检索结果-南通市图书馆

A feasible route to produce 1.1 GPa ferritic-based low-Mn lightweight steels with ductility of 47%

Journal of Materials Science & Technology 2022年第22期117卷 225-237页

作者： Kwang Kyu Ko Hyo Ju Bae eun hye park hyeon-Uk Jeong Hyoung Seok park Jae Seok Jeong Jung Gi Kim Hyokyung Sung Nokeun park Jae Bok Seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea School of Materials Science and Engineering Yeungnam UniversityGyeongbuk 38541South Korea Materials Research Team R&D Hyundai MobisYongin 16891South Korea Materials Technology Development Team Doosan Heavy Industries&ConstructionChangwon 51711South Korea

High- and medium-Mn (H/M-Mn) base lightweight steels are a class of ultrastrong structural materials with high ductility compared to their low-Mn counterparts with low strength and poor ***, producing these H/M-Mn materials requires the advanced or high-tech manufacturing techniques, which can unavoidably provoke labor and cost concerns. Herein, we have developed a facilestrategy that circumvents the strength–ductility trade-off in low-Mn ferritic lightweight steels, by employing low-temperature tempering-induced partitioning (LTP). This LTP treatment affords a typical Fe-2.8Mn-5.7Al-0.3C (wt.%) steel with a heterogeneous size-distribution of metastable austenite embeddedin a ferrite matrix for partitioning more carbon into smaller austenite grains than into the larger austenite ones. This size-dependent partitioning results in slip plane spacing modification and lattice strain,which act through dislocation engineering. We ascribe the simultaneous improvement in strength andtotal elongation to both the size-dependent dislocation movement in austenite grains and the controlleddeformation-induced martensitic transformation. The low-carbon-partitioned large austenite grains increase the strength and ductility as a consequence of the combined martensitic transformation andhigh dislocation density-induced hardening and by interface strengthening. Additionally, high-carbonpartitioned small austenite grains enhance the strength and ductility by planar dislocation glide (inthe low strain regime) and by cross-slipping and delayed martensitic transformation (in the high strainregime). The concept of size-dependent dislocation engineering may provide different pathways for developing a wide range of heterogeneous-structured low-Mn lightweight steels, suggesting that LTP maybe desirable for broad industrial applications at an economic cost.

关键词： Low-Mn lightweight steel Carbon partitioning Metastable austenite Dislocation movement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

引用

Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-Soo Han Ji-Hyun Kang eun hye park Hyo-Jung Lee So-Jeong Jeong Dong-Wook Kim Chun-Woong park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying *** amount and the boiling point of the organic acid affected the degree of *** this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder ***175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid *** ACI and PIV results showed a significant increase in aerodynamic performance of corrugated *** FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 *** microparticles also showed better aerosolization,decreased x-axial velocity,and variable *** dissolution of drug formulationswas observed in *** administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered *** modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

引用

Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG park SeunG HEE CHOI eun-SU KO hye JUNG JANG KYUNG-SOON park Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved antioxidative and cytotoxic activities of chamomile(Matricaria chamomilla) florets fermented by Lactobacillus plantarum KCCM 11613P

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第2期18卷 152-160页

作者： eun-hye park Won-Young BAE Su-Jin EOM Kee-Tae KIM Hyun-Dong PAIK Department of Food Sctence and Btotechnology of Animal Resources Konkuk University Seoul 05029 Korea Bio/Molecular Informatics Center Konkuk University Seoul 05029 Korea

Antioxidative and cytotoxic effects of chamomile（Matricaria chamomilla） fermented by Lactobacillus plantarum were investigated to improve their biofunctional activities. Total polyphenol（TP） content was measured by the Folin-Denis method, and the antioxidant activities were assessed by the 1,1-diphenyl-2-picrylhydrazyl（DPPH） method and β-carotene bleaching method. AGS, HeL a, LoV o, MCF-7, and MRC-5（normal） cells were used to examine the cytotoxic effects by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium（MTT） assay. The TP content of fermented chamomile reduced from 21.75 to 18.76 mg gallic acid equivalent（mg GAE）/g, but the DPPH radical capturing activity of fermented chamomile was found to be 11.1% higher than that of nonfermented chamomile after 72 h of fermentation. Following the β-carotene bleaching, the antioxidative effect decreased because of a reduction in pH during fermentation. Additionally, chamomile fermented for 72 h showed a cytotoxic effect of about 95% against cancer cells at 12.7 mg solid/ml of broth, but MRC-5 cells were significantly less sensitive against fermented chamomile samples. These results suggest that the fermentation of chamomile could be applied to develop natural antioxidative and anticancer products.

