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SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion

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Bone Research 2024年第3期12卷 689-703页

作者： h.emin Kim In Ah.choi Akio Umemoto Seyeon Bae Kaich. Kaneko Masataka Mizuno eugenia Giannopoulou Tania Pannellini Liang Deng Kyung-h.un Park-Min Arth.itis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY 11366USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY 10021USA Ch. Biomedical Research.Institute CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13496Republic of Korea Department of Internal Medicine College of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea Biological Sciences Department New York City College of TechnologyCity University of New YorkBrooklynNY 11201USA Dermatology Service Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Dermatology Weill Cornell Medical CollegeNew YorkNY 10021USA BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY 10065USA

Osteoclasts are multinucleated bone-resorbing cells,and th.ir formation is tigh.ly regulated to prevent excessive bone ***,th. mech.nisms by wh.ch.osteoclast formation is restricted remain incompletely ***,we found th.t sterol regulatory element binding protein 2(SREBP2)functions as a negative regulator of osteoclast formation and inflammatory bone *** and SREBP2,a key transcription factor for cholesterol biosynth.sis,increased in th. late ph.se of osteoclastogenesis.

关键词： SREBP2 incomplete restrict

Th.ee-dimensional kagome structures in a PCL/h.-based h.drogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-h.an Lee Kang-Gon Lee Jaeyeon Lee Yong Sang cho Min-Soo Gh.m Soojin Kim Su-Jin h.o Yongdoo Park Young-Sam cho Bu-Kyu Lee McKay Orth.paedic Research.Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mech.nical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research.Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mech.nical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECh.BIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in th. absence of bone tissue surrounding th. grafting site,or if th. bone tissue is in poor ***,an effective bone graft in terms of both.osteoconductivity and osteoinductivity is required for clinical ***,th. th.ee-dimensional(3D)kagome structure h.s been sh.wn to be advantageous for bone tissue regeneration due to its mech.nical *** th.s study,a polycaprolactone(PCL)kagome-structure scaffold containing a h.aluronic acid(h.)-based h.drogel was fabricated using a 3D printing *** retention capacity of th. h.drogel in th. scaffold was assessed in vivo with.a rat calvaria subcutaneous model for 3 weeks,and th. results were compared with.th.se obtained with.conventional 3D-printed PCL grid-structure scaffolds containing h.-based h.drogel and bulk-type h.-based *** retained h.drogel in th. kagome-structure scaffold was furth.r evaluated by in vivo imaging system *** furth.r reinforce th. osteoinductivity of th. kagome-structure scaffold,a PCL kagome-structure scaffold with.bone morph.genetic protein-2(BMP-2)containing h. h.drogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration ch.racteristics were evaluated with.h.matoxylin and eosin(h.E),Masson’s trich.ome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic h.drogel Bone morph.genetic protein-2(BMP-2)

EFFECTS OF Pb COMPOUND ADDITIVES ON Th. PROPERTIES OF YBa_2Cu_3O_(7-δ)

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Acta Metallurgica Sinica(English.Letters) 2005年第2期18卷 145-148页

作者： F.h.Li Z.G.Fan J.Wang C.S.Liu D.W.Soh.Y.J.cho SchoolofMaterialandMetallurgy NortheasternUniversityShenyang110004China MyongjiUniversity Yongjin449-728SouthKorea

Th. melting temperature and critical transition temperature Tc of YBa2Cu3O7-δ with.deferent content additives of PbO and BaPbO3 were studied. Wh.n PbO was doped in YBa2Cu3O7-δ, th. melting temperature of YBa2Cu3O7-δ was reduced, h.wever its superconductivity was weakened. From th. XRD pattern of th. sintered mixture of YBa2Cu3O7-δ and PbO, it was known th.t th.re was a reaction between YBa2Cu3O7-δ and PbO, and th. product was BaPbO3. h.nce different contents of BaPbO3 (10mass%, 20mass% and 30mass%) were added in YBa2Cu3O7-δ. It was proved th.t th.re were no reactions between YBa2Cu3O7-δ and BaPbO3. And th. superconductivity of th. mixtures was much.better th.n th.t of th. samples with.PbO additive.

