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In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering

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Bioactive materials 2018年第1期3卷 19-27页

作者： Chuying ma ethan Gerhard Qiaoling Lin Silun Xia April Dawn Armstrong Jian Yang Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA CATS College CanterburyKent CT13LQUK Department of Orthopaedics and Rehabilitation College of MedicineThe Pennsylvania State UniversityHersheyPA 17033USA

Citrate based polymer poly(octamethylene citrate)(POC)has shown promise when formulated into composite material containing up to 65 wt%hydroxylapatite(HA)for orthopedic *** significant research into POC,insufficient information about the biocompatibility of the monomers 1,8-Octanediol and Citrate used in its synthesis is ***,we investigated the acute cytotoxicity,immune response,and long-term functionality of both *** results showed a cell-type dependent cytotoxicity of the two monomers:1,8-Octanediol induced less acute toxicity to 3T3 fibroblasts than Citrate while presenting comparable cytotoxicity to MG63 osteoblast-like cells;however,Citrate demonstrated enhanced compatibility with hMSCs compared to 1,*** critical cytotoxic concentration values EC30 and EC50,standard for comparing cytotoxicity of chemicals,were also ***,Citrate showed slower and less inhibitory effects on long-term hMSC cell proliferation compared with 1,***,osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase(ALP)*** monomer triggered undesired pro-inflammatory *** combination with diffusion model analysis of monomer release from cylindrical implants,based on which the maximum concentration of monomers in contact with bone tissue was estimated to be 2.2104 mmol/L,far lower than the critical cytotoxic concentrations as well as the 1,8-Octanediol concentration(0.4 mg/mL or 2.7 mmol/L)affecting hMSCs differentiation,we provide strong evidence for the cytocompatibility of the two monomers degraded from citrate-based composites in the orthopedic setting.

关键词： Biodegradable Poly(octamethylene citrate) Citrate 1,8-Octanediol Cytocompatibility Osteogenic differentiation Surface erosion

Learning from the 2009 H1N1 pandemic:prospects for more broadly effective influenza vaccines

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分子细胞生物学报:英文版 2011年第3期3卷 144-146页

作者： ethan C.Settembre Philip R.Dormitzer Rino Rappuoli Novartis Vaccines and Diagnostics CambridgeMAUSASienaItaly

Calls to develop a universal influenza vaccine have increased in the wake of the 2009 H1N1 influenza *** demand comes at a time when analyses of the human antibody repertoire,informed by structures of complexes between broadly neutralizing antibodies and influenza hemagglutinin,have revealed the target of a class of broadly neutralizing *** studies suggest a path forward to more broadly protective influenza vaccines.

关键词： influenza vaccines protective

Dynamic Pressures on Tunnel Roofs due to Vehicle Passages

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Sound & Vibration 2018年第4期52卷 6-8页

作者： James D.Barnes ethan R.Brush mark S.Newmark Eric E.Ungar Acentech Inc.33 Moulton StreetCambridgeMA02138USA

Pressure and proximity measurements made in a tunnel indicate that a typical vehicle passage produced on the tunnel roof an initial pressure increase of small magnitude,followed by a sharp and more substantial drop in pressure below *** magnitude of the pressure drop was found to increase with smaller clearances between the vehicle top and the tunnel roof,consistent with the Bernoulli relation and the vehicle *** dynamic pressures potentially may have significant effects on the vibration and noise environments on the lower floors of“air rights construction”buildings that span highways.

关键词： Pressure pulses vehicle passages tunnel roofs

微波加热快速合成5-三氟甲基吡啶-2-胺和2-[(5-三氟甲基吡啶-2-基)氧基]乙醇

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山东化工 2024年第1期53卷 12-14,19页

作者：马小云谭斌乙周世欢贵州师范学院化学与材料学院贵州贵阳550018

在微波加热条件下,通过C-N、C-O偶联反应分别合成了5-三氟甲基吡啶-2-胺和2-[(5-三氟甲基吡啶-2-基)氧基]乙醇。探讨了反应底物、反应时间、反应温度及碱对反应产率的影响,通过核磁共振氢谱检测对化合物进行了表征。结果表明,合成5-三... 详细信息

