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Association between metabolic syndrome and agerelated cataract

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 804-811页

作者： Sangshin Park eun-Hee lee Center for International Health Research Rhode Island Hospital The Warren Alpert Medical School of Brown University Department of Visual Optics and Graduate School of Health Science Far East University

·AIM: To determine the effect of metabolic syndrome on age-related cataract formation.·METHODS: We analyzed data for 2852 subjects [41.8%men and 58.2% women; mean(±SD) age, 52.9 ±13.9y],taken from the Korea National Health and Nutrition Examination Survey 2008. Metabolic syndrome was diagnosed by criteria proposed by the Joint Interim Societies. Cataract was diagnosed by using the Lens Opacities Classification System III. The association between metabolic syndrome and cataract was determined using age-adjusted and multivariable logistic regression analyses.· RESULTS: In multivariable analyses, men with metabolic syndrome had a 64% increased risk of nuclear cataract [odds ratio(OR), 1.64; 95% confidence interval(CI), 1.12-2.39]. Women with metabolic syndrome had a56% increased risk of cortical cataract(OR, 1.56; 95% CI,1.06-2.30). Men and women with metabolic syndrome had a 46%(OR, 1.46; 95% CI, 1.01-2.12) and 49%(OR,1.49; 95% CI, 1.07-2.08) increased risk of any cataract,respectively. The prevalence of nuclear and any cataract significantly increased with an increasing number of disturbed metabolic components in men, and prevalence of all types of cataracts increased in women. Men using hypoglycemic medication had an increased risk of nuclear(OR, 2.62; 95% CI, 1.41-4.86) and any(OR, 2.27;95% CI, 1.14-4.51) cataract, and women using antidyslipidemia medication had an increased risk of cortical(OR, 2.18; 95% CI, 1.12-4.24) and any(OR, 2.21;95% CI, 1.14-4.26) cataract.·CONCLUSION: Metabolic syndrome and its components,such as abdominal obesity, high blood pressure, andimpaired fasting glucose, are associated with age-related cataract formation in the Korean population.

关键词： cataract metabolic syndrome obesity diabetes mellitus hypertension

CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage (Brassica rapa)

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Horticulture Research 2023年第6期10卷 135-143页

作者： Ye-Rin lee Muhammad Irfan Siddique Do-Sun Kim eun Su lee Koeun Han Sang-Gyu Kim Hye-eun lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

Fabrication of high-strength duplex nanoporous Cu by dealloying a dual-phase Mg-Cu precursor alloy

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Journal of Magnesium and Alloys 2020年第3期8卷 910-916页

作者： Si-Young lee Soo-Min Baek eun-ji Gwak Na-Ri Kang Ju-Young Kim Su-Hyeon Kim Jung Gu lee Sung Soo Park School of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Korea Institute of Materials Science Changwon 51508Republic of Korea School of Materials Science and Engineering University of UlsanUlsan 44610Republic of Korea

Duplex nanoporous Cu was successfully fabricated by dealloying a dual-phase Mg-Cu precursor alloy consisting of intermetallic Mg2Cu and *** duplex nanoporous Cu with embedded nanoporous struts exhibited highly enhanced strength compared to the typical monolithic nanoporous Cu under both compressive and flexural test conditions at room temperature;the duplex np-Cu sample exhibited a 12 times higher compressive strength and a 40 times greater flexural strength than the monolithic np-Cu *** responsible for the strength enhancement in the duplex nanoporous Cu are discussed.

关键词： Mg-Cu alloy Nanoporous Cu Dealloying Duplex structure Strength

Electrocrystallization of Monodisperse Nanocrystal Copper on Highly Oriented Pyrolytic Graphite Electrode

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Chinese Journal of Chemistry 2005年第2期23卷 121-126页

作者：黄令 lee,eun-Sung KIM,Kwang-Bum DepartmentofChemistry XiamenUniversityXiamenFujian361005China DepartmentofMetaUurgicalEngineering YonseiUniversitySeoul120-749SouthKorea

Mechanism of copper electrocrystallization on highly oriented pyrolytic graphite electrode from a solution of 1 mmol/L CuSO 4 and 1.0 mol/L H 2 SO 4 has been studied using cyclic voltammogram and chronoamperometry. The results show that in copper electrodeposition the charge‐transfer step is fast and the rate of growth is controlled by the rate of mass transfer of copper ions to the growing centers. Reduction of Cu(II) ions did not undergo underpotential deposition. The initial deposition kinetics of Cu electrocrystallization corresponds to a model including progressive nucleation and diffusion controlled growth. Copper nanocrystals with size of 75.6 nm and relative standard deviation of 9% can be obtained by modulation potential electrodeposition.

