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Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

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World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana park Jin Young Yoon Kyeong hye park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Jun Yong park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:The median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognosis

Malicious Traffic Compression and Classification Technique for Secure Internet of Things

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Computers, Materials & Continua 2023年第9期76卷 3465-3482页

作者： Yu-Rim Lee Na-eun park Seo-Yi Kim Il-Gu Lee Department of Future Convergence Technology Engineering SungshinWomen’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the introduction of 5G technology,the application of Internet of Things(IoT)devices is expanding to various industrial ***,introducing a robust,lightweight,low-cost,and low-power security solution to the IoT environment is ***,this study proposes two methods using a data compression technique to detect malicious traffic efficiently and accurately for a secure IoT *** first method,compressed sensing and learning(CSL),compresses an event log in a bitmap format to quickly detect ***,the attack log is detected using a machine-learning classification *** second method,precise re-learning after CSL(Ra-CSL),comprises a two-step *** uses CSL as the 1st step analyzer,and the 2nd step analyzer is applied using the original dataset for a log that is detected as an attack in the 1st step *** the experiment,the bitmap rule was set based on the boundary value,which was 99.6%true positive on average for the attack and benign data found by analyzing the training *** results showed that the CSL was effective in reducing the training and detection time,and Ra-CSL was effective in increasing the detection *** to the experimental results,the data compression technique reduced the memory size by up to 20%and the training and detection times by 67%when compared with the conventional *** addition,the proposed technique improves the detection accuracy;the Naive Bayes model with the highest performance showed a detection rate of approximately 99%.

关键词： IoT security intrusion detection machine learning traffic classification

Benign gallbladder diseases:Imaging techniques and tips for differentiating with malignant gallbladder diseases

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World Journal of Gastroenterology 2020年第22期26卷 2967-2986页

作者： Mi hye Yu Young Jun Kim Hee Sun park Sung Il Jung Department of Radiology Konkuk University Medical CenterKonkuk University School of Medicine120-1 Neungdong-roGwangjin-guSeoul 05030South Korea

Benign gallbladder diseases usually present with intraluminal lesions and localized or diffuse wall *** lesions of the gallbladder include gallstones,cholesterol polyps,adenomas,or sludge and polypoid type of gallbladder cancer must subsequently be *** size,stalk width,and enhancement intensity on contrast-enhanced ultrasound and degree of diffusion restriction may help differentiate cholesterol polyps and adenomas from gallbladder *** gallbladder wall thickening is largely due to segmental or focal gallbladder adenomyomatosis,although infiltrative cancer may present *** of Rokitansky-Aschoff sinuses is pivotal in diagnosing *** layered pattern,degree of enhancement,and integrity of the wall are imaging clues that help discriminate innocuous thickening from gallbladder ***-resolution ultrasound is especially useful for analyzing the layering of gallbladder wall.A diffusely thickened wall is frequently seen in inflammatory processes of the ***,it is important to check for coexistent cancer in instances of acute *** used alone is limited in evaluating complicated cholecystitis and often requires complementary computed *** chronic cholecystitis,preservation of a two-layered wall and weak wall enhancement are diagnostic clues for excluding *** resonance imaging in conjunction with diffusion-weighted imaging helps to differentiate xathogranulomatous cholecystitis from gallbladder cancer by identifying the presence of fat and degree of diffusion *** distinctions require a familiarity with typical imaging features of various gallbladder diseases and an understanding of the roles that assorted imaging modalities play in gallbladder evaluations.

关键词： Cholesterol polyp Gallbladder adenoma Adenomyomatosis Cholecystitis Xathogranulomatous cholecystitis Gallbladder cancer Imaging techniques

Enhanced Electrical Properties in Carbon Nanotube/Poly （3-hexylthiophene） Nanocomposites Formed Through Non-Covalent Functionalization

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Nano Research 2011年第11期4卷 1129-1135页

作者： Sung hye park Sung Hwan Jin Gwang Hoon Jun SeokwoO Jeon Soon Hyung Hong Department of Material Science and Engineering Korea Advanced Institutc of Science Technol0gy Daejeon 305＇701 Republic of Korea

Poly（3-hexylthiophene）（P3HT） has received much attention as a good candidate to replace inorganic semiconductors for flexible electronics due to its solution-processability. However, the low charge mobility of P3HT is an obstacle to its commercialization. To overcome this problem, we propose a new non-covalent functionalization method for carbon nanotubes （CNTs） for use in CNT/P3HT nanocomposites. By using modified pyrene molecules with hydrophobic long alkyl chains, the non-covalently functionalized CNTs can become well dispersed in hydrophobic solutions and organic semiconductor matrices. Fabrication of organic thin-film transistors （OTFTs） from the non-covalently functionalized CNT/organic semiconductor nanocomposites shows that our non-covalent functionalization method significantly reduces damage to CNTs during functionalization when compared with covalent functionalization by treatment with acids. The OTFTs show 15 times enhancement of field effect mobility （1.5 × 10^-2 cm^2/（V.s）） compared to the mobility of OTFTs made from pure P3HT. This enhancement is achieved by addition of only 0.25 wt% of CNTs to P3HT.

