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Epidemiology and Clonal Spread Evidence of Carbapenem-Resistant Organisms in the Center of Care and Protection of Orphaned Children, Vietnam

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Open Journal of Medical Microbiology 2024年第3期14卷 165-189页

作者： Van Kim Nguyen Pirom Noisumdaeng Pol. Maj. Katiya Ivanovitch Stephen Baker eugene Athan Stephanie Jones Le Thi Lan Larry Croft Yin Peng Lee Tara Cassidy Van Hung Tran Thi Hang Phan Huu Tinh Ho Faculty of Public Health Thammasat University Bangkok Thailand Department of Prevention and Infection Control Hung Vuong Hospital HCM City Vietnam Microbiology of Faculty of Public Health Thammasat University Bangkok Thailand Thammasat University Research Unit in Modern Microbiology and Public Health Genomics Thammasat University Bangkok Thailand National Heart & Lung Institute (NHLI) University of Cambridge Cambridge UK Barwon South West Public Health Unit Geelong Australia Center for Innovation in Infectious Disease and Immunology Research (CIIDIR) Geelong Australia School of Medicine Deakin University Burwood Australia Monash Health Berwick Australia Center of Care and Protection of Orphaned Children HCM City Vietnam Charles River Laboratories Microbial Solutions Melbourne Australia Personnel Department of Nhan Dan Gia Dinh Hospital HCM City Vietnam Hung Vuong Hospital HCM City Vietnam Department of Epidemiology Institute of Public Health HCM City Vietnam

Objective: To determine the prevalence of colonization and transmission of carbapenem-resistant Gram-negative organisms in order to develop of an effective infection prevention program. Design: Cross-sectional study with carbapenem-resistant organisms (CRO) colonization detection from the fecal specimens of 20 Health Care Workers (HCWs) and 67 residents and 175 random environment specimens from September 2022 to September 2023. Setting: A Care and Protection Centre of Orphaned Children in South of HCM City. Participants: It included 20 HCWs, 67 residents, and 175 randomly collected environmental specimens. Method: Rectal and environmental swabs were collected from 20 HCWs, 67 residents (most of them were children), and 175 environmental specimens. MELAB Chromogenic CARBA agar plates, Card NID, and NMIC-500 CPO of the BD Phoenix TM Automated Microbiology System and whole genome sequencing (WGS) were the tests to screen, confirm CROs, respectively and determine CRO colonization and transmission between HCWs, residents, and the environment. Result: We detected 36 CRO isolates, including 6, 11 and 19 CROs found in 6 HCWs, 10 residents and 19 environments. The prevalence of detectable CRO was 30% (6/20) in HCWs, 14.92% (10/67) in residents, and 10.86% (19/175) in environmental swabs in our study. WGS demonstrated CRO colonization and transmission with the clonal spread of E. coli and A. nosocomialis, among HCWs and residents (children). Conclusion: Significant CRO colonization and transmission was evident in HCWs, residents, and the center environment. Cleaning and disinfection of the environment and performing regular hand hygiene are priorities to reduce the risk of CRO colonization and transmission.

关键词： Carbapenem-Resistant Organisms Contamination Hand Hygiene Whole Genome Sequencing Infection Prevention

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Complex RNA-DNA hybrid nanoshapes from iterative mix-andmatch screening

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Nano Research 2021年第1期14卷 46-51页

作者： Shi Chen Zhiyuan Zhang eugene Alforque Thomas Hermann Department of Chemistry and Biochemistry University of CaliforniaSan DiegoCA 92093USA Center for Drug Discovery Innovation University of CaliforniaSan DiegoCA 92093USA Materials Science and Engineering Program University of CaliforniaSan DiegoCA 92093USA

Hybrid nucleic acid nanostructures partition architectural and functional roles between ribonucleic acid(RNA)joints and deoxyribonucleic acid(DNA)*** self-assemble from nucleic acid modules through synergistic stabilization of marginally stable base pairing interactions within circularly closed ***,we report the development of hybrid nanoshapes that include multiple different RNA modules such as internal loop and three-way junction(3WJ)*** iterative mix-and-match screening approach was used to identify suitable DNA connectors that furnished stable nanoshapes for combinations of different RNA *** resulting complex multicomponent RNA-DNA hybrid nanoshapes were characterized by atomic force microscopy(AFM)*** research provides proof of concept for modular design,assembly and screening of RNA-DNA hybrid nanoshapes as building blocks for complex extended nucleic acid materials with features at the sub-10 nm scale.

