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Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 40-47页

作者： Zeynep Gural Sezer saglam Serap Yucel esra kaytan-saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral Department of Radiation Oncology Acibadem University Medical Faculty Department of Medical Oncology Istanbul Bilim University Department of Radiation Oncology Istanbul Medical FacultyIstanbul University Department of General Surgery Academia of Clinical Science of Bogazici Department of Medical Biophysics Harran University Medical Faculty Department of Radiology Bezm-i AlemUniversity Department of Pathology Istanbul Medical FacultyIstanbul University

AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, *** Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies.

关键词： Hyperfractionated accelerated radiotherapy Rectal cancer Neoadjuvant chemoradiotherapy

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Neoadjuvant intermediate-course versus long-course chemoradiotherapy in T3-4/N0+rectal cancer:Istanbul R-02 phase II randomized study

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Oncology Research 2023年第5期31卷 689-696页

作者： SUKRAN SENYUREK SEZER saglam esra kaytan saglam HAKAN YANAR KAAN GOK DIDEM TASTEKIN CANAN KOKSAL AKBAS NERGIZ DAGOGLU SAKIN GULBIZ DAGOGLU KARTAL EMRE BALIK METIN KESKIN YASEMIN SANLI MINE GULLUOGLU ZULEYHA AKGUN Department of Radiation Oncology Koc University School of MedicineIstanbul34450Türkiye Department of Medical Oncology Demiroglu Bilim University Faculty of MedicineIstanbul34394Türkiye Department of Radiation Oncology Istanbul University Oncology InstituteIstanbul34093Türkiye Department of General Surgery Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Medical Oncology Istanbul University Oncology InstituteIstanbul34093Türkiye Department of Medical Physics Istanbul University Oncology InstituteIstanbul34093Türkiye Department of Radiology Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of General Surgery Koc University School of MedicineIstanbul34450Türkiye Department of Nuclear Medicine Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Pathology Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Radiation Oncology Memorial Sisli HospitalIstanbul34384Türkiye

Radiation therapy(RT)is typically applied using one of two standard approaches for preoperative treatment of resectable locally advanced rectal cancer(LARC):short-course RT(SC-RT)alone or long-course RT(LC-RT)with concurrent fluorouracil(5-FU)*** Phase II single-arm KROG 11-02 study using intermediate-course(IC)(33 Gy(Gray)/10 fr(fraction)with concurrent capecitabine)preoperative chemoradiotherapy(CRT)demonstrated a pathologically complete response rate and a sphincter-sparing rate that were close to those of *** current trial aim to compare the pathological/oncological outcomes,toxicity,and quality of life results of LC-CRT and IC-CRT in cases of *** prescribed dose was 33 Gy/10 fr for the IC-CRT group and 50.4 Gy/28 fr for the LC-CRT *** chronomodulated capecitabine(Brunch regimen)1650 mg/m2/daily chemotherapy treatment was applied in both *** European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer Module(EORTC QLQ-CR29)was administered at baseline and at three and six months after CRT.A total of 60 patients with LARC randomized to receive IC-CRT(n=30)or LC-CRT(n=30)were included in this phase II randomized *** significant difference was noted between groups in terms of pathological outcomes,including pathological response rates(ypT0N0-complete response:23.3%vs.16.7%,respectively,and ypT0-2N0-downstaging:50%for each;p=0.809)and Dworak score-based pathological tumor regression grade(Grade 4-complete response:23.3 vs.16.7%,p=0.839).The 5-year overall survival(73.3 vs.86.7%,p=0.173)rate was also *** acute radiation dermatitis(p<0.001)and any hematological toxicity(p=0.004)rates were significantly higher in the LC-CRT group,while no significant difference was noted between treatment groups in terms of baseline,third month,and sixth month EORTC QLQ-CR29 scores.

关键词： Chemoradiotherapy Rectal cancer Neoadjuvant therapy

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Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study

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Oncology Research 2023年第3期31卷 299-306页

作者： OZAN CEM GULER EZGI OYMAK GOZDE YAZICI OZLEM OZKAYA AKAGUNDUZ OGUZ CETINAYAK PETEK ERPOLAT ATIL AKSOY MURSEL DUZOVA BERNA AKKUS YILDIRIM MERAL KURT EMINE CANYILMAZ GULER YAVAS SERAP AKYUREK DIDEM COLPAN OKSUZ esra kaytan saglam OMUR KARAKOYUN CELIK ENIS OZYAR MUSTAFA CENGIZ CEM ONAL Department of Radiation Oncology Faculty of MedicineBaskent UniversityAdana Dr.Turgut Noyan Research and Treatment CenterAdanaTurkey Radiation Oncology Unit Iskenderun Gelisim HospitalHatayTurkey Department of Radiation Oncology Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineEge UniversityIzmirTurkey Department of Radiation Oncology Faculty of Medicine9 Eylul UniversityIzmirTurkey Department of Radiation Oncology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAkdeniz UniversityAntalyaTurkey Department of Radiation Oncology Faculty of MedicineSelcuk UniversityKonyaTurkey Radiation Oncology Unit Prof.Dr.Cemil Tascioglu HospitalİstanbulTurkey Department of Radiation Oncology Faculty of MedicineUludag UniversityBursaTurkey Department of Radiation Oncology Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Department of Radiation Oncology Faculty of MedicineBaskent UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAnkara UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineIstanbul University CerrahpasaIstanbulTurkey Radiation Oncology Unit Memorial Sisli HospitalIstanbulTurkey Department of Radiation Oncology Faculty of MedicineCelal Bayar UniversityManisaTurkey Department of Radiation Oncology Acibadem University Maslak HospitalIstanbulTurkey