关键词： electrocrystallization electrodeposition nucleation and growth nanocrystal copper

Structural and Dielectric Properties of Dy-doped(Ba,Sr,Ca) TiO_3 Thick Films

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材料科学与工程学报 2007年第6期25卷 928-931页

作者： Hyun-ji Noh Sung-Gap lee Sang-Man Park Sang-eun Yun Dept.of ceramic Engineering Eng.Res.Insti.Gyeongsang National University 900 GajwaJinju-siGyeongnam 660-701Korea

Preparation and electrocatalytic activities of Pt-TiO_2 nanotubes(Ba_ 0.57Sr_ 0.33Ca_ 0.10)TiO_3 powders,prepared by the sol-gel method,were doped MnCO_3 as acceptor and Dy_2O_3 as *** powder was mixed with an organic vehicle and BSCT thick films were fabricated by the screen-printing techniques on alumina *** structural and dielectric properties of BSCT thick films were investigated with variation of Dy_2O_3 *** a result of the differential thermal analysis(DTA),exothermic peak was observed at around 670℃ due to the formation of the polycrystalline perovskite *** the BSCT thick films showed the XRD patterns of a typical polycrystalline perovskite *** average grain size of BSCT thick films decreased with increasing amount of Dy_2O_*** relative dielectric constant and dielectric loss of the BSCT thick film doped Dy_2O_3 0.1mol% were 4637.4 and 1.6% at 1kHz,respectively.

关键词：介电性能结构性能镝厚膜丝网印刷术

Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-na?ve Korean patients infected with genotype C2

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World Journal of Gastroenterology 2017年第23期23卷 4222-4232页

作者： ji-eun Kim So-Young lee Hong Kim Ki-Jeong Kim Won-Hyeok Choe Bum-Joon Kim Department of Biomedical Sciences Microbiology and Immunologyand Liver Research InstituteSeoul National University College of Medicine Department of Microbiology School of MedicineJoong-Ang University Department of Internal Medicine Konkuk University School of Medicine

AIM To report naturally occurring mutations in the reverse transcriptase region(RT) of hepatitis B virus(HBV) polymerase from treatment na?ve Korean chronic patients infected with genotype *** Here, full-length HBV reverse transcriptase RT sequences were amplified and sequenced from 131 treatment na?ve Korean patients chronically infected with hepatitis B genotype C2. The patients had two distinct clinical statuses: 59 patients with chronic hepatitis(CH) and 72 patients with hepatocellular carcinoma(HCC). The deduced amino acids(AAs) at42 previously reported potential nucleos(t)ide analog resistance(NAr) mutation positions in the RT region were analyzed. RESULTS Potential NAr mutations involving 24 positions were found in 79 of the 131 patients(60.3%). Notably, AA substitutions at 2 positions(rt184 and rt204) involved in primary drug resistance and at 2 positions(rt80 and rt180) that functioned as secondary/compensatory mutations were detected in 10 patients(1 CH patient and 9 HCC patients) and 7 patients(1 CH and 6 HCC patients), respectively. The overall mutation frequencies in the HCC patients(3.17%, 96/3024 mutations) were significantly higher than the frequencies in the CH patients(2.09%, 52/2478 mutations)(P = 0.003). In addition, a total of 3 NAr positions, rt80, rt139 and rt204 were found to be significantly related to HCC from treatment na?ve Korean patients. CONCLUSION Our data showed that naturally occurring NAr mutations in South Korea might contribute to liver disease progression(particularly HCC generation) in chronic patients with genotype C2 infections.

关键词： Hepatitis B virus Polymerase Reverse transcriptase Potential nucleos(t)ide analog resistance Chronic hepatitis Hepatocellular carcinoma

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 315-322页

作者： eun-jin YANG ji-Young MOON Min-jin KIM Dong Sam KIM Chan-Shick KIM Wook Jae lee Nam Ho lee Chang-Gu HYUN Jeju Biodiversity Research Institute(JBRI) Jeju High-Tech Development Institute(HiDI) Jeju 699-943Korea Jeju Seaweed Industry Development Agency Cheju National UniversityJeju 690-756Korea Faculty of Biotechnology Cheju National UniversityJeju 690-756Korea Department of Chemistry Cheju National UniversityJeju 690-756Korea

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and *** the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of *** study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory *** results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response.