关键词： nucleic acid nanotechnology nanoshapes ribonucleic acid(RNA)three-way junction(3WJ) RNA deoxyribonucleic acid(DNA) sub-10 nm features

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NSTEMI患者PCI术后再入院风险预测模型的建立及验证

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川北医学院学报 2024年第5期39卷 598-602页

作者：刘延旭罗豪文聪崔扬扬杜林芹周阳 Ofe eugene Kwaku 岳荣川川北医学院附属医院心血管内科四川南充637000

目的:探讨急性非ST段抬高型心肌梗死(NSTEMI)患者行直接PCI术后再入院的影响因素,并建立预测模型。方法:选取166例NSTEMI患者为研究对象,依据患者PCI术后1年内是否因心梗及心肌梗死并发症再入院分为再入院组(n=110)和未再入院组(n=56)... 详细信息

目的:探讨急性非ST段抬高型心肌梗死(NSTEMI)患者行直接PCI术后再入院的影响因素,并建立预测模型。方法:选取166例NSTEMI患者为研究对象,依据患者PCI术后1年内是否因心梗及心肌梗死并发症再入院分为再入院组(n=110)和未再入院组(n=56)。分析NSTEMI患者行直接PCI术后再入院的独立影响因素,并构建其风险预测模型列线图,绘制受试者工作特征(ROC)曲线来评估模型区分度,采用Hosmer-Lemeshow对模型进行拟合优度检验,绘制校准曲线评估模型准确度。结果:心率、有无肺炎病史、病变血管数、甘油三酯、B型利钠肽为NSTEMI患者经直接PCI术后再入院的独立预测因素(P<0.05)。构建预测模型列线图,ROC曲线显示,曲线下面积(AUC)为0.773,敏感度为70.9%,特异度为76.8%,Hosmer-Lemeshow拟合优度检验显示,差异无统计学意义(χ^(2)=8.329,P=0.351)。通过模型校准曲线提示列线图模型的实际曲线接近理想曲线。结论:心率、有无肺炎病史、病变血管数、甘油三酯、B型利钠肽为NSTEMI患者直接PCI术后再入院的独立预测因素,以此建立的预测模型列线图可直观、快捷的对该类患者再入院的风险进行评估。

关键词：非ST抬高型心肌梗死 PCI 再入院预测模型

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The role of chemokines in acute and chronic hepatitis C infection

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Cellular & Molecular Immunology 2014年第1期11卷 25-40页

作者： Stephen Fahey eugene Dempsey Aideen Long Institute of Molecular Medicine Trinity College Dublin Trinity Centre for Health Sciences St James's Hospital Dublin Ireland School of Biomolecular and Biomedical Science Conway Institute University College Dublin Dublin Ireland

Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of elaborate evasion strategies, hepatitis C virus （HCV） succeeds as a persistent human virus. It has an extraordinary capacity to subvert the immune response enabling it to establish chronic infections and associated liver disease. Chemokines are low molecular weight chemotactic peptides that mediate the recruitment of inflammatory cells into tissues and back into the lymphatics and peripheral blood. Thus, they are central to the temporal and spatial distribution of effector and regulatory immune cells. The interactions between chemokines and their cognate receptors help shape the immune response and therefore, have a major influence on the outcome of infection. However, chemokines represent a target for modulation by viruses including the HCV. HCV is known to modulate chemokine expression in vitro and may therefore enable its survival by subverting the immune response in vivo through altered leukocyte chemotaxis resulting in impaired viral clearance and the establishment of chronic low-grade inflammation. In this review, the roles of chemokines in acute and chronic HCV infection are described with a particular emphasis placed on chemokine modulation as a means of immune subversion. We provide an in depth discussion of the part played by chemokines in mediating hepatic fibrosis while addressing the potential applications for these chemoattractants in prognostic medicine.

关键词： chemokine chemokine receptor hepatic fibrosis hepatitis C virus immune evasion

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Understanding the relationship between High Reliability Theory (HRT) ofmindful organizing and Safety Management Systems (SMS) within theaerospace industry: A cross-sectional quantitative assessment

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Journal of Safety Science and Resilience 2022年第2期3卷 105-114页

作者： Brian eugene Teske Daniel Kwasi Adjekum Department of Space Studies John D.Odegard School of Aerospace SciencesUniversity of North Dakota4149 University AvenueStop 9008Grand ForksND 58202-9008USA Department of Aviation John D.Odegard School of Aerospace SciencesUniversity of North Dakota.4149 University AvenueStop 9036Grand ForksND 58202-9008USA