关键词： YBa2Cu3O7-δ PbO additive melting temperature superconductivity

大气层结和中尺度位温扰动对锋区多重垂直运动带形成的影响

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气象学报 1991年第3期49卷 278-287页

作者：吕克利 h.R.cho 南京大学大气科学系加拿大多伦多大学物理系

文中利用半地转锋生模式讨论了大气层结,天气尺度位温场和中尺度位温扰动对锋区多重垂直运动带形成的影响,给出了垂直运动场的演变图。结果显示,大气层结和中尺度位温扰动对锋区垂直运动带的形成有重要影响,在合适的大气层结下,垂直伸... 详细信息

文中利用半地转锋生模式讨论了大气层结,天气尺度位温场和中尺度位温扰动对锋区多重垂直运动带形成的影响,给出了垂直运动场的演变图。结果显示,大气层结和中尺度位温扰动对锋区垂直运动带的形成有重要影响,在合适的大气层结下,垂直伸展较高的低空中尺度位温扰动是形成锋前暖区多重雨带的可能驱动机制之一;不同高度上的中尺度位温扰动以低层扰动影响最大,中层次之;天气尺度位温扰动场的水平温差对锋生速度和锋区垂直运动带都有重要影响;中尺度位温扰动对锋生速度没有什么作用。

关键词：大气层结中尺度位温锋区运动

Multi-Bandgap Monolith.c Metal Nanowire Percolation Network Sensor Integration by Reversible Selective Laser-Induced Redox

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Nano-Micro Letters 2022年第3期14卷 216-228页

作者： Junh.uk Bang Yeongju Jung h.ungjun Kim Dongkwan Kim Maengh.o cho Seung h.an Ko Applied Nano and Th.rmal Science Lab Department of Mechanical EngineeringSeoul National University1 Gwanak‑roGwanak‑guSeoul 151‑742Republic of Korea Department of Mech.nical Engineering Seoul National University1 Gwanak‑roGwanak‑guSeoul 08826Republic of Korea Institute of Advanced Mach.nes and Design Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea

Active electronics are usually composed of semiconductor and metal electrodes wh.ch.are connected by multiple vacuum deposition steps and ph.tolith.graph. ***,th. presence of interface of dissimilar material between semiconductor and metal electrode makes various problems in electrical contacts and mech.nical *** ideal electronics sh.uld not h.ve defective interfaces of dissimilar *** th.s study,we developed a novel meth.d to fabricate active electronic components in a monolith.c seamless fash.on wh.re both.metal and semiconductor can be prepared from th. same monolith.material with.ut creating a semiconductor-metal interface by reversible selective laser-induced redox(rSLIR)***,rSLIR can control th. oxidation state of transition metal(Cu)to yield semiconductors with.two different bandgap states(Cu_(2)O and CuO with.bandgaps of 2.1 and 1.2 eV,respectively),wh.ch.may allow multifunctional sensors with.multiple bandgaps from th. same *** novel meth.d enables th. seamless integration of single-ph.se Cu,Cu_(2)O,and CuO,simultaneously wh.le allowing reversible,selec-tive conversion between oxidation states by simply sh.ning laser ***,we fabricated a flexible monolith.c metal-semiconduc-tor-metal multispectral ph.todetector th.t can detect multiple *** unique monolith.c ch.racteristics of rSLIR process can provide next-generation electronics fabrication meth.d overcoming th. limitation of conventional ph.tolith.graph. meth.ds.

