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Tracheal relaxation of five medicinal plants used in Mexico for the treatment of several diseases

Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 179-183页

作者： Amanda Snchez-Recillas Paul Mantecón-Reyes Patricia Castillo-Espaa Rafael Villalobos-Molina Maximiliano Ibarra-Barajas samuel estra.a.soto Facultad de Farmacia Universidad Autonoma del Estado de MorelosAvenida Universidad 1001.Col.ChamilpaCuernavacaMorelos 62209México Centro de Investigación en Riotecnología Universidad Autónoma del Estado de Morelos.Avenida Universidad 1001Col.ChamilpaCuernavacaMorelos 62209México Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantlaEstudo de Mexico 54090México

Objective:To assess the relaxant effect of several organic extracts obtained from Agastache mexicana(***),Cochlospermum vitifolium(***),Cordia morelosana(***),Lepechinia caulescens(***)and Talauma mexicana(71 mexicana)used in Mexican traditional medicine for the treatment of several ***:Extracts were obtained by maceration at room temperature using hexane,dicliloromethane and methanol for each plant *** organic extracts were evaluated ex vivo to determine their relaxant activity on the contractions induced by carbaehol(cholinergic receptor agonist,1μmol/L in isolated rat tracheal ***:A total of 15 extracts were evaluated(three for each species).All test samples showed significant relaxant effect,in a concentration-dependent manner,on the contractions induced by 1μmol/L carbachol,with exception of extracts from *** extracts were less potent than theophylline[phosphodiesterase inhibitor,EC_(50):(28.79±0.82)μg/mL]that was used as positive ***-response curves revealed that the extracts with more significant effects were dichloromethanic extracts of ***[E_(max):(103.03±3.32)%and EC_(50):(159.39±3.72)μg/mL)and ***[Emax:(106.58±2.42)%and EC_(50):(219.54±7.61)μg/mL].Finally,hexanic and dichloromethanic extracts from *** were fully effective but less potent than ***,and ***:Less polar extracts obtained from ***,71 mexicana and *** exhibited greater relaxant effect on tracheal rat rings,which allows us to suggest them as sources for the isolation of bioactive molecules with potential therapeutic value in the treatment of asthma.

关键词： Asthma Mexican medicinal plants Trachea Relaxant effect

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Vasorelaxant activity of extracts obtained from Apium graveolens:Possible source for vasorelaxant molecules isolation with potential antihypertensive effect

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 776-779页

作者： Vergara-Galicia Jorge Jimenez-Ramirez Luis Angel Tun-Suarez Adrian Aguirre-Crespo Francisco Salazar-Gomez Anuar estra.a.soto samuel Sierra-Ovando Angel Hernandez-Nunez Emmanuel Division of Health Sciences University of Quintana rooChetumalQuintana Ron.Mexico Department of Biotechnology Polytechnic University of the State of MorelosJiutepecMorelosMexico College of Pharmacy.University of the State of Morelos CuernavacaMorelosMexico Division of Health Sciences.Juarez Autonomous University of Tabasco VillahermosaTabascoMexico School of Engineering University of YucatanMeridaYucatanMexico

Objective:To investigate the vasorelaxant effect of organic extracts from Apium graveolens(***)which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive ***:An ex vivo method was employed to assess the vasorelaxant *** consisted of using rat aortic rings with and without endothelium precontracted with ***:All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium;the most active extracts were Dichloromethane and Ethyl Acetate extracts from *** results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium ***,our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from *** is mediated probably by calcium ***:*** represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

关键词： Aortic ring Apium graveolens Medicinal plant Vasorelaxant

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The Acute and Chronic Effects of Co-Administration of Turmeric and Black Pepper Extracts in Genetic Hypertension

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Journal of Biosciences and Medicines 2023年第8期11卷 114-128页

作者： Ma. Guadalupe Calderón-Gallardo Lilia Castillo-Martínez samuel estra.a.soto Itzell A. Gallardo-Ortíz Rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud Doctorado en Investigación Clínica Experimental en Salud Universidad Nacional Autónoma de México Ciudad de México México Instituto Nacional de Nutrición Salvador Zubirán Ciudad de México México Facultad de Farmacia Universidad Autónoma del Estado de Morelos Cuernavaca México

High blood pressure is the main risk factor for cardiovascular diseases, it affects many people worldwide and is a public health problem. This study explored the acute and chronic actions of a mixture of turmeric (95% curcumin) plus black pepper (95% piperine) extracts, in the blood pressure pattern in spontaneously hypertensive rats (SHR) along they age. For the acute study male adult (4 - 7 months old) SHR and their control Wistar Kyoto rats (WKY) were used. A single oral dose of the mixture of turmeric/black pepper extracts (200 mg/2mg, respectively) suspension was administered. Tail-cuff was used to determine blood pressure during 180 min. For the chronic study, young (1-month-old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In a second chronic assay adult (5 months old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In all three studies, a decrease in systolic, diastolic and mean blood pressure was observed, being higher in SHR and negligible in WKY rats. The mixture of turmeric/black pepper extracts showed antihypertensive actions in SHR rats with no effect on WKY rats. The mixture delayed the onset of hypertension in young SHR rats.

关键词： Curcuma longa L. Peper nigrum L. Hypertension Polyphenol SHR

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Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 185-190页

作者： María Eva González-Trujano Hilda Ponce-Muoz Sergio Hidalgo-Figueroa Gabriel Navarrete-Vázquez samuel estra.a.soto Laboratorio de Neurofarmacologia de Productos Naturales de la Directión de Investigaciones en Neurociencias.Instituto National de Psiquiatria "Ramón de la Fuente Muiz" México D.F.14370México Facultad de Farmacia Universidad Autonoma del Estado de MorelosCuernavaca.Morelos.México

Objective:To determine the depressant-like effects and the possible mechanism of action of tilianin isolated from active methanol extract of Agastache mexicana(***).Also,to establish the pharmacophoric requirements of tilianin,as a possible ligand of GABA_A/BZD receptor,by the alignment of ***-9896 and diindole,using a previously described pharmacophoric ***:Tilianin(30 to 300 mg/*** 300 mg/kg,pa.) and methanol crude extract(10 to 300 mg/kg,*** 300 mg/kg po.) from *** were evaluated for potential sedative and anxiolytic-like response drugs by using open-field,hole-board,cylinder of exploration,plus-maze and sodium pentobarbital-induced hypnosis mice ***:Methanol extract and tilianin showed anxiolytic-like activity from a dosage of 30 mg/kg,*** 300 mg/kg,*** were less potent than diazepam 0.1 mg/kg.a reference anxiolytic drug ***,depressant activity of both potentiates sodium pentobarbital(SP)-induced sleeping *** anxiolytic-like effect of 30 mg/kg *** for the extract and tilianin,by using the plus-maze model,was partially prevented in the presence of flumazenil(a GABA_A/BZD antagonist,5 mg/kg ip.) but not in the presence of WAY100635(a selective 5-HT_(1A) receptor antagonist,0.32 mg/***.).Pharmacophoric modeling alignments of three agonist of GABA_A/BZD allow identify seven chemical *** contains six of the seven features previously ***:Results indicate that tilianin is one of the bioactive metabolites in the anxiolytic-like activity of *** its central nervous system uses,where GABA_A/BZD,but not 5-HT_(1A),receptors are partially involved.

关键词： Agastache mexicana Anxiety Benzodiazepine Central nervous system Sedative Tilianin

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