The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma(CEC)patients who underwent definitive chemoradiotherapy(CRT).The clinical data of 175 biopsyconfirmed CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively *** prognostic factors predicting overall survival(OS),progression-free survival(PFS),and local recurrence-free survival(LRFS)were assessed in uni-and multivariable *** median age of the entire cohort was 56 years(range:26–87 years).All patients received definitive radiotherapy with a median total dose of 60 Gy,and 52%of the patients received cisplatin-based concurrent *** 2-year OS,PFS,and LRFS rates were 58.8%,46.9%,and 52.4%,respectively,with a median follow-up duration of 41.6 ***’performance status,clinical nodal stage,tumor size,and treatment response were significant prognostic factors for OS,PFS,and LRFS in univariate ***-complete treatment response was an independent predictor for poor OS(HR=4.41,95%CI,2.78–7.00,p<0.001)and PFS(HR=4.28,95%CI,2.79–6.58,p<0.001),whereas poor performance score was a predictor for worse LRFS(HR=1.83,95%CI,1.12–2.98,p=0.02)in multivariable ***-two patients(29.7%)experienced grade II or higher *** this multicenter study,we demonstrated that definitive CRT is a safe and effective treatment for patients with *** radiation doses were found to have no effect on treatment outcomes,but a better response to treatment and a better patient performance status did.

关键词： Esophageal cancer Chemoradiotherapy Radiotherapy Local control Toxicity Survival

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Manakov model of coupled NLS equation and its optical soliton solutions

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Journal of Ocean Engineering and Science 2024年第4期9卷 364-372页

作者： esra Unal Yilmaz Farid Samsami Khodad Yesim saglam Ozkan Reza Abazari A.E.Abouelregal Mayssam Tarighi Shaayesteh Hadi Rezazadeh Hijaz Ahmad Department of Mathematics Bolu Abant Izzet Baysal UniversityBoluTurkey Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Department of Mathematics Bursa Uludag UniversityBursaTurkey Department of Mathematics and Applications University of Mohaghegh ArdabiliArdabilIran Department of Mathematics College of Science and ArtsAl-QurayatJouf UniversitySaudi Arabia Basic Sciences Research Unit Jouf UniversitySaudi Arabia Amir Kabir University TehranIran Mathematics in Applied Sciences and Engineering Research Group Scientific Research CenterAl-Ayen UniversityNasiriyah 64001Iraq Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele II39Roma 00186Italy

In the field of maritime transport,motion and energy,the dynamics of deep-sea waves is one of the major problems in ocean science.A mathematical modeling of dynamics of solitary waves in deep sea under the two-layer stratification leads to NLS equation,and consequently,the interaction two of them can be formulated by coupled NLS *** this work,extended auxiliary equation and the exp(−ω(χ))-expansion methods are employed to make the optical solutions of the Manakov model of coupled NLS *** methods used in this paper,in addition to providing the analysis of individual wave solutions,also provide general optical *** previously known solutions can be obtained by some special selections of parameters obtained by solving systems of algebraic *** this stage,it is more practical and convenient to apply methods with a symbolic calculation system.

关键词： Manakov model Extended auxiliary equation method Optical solutions Solitons

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Morphological and Physico-Chemical Characteristics and Classification of Vertisol Developed on Deltaic Plain

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Open Journal of Soil Science 2012年第1期2卷 20-27页

作者： Orhan Dengiz Mustafa saglam F. esra Sarioglu Fikret Saygin Cagla Atasoy Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayis UniversitySamsunTurkey

The name of Vertisol is derived from Latin “vertere” meaning to invert. This case restricts development of soil horizons in profile. These soils have the capacity to swell and shrink, inducing cracks in the upper parts of the soil and distinctive soil structure throughout the soil. The formation of these specific features are caused by a heavy texture, a dominance of swelling clay in the fine fraction and marked changes in moisture content. The swell-shrink behavior is attributed to the wetting and drying of the soil mass. In this study, morphology, physico-chemical characteristics and classification of vertisols that were formed on alluvial delta plains, were investigated. Those soils formed on the Bafra Plain found in the K?z?l?rmak Delta and located in the central Black Sea region of Turkey. All studied Vertisols are characterised by a dark colour in surface soil, a heavy clayey texture, hardpan formation under top soil (high bulk density a high compaction) and very high COLE values. In addition, they have deep wide-opened desiccation cracks at the surface, slickensides at the middle part of the profiles and a poor differentiation of their horizons. Physico-chemically, the studied soils are slightly basic to very basic, non-saline and poor in organic matter, which is slightly higher in the surface horizon. In addition, cation exchange capacity, sum of exchangeable bases and base saturation of soils are very high. On the basis of morphological and physicochemical analysis, soil profiles were classified as Sodic Haplustert, Typic Calciaquert, Sodic Calciustert according to Soil Taxonomy (Soil Survey Staff, 1975 and 1999) and as Sodic Vertisol and Calcic Vertisol according to FAO/ISRIC (2006) classification systems.

关键词： Vertisol Soil Morphology Soil Classification Bafra Delta Plain

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