在微波加热条件下,通过C-N、C-O偶联反应分别合成了5-三氟甲基吡啶-2-胺和2-[(5-三氟甲基吡啶-2-基)氧基]乙醇。探讨了反应底物、反应时间、反应温度及碱对反应产率的影响,通过核磁共振氢谱检测对化合物进行了表征。结果表明,合成5-三氟甲基吡啶-2-胺的最佳反应条件为:碘化亚铜为催化剂、乙二醇为溶剂的条件下,2-溴-5-三氟甲基吡啶与氨在110℃反应30 min。合成2-[(5-三氟甲基吡啶-2-基)氧基]乙醇的最佳反应条件为:碘化亚铜为催化剂、磷酸钾为碱的条件下,2-溴-5-三氟甲基吡啶与乙二醇在130℃反应20 min。最佳反应条件下,5-三氟甲基吡啶-2-胺和2-[(5-三氟甲基吡啶-2-基)氧基]乙醇的产率分别为83%和87%。

关键词：三氟甲基吡啶偶联反应微波辅助合成

ACP-103,a potent 5-HT2A Receptor Inverse Agonist,as an Adjunctive Therapy in Schizophrenia

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ACP-103,a potent 5-HT2A Receptor Inverse Agonist,as an Adjun...

Unraveling the Effect of Stacking Configurations on Charge Transfer in WS_(2) and Organic Semiconductor Heterojunctions

第十五届国际药理学大会

作者： Vanover Kimberly E. Lameh Jelveh Gardell Luis R. Ott Thomas R. ma Jian-Nong Burstein ethan S. van Kammen Daniel Davis Robert E. Weiner David M. Brann mark R. ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals

＜正＞ ACP- 103 is a potent and selective 5 - HT2A receptor inverse agonist,with nanomolar potency at 5 - HT2A receptors and 7-50 fold lower potency at 5 -HT2C receptors in a variety of in vitro assays. ACP - 103 lacks significant activity at D2 and over 50 other human receptors at concentrations up to 10 uM. In mice. ACP - 103 was a potent inhibitor of head - twitch behaviors induced by 5 - HT2 agonist DOI, and enhanced haloperidol - or risperidone - mediated decreases in dizocilpine - or amphetamine - induced hyperactivity. ACP - 103 also reduced haloperidol - or risperidone - induced catalepsy and hyperprolactinemia in rats. The ability of ACP - 103 to reduce neuroleptic - induced side effects in animals was extended into the clinic. Initial clinical studies indicate that ACP - 103 was generally safe and well tolerated,had a long plasma half - life,and occupied 5 -HT2A receptors in human brain after oral administration. Moreover. ACP- 103 administration reduced haloperidol - induced hyperprolactinemia in healthy volunteers,and haloperidol - induced akathisia in both healthy volunteers and schizophrenic subjects. Based on these observations. ACP - 103 may have potential as an adjunctive therapy in schizophrenia with a wide therapeutic index.

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Precision Chemistry 2023年第7期1卷 443-451页

作者： Shuchen Zhang Dewei Sun Jiaonan Sun Ke ma Zitang Wei Jee Yung Park Aidan H.Coffey Chenhui Zhu Letian Dou Libai Huang Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana 47907United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States Department of Chemistry Purdue UniversityWest LafayetteIndiana 47907United States

Photoinduced interfacial charge transfer plays a critical role in energy conversion involving van der Waals(vdW)heterostructures constructed of inorganic nanostructures and organic ***,the effect of molecular stacking configurations on charge transfer dynamics is less *** this study,we demonstrated the tunability of interfacial charge separation in a type-Ⅱ heterojunction between monolayer(ML)WS_(2) and an organic semiconducting molecule[2-(3″′,4′-dimethyl-[2,2′:5′,2′:5″,2″′-quaterthiophen]-5-yl)ethan-1-ammonium halide(4Tm)]by rational design of relative stacking *** assembly between ML-WS_(2) and the 4Tm molecule forms a face-to-face stacking when 4Tm molecules are in a selfaggregation *** contrast,a face-to-edge stacking is observed when 4Tm molecule is incorporated into a 2D organic-inorganic hybrid perovskite *** face-to-face stacking was proved to be more favorable for hole transfer from WS_(2) to 4Tm and led to interlayer excitons(IEs)*** absorption measurements show that the hole transfer occurs on a time scale of 150 *** the other hand,the face-to-edge stacking resulted in much slower hole transfer without formation of *** inefficient hole transfer occurs on a similar time scale as A exciton recombination in WS_(2),leading to the formation of negative *** investigations offer important fundamental insights into the charge transfer processes at organic−inorganic interfaces.

