study of CNH and sulfurdoped CNH(S-CNH)electrodes,which differ only in the presence or absence of sulfur,revealed that sulfur doping can cause lower electrochemical series resistance,higher CE value,and better cycling stability in a wide range of current densities and number of ***,S-CNH-based LMAs showed high electrochemical performance in full-cell Li-S battery tests using a sulfur copolymer cathode,where a high energy density of 1370Wh kgelectrode−1 and an excellent power density of 4120Wkgelectrode−1 were obtained.

关键词： carbon template Li-S batteries lithium metal anode lithium metal batteries nanoporous carbon sulfur doping

Evaluation of vitamin D level in patients from neurosurgical intensive care unit

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Neural Regeneration Research 2013年第16期8卷 1528-1534页

作者： Ho Jun Yi Je Hoon Jeong eun-Sun jin Il Young Shin Hyung Sik Hwang Seung-Myung Moon Department of Neurosurgery Hangang Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Soon Chun Hyang University Bucheon Hospital Gyeonggi-do Department of Cardiology Kyung Hee University Hospital at Kangdong Kyung Hee University

Vitamin D plays an important role in maintaining normal bone metabolism. Recent studies have suggested that vitamin D influences many other physiological processes, including muscle function, cardiovascular homeostasis, nerve function, and immune response. Furthermore, accumulated evidence suggests that vitamin D also mediates the immune system response to infection. Critical neurosurgical patients have higher infection and mortality rates. To correlate vitamin D deficiency to the immunological status of neurosurgical intensive care unit patients, we detected serum vitamin D level in 15 patients with clinically suspected infection and 10 patients with confirmed infection. Serum level of 25-hydroxyvitamin D, the primary circulating form of vitamin D, was significantly decreased in patients with suspected or confirmed infection after a 2-week neurosurgical intensive care unit hospitalization, while serum level of 1,25-dihydroxyvitamin D, the active form of vitamin D, was significantly decreased in patients after a 4-week neurosurgical intensive care unit hospitalization. These findings suggest that vitamin D deficiency is linked to the immunological status of neurosurgical intensive care unit patients and vitamin D supplementation can improve patient＇s immunological status.

关键词： neural regeneration vitamin D white blood cell immune deficiency infectious diseases intensivecare unit neurosurgery neuroregeneration

微量血和常量血血清样本在0~6岁儿童维生素D水平检测中的应用比较

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临床和实验医学杂志 2024年第2期23卷 207-210页

作者：哈丽君杨金翘石艳荣汪际英银川市妇幼保健院儿保科宁夏银川750000 银川市妇幼保健院放射科宁夏银川750000 银川市妇幼保健院群体保健科宁夏银川750000

目的探究微量血与常量血血清样本在0~6岁儿童维生素D水平检测中的应用效果。方法前瞻性选取2020年2月至2022年2月银川市妇幼保健院儿保科门诊就诊的147名0~6岁健康体检儿童作为本次研究的对象,同时对入组对象采集微量血(末梢取血)和常量... 详细信息

目的探究微量血与常量血血清样本在0~6岁儿童维生素D水平检测中的应用效果。方法前瞻性选取2020年2月至2022年2月银川市妇幼保健院儿保科门诊就诊的147名0~6岁健康体检儿童作为本次研究的对象,同时对入组对象采集微量血(末梢取血)和常量血(静脉取血),测定其25-羟基维生素D3[25(OH)D3]水平,并对末梢采样结果进行校正。比较两种采血方式下25(OH)D3的水平,并比较不同采血季节(春季、夏季、秋季、冬季)时25(OH)D3的水平差异。记录不同采血方式下,平均穿刺时间、次数,呼吸频率上升值及疼痛情况,比较两种采血方式的采血满意度。结果静脉取血和末梢取血测定的25(OH)D3水平中位数分别为29.10(24.40,34.30)ng/mol和28.80(22.20,36.30)ng/mol,两种采血方式测定的25(OH)D3水平差异无统计学意义(P>0.05)。不同采血季节下静脉取血和末梢取血时25(OH)D3的检测结果组间比较差异有统计学意义(P0.05),末梢取血的呼吸频率上升值为(8.13±0.98%),高于静脉取血[(7.16±0.67%)],末梢取血平均穿刺次数为(1.45±0.49)次,少于静脉取血[(2.09±0.57)次],差异均有统计学意义(P<0.05)。末梢取血的取样满意度为95.24%,高于静脉采血(87.07%),差异有统计学意义(P<0.05)。结论对0~6岁儿童采取微量血进行维生素D检测,结果与常量血检测无明显差异,但可减少穿刺次数,提高满意度,且以夏季检测值最高,春季检测值最低。

