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Blossom-end rot:a century-old problem in tomato(Solanum lycopersicum L.)and other vegetables

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Molecular Horticulture 2022年第1期2卷 1-10页

作者： Yasin Topcu Savithri U.Nambeesan esther van der Knaap Institute of Plant Breeding Genetics and GenomicsUniversity of GeorgiaAthensGA 30602USA 2Department of HorticultureUniversity of GeorgiaAthensGA 30602USA

Blossom-end rot(BER)is a devastating physiological disorder affecting vegetable production *** research into the physiological aspects of the disorder has demonstrated that the underlying causes of BER are associated with perturbed calcium(Ca^(2+))homeostasis and irregular watering conditions in predominantly cultivated ***,Reactive Oxygen Species(ROS)are critical players in BER development which,combined with unbalanced Ca^(2+)concentrations,greatly affect the severity of the *** availability of a high-quality reference tomato genome as well as the whole genome resequencing of many accessions has recently permitted the genetic dissection of BER in segregating populations derived from crosses between cultivated tomato *** has led to the identification of five loci contributing to BER from several *** eventual cloning of the genes contributing to BER would result in a deeper understanding of the molecular bases of the *** will undoubtedly create crop improvement strategies for tomato as well as many other vegetables that suffer from BER.

关键词： Blossom-end rot(BER) Reactive Oxygen Species(ROS) Ca^(2+)deficiency Abiotic stress Cell wall Tomato Antioxidants Plant growth regulators Fruit morphology

Challenges in the implementation of food safety and quality assurance systems in small-scale fisheries

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Food Quality and Safety 2023年第1期7卷 178-186页

作者： esther GarridoGamarro Cecilie Smith Svanevik Anne-Katrine Lundebye Monica Sanden Enrica D'Agostino Marian Kjellevold Lauren Pincus Johannes Pucher Fisheries and Aquaculture Division Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Institute of Marine Research BergenNorway WorldFish Jalan Batu MaungBatu MaungPenangMalaysia German Federal Institute for Risk Assessment Department Experimental Toxicology and ZEBETBerlinGermany Shared first authorship

Ninety percent of the world’s fishers are directly involved in small-scale fisheries(SSFs),and many food safety and quality issues along the food value chains may be both irreversible and *** safe,high-quality aquatic products are key to sustaining life,promoting good health,and avoiding adverse health *** This paper aimed to highlight factors preventing the implementation of safety and quality assurance systems in SSFs by analysing the results from surveys on the implementation of Article 11 of the Food and Agriculture Organization of the United Nations(FAO)Code of Conduct for Responsible Fisheries(2017,2019,and 2022).Materials and methods The analysis considered responses to 15 closed-ended questions on food safety and quality obtained from 143 FAO Members and the European Union,and 87 open-ended replies addressing challenges in *** The major factors preventing the implementation of the Code’s food safety and quality provisions were lack of sanitation and monitoring programmes,lack of infrastructure(particularly refrigeration facilities)lack of technical capacities and limited management of food safety risks along the value *** and quality assurance efforts were focused on international markets,resulting in less attention being paid to domestic markets where a high degree of informality was *** Improved implementation of safety and quality assurance systems will lead to safer food with higher nutritional quality,extended shelf-life and reduced post-harvest *** awareness of food safety issues in SSFs is a prerequisite for achieving several of the UN Sustainable Development Goals.

关键词： Food security policy monitoring legislation value chain domestic market international trade

Computational Resolution of a Boolean Equation of 21 Variables

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American Journal of Operations Research 2022年第5期12卷 157-178页

作者： esther Claudine Bitye Mvondo Department of Mathematics University of Yaounde I Yaounde Cameroon

The Alienor method has been elaborated at the beginning of the 1980s by Yves Cherruault and Arthur Guillez (1983). The following people have also greatly contributed to the improvement of this new optimization method: Blaise Somé, Gaspar Mora, Balira Konfé, Jean Claude Mazza and esther Claudine Bityé Mvondo. The basic idea consists in using a reducing transformation allowing us to simplify a multivariable optimization problem to a new optimization problem according to a single variable. The rational gestion of enterprises leads generally to the use of Operational Research, often called management science. The term Operational Research means a scientific approach to decision making, that seeks optimization in a system. Consequently, it is better to take the right decisions. Otherwise, fatal consequences can occur instantaneously [1]. Generally, we have to maximize the global profit margin, taking into account some constraints. For instance, in an integer programming problem, some or all the variables are required to be nonnegative integers. In this paper, we present new reducing transformations for global optimization in integer, binary and mixed variables as well as the applications in Boolean algebra by solving a Boolean Equation of 21 variables. The applications in Operational Research are presented on various examples, resolved by using the tabulator Excel of Microsoft.