关键词： Carbon nanotubes conjugated polymers nanocomposites organic thin film transistors

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

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Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： Han Saem Son Jiae Lee hye In Lee Narae Kim You-Jin Jo Gong-Rak Lee Seong-eun Hong Minjeong Kwon Nam Young Kim Hyun Jin Kim Jin Ha park Soo Young Lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(BA)has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** reporter assay and the inhibitor study of IL-1βtranscription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β*** also promoted osteoblast ***,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator protein-1

The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells

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The Journal of Biomedical Research 2020年第1期34卷 36-43页

作者： Ho-eun park Kyung-Hyo Do Wan-Kyu Lee College of Veterinary Medicine Chungbuk National UniversityCheongjuChungbuk 28644Republic of Korea.

The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15(JW15)isolated from Kimchi in RAW 264.7 *** immune effects were evaluated by measuring the production of NO,cytokines,inflammatory enzyme,and activation of NF-κ*** JW15 executed higher activity on stimulating the release of TNF-αas well as activating NF-κB compared to that of heatkilled ***,viable and heat-killed JW15 significantly increased the production of NO,IL-6 and TNF-αmore than that of Lactobacillus rhamnosus GG(LGG).Furthermore,viable JW15 induced higher production of i NOS compared with that of viable ***,our finding indicates that viable JW15 had similar,if not more,immune-enhancing activities as heat-killed *** addition,viable JW15 had higher immune-enhancing activity than commercial strain ***,viable JW15 has the potential to be used as a functional food to improve the host immune response.

关键词： Weissella cibaria JW15 probiotics immune-enhancing effect heat-killed probiotics viable probiotics

Long-Term Outcome and Risk Factor Analysis of Surgical Pulmonary Valve Replacement in Congenital Heart Disease

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Congenital Heart Disease 2022年第3期17卷 335-350页

作者： Woo Young park Gi Beom Kim Sang Yun Lee Mi Kyoung Song hye Won Kwon Hyo Soon An eun Jung Bae Sungkyu Cho Jae Gun Kwak Woong-Han Kim Department of Pediatrics Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea

Objectives:To establish long-term outcome of surgical pulmonary valve replacement(PVR)in congenital heart disease(CHD)and to identify risk factors for overall mortality,operative mortality,and repetitive ***:This is a retrospective study of 375 surgical PVR in 293 patients who underwent surgical PVR for CHD between January 2000 and May *** only included patients with index PVR with previous open-heart surgery regardless of the number of *** previous surgical history of patients who underwent PVR during the study period was also *** who underwent the Rastelli operation,and those who underwent single PVR without previous open-heart surgery were ***:The median age of the patients at the time of surgical PVR was 14.9 years(Interquartile range,IQR,11.0–22.0).The median follow-up duration was 10.5 years(IQR,5.5–14.8 years).There were 3 patients with operative mortality(1.0%)and 15 patients with overall mortality(5.1%).The survival rate was 95.1%over 20 years follow-up *** analysis demonstrated that more than 3 times of previous open-heart surgeries before surgical PVR,older age at the first operation,longer cardiopulmonary bypass(CPB)time and longer intensive care unit(ICU)stay were predictors for overall *** who underwent surgical PVR after more than 3 times of previous open-heart surgeries had significantly higher mortality than those who underwent open-heart surgeries less than 3 times(P<0.001).Age younger than 10 years,male,multiple valve problems and longer ICU stay were significant predictors for repetitive PVR by multivariate ***:Though surgical PVR has excellent long-term outcome,it should be performed with caution for those who previously underwent multiple open-heart surgeries,especially if patient received more than 3 times of open-heart surgeries.

关键词： Pulmonary valve replacement mortality operative mortality repetitive pulmonary valve replacement risk factor analysis childhood

Dynamic enhanced computed tomography imaging findings of an inflammatory fibroid polyp with massive fibrosis in the stomach

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World Journal of Gastroenterology 2017年第11期23卷 2090-2094页

作者： eun Jung Shim Sung eun Ahn Dong Ho Lee Seong Jin park Youn Wha Kim Department of Radiology Kyung Hee University HospitalGraduate SchoolKyung Hee University Department of Pathology Kyung Hee University HospitalGraduate SchoolKyung Hee University

Inflammatory fibroid polyp(IFP) is a rare benign lesion of the gastrointestinal tract. We report a case of computed tomography(CT) imaging finding of a gastric IFP with massive fibrosis. CT scans showed thickening of submucosal layer with overlying mucosal hyperenhancement in the gastric antrum. The submucosal layer showed increased enhancement on delayed phase imaging. An antrectomy with gastroduodenostomy was performed because gastric cancer was suspected, particularly signet ring cell carcinoma. The histopathological diagnosis was an IFP with massive fibrosis. The authors suggest that when the submucosal layer of the gastric wall is markedly thickened with delayed enhancement and preservation of the mucosal layer, an IFP with massive fibrosis should be considered in the differential diagnosis.

关键词： Inflammatory fibroid polyp Gastric polyp Gastric submucosal tumor Signet ring cell carcinoma Computed tomography imaging finding

Design and evaluation of nicorandil extended-release tablet

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 108-113页

作者： Ju-Young Kim Chun-Woong park Beom-Jin Lee eun-Seok park Yun-Seok Rhee College of Pharmacy Woosuk UniversityWanju-gun 565-701Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 361-763Republic of Korea College of Pharmacy Ajou UniversitySuwon 443-749Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National UniversityJinju 660-701Republic of Korea

The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

关键词： Nicorandil In vitro In vivo Pharmacokinetic Extended-release