关键词：儿童维生素D 静脉血末梢血

Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder:a prospective cohort study

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Translational Neurodegeneration 2023年第1期12卷 514-528页

作者： Jung Hwan Shin Heejung Kim Yu Kyeong Kim eun jin Yoon Hyunwoo Nam Beomseok Jeon Jee-Young Lee Department of Neurology Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Department of Nuclear Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Institute of Radiation Medicine Medical Research CenterSeoul National UniversitySeoulSouth Korea Department of Neurology Seoul National University Hospital and Seoul National University College of MedicineSeoulSouth Korea

Background The isolated rapid-eye-movement sleep behavior disorder(iRBD)is a prodromal condition of Lewy body disease including Parkinson’s disease and dementia with Lewy bodies(DLB).We aim to investigate the longitudinal evolution of DLB-related cortical thickness signature in a prospective iRBD cohort and evaluate the possible predictive value of the cortical signature index in predicting dementia-first phenoconversion in individuals with *** We enrolled 22 DLB patients,44 healthy controls,and 50 video polysomnography-proven iRBD *** underwent 3-T magnetic resonance imaging(MRI)and clinical/neuropsychological *** characterized DLB-related whole-brain cortical thickness spatial covariance pattern(DLB-pattern)using scaled subprofile model of principal components analysis that best differentiated DLB patients from age-matched *** analyzed clinical and neuropsychological correlates of the DLB-pattern expression scores and the mean values of the whole-brain cortical thickness in DLB and iRBD *** repeated MRI data during the follow-up in our prospective iRBD cohort,we investigated the longitudinal evolution of the cortical thickness signature toward Lewy body ***,we analyzed the potential predictive value of cortical thickness signature as a biomarker of phenoconversion in iRBD *** The DLB-pattern was characterized by thinning of the temporal,orbitofrontal,and insular cortices and relative preservation of the precentral and inferior parietal *** DLB-pattern expression scores correlated with attentional and frontal executive dysfunction(Trail Making Test-A and B:R=−0.55,P=0.024 and R=−0.56,P=0.036,respectively)as well as visuospatial impairment(Rey-figure copy test:R=−0.54,P=0.0047).The longitudinal trajectory of DLB-pattern revealed an increasing pattern above the cut-off in the dementia-first phenoconverters(Pearson’s correlation,R=0.74,P=6.8×10−4)but no significant change in parki

关键词： Rapid eye movement sleep behavior disorder Dementia with Lewy bodies Lewy body disease Cortical thickness Spatial covariance pattern Magnetic resonance imaging

Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY^1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

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Chinese Journal of Integrative Medicine 2018年第9期24卷 670-675页

作者： jin-Woo Jung Seung Hwan Jeon Woong jin Bae Su jin Kim Mun Su Chung Byung II Yoon Sae Woong Choi U Syn ha Sung Yeoun Hwang Sae Woong Kim Department of Urology International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Republic of Korea Institute for Bio-Medical Convergence College of Medicine Catholic Kwandong University Gangneungsi Gangwon-do Republic of Korea Department of Urology College of Medicine The Catholic University of Korea Seoul Republic of Korea Catholic Integrative Medicine Research Institute College of Medicine The Catholic University of Korea Seoul Republic of Korea Korea Bio Medical Science Institute Seoul Republic of Korea

Objective： To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan （WSY-1075） in a detrusor underactivity rat model. Methods： Rats were randomly allocated to three groups： sham- operated （control）, bladder outlet obstruction-induced detrusor underactivity （BOO-DU）, and BOO-DU with WSY-1075 （WSY） groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks pdor to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders. Results： Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure （P〈0.05）. WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group （P〈0.05）. Conclusion： WSY-1075 had beneficial effect on prevention of BOO-DU.

关键词： detrusor underactivity anti-oxidant herbal