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Assembly of multicomp on ent structures from hundreds of micron-scale building blocks using optical tweezers

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Microsystems & Nanoengineering 2021年第3期7卷 163-171页

作者： Jeffrey E.Melzer euan McLeod Wyant College of Optical Sciences The University of ArizonaTucsonArizona85721USA

The fabrication of three-dimensional(3D)microscale structures is critical for many applications,including strong and lightweight material development,medical device fabrication,microrobotics,and photonic *** 3D microfabrication has seen progress over the past decades,complex multicomponent integration with small or hierarchical feature sizes is still a *** this study,an optical positioning and linking(OPAL)platform based on optical tweezers is used to precisely fabricate 3D microstructures from two types of micron-scale building blocks linked by biochemical interactions.A computer-controlled interface with rapid on-the-fly automated recalibration routines main tains accuracy eve n after placi ng many buildi ng *** achieves a 60-nm positional accuracy by optimizing the molecular functionalization and laser power.A two-component structure consisting of 4481-pm building blocks is assembled,representing the largest number of building blocks used to date in 3D optical tweezer *** optical tweezers have previously been used for microfabrication,those results were generally restricted to single-material structures composed of a relatively small number of larger-sized building blocks,with little discussion of critical process *** is anticipated that OPAL will enable the assembly,augmentation,and repair of microstructures composed of specialty micro/nanomaterial building blocks to be used in new photonic,microfluidic,and biomedical devices.

关键词： hundreds blocks sized

Simulating robust far-field coupling to traveling waves in large three-dimensional nanostructured high-Q microresonators

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Photonics Research 2019年第9期7卷 967-976页

作者： LEI CHEN CHENG LI YU-MIN LIU JUDITH SU euan MCLEOD State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing100876China College of Optical Sciences University of ArizonaTucsonArizona85721USA Department of Biomedical Engineering University of ArizonaTucsonArizona85721USA

Ultra-high quality(Q) whispering gallery mode(WGM) microtoroid optical resonators have demonstrated highly sensitive biomolecular detection down to the single molecule limit;however, the lack of a robust coupling method has prevented their widespread adoption outside the laboratory. We demonstrate through simulation that a phased array of nanorods can enable free-space coupling of light both into and out of a microtoroid while maintaining a high Q. To simulate large nanostructured WGM resonators, we developed a new approach known as FloWBEM,which is an efficient and compact 3D wedge model with custom boundary conditions that accurately simulate the resonant Fano interference between the traveling WGM waves and a nanorod array. Depending on the excitation conditions, we find loaded Q factors of the driven system as high as 2.1 × 10~7 and signal-to-background ratios as high as 3.86%, greater than the noise levels of many commercial detectors. These results can drive future experimental implementation.

关键词： domain Simulating robust far-field coupling to traveling waves in large three-dimensional nanostructured high-Q microresonators WGM

Amnion epithelial cells——a novel therapy for ischemic stroke?

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Neural Regeneration Research 2018年第8期13卷 1346-1349页

作者： Megan A.Evans Brad R.S.Broughton Grant R.Drummond Henry Ma Thanh G.Phan euan M.Wallace Rebecca Lim Christopher G.Sobey Department of Physiology Anatomy & Microbiology La Trobe University Cardiovascular Disease Program Department of Pharmacology Biomedicine Discovery Institute Monash University Department of Medicine Monash University The Ritchie Centre Hudson Institute of Medical Research Department of Obstetrics and Gynaecology Monash University

Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells（h AECs）, which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days poststroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that h AECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy.

关键词： ischemic stroke cerebral infarction stem cells human amnion epithelial cells inflammation immunosuppression brain repair mouse non-human primate

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起重量与车桥数量的对话

建筑机械 2009年第16期 30-33页

作者： euan Youdale

几年来,市场上4桥和5桥全地面起重机的数量一直在稳步上升,每家制造商都能提供几款这样的产品,其中至少有一家的机型数量达到了两位数字。

关键词：全地面起重机制造商起重量桥荷特雷克斯副臂

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旋风一样的增长

建筑机械 2008年第Z1期 38-40页

作者： euan Youdale

风能的开发在过去的10年里经历了一个高速发展的阶段。各国政府和其他拨款机构终于看到了风能的巨大优点,它可以将风能这个强大可靠的资源变成源源不断的电力,重型起重机的供应商们也从中获利颇丰。