关键词： Alpha-Dense Curves Boolean Equations Diophantine Equations Global Optimization and Operational Research

New therapeutic approaches to metastatic gastroenteropancreatic neuroendocrine tumors:A glimpse into the future

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 4-20页

作者： esther Una Cidon Department of Medical Oncology Royal Bournemouth HospitalBournemouthDorset BH5 2AZUnited Kingdom

Neuroendocrine(NE) gastroenteropancreatic tumors are a heterogeneous group of neoplasias arising from neuroendocrine cells of the embryological gut. Their incidence have increased significantly over the past 3 decades probably due to the improvements in imaging and diagnosis. The recent advances in molecular biology have translated into an expansion of therapeutic approaches to these patients. Somatostatin analogs, which initially were approved for control of hormonal syndromes, have recently been proven to inhibit tumor growth. Several new drugs such as antiangiogenics and others targeting mammalian target of rapamycin pathways have been approved to treat progressive pancreatic neuroendocrine tumors(NETs) although their role in nonpancreatic is still controversial. The treatment of NETs requires a coordinated multidisciplinary approach. The management of localized NETs primarily involves surgical resection followed by surveillance. However, the treatment of unresectable and/or metastatic disease may involve a combination of surgical resection, systemic therapy, and liver-directed therapies with the goal of alleviating symptoms of peptide release and controlling tumor growth. This article will review the current therapeutic strategies for metastatic gastroenteropancreatic NETs and will take a glimpse into the future approaches.

关键词： Gastroenteropancreatic neuroendocrine 肿瘤肽受体放射性核种治疗 Somatostatin 类似物 Octreotide Transarterial chemoembolization 良性肿瘤症候群 Setotonin Chromogranin

Surgical and nutritional interventions for endometrial receptivity:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12295-12304页

作者： Dinorah Hernández-Melchor Cecilia Palafox-Gómez Ivan Madrazo Ginna Ortiz America Padilla-Viveros esther López-Bayghen Science Technology and Society ProgramCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Clinical Research Instituto Regenera SCMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Investigación Clínica Instituto de Infertilidad y Genética México SCINGENESMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMéxico

BACKGROUND Polycystic ovary syndrome(PCOS)is an endocrine disease that combines metabolic,reproductive,and psychological *** disorders and impaired endometrial receptivity in PCOS can cause *** resistance(IR)is a pathological state of inadequate response to insulin that affects reproduction in PCOS,as damage caused by IR at the endometrial level becomes an obstacle for embryo *** IR resulted in spontaneous pregnancies in PCOS patients,indicating that metabolic corrections improve endometrial *** stem-cell treatment has also corrected endometrial quality and lead to pregnancies in patients with Asherman’s *** propose a combination of nutritional intervention with the surgical placement of stem cells to improve endometrial quality to achieve pregnancy in a PCOS patient undergoing in vitro fertilization(IVF)*** SUMMARY After two failed IVF cycles,a metabolic intervention,consisting of a ketogenic diet with daily consumption of 50 g of carbohydrates(CH),was indicated until *** Syndrome was assessed using the Harmonizing Definition(3 of 5 pathologies:Central obesity,hypertension,hyperglycemia,hypertriglyceridemia,and dyslipidemia),and the Homeostatic Model Assessment of IR(HOMA-IR)was used to measure the level of *** IR improved,endometrial quality ***,two day 5-thawed embryos(euploid,donated oocyte–partner's sperm)failed to implant,suggesting endometrial quality improvement was ***,transmyometrial implantation of mesenchymal stem cells from the stromal vascular fraction of adipose tissue was performed to enrich the endometrial stem cell *** endometrial mean thickness for embryo transfer(6.9 mm)was achieved three months after stem cell treatment and continuous dietary control of *** euploid-day 5-thawed embryos(donated oocyte–partner's sperm)were transferred,and embryo implantation was confirmed on day 14 byβ-hCG s

关键词： Polycystic ovarian syndrome Insulin resistance Nutritional intervention Endometrial quality Stem cell treatment Case report

