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Topical Moltkia coerulea hydroethanolic extract accelerates the repair of excision wound in a rat model

Chinese Journal of Traumatology 2016年第2期19卷 97-103页

作者： Mohammad Reza Farahpour Aydin Dilmaghanian Maisam Faridy esmaeil karashi Department of Clinical Sciences Faculty of Veterinary Medicine Urmia Branch Islamic Azad University Urmia Iran Department of Basic Sciences Faculty of Veterinary Medicine University of Tehran Tehran 14155-6453 Iran Faculty of Veterinary Medicine Urmia Branch Islamic Azad University Urmia Iran

Purpose： To evaluate the effect of a hydroethanolic extract of Moltkia coerulea ointment （MCO） on the healing of excision wound in a rat model. Methods： Circular surgical full thickness excision wound, with 314 mm2 size, was induced in the anterior-dorsal side of each rat. Three different doses of MCO （1%, 3% and 6%） were administrated. On Day 3, 7, 14 and 21, the tissue was sampled and immune cells, fibroblasts and fibrocytes distribution per one mm2 of wound area, collagen density and re-epithelialization were analyzed. Moreover, the total flavnoid, phenols and anti-oxidant potential of the MCO were evaluated. Ultimately, the percentage of wound contraction in different groups was compared with each other. Results： Hydroethanolic extract of MCO significantly （p 〈 0.05） increased wound contraction percentage. The animals in medium and high dose MCO-treated groups exhibited remarkably （p 〈 0.05） higher fibroblast and fibrocyte distribution and signifcantly （p 〈 0.05） lower immune cells infiltration. On Day 7 after injury, MCO up-regulated neovascularization in a dose-dependent way. Conclusion： Our data showed that MCO shortened the inflammation phase by provoking the fibroblast proliferation. Moreover, MCO promoted the healing process by up-regulating the angiogenesis and provoking the structural cells proliferation as well as increasing the collagen synthesis, cross-linking, and deposition.

关键词： Moltkia coeruleaExcision wound healingCollagen synthesisAnti-oxidantRats

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