关键词：履带起重机大风履带吊自行式起重机风力发电机风力发电场发电厂风能气候资源装机容量发电容量安装作业马尼托

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大型复合作业

建筑机械 2008年第10期 22-23页

作者： euan Youdale

Fagioli公司在西班牙一座大型混凝土气化站的建设中使用了特殊起重作业方式。该气化站建造好后,被运往意大利亚的里亚海。

关键词：气化站混凝土模块化无机非金属材料挂车拖车液化气液化天然气通风结构塔柱中心力重力自行式

CAR+大师交功课这将会是一款新的经典小车吗? YVES BEHAR的最新研究

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汽车生活 2011年第1期 40-41页

作者： Sanna Charles euan Sey

其实,Yves Behar并不太想让人们了解他的车。＂杂志社给我的这个题目可真怪＂这位获奖无数的著名产品设计师正在向MissionMotor的CEO Forest North抱怨,＂《Intersection》杂志在做一期人物和他的交通工具的专题,比如我和我的车。但我... 详细信息

其实,Yves Behar并不太想让人们了解他的车。＂杂志社给我的这个题目可真怪＂这位获奖无数的著名产品设计师正在向MissionMotor的CEO Forest North抱怨,＂《Intersection》杂志在做一期人物和他的交通工具的专题,比如我和我的车。但我拒绝了。因为我找不到有什么能让人兴奋的理由。＂

关键词：小车交通工具杂志社 CEO 设计师

ACNE广告大巴 50 CARS=1 BUS

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汽车生活 2011年第1期 22-23页

作者： Sanna Charles euan Sey

说起来,很多远途上班族和无所事事的家庭主妇都靠数独游戏打发无聊时光,CBS（哥伦比亚广播公司）也在热播犯罪剧集《Numb3rs》，数学一下子受到了前所来有的关注。在这个信息泛滥的的时代，数字是最能让人一目了然的指标，所以人们喜欢... 详细信息

说起来,很多远途上班族和无所事事的家庭主妇都靠数独游戏打发无聊时光,CBS（哥伦比亚广播公司）也在热播犯罪剧集《Numb3rs》，数学一下子受到了前所来有的关注。在这个信息泛滥的的时代，数字是最能让人一目了然的指标，所以人们喜欢蔷数字。

关键词： BUS 广告家庭主妇哥伦比亚上班族 CBS 信息

拉米夫定治疗乙型肝炎病毒相关性肾炎的临床研究

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中国现代医药杂志 2017年第5期19卷 41-43页

作者：黄欢广东省肇庆市广宁县人民医院 526300

目的探讨拉米夫定治疗乙型肝炎病毒相关性肾炎的临床疗效。方法选择2014年1月~2016年6月在我院诊断治疗的乙型肝炎病毒相关性肾炎患者22例为研究对象。所有患者口服拉米夫定。比较治疗前后24h蛋白尿、血清白蛋白、ALT、HBV-DNA定量水平... 详细信息

目的探讨拉米夫定治疗乙型肝炎病毒相关性肾炎的临床疗效。方法选择2014年1月~2016年6月在我院诊断治疗的乙型肝炎病毒相关性肾炎患者22例为研究对象。所有患者口服拉米夫定。比较治疗前后24h蛋白尿、血清白蛋白、ALT、HBV-DNA定量水平及Hbe Ag阳性率。分析治疗总有效率。结果 22例患者中9例显效,10例有效,总有效率86.4%。治疗后HBe Ag阳性率显著下降,HBV-DNA及ALT水平较治疗前显著下降,差异有统计学意义(P<0.05)。治疗后患者血清总蛋白水平显著升高,24h尿蛋白定量显著下降,与治疗前比较,差异有统计学意义(P<0.05)。结论拉米夫定治疗乙型肝炎病毒相关性肾炎能够显著改善肾炎症状,降低乙型肝炎相关指标,具有较好的临床疗效。

关键词：拉米夫定乙型肝炎病毒肾炎