关键词： Chamomile Flavonoid Lactobacillus plantarum Matricaria chamomilla Antioxidant Cytotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antimelanogenic effects of Inula britannica flower petal extract fermented by Lactobacillus plantarum KCCM 11613P

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 816-824页

作者： eun-hye park Won-young BAE Jae-yeon KIM Kee-tae KIM Hyun-dong PAIK Department of Food Science and Biotechnology of Animal Resources Konkuk University Bio/Molecular Informatics Center Konkuk University

The inhibitory effects of Lactobacillus plantarum-fermented and non-fermented Inula britannica extracts on the tyrosinase activity were comparatively investigated to examine whether and how they improve the whitening activity, and the contents of total flavonoids and polyphenolics as bioactive compounds were determined. The skin whitening activity using in vitro or ex vivo tyrosinase and L-3,4-dihydroxyphenylalanine(L-DOPA) staining was examined. The total flavonoid content(TFC) was increased by 13.4% after 72h-fermentation. The viabilities of the B16F10 cells treated with the fermented and non-fermented control extracts were 100.26% and 92.15% at 500μg/ml, respectively. In addition, the inhibition of tyrosinase activity was increased by the fermented samples from 29.33% to 41.74% following fermentation for up to 72h. The tyrosinase activity of the untreated control group was increased to 145.69% in B16F10 cells. The results showed that I. britannica fermented by L. plantarum dose-dependently inhibited tyrosinase activity, which was stimulated by α-melanocyte stimulating hormone. These results suggest that lactic fermented I. britannica extracts can be used as effective skin-whitening materials.

关键词： Inula britannica Flavonoid Lactobacillus plantarum Antioxidant Tyrosinase inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

引用

Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： Young-Joon park Bo eun Nam Chung-Mo park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine learning for CO_(2) capture and conversion:A review

引用

Energy and AI 2024年第2期16卷 512-527页

作者： Sung eun Jerng Yang Jeong park Ju Li Department of Environmental and Energy Engineering The University of Suwon17Wauan-gilBongdam-eupHwaseong-si18323Gyeonggi-doRepublic of Korea Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America Department of Nuclear Science and Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America MIT-IBM Watson AI Lab 75 Binney StreetCambridge02142MAUnited States of America

Coupled electrochemical systems for the direct capture and conversion of CO have garnered significant attention owing to their potential to enhance energy-and cost-efficiency by circumventing the amine regeneration ***,optimizing the coupled system is more challenging than handling separated systems because of its complexity,caused by the incorporation of solvent and heterogeneous ***,the deployment of machine learning can be immensely beneficial,reducing both time and cost owing to its ability to simulate and describe complex systems with numerous parameters *** this review,we summarized the machine learning techniques employed in the development of CO_(2)capture solvents such as amine and ionic liquids,as well as electrochemical CO_(2)conversion *** optimize a coupled electrochemical system,these two separately developed systems will need to be combined via machine learning techniques in the future.

关键词： Machine learning CO_(2)conversion CO_(2)capture Amine Ionic liquids Single-atom alloys High-entropy catalysts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

引用

World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik park Sook-Hyun park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho Han Jeong eun Shin Ho Seon eun Min Soo park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

引用

Research 2024年第1期2023卷 165-180页

作者： hye-Seon Kim Jeongeun park Hyun-Su Ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji park Jueun Kim Se Won Yi Hak-Joon Sung Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TMD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha eun Shin Jun-hyeok Han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho park Chun Gwon park Wooram park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：