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Surgical and nutritional interventions for endometrial receptivity:A case report and review of literature

World Journal of Clinical Cases 2022年第33期10卷 12295-12304页

作者： Dinorah Hernández-Melchor Cecilia Palafox-Gómez Ivan Madrazo Ginna Ortiz America Padilla-Viveros esther López-Bayghen Science Technology and Society ProgramCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Clinical Research Instituto Regenera SCMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Investigación Clínica Instituto de Infertilidad y Genética México SCINGENESMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMéxico

BACKGROUND Polycystic ovary syndrome(PCOS)is an endocrine disease that combines metabolic,reproductive,and psychological *** disorders and impaired endometrial receptivity in PCOS can cause *** resistance(IR)is a pathological state of inadequate response to insulin that affects reproduction in PCOS,as damage caused by IR at the endometrial level becomes an obstacle for embryo *** IR resulted in spontaneous pregnancies in PCOS patients,indicating that metabolic corrections improve endometrial *** stem-cell treatment has also corrected endometrial quality and lead to pregnancies in patients with Asherman’s *** propose a combination of nutritional intervention with the surgical placement of stem cells to improve endometrial quality to achieve pregnancy in a PCOS patient undergoing in vitro fertilization(IVF)*** SUMMARY After two failed IVF cycles,a metabolic intervention,consisting of a ketogenic diet with daily consumption of 50 g of carbohydrates(CH),was indicated until *** Syndrome was assessed using the Harmonizing Definition(3 of 5 pathologies:Central obesity,hypertension,hyperglycemia,hypertriglyceridemia,and dyslipidemia),and the Homeostatic Model Assessment of IR(HOMA-IR)was used to measure the level of *** IR improved,endometrial quality ***,two day 5-thawed embryos(euploid,donated oocyte–partner's sperm)failed to implant,suggesting endometrial quality improvement was ***,transmyometrial implantation of mesenchymal stem cells from the stromal vascular fraction of adipose tissue was performed to enrich the endometrial stem cell *** endometrial mean thickness for embryo transfer(6.9 mm)was achieved three months after stem cell treatment and continuous dietary control of *** euploid-day 5-thawed embryos(donated oocyte–partner's sperm)were transferred,and embryo implantation was confirmed on day 14 byβ-hCG s

关键词： Polycystic ovarian syndrome Insulin resistance Nutritional intervention Endometrial quality Stem cell treatment Case report

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Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse

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World Journal of Gastroenterology 2016年第21期22卷 4977-4987页

作者： Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders esther CJ Consten Meander Medical Centre Department of Surgery Twente University Faculty of Science and Technology Institute of Technical Medicine Wesley Medical Centre Department of Surgery

External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented.

关键词： Laparoscopic ventral mesh rectopexy Robot Rectal prolapse External rectal prolapse Internal rectal prolapse Rectocele Mesh erosion Obstructed defecation Faecal incontinence Biological mesh

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Climate Change and Human Health in Nigeria

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Sociology Study 2013年第11期3卷 858-865页

作者： esther Englama Tanimu Tubayini Zakariah Fct College of Education

This paper investigates the impact of climate change on human health in Nigeria. The paper relies on secondary data, sourced from journals, government documents and private individuals. From these sources the paper discovered that climate change poses a wide range of health risks to human health which include direct effects on human health resulting from increase in temperature and amplified air pollution that increase in temperature needs high incidence of vector-borne diseases such as malaria, dysentery and cholera among others. Climate change also leads to rising sea levels which contaminates coastal fresh water and makes low-lying areas vulnerable to flooding. Flooding results in frequent incidences of malaria, cholera, typhoid to mention but few. It also leads to the displacement of people and resource conflicts, e.g., land and water, and post-disaster mental health problem. Finally the paper suggests that after flooding, affected settlements should be fumigated before people pack tack in order to reduce the incidences of cholera, malaria and dysentery among others, and that to reduce the discharge of carbon into the atmosphere alternative source of energy to fuel wood, must be put in place by the government.