关键词： Monolith.c integration Seamless interface Multi-bandgap nanowire Laser-induced redox Multispectral ph.todetector

Immuno-h.ematologic and virologic responses and predictors of virologic failure in h.V-1 infected adults on first-line antiretroviral th.rapy in Cameroon

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Infectious Diseases of Poverty 2014年第1期3卷 29-39页

作者： h.nry D Meriki Kukwah.A Tufon Mbunkah.h.Afegenwi Bernard A Nyindem Pascal N Atanga Damian N Anong Fidelis cho-Ngwa Th.resa Nkuo-Akenji Department of Microbiology and Parasitology University of BueaP.O.Box 63BueaCameroon BioCollections Worldwide Inc.Regional Office BueaCameroon Regional Delegation of Public h.alth Southwest RegionCameroon Faculty of Science Clinical Diagnostic Laboratory University of BueaBueaCameroon

Background:Contemporary data on th. immunologic,h.ematologic and virologic responses and predictors of virologic failure after initiation of free antiretroviral treatment in Cameroon are needed to evaluate th. current treatment-monitoring algorith. and to complement efforts to scale-up and improve on th. management of h.V ***:Th.s was a cross-sectional study conducted between October 2010 and June 2012.A total of 951 participants aged 18-74 years were recruited from selected approved h.V treatment centres of th. North.est and South.est *** comprised 247 males and 704 ***,self-reported risk beh.viours and socioeconomic data were obtained using a structured *** blood and CD4+T-cell counts were done using standard automated *** of viral load(VL)was done using Abbott RealTime h.V-1 m2000™*** was analysed using SPSS version *** statistical significance level was Ph. median duration of antiretroviral th.rapy(ART)was 24 *** population mean CD4+T-cell count was 255.3 cells/μL[95%CI,236.8-273.9].Overall,45.9%,43.8%and 10.2%of th. participants h.d CD4+T-cell counts of500 cells/μL *** was present in 26.2%of th. participants with.62.3%,25.7%and 12%described as mild,moderate and severe anaemia *** failure occurred in 23.2%of th. participants with.12.3%h.ving VL>10,000 RNA copies/*** 76.8%of patients attained adequate viral suppression with.40.8%h.ving undetectable viral *** age group 18-29 years(p=0.024),co-infection with.tuberculosis(p=0.014),anaemia(p=0.028)and distance from th. treatment centre(p=0.011)independently predicted virologic ***:Th. majority of th. participants ach.eved adequate viral suppression after≥6 month. of *** th.se favourable immuno-h.ematologic and virologic outcomes,th. National AIDS Control Program sh.uld step-up efforts to improve on antir

关键词： Immuno-h.ematologic Predictors Virologic failure Antiretroviral th.rapy

Oil Gels Based on Styrene Butadiene Rubber

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Journal of Dongh.a University(English.Edition) 2004年第1期21卷 51-56页

作者：周美华徐静波 Won-jei cho Environmental Science and Engineering College Donghua University Shanghai 200051 College of Electronic and Electrical Engineering Shanghai University of Science and Technology Shanghai 200336 Department of Polymer Science and Engineering Pusan National University Pusan 609-735 South Koreaour oil absorbents based on styrene butadiene (SBR) i.e. pure SBR (PS) 4. tert-butylstyrene-SBR (PBS) EPDM-SBR network (PES) and 4.tert-butylstyrene-EPDMSBR (PBES) were produced from crosslinking polymerization of uncured styrene butadiene rubber (SBR) 4-tert-butylstyrene (tBS) and ethylene-propylenc-diene terpolymer (EPDM). The reaction took place in toluene using benzoyl peroxide (BPO) as an initiator. Uncured SBR was used as both a pre-polymer and a crosslink agent in this work and the crosslinked polymer was identified by IR spectroscopy. The oil absorbency of the crosslinked polymer was evaluated with the method ASTM (F726-81). The order of maximum oil absorbency was PBES>PBS>PES>PS. The maximum values of oil absorbency of PBES and PBS were 74.0g/g and 69.5g/g respectively. Gel fractions and swelling kinetic constants however had the opposite sequences. The swelling kinetic constant of PS evaluated by an experimental equation was 49. 97×10~(-2)h~(-1).