There seems to be a paucity in extant literature that assesses the relationship between Safety Management Systems (SMS) and High Reliability Theory (HRT) behavior process of mindful organizing (MO) among aerospaceorganizations. There could be benefits for organizational safety by exploring this relationship in high-reliabilityorganizations (HROs) like the aerospace industry. Using a modified Safety Organizing Scale (SOS) by Vogus andSutcliffe (2007) and a validated SMS scale, the relationship between SMS and MO was measured. The perceptionsof a cross-section of respondents from commercial airlines with SMS and commercial space licensees without SMSin the United States (U.S.) was assessed. A four-factor model of MO had acceptable fit. A model showing the relationship between SMS and MO had good fit and showed a high significant strength of relationship (r = 0.82,p = 0.000) with a big effect size. There were also significant differences in mean responses among managementpersonnel and non-management personnel on the MO factor “sensitivity to operations” and the result suggestsmanagers were better at identifying personnel with skills and knowledge to ensure safer task accomplishmentthan non-management personnel. The study results suggest that the SMS requirements for commercial airlines inthe U.S. can enrich the identification and understanding of MO factors and it may be beneficial for the commercial space industry to formally adopt SMS. Future research studies may include direct comparisons in multipleaerospace organizations using a larger sample size to determine the overall understanding of MO factors and howit affects SMS.

关键词： Mindful organizing Safety Management Systems High-reliability organization Aerospace Commercial airlines Commercial space licensees Organization safety

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Theories of Translation

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外国语 1989年第6期12卷 4-10,74页

作者： eugene A. Nida

当代著名语言学家、翻译理论家尤金·奈达教授于1989年3月在上海外国语学院英语系讲学十余天。应本刊编辑部特约,奈达教授将自己的讲学主要内容整理成文,现全文发表于下。

关键词：翻译理论奈达语言学家外国语语系编辑部讲学当代主要内容教授

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Microstructures,Strength Characteristics and Wear Behavior of the Fe-based P/M Composites after Sintering or Infiltration with Cu–Sn Alloy

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Journal of Materials Science & Technology 2015年第12期31卷 1226-1231页

作者： Larisa N.Dyachkova eugene E.Feldshtein Institute of Powder Metallurgy Belarusian National Academy of Sciences Department of Mechanical Engineering University of Zielona Góra

Some properties of the Fe-based P/M composites sintered and reinforced by infiltration with Cu-Sn alloy were *** is shown that the hardness of the sintered material is 2.5 times lower,tensile strength is 1.7 times lower and the wear resistance is 2.5-3.3 times lower in comparison with those of the infiltrated *** presence of pores on the friction surface of the sintered material affects the features of the wear *** to the specific morphology of copper in the infiltrated material,the phenomenon of selective mass transfer is observed and worn surfaces have a spongy-capillary texture.

关键词： Metal matrix composites(MMCs) Sintering Infiltration Strength characteristics Wear

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Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

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World Journal of Gastroenterology 2017年第17期23卷 3193-3194页

作者： eugene Lipov Ken Candido department of anesthesiology advocate illinois masonic medical center

Sympathetic system modulation by stellate ganglion blockade may modulate immune dysfunction and significantly improve symptoms of chronic ulcerative colitis.

关键词： Stellate ganglion block Ulcerative colitis Immune function Chronic ulcerative colitis

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Just us

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Ecosystem Health and Sustainability 2017年第12期3卷 21-24页

作者： R.eugene Turner Department of Oceanography and Coastal Sciences Louisiana State UniversityBaton RougeLAUSA

Introduction:A thorough understanding of ecology is a necessity as the Earth becomes crowded,there is more intense resource use and exhaustion,and the exposure to pollutants has ***:Everyone must be involved as we develop the moral compass and maps for a desirable *** transition will be made within the context of complex social forces,which must be engaged in purposeful collaboration and *** individuals have the embryonic need and possess diverse abilities to contribute to the transcendence of problems arising from the human response to social ***:These will be difficult and nuanced *** example is the Balinese water distribution system,whose site-specific adjustments developed over thousands of *** from country-to-country comparisons show that Eco-civilizations,to be'civil',must be fair,inclusive,and joyful,and more than about misleading metrics like Gross Domestic Product,individuality,material accumulations and ***:We are in this together;it is not'them or us'-it is only'Us'.

关键词： Adaptation Bali science-policy shared governance social equity transitions

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Language,Culture,andTranslation

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外国语 1998年第3期21卷 30-34页

作者： eugene Nida 

论文作者对翻译过程中涉及的语言与文化这两个密切相关的因素提出了中肯的分析，包括语言与文化的关系和语言与文化意义的表现，作者强调：１）语言与文化不可能脱离另一方面而单独存在；２）语言不仅反映文化，同时也塑造文化；３）由... 详细信息

论文作者对翻译过程中涉及的语言与文化这两个密切相关的因素提出了中肯的分析，包括语言与文化的关系和语言与文化意义的表现，作者强调：１）语言与文化不可能脱离另一方面而单独存在；２）语言不仅反映文化，同时也塑造文化；３）由于文化通常比语言的变化速度快。

关键词：语言文化翻译

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