关键词： Climate change human health greenhouse gases (GHG) greenhouse effect (GHE)

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The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria esther Perez-Perez Adeline Mauries Alexandre Maes Nicolas J. Tourasse Marion Hamon Stephane D. Lemaire Christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways and cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are scarce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

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Gender, Poverty and Climate Change in Nigeria

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Journal of Earth Science and Engineering 2014年第3期4卷 134-140页

作者： Tanimu Tubayini Zakariah esther Englama Department of Geography School of Arts and Social Sciences FCT (Federal Capital Territory) College of Education Zuba Abuja 23401 or 110001 or 00176 Nigeria

The purpose of this paper is to examine the impact of climate change on gender and poverty in Nigeria. The paper relies mainly on secondary data generated by private individuals, government and non-government bodies. From these sources, the paper reveals that climate change has resulted in higher temperature increase frequency on extreme weather events in the country, such as storms or record drought resulting in the dislocation of agricultural areas and its consequence food shortage. Women are the hardest hit because they produce food and do not have control over land to make most communities vulnerable to flooding as seen in Lokoja, Bauchi and Kaduna among others in Nigeria. Flooding has increased the frequency of vector-borne diseases such as malaria, dysentery, typhoid, cholera, etc.. Women who clean the mess left behind after the flood are mostly affected. It is also revealed that climate change has resulted in great economic losses, with most of the losses to be in agricultural production, the engine of growth and the mainstay of the economy. Finally, the paper suggests measures such as reduction in deforestation by provision of alternative source of energy and environmental friendly industrial activities will help reduce the rate of discharge of carbon-dioxide into the atmosphere.

关键词： Gender poverty climate change.

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Liver histological changes and lipid peroxidation in the amphibian Ambystoma mexicanum induced by sediment elutriates from the Lake Xochimilco

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Journal of Environmental Sciences 2016年第8期28卷 156-164页

作者： Esperanza Ortiz-Ordonez Eugenia López-López Jacinto Elías Sedeno-Díaz esther Uría Ignacio Andrés Morales María Estela Pérez Mineko Shibayama Instituto Politécnico Nacional Depto.de Formación Básica e InterdisciplinariaCICS-USTAv.de los Maestros s/n.Col.Sto Instituto Politécnico Nacional Laboratorio de Evaluación de la Salud de Ecosistemas AcuáticosENCBProl.de Carpio y Plan de Ayala s/n.Col.Sto Instituto Politécnico Nacional Coordinación Politécnica para la SustentabilidadEdificio de la Biblioteca Nacional3er PisoAv.Instituto Politécnico Nacional s/nesq.Wilfrido MassieuCol Instituto Politécnico Nacional Laboratorio de HistologíaENCBProl.de Carpio y Plan de Ayala s/n.Col.Sto Unidad de Servicio Académico Acuario BiologíaFacultad de CienciasUniversidad Autónoma de MéxicoCiudad Universitaria Laboratorio de Infectómica Centro de Investigación y de Estudios Avanzados del IPNAv.Instituto Politécnico Nacional

Lacustrine sediments accumulate pollutants that input from the lake watershed and can be released to the water column by sediment resuspension; thus, pollutants can change their bioavailability and exert adverse effects to aquatic biota. Shallow-urban lakes are particularly susceptible to receive pollutants from urban discharges and sediment resuspension. Lake Xochimilco, in Mexico City, an urban-shallow lake, faces multiple problems： urban sprawl, overexploitation of aquifers, drying of springs, discharge of wastewater from treatment plants, and sediment resuspension. The aquatic biota living in this ecosystem is continuously exposed to the release of pollutants from the sediments. We assessed the risk that pollutants released from sediments from Lake Xochimilco, Touristic（TZ） and Agriculture zone（AZ）, can exert on a native amphibian species of the lake（Ambystoma mexicanum） through exposure bioassays to sediment elutriates. We evaluate alterations in the amphibian by three approaches： biochemical（level of lipid peroxidation,LPO）, cellular（ultrastructure） and the liver histology of A. mexicanum and we compare them with a batch control. Additionally, we assessed heavy metals（Pb, Cd and Hg） in *** from TZ showed the highest concentrations of the metals assessed. Organisms exposed to sediment elutriates from either study sites showed higher LPO values than control organisms（p 〈 0.05）. Organisms exposed to elutriates from the TZ showed the most conspicuous damages： hepatic vasodilation of sinusoids, capillaries with erythrocytes,leukocyte infiltration and cytoplasmic vacuolation in hepatocytes. The biological responses assessed reflected the risk that faces A. mexicanum when is exposed for prolonged periods to sediment resuspension in Lake Xochimilco.