Small mammal diversity of Mt. Kenya based oncarnivore fecal and surface bone remains

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Zoological Research 2019年第1期40卷 61-69页

作者： Ogeto Mwebi esther Nguta Veronica Onduso Ben Nyakundi Xue-Long Jiang esther N.Kioko Osteology Section Department of Zoology National Museums of Kenya Kunming Institute of Zoology Chinese Academy of Sciences Sino-African Joint Research Center Chinese Academy of Sciences

Ecological dynamics and faunal diversity documentation is normally conducted by direct observation and trapping of live animals. However,surveys of carnivore scat prey and surface bone remains, which are relatively inexpensive, can provide complementary data that expand carnivore diet breadth and may improve accuracy regarding inferences of the ecological dynamics of a given ecosystem. We used this inexpensive method to document species diversity variation with elevation on the leeward(Sirimon) and windward(Chogoria)areas of Mt. Kenya. Bone and fecal specimens were opportunistically collected by walking 2 km in opposite directions from transect points selected at 200-m intervals along the elevational gradient of the study areas. We collected a total of 220 carnivore fecal and owl pellet specimens from both study sites, which were mainly deposited by the spotted hyena(Crocuta crocuta), leopard(Panthera pardus),serval(Leptailurus serval), genet(Genetta sp.), and Mackinder's Cape owl(Bubo capensis mackinderi).Serval scats were the most common, followed by those of the spotted hyena. Scats and bones were found at the lowest density at the lowest elevations,peaked at mid-higher elevations, and then declined at the highest elevations. Based on skeletal analysis only, there were more species in Sirimon(19) than in Chogoria(12). Small fauna(rodents to duiker size bovids) formed the bulk of the identified remains,representing 87.9% of the Sirimon fauna and 90.9% of the Chogoria fauna. The genus Otomys was the dominant prey of the owl and serval in both sites. Three giraffe teeth were found at 3 500 m a.s.l. in Chogoria on the edge of Lake El is, suggesting that it is an occasional visitor to such high elevations. This study underscores the value of fecal and bone surveys in understanding the diet and diversity of mammals in ecological ecosystems,but such surveys should be complemented with analysis of hairs found in scats to obtain a more complete list of carnivore prey at M

关键词： Ecological dynamics Faunal diversity Scats Pellets Mt.Kenya

Knowledge and awareness of glaucoma in Mexican patients with and without glaucoma diagnosis in an Ophthalmology Referral Center

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 990-996页

作者： Valeria Becerril-Ledezma Daniela Alvarez-Ascencio Clarisa esther del Hierro-Gutiérrez Alejandra Hernandez-Oteyza Jesús Jiménez-Román Association to Prevent Blindness in Mexico Private Assistance Institution(APEC)Mexico City 04030Mexico

AIM: To assess and compare knowledge and awareness of glaucoma in subjects with and without glaucoma diagnosis attending an Ophthalmology Referral ***: This cross-sectional study was conducted at Asociación Para Evitar la Ceguera in Mexico City, using a questionnaire formulated by a group of experts following the Delphi panel rules, and pre-tested in a pilot *** questionnaire was applied and compared between:glaucoma patients, relatives of glaucoma patients and patients without glaucoma. Socio-demographic data was collected to assess correlation with the level of knowledge using Logistic regression models, estimating the odds ratios(OR), 95% confidence intervals, and P<***: Three hundred and ninety-four subjects were enrolled;with a median age of 61y. One hundred and thirty-four(34%) were patients with glaucoma, 152(38.6%)patients without glaucoma, and 108(27.4%) relatives of patients with glaucoma. Two hundred and ninety-one(73.9%) participants were aware of the term “glaucoma”.Regarding knowledge 46.7% had moderate knowledge,37.8% had poor knowledge, and 15.5% good ***, relatives of glaucoma patients had the highest scores, and patients without glaucoma got the lowest scores. A positive correlation was found between better knowledge and frequent ophthalmological examinations OR 2.24(P=0.02), higher education level OR 4.17(P=0.00) and having a family member with glaucoma OR 3.28(P=0.00).CONCLUSION: Awareness and knowledge of glaucoma in subjects attending an Ophthalmology Referral Center is predominantly moderate or poor. This has important implications regarding attitudes that can result in lack of follow up in ophthalmological care.

