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Performance comparison of training algorithms for the estimation of b?hme abrasion resistance using neural networks

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journal of Mountain Science 2023年第12期20卷 3732-3742页

作者： Ali Can OZDEMIR esma KAHRAMAN Department of Mining Engineering Çukurova UniversityAdana 01250Türkiye

Natural stones used as floor and wall coverings are exposed to many different abrasive forces,so it is essential to choose suitable materials for wear resistance in terms of the life of the *** abrasion resistance of natural stones can be determined in the laboratory by applying the b?hme abrasion resistance(bAR)***,the direct analysis of bAR in the laboratory has disadvantages such as wasting time and energy,experimental errors,and health *** eliminate these disadvantages,the estimation of bAR using artificial neural networks(ANN)was *** natural stone samples were collected from Türkiye,and uniaxial compressive strength(UCS),flexural strength(FS),water absorption rate(WA),unit volume weight(UW),effective porosity(n),and bAR tests were carried *** outputs of these tests were gathered and a data set,consisting of a total of 105 data,was randomly divided into two groups:testing and *** the current study,the success of three different training algorithms of Levenberg-Marquardt(LM),bayesian regularization(bR),and scaled conjugate gradient(SCG)were compared for bAR prediction of natural *** criteria such as coefficient of determination(R~2),mean square error(MSE),mean square error(RMSE),and mean absolute percentage error(MAPE),which are widely used and adopted in the literature,were used to determine predictive *** findings of the study indicated that ANN is a valid method for estimating the bAR ***,the LM algorithm(R~2=0.9999,MSE=0.0001,RMSE=0.0110,and MAPE=0.0487)in training and the bR algorithm(R~2=0.9896,MSE=0.0589,RMSE=0.2427,and MAPE=1.2327)in testing showed the best prediction *** has been observed that the proposed method is quite practical to *** the artificial neural networks method will provide an advantage in similar laborintensive experimental studies.

关键词： böhme abrasion resistance Neural networks Levenberg-Marquardt bayesian regularization Scaled conjugate gradient

Singular solitons and other solutions to a couple of nonlinear wave equations

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Chinese Physics b 2013年第6期22卷 115-121页

作者： Mustafa Inc esma Ulutas Anjan biswas Firat University Department of Mathematics23119 ElazgTürkiye bitlis Eren University Deparment of StatisticBitlis Türkiye Department of Mathematical Sciences Delaware State UniversityDover DE 19901-2277 USA

This paper addresses the extended （G′/G）-expansion method and applies it to a couple of nonlinear wave equations. These equations are modified the benjamin-bona-Mahoney equation and the boussinesq equation. This extended method reveals several solutions to these equations. Additionally, the singular soliton solutions are revealed, for these two equations, with the aid of the ansatz method.

关键词： (G′/G)-expansion method travelling wave solutions singular soliton mbbM and boussinesqequations

Adsorptive stripping voltammetric methods for determination of aripiprazole

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journal of Pharmaceutical Analysis 2012年第3期2卷 193-199页

作者： Derya Asangil brahim Hüdai Tasdemir esma KIlI Ankara University Faculty of ScienceDepartment of Chemistry06100 AnkaraTurkey Amasya University Faculty of Arts and ScienceDepartment of Chemistry05100 AmasyaTurkey

Anodic behavior of aripiprazole(ARP) was studied using electrochemical *** transfer,diffusion and surface coverage coefcients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorp-tion-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in britton-Robinson buffer(bR) on glassy carbon *** methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were *** range is found as from 11.4 μM(5.11 mg/L) to 157 μM(70.41 mg/L) without stripping mode and it is found as from 0.221 μM(0.10 mg/L) to 13.6 μM(6.10 mg/L) with stripping *** of detection(LOD) was found to be 0.11 μM(0.05 mg/L) in stripping *** were successfully applied to assay the drug in tablets,human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%.

关键词： Adsorptive stripping voltammetry Aripiprazole Electrochemical behavior Human serum and urine Pharmaceuticals

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth

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journal of Molecular Cell biology 2018年第3期10卷 195-204页

作者： Rachel Xi-Yeen Ho Rosana D. Meyer Kevin b. Chandler esma Ersoy Michael Park Philip A. bondzie Nima Rahimi Huihong Xu Catherine E. Costello Nader Rahimi Department of Pathology School of Medicine Boston University Medical Campus Boston MA 02118 USA Department of biochemistry and Center for biomedical Mass Spectrometry School of Medicine Boston University Medical Campus Boston MA 02118 USA

Intrinsically disordered proteins （IDPs）/intrinsicaUy unstructured proteins are characterized by the lack of fixed or stable tertiary structure, and are increasingly recognized as an important class of proteins with major roles in signal transduction and transcriptional regulation. In this study, we report the identification and functional characterization of a previously uncharacterized protein （UPFO258/KIAA1024）, major intrinsically disordered Notch2-associated receptor 1 （MINAR1）. While MINAR1 carries a single transmembrane domain and a short cytoplasmic domain, it has a large extraceUular domain that shares no similarity with known protein sequences. Uncharacteristically, MINAR1 is a highly IDP with nearly 70% of its amino acids sequences unstructured. We demonstrate that MINAR1 physically interacts with Notch2 and its binding to Notch2 increases its stability and function. MINAR1 is widely expressed in various tissues including the epithelial cells of the breast and endothelial cells of blood vessels. MINAR1 plays a negative role in angioganesis as it inhibits angioganesis in cell culture and in mouse matrigal plug and zebraflsh anglo- genesis models. Furthermore, while MINAR1 is highly expressed in the normal human breast, its expression is significantly down- regulated in advanced human breast cancer and its re-expression in breast cancer cells inhibited tumor growth. Our study demonstrates that MINAR1 is an IDP that negatively regulates angioganesis and growth of breast cancer cells.