关键词： Charge transfer two-dimensional materials organic semiconductors heterojunction stacking configuration interlayer exciton

Retinoic acid signaling acts as a rheostat to balance Treg function

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Cellular & Molecular Immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi ethan G.Aguilar Scott N.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.macDonald William J.Murphy Ivan maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey C.Rathmell Hongbo Chi Randolph J.Noelle Bruce R.Blazar Department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA Center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA Department of Pediatrics University of WashingtonSeattleWAUSA Fred Hutchinson Cancer Research Center SeattleWAUSA Howard Hughes Medical Institute Immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Microbiology and Immunology.Geisel School of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA Department of Immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia Departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia Cancer Center Augusta UniversityAugustaGAUSA Department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston Children's Hospital and the Dana-Farber Cancer Institute BostonMAUSA Department of Immunology St.Jude Children's ResearchHospitalMemphisTNUSA

Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and ***,it is unknown how RA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T *** the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTORC1 signaling and supersuppressor ***,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-RAR ***,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA *** findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： Retinoic acid Tregulatory cells Autoimmunity Metabolism mTORC1 STAT5

美国高等教育的发展趋势和面临的挑战:在线学习,移动学习和MOOCs——访美国圣地亚哥州立大学副校长依山·辛格(ethan Signer)博士

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中国电化教育 2014年第6期 1-5,29页

作者：孙众王敏娟马小强石长地首都师范大学信息工程学院北京100048 美国圣地亚哥州立大学中央电化教育馆北京100031

依山·辛格博士,美国圣地亚哥州立大学(San Diego State University)资深名誉学术事务副校长,兼电教中心主管。他积极推动了该校对网络教学的发展和评估,并且推动了SDSU跟附近中小学的大力合作。他在校长职位30余年,负责学术事务部1.8... 详细信息

依山·辛格博士,美国圣地亚哥州立大学(San Diego State University)资深名誉学术事务副校长,兼电教中心主管。他积极推动了该校对网络教学的发展和评估,并且推动了SDSU跟附近中小学的大力合作。他在校长职位30余年,负责学术事务部1.8亿的财政预算和支出。他知识渊博,熟悉美国的教育制度,跟美国白宫有合作办学项目,对美国的高等教育有着深刻的体会和独到的见解。辛格校长对中国有浓厚的兴趣,积极开展与中国的沟通和交流。他于2013年9月受邀访问国内多所高校,并举办了多场学术讲座。本刊特邀访谈者就此机会,对这位在校长职位上工作超过三十年的学者进行访谈,请他以圣地亚哥州立大学近几年用技术改革高等教育的策略和作法为切入点,从教育管理者和领导者的角度,阐述在线教育、MOOCs等技术力量在美国高等教育发展中的动力、影响及发展趋势。中美两国在高等教育体系各有特点,而我国同样面临着在线课程、开放课程、移动学习对教育的冲击和挑战。因此借鉴他人的思想和经验,有利于我国教育研究者发展出符合中国国情的、技术支持下的高等教育发展之路。

关键词：高等教育在线学习移动学习 MOOCs

节点或面：张艺谋翻拍《血迷宫》的跨文化误读

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上海大学学报（社会科学版） 2014年第1期31卷 1-11页

作者：西蒙·劳伦斯马修伦(译) 周学麟(校) 奥克兰大学电影电视传媒系新西兰奥克兰市

"创造性误读"指的是一种文化试图理解另一种文化并转为己用时,最终会对所借鉴文化产生误解或误用。前一种文化在这种互动中会产生出新鲜的东西,但这种新鲜的东西与原文化含义可能不同,甚至相反;从文化交流与增长的角度来看,这是一个重... 详细信息

"创造性误读"指的是一种文化试图理解另一种文化并转为己用时,最终会对所借鉴文化产生误解或误用。前一种文化在这种互动中会产生出新鲜的东西,但这种新鲜的东西与原文化含义可能不同,甚至相反;从文化交流与增长的角度来看,这是一个重要且非常普遍的过程。创造性的跨文化误读是跨文化电影翻拍的标志,其中对"他者"的理解更非简单的"翻译"。2009年,张艺谋把科恩兄弟的惊悚片《血迷宫》(1984),翻拍成中国电影《三枪拍案惊奇》便是一个典型的案例,由此可以展示跨文化误读产生的丰富性特征。

关键词：创造性误读电影翻拍张艺谋血迷宫