关键词： glaucoma awareness knowledge vision loss treatment

A novel technique for unilateral dissection of the penile neurovascular bundle to prevent loss of penile sensation during treatment of Peyronie's disease-Initial results of a pilot study

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Current Urology 2023年第4期17卷 299-302页

作者： Alexandr M.Pinkhasov Matthew Beamer Daniel Shulman Rachel Yakubov esther Pinkhasov Sergey Kravchick Department of Urology SUNY Upstate Medical University HospitalSyracuseNY 13202USA

Background:Plaque incision/excision and grafting are surgical techniques used to treat patients with Peyronie's disease who are refractory to less invasive interventions,have severe penile curvature,or have an hourglass ***,the procedure carries the risk of penile sensory loss because of the need for dissection of the neurovascular bundle(NVB).The aim of this study was to assess the feasibility of a novel technique for unilateral NVB dissection and its ability to preserve penile sensitivity while maintaining adequate correction of the penile *** and methods:Charts of patients who underwent unilateral NVB dissection during Peyronie's plaque incision/excision and grafting were retrospectively *** patients received preprocedural intracavernosal injections of TriMix,and the curvature was measured to be>70 *** 3 cases,an incision and minimal excision of the plaque were performed at the point of maximum curvature on the concave side of the *** 3 cases,Tutoplast allografts(Coloplast US,Minneapolis,MN)were used,whereas autografts were used in 2 other *** patients were examined at 1,3,and 6 months after the procedure when curvature and penile sensation were ***:Five patients underwent this *** mean age of patients was 55 years(45-70 years).All plaques were dorsally *** mean preoperative curvature was 78 degrees(75-90 degrees).At the 6-month follow-up,all patients had<15 degrees residual curvature and were satisfied with their cosmetic *** 1 patient continued with phosphodiesterase-5 inhibitors to improve potency at the 6-month *** patients reported normal penile glans *** patients experienced decreased sensation at the site of NVB dissection,but this was only detected when compared with the contralateral *** 2 patients reported a difference after 6 months,and only a minor area of involvement was ***:Unilateral NVB dissection is a feasi

关键词： Peyronie's disease Neurovascular bundle dissection

The effect of selected hemp seed protein hydrolysates in modulating vascular function

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Food Bioscience 2022年第1期45卷 249-256页

作者： Raiyan Mahbub esther Callcott Shiwangni Rao Omid Ansari Daniel L.E.Waters Christopher L.Blanchard Abishek B.Santhakumar Graham Centre for Agricultural Innovation Charles Sturt UniversityWagga WaggaNew South Wales2650Australia School of Dentistry and Medical Sciences Faculty of Science and HealthCharles Sturt UniversityWagga Wagga2650New South WalesAustralia School of Animal and Veterinary Sciences Faculty of ScienceCharles Sturt UniversityWagga Wagga2650New South WalesAustralia Agriculture Victoria Research HorshamVictoria3400Australia Ecofibre Limited VirginiaQueensland4014Australia Ananda Food New South Wales2322Australia Ananda Hemp Ltd CynthianaKYUSA

Reduced bioavailability of nitric oxide along with an increase in inflammatory cytokines,reactive oxygen species,cell adhesion molecules,and platelet hyperactivity are underlying causes of endothelial *** peptides derived from various plants have been shown to attenuate biomarkers of endothelial *** objective of this study was to determine the effects of hemp seed protein hydrolysates(HSPH)in modulating biomarkers of endothelial dysfunction using an in vitro cell culture model and an ex vivo platelet activity *** cells were treated with HSPH from commercial variant X and ECO-commercial variant Y,followed by hydrogen peroxide to simulate oxidative stress and *** of endothelial dysfunction were then measured to determine the protective properties of *** samples collected from healthy volunteers were used to determine the effect of the HSPH on ADP and hydrogen peroxide-induced platelet activity,using flow *** HSPH reduced the production of reactive oxygen species,inflammatory cytokines IL-8,IL-12p70 and IL-1β,and adhesion molecule vascular cell adhesion molecule ***,treatment with HSPH also reduced platelet activation marker CD62P ex *** results obtained from this study suggest HSPH alleviates biomarkers of endothelial dysfunction by reducing oxidative stress,inflammation and platelet activation.

关键词： Hemp seed Protein hydrolysates Endothelial dysfunction Platelet activity Inflammation Antioxidant properties