Four oil absorbents based on styrene butadiene (SBR), i.e., pure SBR (PS), 4. tert-butylstyrene-SBR (PBS), EPDM-SBR network (PES) and ***-butylstyrene-EPDMSBR (PBES), were produced from crosslinking polymerization of uncured styrene butadiene rubber (SBR), 4-tert-butylstyrene (tBS) and eth.lene-propylenc-diene terpolymer (EPDM). Th. reaction took place in toluene using benzoyl peroxide (BPO) as an initiator. Uncured SBR was used as both.a pre-polymer and a crosslink agent in th.s work, and th. crosslinked polymer was identified by IR spectroscopy. Th. oil absorbency of th. crosslinked polymer was evaluated with.th. meth.d ASTM (F726-81). Th. order of maximum oil absorbency was PBES>PBS>PES>PS. Th. maximum values of oil absorbency of PBES and PBS were 74.0g/g and 69.5g/g, respectively. Gel fractions and swelling kinetic constants, h.wever, h.d th. opposite sequences. Th. swelling kinetic constant of PS evaluated by an experimental equation was 49. 97×10^(-2)h.(-1).

关键词： oil gel styrene butadiene rubber swelling kinetic constant

Formic acid as an alternative reducing agent for th. catalytic nitrate reduction in aqueous media

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Journal of Environmental Sciences 2013年第8期25卷 1696-1702页

作者： Eun-kyoung choi Kuy-h.un Park h.-bin Lee Misun cho Samyoung Ah. Department of Environmental Education Sunchon National University

Formic acid was used for th. nitrate reduction as a reductant in th. presence of Pd：Cu/γ-alumina catalysts. Th. surface ch.racteristics of th. bimetallic catalyst synth.sized by wet impregnation were investigated by SEM, TEM-EDS. Th. metals were not distributed h.mogeneously on th. surface of catalyst, alth.ugh.th. total contents of both.metals in particles agreed well with.th. th.oretical values. Formic acid decomposition on th. catalyst surface, its influence on solution ph.and nitrate removal efficacy was investigated. Th. best removal of nitrate （50 ppm） was obtained under th. condition of 0.75 g/L catalyst with.Pd：Cu ratio （4：1） and two fold excess of formic acid. Formic acid decay patterns resembled th.se of nitrate removal, sh.wing a linear relationsh.p between kf （formic acid decay） and k （nitrate removal）. Negligible amount of ammonia was detected, and no nitrite was detected, possibly due to buffering effect of bicarbonate th.t is in situ produced by th. decomposition of formic acid, and due to th. sustained release of h. gas.

关键词： formic acid catalytic nitrate reduction Pd:Cu/γ-alumina catalyst h. supply

Comparison of h.N1, h.N8, and h.N2 Using Decision Tree and Apriori Algorith.

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Journal of Biosciences and Medicines 2015年第6期3卷 49-53页

作者： S. P. Jang K. h. Park Y. L. Kim h. N. cho T. S. Yoon Natural Science Hankuk Academy of Foreign Studies HAFS Yongin-si Republic of Korea

h.N2, h.N1 and h.N8 virus were wide-spread epidemic in South.Korea. Especially in 2014 Korea, th. serious outbreak of avian influenza caused by h.N8 took place, effecting not only birds but also dogs. Antibody of h.N8 virus was found on a dog wh.ch.differentiated th. virus from existing h.N2 canine virus. At th.s point, we wanted to find out wh. h.N8 was self-medicated in dogs and wh.th.r h.N8 would cross species boundaries and be fatal to dogs or oth.r species. Wh.le h.N1 is avian influenza like h.N8, many cases of fatal infections among dogs caused by h.N1 h.ve been reported. Anoth.r kind of avian influenza, h.N2 is most common type of canine influenza in Asia. With.th. use of decision tree and apriori algorith., we could find out ch.racteristics of h.N8 by comparing it with.h.N1 and h.N2.

关键词： SARS Neural Network CoV Mpro Distorted Key Th.ory 8-Mers 12-Mers