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Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

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Neural Regeneration Research 2024年第8期19卷 1768-1771页

作者： Federica Azzolini ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari Unit of Neurology IRCCS NeuromedPozzilliItaly Department of System Medicine University of Tor VergataRomeItaly Synaptic Immunopathology Lab Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying *** r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple *** evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully ***,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and *** humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal *** present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关键词： disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis neuroplasticity neuroprotection physical exercise synaptopathy

Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer:A meta-analysis and systematic review

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Asian Journal of Urology 2024年第2期11卷 191-207页

作者： Stefano Salciccia Marco Frisenda Giulio Bevilacqua Pietro Viscuso Paolo Casale ettore De Berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco Del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci Department of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly Department of Urology Humanitas20089 RozzanoMIItaly

Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic ***: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect ***: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.

关键词： Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyteratio Meta-analysis Radical prostatectomy Metastatic

Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco Del Giudice ettore De Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

On the Proper Homotopy Invariance of the Tucker Property

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Acta Mathematica Sinica,English Series 2007年第3期23卷 571-576页

作者： Daniele ettore OTERA Universitádi Palermo Dipartimento di Matematica ed Applicazionivia Archirafi 3490123-PalermoItaly and Université Paris-SudMathématiquesBt 42591405 Orsay Cedex-France

A non-compact polyhedron P is Tucker if, for any compact subset K begong to P, the fundamental group π1 （P - K） is finitely generated. The main result of this note is that a manifold which is proper homotopy equivalent to a Tucker polyhedron is Tucker. We use Poenaru＇s theory of the equivalence relations forced by the singularities of a non-degenerate simplicial map.

关键词： proper homotopy Φ/ψ-theory tucker property

Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:Results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi Rocco Simone Flammia Antonio Tufano Michele Morelli Antonio Galfano Lorenzo Giuseppe Luciani Leonardo Misuraca Paolo Dell’Oglio Gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove Riccardo Mastroianni Francesco Prata Isabella Sperduti Giovanni Petralia SilviaSecco ettore Di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi Giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:Recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(RARP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“RARP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their RARP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-Dindo Grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided p<0.05 was considered ***:A proficiency score was achieved in 42.3%*** univariable level,proficiency score was associated with 1-year trifecta achievement(odds ratio,8.77;95%confidence interval,2.42–31.7;p=0.001).After multivariable adjustments for age,nerve-sparing,and surgical technique,the proficiency score independently predicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve Robot-assisted radical prostatectomy High-risk prostate cancer

Recent developments in Boolean networks control

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Journal of Control and Decision 2016年第1期3卷 1-18页

作者： ettore Fornasini Maria Elena Valcher Dipartimento di Ingegneria dell’Informazione Universitàdi PadovaPadovaItaly

The aim of this survey paper is to provide the state of the art of the research on control and optimal control of Boolean control networks,under the assumption that all the state variables are accessible and hence available for *** and sufficient conditions for stabilisability to a limit cycle or to an equilibrium point are ***,it is shown that when such conditions are satisfied,stabilisation can always be achieved by means of state *** results are obtained for the safe control problem that is investigated for the first time in this *** and infinite horizon optimal control are subsequently considered,and solution algorithms are provided,based on suitable adaptations of theRiccati difference and algebraic ***,an appropriate definition of the cost function allows to restate and to solve both stabilisation and safe control as infinite horizon optimal control problems.

关键词： Boolean control networks algebraic representation controllability stabilisation optimal control safe control

Impacts of COVID-19 Pandemic on Italian Electricity Demand and Markets

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 824-827页

作者： Mahmood Hosseini Imani ettore Bompard Pietro Colella Tao Huang Politecnico di Torino Dipartimento EnergiaTurin10129Italy

In this paper,the short-,medium-,and long-term effects of the COVID-19 pandemic on the Italian power system,particularly electricity consumption behavior and electricity market prices,are investigated by defining various *** investigation reveals that COVID-19 lockdown caused a drop in load consumption and,consequently,a decrement in day-ahead market prices and an increase in ancillary service prices.

关键词： Ancillary service market price COVID-19 day-ahead market price Italian electricity markets load consumption

Kinetics of defect formation in chemically vapor deposited （CVD） graphene during laser irradiation： The case of Raman investigation

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Nano Research 2015年第12期8卷 3972-3981页

作者： Giampiero Amato Gianluca Milano Umberto Vignolo ettore Vittone Quantum Research Laboratory INRIM Strada delle Cacce 91 Torino Italy Department of Physics NIS Research Center University of Torino via Pietro Giuria 1 10125 Torino Italy

The effect of laser irradiation on chemically vapor deposited （CVD） graphene was studied by analyzing the temporal evolution of Raman spectra acquired under various illumination conditions. The spectra showed that the normalized intensity of the defect-related peak increases with the square root of the exposure time and varies almost linearly with the laser power density. Furthermore, the hardness of graphene to radiation damage depends on its intrinsic structural quality. The results suggest that, contrary to the common belief, micro-Raman spectroscopy cannot be considered a noninvasive tool for the characterization of graphene. The experimental observations are compatible with a model that we derived from the interpretative approach of the Staebler-Wronski effect in hydrogenated amorphous silicon; this approach assumes that the recombination of photoexcited carriers induces the breaking of weak C-C bonds.

关键词： chemically vapor deposited (CVD) graphene Raman spectroscopy defect kinetics laser irradiation

Does kinship affect spatial organization in a small and isolated population of a solitary felid: The Eurasian lynx?

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Integrative Zoology 2016年第5期11卷 334-349页

作者： Krzysztof SCHMIDT Francesca DAVOLI Rafał KOWALCZYK ettore RANDI Mammal Research Institute Polish Academy of SciencesBiałowieżaPoland Laboratory of Genetics Institute for Environmental Protection and ResearchOzzano EmiliaItaly Aalborg University Department of BiotechnologyChemistry and Environmental EngineeringAalborgDenmark

Social organization in wild carnivores is mostly determined by patterns of family bonds,which may shape the degree of relatedness among individuals in the *** studied kinship in a small and isolated population of a solitary carnivore,the Eurasian lynx(Lynx lynx)to evaluate its effect on spatial distribution of *** investigated the relationship between spatial location and pair-wise kinship among 28 lynx individuals identified in 2004-2011 by telemetry,non-invasive sampling and genotyping with the use of 12 autosomal microsatellites in the Białowieża Primeval Forest,*** average relatedness of the lynx population was relatively low(Lynch and Ritland’s R=0.03).Females were significantly more related to each other than males with other *** inferred pedigree showed that the population was dominated by only 2 familial *** did not find significant correlations between the relatedness and the extent of home range overlap or the straight-line distances between the home ranges’central *** results suggest that the dynamics of kinship in this solitary felid may not differ from the random mating processes described in social *** the chances of random mating could be limited to a few resident males and females,the presence of unrelated floaters may provide a“breeding buffer”that may prevent an increase of relatedness and likely inbreeding in the pop*** system is likely to fail in preserving genetic diversity in small,highly isolated populations;therefore,restoring habitat connectivity is crucial to ensure sufficient immigration from neighboring populations.

关键词： genetic variability inbreeding mating system relatedness social organization