关键词： Nitric oxide Interleukin-(IL-) Prostaglandin E(PGE) Tumor necrosis factor-α(TNF-α) Seaweeds Pro-inflammatory mediators

Analysis of the current density characteristics in through-mask electrochemical micromachining(TMEMM) for fabrication of micro-hole arrays on invar alloy film

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Chinese Journal of Aeronautics 2017年第3期30卷 1231-1241页

作者： Da-som jiN Kwang-ho CHUN eun-sang lee School of Mechanical Engineering Inha University Incheon 22212 Republic of Kore Department of Mechanical Engineering Inha University Incheon 22212 Republic of Korea

Invar alloy consisting of 64% iron and 36% nickel has been widely used for the production of shadow masks for organic light emitting diodes（OLEDs） because of its low thermal expansion coefficient（1.86 × 10^-6cm/°C）.To fabricate micro-hole arrays on 30 lm invar alloy film,through-mask electrochemical micromachining（TMEMM） was developed and combined with a portion of the photolithography etching *** precise hole shapes,patterned photoresist（PR） film was applied as an insulating *** investigate the relationship between the current density and the material removal rate,the principle of the electrochemical machining was studied with a focus on the *** finite element method（FEM） was used to verify the influence of each parameter on the current density on the invar alloy film *** parameters considered were the thickness of the PR mask,inter-electrode gap（IEG）,and electrolyte *** of experiments（DOE） was used to figure out the contribution of each parameter.A simulation was conducted with varying parameters to figure out their relationships with the current *** was conducted to select the suitable *** experiment was carried out to verify the simulation *** was possible to fabricate micro-hole arrays on invar alloy film using TMEMM,which is a promising method that can be applied to fabrications of OLEDs shadow masks.

关键词： Electrochemical Invar alloy film Micromachining OLED shadow mask Photoresist film mask(PR film mask) Through-mask electrochemical micromachining(TMEMM)

Porous g-C_(3)N_(4)-encapsulated TiO_(2) hollow sphere as a high-performance Z-scheme hybrid for solar-induced photocatalytic abatement of environmentally toxic pharmaceuticals

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Journal of Materials Science & Technology 2021年第23期82卷 21-32页

作者： Dong-eun lee Satyanarayana Moru Wan-Kuen Jo Surendar Tonda School of Architecture CivilEnvironmental and Energy EngineeringKyungpook National University80 Daehak-roBuk-guDaegu41566Republic of Korea Department of Electrical and Computer Engineering Iowa State UniversityCoover HallOsborn DriveAmesIowa 50011USA Department of Physical Sciences Kakatiya Institute of Technology and ScienceWarangal506015TelanganaIndia

Herein,we rationally constructed a hybrid heterostructure comprising porous g-C_(3)N_(4)(CN)-encapsulated anatase TiO_(2) hollow spheres(TOHS)via a synthesis method that involves hydrothermal and calcination *** fabricated hybrid,termed CN/TOHS,demonstrated extraordinary activity toward the degradation of environmentally toxic pharmaceutical substances(acetaminophen and ciprofloxacin)in aqueous solutions under simulated sunlight irradiation;the activity of CN/TOHS was superior to that attained for individual TOHS and CN *** particular,the CN/TOHS hybrid containing 13.3 wt.%of CN on TOHS displayed the optimum degradation activity among the tested catalysts used in this study,and it also possessed exceptional recyclability and stability during consecutive degradation *** remarkable photocatalytic activity and stability of the hybrid were predominantly ascribed to the large solid interfacial contact between constituents,TOHS and CN,induced by effective hybrid structure,which boosted the interfacial charge transfer and impeded with the direct recombination of photo-induced ***,the results of the liquid chromatography-mass spectrometry analysis corroborated the effective mineralization of model pharmaceutical pollutants in the presence of the CN/TOHS *** simple interfacial engineering strategy presented in this study offers a potential route for the rational design of novel catalysts for application in environmental remediation and solar energy conversion.

关键词： TiO_(2)hollow sphere g-C3N4 Hybrid heterostructure Z-scheme charge transfer Pollutant degradation