关键词： intrinsically disordered proteins Notch2 angiogenesis breast cancer MINAR1

SNHG8 and its role in Epstein-barr virus-associated gastric cancer:Is NF-κb involved?

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Cancer Pathogenesis and Therapy 2023年第3期1卷 224-226页

作者： esma'il Akade Mohammad bahadoram Mehdi Parsanahad Department of Medical Virology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz***Iran Thalassemia and Hemoglobinopathy Research Center Research Institute of HealthAhvaz Jundishapur University of Medical SciencesAhvaz***Iran

Managing Editor:Peng ***-barr virus(EbV),a member of the Herpesviridae family,is known for its involvement in gastric *** of its relatively high prevalence,The Cancer Genome Atlas classifies EbV-associated gastric cancers(EbVaGCs)as one of the four major molecular subtypes of gastric *** some studies have shown that EbV is present in all the cancerous cells and not in other surrounding mucosal cells,EbV infection is considered to have a causal role in EbVaGCs.1 In recent years,the pathogenic mechanism of EbVaGC has been the subject of intense *** is believed that EbV contributes to gastric cancer through four major mechanisms.

关键词： gastric involvement cancer

The Frequency of Fibromyalgia Syndrome and the Quality of Life in Patients with Peritoneal Dialysis

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Open journal of Rheumatology and Autoimmune Diseases 2012年第4期2卷 88-93页

作者： Muyesser Okumus Hulya Parpucu Seher Kocaoglu esma Ceceli Murat Duranay P?nar borman The Ministry of Health Ankara Training and Research Hospital Clinics of Physical Medicine and Rehabilitation and Clinics of NephrologyAnkaraTurkey

,b>Objective: The aim of this study was to determine the frequency of fibromyalgia (FM) in patients on Peritoneal Dialysis (PD) and to investigate its impact on the quality of life of that population. Methods: A hundred and twenty four patients with end stage renal disease who had undergone PD, and a control group of 54 age and sex-matched healthy volunteers were included to the study. Demographic characteristics including age, sex, disease and dialysis duration were recorded. Fibromyalgia Impact Questionnaire (FIQ) and Nottingham Health Profile (NHP) were also measured. Results: The mean age of the patients (68 female, 56 male) and control subjects (36 female, 18 male) were 43.5 ± 13.4 and 41.2 ± 9.2 years respectively. The prevalence of FM in the PD patients and controls were determined as 9.7% (12 patients) and 11.1% (6 controls) respectively and were found to be similar (p = 0.983). The mean score of sub- groups of NHP except pain and emotion subgroups, were significantly higher in PD patients than in the control group. The mean FIQ levels, the scores of all the subgroups of NHP except the social subgroup were significantly higher in PD patients with FM than in those without FM. Conclusion: In conclusion although the prevalence of FM appears to be similar in PD patients and control subjects, the functional disability is common and quality of life is worse in PD patients with FM than in patients without FM. Detection and treatment of FM may lead to improvement in the quality of life of PD patients with this syndrome.

关键词： Fibromyalgia Dialysis Chronic Kidney Disease Quality of Life

Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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Chinese journal of Cancer Research 2015年第4期27卷 408-416页

作者： Nedim Turan Mustafa benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu esma Turkmen Nalan Akgül babacan Gulnihal Tufan Zuhat Urakci basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem balvan Ercelep burcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli berk Ozan balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman buyukberber Department of Medical Oncology Faculty of Medicine Cumhuriyet University Department of Medical Oncology Faculty of Medicine Gazi University Department of Medical Oncology Faculty of Medicine Dokuz Eylul University Department of Medical Oncology Faculty of Medicine Necmettin Erbakan University Department of Medical Oncology Faculty of Medicine Marmara University Department of Radiation Oncology Faculty of Medicine Gazi University Department of Medical Oncology Numune Education and Research Hospital Department of Medical Oncology Faculty of Medicine Karadeniz Technical University Department of Medical Oncology Faculty of Medicine Trakya University Department of Medical Oncology Rize Education and Research Hospital Department of Medical Oncology Faculty of Medicine Dicle University Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research Hospital Department of Medical Oncology Sakarya Education and Research Hospital Department of Medical Oncology Faculty of Medicine Pamukkale University Department of Medical Oncology Faculty of Medicine Inonu University Department of Medical Oncology Faculty of Medicine Firat University Department of Medical Oncology Dr.Abdurrahman Yurtaslan Education and Research Hospital Department of Medical Oncology Faculty of Medicine Yuzuncu Yil University Department of Medical Oncology Faculty of Medicine Erciyes University Department of Medical Oncology Faculty of Medicine Sutcu Imam University Department of Medical Oncology Diyarbakir Education and Research Hospital Department of Medical Oncology Faculty of Medicine Kocatepe University Department of Medical Oncology Dr.Ersin Arslan State Hospital Department of Medical Oncology Education and Research Hospital Ad?yaman University Department of Medical Oncology Faculty of Medicine Mustafa Kemal University Department of Medical Oncology Faculty of Medicine Ataturk University

background： We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma（PAC）.Methods： A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and ***： Of 563 patients, 472 received adjuvant chemotherapy（CT） alone, chemoradiotherapy（CRT） alone, and chemoradiotherapy plus chemotherapy（CRT-CT） were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival（RFS） and overall survival（OS） were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were ***： Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.

关键词： Pancreatic adenocarcinoma adjuvant chemotherapy(adjuvant CT) adjuvant radiotherapy