关键词： Elutriates Amphibian Liver Histological alterations Ultrastructure Oxidative stress Metals Urban lake

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Forces behind the Use of Herbs during Pregnancy by Zimbabwean Women: A Case of Gweru District

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Journal of Biosciences and Medicines 2021年第5期9卷 37-49页

作者： Panganai Tsitsi Shoko Tabona Mufunda esther Heath Science Department Zimbabwe Open University Harare Zimbabwe Department of Religious Studies University of Zimbabwe Harare Zimbabwe

Purpose: The use of herbal remedies is gradually increasing worldwide and Zimbabwe is not left behind. This study therefore sought to explore the forces behind the use of herbs during pregnancy by Zimbabwean women. Materials and methods: A qualitative approach was chosen using the case study design to evaluate the forces. The study was carried out at three maternity hospitals in Gweru. Thirty (30) women who used herbs during pregnancy were purposefully samples and interviewed using a structured interview schedule. The date was analyzed thematically. Results: It was noted that culture and belief system, previous experience as well as significant people in the woman’s life were the forces behind the use of herbs in pregnancy. Conclusion: The study concluded that these forces promoted the indiscriminate use of herbs which are passed from mother to daughter without considering the safety of the herbs to the mother and baby. Therefore, more research is needed to analyze the safety of these herbs to ensure that the mother and baby are safe.

关键词： Pregnancy Medicinal Plants Safety Delivery

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Alternatives to animal testing includes much more than in vitro alternatives

Alternatives to animal testing includes much more than in vi...

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中国毒理学会第六届全国毒理学大会

作者： esther PATRICK Access Business Group

The EU marketing ban on use of ingredients tested in acute animal studies after March 9, 2009 and tested in repeated dose animal studies after March 13,2013 is now in *** presents unique challenges to cosmetic safety assessors because fully validated in vitro alternatives are not available for all safety *** the same time companies doing business in China must provide safety data to satisfy "new to China" regulations for cosmetic ***,for a global company like Amway, whom tends to place products in multiple markets including EU and China,strategies that may be useful for meeting both requirements from EU and China are *** present article summarizes the methods used by Amway global safety group during the safety assessment of *** of the methods are alternatives to animal testing,while at the same time,could effectively ensure the safety requirements of a *** example,we would determine the acceptable exposure level of an ingredient by investigating its manufacturing process and its historical human exposure for food or *** would also apply "read through" principle,which is adopted by chemical inventory safety initiatives like HPV,OECD SIDS,and EU Reach,to cosmetic ingredients to fill data *** is determined by dose,applying threshold principles routinely used for food additives is warranted in some *** addition, in many cases the data mining strategies discussed in combination with in vitro alternatives and human clinical studies can adequately cover all safety endpoints with no new animal studies.

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Impact,Mechanism,Monitoring of Land Subsidence in Coastal Cities(Annual Work of IGCP 663)

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Acta Geologica Sinica(English Edition) 2019年第S01期93卷 158-159页

作者： YAN Xuexin YANG Tianliang XU Yan Luigi TOSI esther STOUTHAMER Heri ANDREAS LIN Jinxin HUANG Xinlei Key Laboratory of Land Subsidence Monitoring and Prevention Ministry of Land and ResourcesShanghai 200072China Shanghai Institute of Geological Survey Shanghai 200072China Shanghai Engineering Technology Research Center of Land Subsidence Shanghai 200072China Institute of Marine Sciences National Research CouncilArsenale Tesa104-Castello 2737/F30122-VeniceItaly Institute of Geosciences and Earth Resources National Research Councilvia G.Gradenigo635131-PaduaItaly Department of Physical Geography Faculty of GeosciencesUtrecht University3584 CSUtrechtthe Netherlands Geodesy Research Division Institute of Technology BandungBandung 40132Indonesia

Land subsidence is a worldwide geohazard consisting in the lowering of the ground surface due to natural and human-induced processes occurring in the shallow and deep *** the last two decades,land subsidence has caused damages and widespread impacts to a variety of infrastructures in coastal cities(Ma et al.,2011;Liu et al.,2016;Minderhoud et al.,2018).

关键词： land subsidence coastal cities case studies reclaimed soil

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Tourism in changing natural environments

Tourism in changing natural environments

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作者： edited by Natalie Ooi esther A. Duke and Joseph O'Leary.

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